NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

Molecular Cell

Volumn 68, Issue 1, 2017, Pages 224-232.e4

  Chen, Delin ^a   Tavana, Omid ^a   Chu, Bo ^a   Erber, Luke ^b   Chen, Yue ^b   Baer, Richard ^a   Gu, Wei ^a  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

ARF; ferroptosis; NRF2; oxidative stress; p53; ROS; transcriptional regulation

Indexed keywords

ARF PROTEIN; BINDING PROTEIN; CARRIER PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SLC7A11 PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; AMINO ACID TRANSPORTER; CDKN2A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2C; NFE2L2 PROTEIN, HUMAN; SLC7A11 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; FERROPTOSIS; GENE ACTIVATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REGULATORY MECHANISM; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; BONE TUMOR; CYTOLOGY; EPITHELIUM CELL; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; METABOLISM; NUDE MOUSE; OSTEOBLAST; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; BONE NEOPLASMS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P18; EPITHELIAL CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HETEROGRAFTS; HUMANS; MICE; MICE, NUDE; NF-E2-RELATED FACTOR 2; OSTEOBLASTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85030669999     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.09.009     Document Type: Article

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