Erastin disrupts mitochondrial permeability transition pore (mPTP) and induces apoptotic death of colorectal cancer cells

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Huo, Haizhong ^a   Zhou, Zhiyuan ^a   Qin, Jian ^a   Liu, Wenyong ^a   Wang, Bing ^a   Gu, Yan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BONGKREKIC ACID; CASPASE 3; CASPASE 9; CYCLOPHILIN D; CYCLOSPORIN A; ERASTIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; SANGLIFEHRIN A; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 1; CARRIER PROTEIN; PIPERAZINE DERIVATIVE; VDAC1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG TOLERABILITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; TREATMENT OUTCOME; TUMOR XENOGRAFT; VDAC 1 GENE; ANIMAL; CELL PROLIFERATION; COLORECTAL TUMOR; DRUG EFFECTS; DRUG SCREENING; HT-29 CELL LINE; METABOLISM; PATHOLOGY; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; HT29 CELLS; HUMANS; MICE, SCID; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PIPERAZINES; REACTIVE OXYGEN SPECIES; VOLTAGE-DEPENDENT ANION CHANNEL 1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84971328526     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154605     Document Type: Article

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