JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

Gastroenterology

Volumn 154, Issue 5, 2018, Pages 1480-1493

  Song, Xinxin ^a,b   Zhu, Shan ^a   Xie, Yangchun ^b   Liu, Jiao ^a   Sun, Lingyi ^c   Zeng, Dexing ^c   Wang, Pengcheng ^d   Ma, Xiaochao ^d   Kroemer, Guido ^{e,f,g,h,i,j,k}   Bartlett, David L ^b   Billiar, Timothy R ^b   Lotze, Michael T ^b   Zeh, Herbert J ^b   Kang, Rui ^b   Tang, Daolin ^a,b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f CENTRE DE RECHERCHE DES CORDELIERS   (France)

^g INSERM   (France)

^h SORBONNE UNIVERSITÉ   (France)

ⁱ INSTITUT GUSTAVE ROUSSY   (France)

^j HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^k KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

more..

Author keywords

Drug Development; Pancreas; Targeted Therapy; Tumor Microenvironment

Indexed keywords

ACTIN; CASPASE 3; CASPASE 9; CYCLOHEXIMIDE; G PROTEIN COUPLED RECEPTOR; GEMCITABINE; GLUTATHIONE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K RAS PROTEIN; LAPATINIB; MESSENGER RNA; MIXED LINEAGE KINASE DOMAIN LIKE PSEUDOKINASE; N (4 AMINO 2 METHYL 6 QUINOLINYL) 2 (4 ETHYLPHENOXYMETHYL)BENZAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROTEIN; PROTEIN P53; RECEPTOR INTERACTING SERINE THREONINE KINASE 3; SEQUESTOSOME 1; STAUROSPORINE; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CA9 PROTEIN, HUMAN; CAR9 PROTEIN, MOUSE; CARBONATE DEHYDRATASE IX; N-(4-AMINO-2-METHYLQUINOLIN-6-YL)-2-(4-ETHYLPHENOXYMETHYL)BENZAMIDE; TUMOR ANTIGEN; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CENTRAL NERVOUS SYSTEM CANCER; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; MALE; MELANOMA; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREATIC STELLATE CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TUMOR XENOGRAFT; ADENOCARCINOMA; ANIMAL; C57BL MOUSE; CANCER STEM CELL; CELL DEATH; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HCT 116 CELL LINE; METABOLISM; NUDE MOUSE; PANCREAS TUMOR; PATHOLOGY; PH; SECONDARY; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR MICROENVIRONMENT; TUMOR VOLUME;

ADENOCARCINOMA; AMINOQUINOLINES; ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BENZAMIDES; BIOMARKERS, TUMOR; CARBONIC ANHYDRASE IX; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MICE, INBRED C57BL; MICE, NUDE; NEOPLASTIC STEM CELLS; NF-KAPPA B; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR BURDEN; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85044618366     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2017.12.004     Document Type: Article

References (18)

1. Galluzzi, L., Bravo-San Pedro, J.M., Vitale, I., et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ 22 (2015), 58–73.
2. Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
3. O'Hayre, M., Vazquez-Prado, J., Kufareva, I., et al. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer 13 (2013), 412–424.
4. Pikarsky, E., Porat, R.M., Stein, I., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004), 461–466.
5. Xie, Y., Zhu, S., Zhong, M., et al. Inhibition of aurora kinase A induces necroptosis in pancreatic carcinoma. Gastroenterology 153 (2017), 1429–1443.e5.
6. Noszal, B., Visky, D., Kraszni, M., Population, acid-base, and redox properties of N-acetylcysteine conformers. J Med Chem 43 (2000), 2176–2182.
7. Platzer, G., Okon, M., McIntosh, L.P., pH-dependent random coil (1)H, (13)C, and (15)N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements. J Biomol NMR 60 (2014), 109–129.
8. Yamada, H., Nakamoto, H., Suzuki, Y., et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br J Pharmacol 135 (2002), 323–332.
9. Millan, O., Ballester, A., Castrillo, A., et al. H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis. Oncogene 22 (2003), 477–483.
10. Webb, B.A., Chimenti, M., Jacobson, M.P., et al. Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer 11 (2011), 671–677.
11. Tamai, H., Sawamura, S., Takeda, K., et al. Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation. Eur J Pharmacol 510 (2005), 223–228.
12. Kang, R., Xie, Y., Zhang, Q., et al. Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer. Cell Res 27 (2017), 916–932.
13. Furlong, I.J., Ascaso, R., Lopez Rivas, A., et al. Intracellular acidification induces apoptosis by stimulating ICE-like protease activity. J Cell Sci 110 (1997), 653–661.
14. Wang, Y.Z., Wang, J.J., Huang, Y., et al. Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. Elife, 4, 2015.
15. Nakamura, N., Matsuura, A., Wada, Y., et al. Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae. J Biochem 121 (1997), 338–344.
16. Lawrence, T., The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol, 1, 2009, a001651.
17. Hayden, M.S., Ghosh, S., NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 26 (2012), 203–234.
18. Benej, M., Pastorekova, S., Pastorek, J., Carbonic anhydrase IX: regulation and role in cancer. Subcell Biochem 75 (2014), 199–219.