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Volumn 77, Issue 8, 2017, Pages 2064-2077

HSPA5 regulates ferroptotic cell death in cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN A5; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; UNCLASSIFIED DRUG; ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC ANTIMETABOLITE; ATF4 PROTEIN, HUMAN; ATF4 PROTEIN, MOUSE; DEOXYCYTIDINE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 4, MOUSE; MOLECULAR CHAPERONE GRP78; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE;

EID: 85018823202     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-16-1979     Document Type: Article
Times cited : (398)

References (43)
  • 2
    • 84958103915 scopus 로고    scopus 로고
    • Ferroptosis: Death by lipid peroxidation
    • Yang WS, Stockwell BR. Ferroptosis: death by lipid peroxidation. Trends Cell Biol 2016;26:165-76.
    • (2016) Trends Cell Biol , vol.26 , pp. 165-176
    • Yang, W.S.1    Stockwell, B.R.2
  • 5
    • 84947786974 scopus 로고    scopus 로고
    • Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis
    • Chen L, Hambright WS, Na R, Ran Q. Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis. J Biol Chem 2015;290: 28097-106.
    • (2015) J Biol Chem , vol.290 , pp. 28097-28106
    • Chen, L.1    Hambright, W.S.2    Na, R.3    Ran, Q.4
  • 8
    • 85024121807 scopus 로고    scopus 로고
    • The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents
    • Yu Y, Xie Y, Cao L, Yang L, Yang M, Lotze MT, et al. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. Mol Cell Oncol 2015;2:e1054549.
    • (2015) Mol Cell Oncol , vol.2 , pp. e1054549
    • Yu, Y.1    Xie, Y.2    Cao, L.3    Yang, L.4    Yang, M.5    Lotze, M.T.6
  • 9
    • 84965000436 scopus 로고    scopus 로고
    • Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
    • Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol 2016;12:497-503.
    • (2016) Nat Chem Biol , vol.12 , pp. 497-503
    • Shimada, K.1    Skouta, R.2    Kaplan, A.3    Yang, W.S.4    Hayano, M.5    Dixon, S.J.6
  • 10
    • 84897036337 scopus 로고    scopus 로고
    • Glucose-regulated proteins in cancer: Molecular mechanisms and therapeutic potential
    • Lee AS.Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer 2014;14:263-76.
    • (2014) Nat Rev Cancer , vol.14 , pp. 263-276
    • Lee, A.S.1
  • 11
    • 84856111924 scopus 로고    scopus 로고
    • The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
    • Hetz C.The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012;13:89-102.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 89-102
    • Hetz, C.1
  • 12
    • 84901323900 scopus 로고    scopus 로고
    • Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis
    • Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife 2014;3:e02523.
    • (2014) Elife , vol.3 , pp. e02523
    • Dixon, S.J.1    Patel, D.N.2    Welsch, M.3    Skouta, R.4    Lee, E.D.5    Hayano, M.6
  • 13
    • 0025183865 scopus 로고
    • Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion
    • Weitzel F, Ursini F, Wendel A. Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion. Biochim Biophys Acta 1990;1036:88-94.
    • (1990) Biochim Biophys Acta , vol.1036 , pp. 88-94
    • Weitzel, F.1    Ursini, F.2    Wendel, A.3
  • 14
    • 0344420108 scopus 로고    scopus 로고
    • Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants
    • Sneddon AA, Wu HC, Farquharson A, Grant I, Arthur JR, Rotondo D, et al. Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. Atherosclerosis 2003;171:57-65.
    • (2003) Atherosclerosis , vol.171 , pp. 57-65
    • Sneddon, A.A.1    Wu, H.C.2    Farquharson, A.3    Grant, I.4    Arthur, J.R.5    Rotondo, D.6
  • 15
    • 79960191503 scopus 로고    scopus 로고
    • Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wildtype selenoenzyme
    • Mannes AM, Seiler A, Bosello V, Maiorino M, Conrad M. Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wildtype selenoenzyme. FASEB J 2011;25:2135-44.
    • (2011) FASEB J , vol.25 , pp. 2135-2144
    • Mannes, A.M.1    Seiler, A.2    Bosello, V.3    Maiorino, M.4    Conrad, M.5
  • 16
    • 0037932865 scopus 로고    scopus 로고
    • Identification of genotypeselective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
    • Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotypeselective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003;3:285-96.
    • (2003) Cancer Cell , vol.3 , pp. 285-296
    • Dolma, S.1    Lessnick, S.L.2    Hahn, W.C.3    Stockwell, B.R.4
  • 17
    • 84947035915 scopus 로고    scopus 로고
    • HSPB1 as a novel regulator of ferroptotic cancer cell death
    • Sun X,OuZ, Xie M, Kang R, Fan Y, Niu X, et al.HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene 2015;34:5617-25.
    • (2015) Oncogene , vol.34 , pp. 5617-5625
    • Sun, X.1    Ou, Z.2    Xie, M.3    Kang, R.4    Fan, Y.5    Niu, X.6
  • 18
    • 18944390015 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induction of the Grp78/BiP promoter: Activatingmechanisms mediated by YY1 and its interactive chromatin modifiers
    • Baumeister P, Luo S, Skarnes WC, Sui G, Seto E, Shi Y, et al. Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activatingmechanisms mediated by YY1 and its interactive chromatin modifiers. Mol Cell Biol 2005;25:4529-40.
    • (2005) Mol Cell Biol , vol.25 , pp. 4529-4540
    • Baumeister, P.1    Luo, S.2    Skarnes, W.C.3    Sui, G.4    Seto, E.5    Shi, Y.6
  • 19
    • 20444433944 scopus 로고    scopus 로고
    • Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: Role of TFII-I and its tyrosine phosphorylation
    • Hong M, Lin MY, Huang JM, Baumeister P, Hakre S, Roy AL, et al. Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation. J Biol Chem 2005;280:16821-8.
    • (2005) J Biol Chem , vol.280 , pp. 16821-16828
    • Hong, M.1    Lin, M.Y.2    Huang, J.M.3    Baumeister, P.4    Hakre, S.5    Roy, A.L.6
  • 20
    • 0141621215 scopus 로고    scopus 로고
    • Induction of Grp78/BiP by translational block: Activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
    • Luo S, Baumeister P, Yang S, Abcouwer SF, Lee AS. Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem 2003;278:37375-85.
    • (2003) J Biol Chem , vol.278 , pp. 37375-37385
    • Luo, S.1    Baumeister, P.2    Yang, S.3    Abcouwer, S.F.4    Lee, A.S.5
  • 21
    • 0034282912 scopus 로고    scopus 로고
    • Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
    • Wang Y, Shen J, Arenzana N, Tirasophon W, Kaufman RJ, Prywes R. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem 2000;275:27013-20.
    • (2000) J Biol Chem , vol.275 , pp. 27013-27020
    • Wang, Y.1    Shen, J.2    Arenzana, N.3    Tirasophon, W.4    Kaufman, R.J.5    Prywes, R.6
  • 22
    • 34547746722 scopus 로고    scopus 로고
    • Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)
    • Scheerer P, Borchert A, Krauss N, Wessner H, Gerth C, Hohne W, et al. Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4). Biochemistry 2007;46:9041-9.
    • (2007) Biochemistry , vol.46 , pp. 9041-9049
    • Scheerer, P.1    Borchert, A.2    Krauss, N.3    Wessner, H.4    Gerth, C.5    Hohne, W.6
  • 23
    • 33749460895 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78
    • Ermakova SP, Kang BS, Choi BY, Choi HS, Schuster TF, Ma WY, et al. (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res 2006;66:9260-9.
    • (2006) Cancer Res , vol.66 , pp. 9260-9269
    • Ermakova, S.P.1    Kang, B.S.2    Choi, B.Y.3    Choi, H.S.4    Schuster, T.F.5    Ma, W.Y.6
  • 24
    • 84901917562 scopus 로고    scopus 로고
    • Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
    • Ayala A, Munoz MF, Arguelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014;2014:360438.
    • (2014) Oxid Med Cell Longev , vol.2014 , pp. 360438
    • Ayala, A.1    Munoz, M.F.2    Arguelles, S.3
  • 25
    • 84954379174 scopus 로고    scopus 로고
    • Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
    • Hayano M, Yang WS, Corn CK, Pagano NC, Stockwell BR. Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. Cell Death Differ 2016;23:270-8.
    • (2016) Cell Death Differ , vol.23 , pp. 270-278
    • Hayano, M.1    Yang, W.S.2    Corn, C.K.3    Pagano, N.C.4    Stockwell, B.R.5
  • 26
    • 84926387317 scopus 로고    scopus 로고
    • Ferroptosis as a p53-mediated activity during tumour suppression
    • Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature 2015;520: 57-62.
    • (2015) Nature , vol.520 , pp. 57-62
    • Jiang, L.1    Kon, N.2    Li, T.3    Wang, S.J.4    Su, T.5    Hibshoosh, H.6
  • 27
    • 84952639010 scopus 로고    scopus 로고
    • Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
    • Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 2016;63:173-84.
    • (2016) Hepatology , vol.63 , pp. 173-184
    • Sun, X.1    Ou, Z.2    Chen, R.3    Niu, X.4    Chen, D.5    Kang, R.6
  • 28
    • 84978997718 scopus 로고    scopus 로고
    • Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis
    • Sun X, Niu X, Chen R, He W, Chen Kang R, et al. Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis. Hepatology 2016;64:488-500.
    • (2016) Hepatology , vol.64 , pp. 488-500
    • Sun, X.1    Niu, X.2    Chen, R.3    He, W.4    Chen Kang, R.5
  • 30
    • 84994182403 scopus 로고    scopus 로고
    • Identification of ACSL4 as a biomarker and contributor of ferroptosis
    • Yuan H, Li X, Zhang X, Kang R, Tang D. Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem Biophys Res Commun 2016;478:1338-43.
    • (2016) Biochem Biophys Res Commun , vol.478 , pp. 1338-1343
    • Yuan, H.1    Li, X.2    Zhang, X.3    Kang, R.4    Tang, D.5
  • 31
  • 32
    • 84899883801 scopus 로고    scopus 로고
    • GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure
    • Suyama K, Watanabe M, Sakabe K, Otomo A, Okada Y, Terayama H, et al. GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure. PLoS ONE 2014;9:e86951.
    • (2014) PLoS ONE , vol.9 , pp. e86951
    • Suyama, K.1    Watanabe, M.2    Sakabe, K.3    Otomo, A.4    Okada, Y.5    Terayama, H.6
  • 33
    • 84859494099 scopus 로고    scopus 로고
    • Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress
    • Vladykovskaya E, Sithu SD, Haberzettl P, Wickramasinghe NS, Merchant ML, Hill BG, et al. Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem 2012;287:11398-409.
    • (2012) J Biol Chem , vol.287 , pp. 11398-11409
    • Vladykovskaya, E.1    Sithu, S.D.2    Haberzettl, P.3    Wickramasinghe, N.S.4    Merchant, M.L.5    Hill, B.G.6
  • 34
    • 20144378800 scopus 로고    scopus 로고
    • The oxidative stressor arsenite activates vascular endothelial growth factor mRNAtranscription by an ATF4-dependent mechanism
    • Roybal CN, Hunsaker LA, Barbash O, Vander Jagt DL, Abcouwer SF. The oxidative stressor arsenite activates vascular endothelial growth factor mRNAtranscription by an ATF4-dependent mechanism. J BiolChem2005; 280:20331-9.
    • (2005) J BiolChem , vol.280 , pp. 20331-20339
    • Roybal, C.N.1    Hunsaker, L.A.2    Barbash, O.3    Vander Jagt, D.L.4    Abcouwer, S.F.5
  • 35
    • 0037353039 scopus 로고    scopus 로고
    • An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
    • Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003;11:619-33.
    • (2003) Mol Cell , vol.11 , pp. 619-633
    • Harding, H.P.1    Zhang, Y.2    Zeng, H.3    Novoa, I.4    Lu, P.D.5    Calfon, M.6
  • 36
    • 33748789479 scopus 로고    scopus 로고
    • Mediators of endoplasmic reticulum stress-induced apoptosis
    • Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006;7:880-5.
    • (2006) EMBO Rep , vol.7 , pp. 880-885
    • Szegezdi, E.1    Logue, S.E.2    Gorman, A.M.3    Samali, A.4
  • 37
    • 0037438730 scopus 로고    scopus 로고
    • Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells
    • Imai H, Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic Biol Med 2003;34:145-69.
    • (2003) Free Radic Biol Med , vol.34 , pp. 145-169
    • Imai, H.1    Nakagawa, Y.2
  • 38
    • 33746500168 scopus 로고    scopus 로고
    • GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development
    • Luo S, Mao C, Lee B, Lee AS. GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol 2006;26:5688-97.
    • (2006) Mol Cell Biol , vol.26 , pp. 5688-5697
    • Luo, S.1    Mao, C.2    Lee, B.3    Lee, A.S.4
  • 39
    • 0037441379 scopus 로고    scopus 로고
    • The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults
    • Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, et al. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med 2003; 34:496-502.
    • (2003) Free Radic Biol Med , vol.34 , pp. 496-502
    • Yant, L.J.1    Ran, Q.2    Rao, L.3    Van Remmen, H.4    Shibatani, T.5    Belter, J.G.6
  • 40
    • 84946222789 scopus 로고    scopus 로고
    • Elevated GRP78 expression is associated with poor prognosis in patientswith pancreatic cancer
    • Niu Z, Wang M, Zhou L, Yao L, Liao Q, Zhao Y. Elevated GRP78 expression is associated with poor prognosis in patientswith pancreatic cancer. Sci Rep 2015;5:16067.
    • (2015) Sci Rep , vol.5 , pp. 16067
    • Niu, Z.1    Wang, M.2    Zhou, L.3    Yao, L.4    Liao, Q.5    Zhao, Y.6
  • 41
    • 48349114983 scopus 로고    scopus 로고
    • The xc-cystine/glutamate antiporter: A mediator of pancreatic cancer growth with a role in drug resistance
    • Lo M, Ling V, Wang YZ, Gout PW. The xc-cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance. Br J Cancer 2008;99:464-72.
    • (2008) Br J Cancer , vol.99 , pp. 464-472
    • Lo, M.1    Ling, V.2    Wang, Y.Z.3    Gout, P.W.4
  • 42
    • 24344457766 scopus 로고    scopus 로고
    • Sulfasalazine: A reviewof its use in the management of rheumatoid arthritis
    • PloskerGL, Croom KF. Sulfasalazine: a reviewof its use in the management of rheumatoid arthritis. Drugs 2005;65:1825-49.
    • (2005) Drugs , vol.65 , pp. 1825-1849
    • Plosker, G.L.1    Croom, K.F.2
  • 43
    • 84937525519 scopus 로고    scopus 로고
    • Glutaminolysis and transferrin regulate ferroptosis
    • Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and transferrin regulate ferroptosis. Mol Cell 2015;59:298-308.
    • (2015) Mol Cell , vol.59 , pp. 298-308
    • Gao, M.1    Monian, P.2    Quadri, N.3    Ramasamy, R.4    Jiang, X.5


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