메뉴 건너뛰기




Volumn 212, Issue 4, 2015, Pages 555-568

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; MEMBRANE LIPID; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; VITAMIN;

EID: 84928238774     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20140857     Document Type: Article
Times cited : (493)

References (55)
  • 2
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: signaling and modulation
    • Ashkenazi, A., and V.M. Dixit. 1998. Death receptors: signaling and modulation. Science. 281:1305-1308. http://dx.doi.org/10.1126/science.281.5381.1305
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 3
    • 0037448076 scopus 로고    scopus 로고
    • Coxsackievirus B3-resistant mice become susceptible in Se/vitamin E deficiency
    • Beck, M.A., D. Williams-Toone, and O.A. Levander. 2003. Coxsackievirus B3-resistant mice become susceptible in Se/vitamin E deficiency. Free Radic. Biol. Med. 34:1263-1270. http://dx.doi.org/10.1016/S0891-5849(03)00101-1
    • (2003) Free Radic. Biol. Med. , vol.34 , pp. 1263-1270
    • Beck, M.A.1    Williams-Toone, D.2    Levander, O.A.3
  • 4
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature. 414:813-820. http://dx.doi.org/10.1038/414813a
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 5
    • 77955475969 scopus 로고    scopus 로고
    • Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
    • Carr, E.L., A. Kelman, G.S. Wu, R. Gopaul, E. Senkevitch, A. Aghvanyan, A.M. Turay, and K.A. Frauwirth. 2010. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J. Immunol. 185:1037-1044. http://dx.doi.org/10.4049/jimmunol.0903586
    • (2010) J. Immunol. , vol.185 , pp. 1037-1044
    • Carr, E.L.1    Kelman, A.2    Wu, G.S.3    Gopaul, R.4    Senkevitch, E.5    Aghvanyan, A.6    Turay, A.M.7    Frauwirth, K.A.8
  • 7
    • 66449133280 scopus 로고    scopus 로고
    • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    • Cho, Y.S., S. Challa, D. Moquin, R. Genga, T.D. Ray, M. Guildford, and F.K.-M. Chan. 2009. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell. 137:1112-1123. http://dx.doi.org/10.1016/j.cell.2009.05.037
    • (2009) Cell , vol.137 , pp. 1112-1123
    • Cho, Y.S.1    Challa, S.2    Moquin, D.3    Genga, R.4    Ray, T.D.5    Guildford, M.6    Chan, F.K.-M.7
  • 9
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules:mechanisms that generate specificity in ROS homeostasis
    • D'Autréaux, B., and M.B. Toledano. 2007. ROS as signalling molecules:mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell Biol. 8:813-824. http://dx.doi.org/10.1038/nrm2256
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 813-824
    • D'Autréaux, B.1    Toledano, M.B.2
  • 10
    • 67650638892 scopus 로고    scopus 로고
    • RIP kinases at the crossroads of cell death and survival
    • Declercq, W., T. Vanden Berghe, and P. Vandenabeele. 2009. RIP kinases at the crossroads of cell death and survival. Cell. 138:229-232. http://dx.doi.org/10.1016/j.cell.2009.07.006
    • (2009) Cell , vol.138 , pp. 229-232
    • Declercq, W.1    Vanden Berghe, T.2    Vandenabeele, P.3
  • 12
    • 0037033433 scopus 로고    scopus 로고
    • Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression
    • Devadas, S., L. Zaritskaya, S.G. Rhee, L. Oberley, and M.S. Williams. 2002. Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J. Exp. Med. 195:59-70. http://dx.doi.org/10.1084/jem.20010659
    • (2002) J. Exp. Med. , vol.195 , pp. 59-70
    • Devadas, S.1    Zaritskaya, L.2    Rhee, S.G.3    Oberley, L.4    Williams, M.S.5
  • 15
    • 50049086939 scopus 로고    scopus 로고
    • Comparison between the effects of normoxia and hypoxia on antioxidant enzymes and glutathione redox state in ex vivo culture of CD34(+) cells
    • Fan, J., H. Cai, S. Yang, L. Yan, and W. Tan. 2008. Comparison between the effects of normoxia and hypoxia on antioxidant enzymes and glutathione redox state in ex vivo culture of CD34(+) cells. Comp. Biochem. Physiol. 151:153-158. http://dx.doi.org/10.1016/j.cbpb.2008.06.008
    • (2008) Comp. Biochem. Physiol. , vol.151 , pp. 153-158
    • Fan, J.1    Cai, H.2    Yang, S.3    Yan, L.4    Tan, W.5
  • 16
    • 79960286223 scopus 로고    scopus 로고
    • Signal transduction by reactive oxygen species
    • Finkel, T. 2011. Signal transduction by reactive oxygen species. J. Cell Biol. 194:7-15. http://dx.doi.org/10.1083/jcb.201102095
    • (2011) J. Cell Biol. , vol.194 , pp. 7-15
    • Finkel, T.1
  • 17
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis (*)
    • Galkina, E., and K. Ley. 2009. Immune and inflammatory mechanisms of atherosclerosis (*). Annu. Rev. Immunol. 27:165-197. http://dx.doi.org/10.1146/annurev.immunol.021908.132620
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 165-197
    • Galkina, E.1    Ley, K.2
  • 18
    • 34548817270 scopus 로고    scopus 로고
    • Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues
    • Hameyer, D., A. Loonstra, L. Eshkind, S. Schmitt, C. Antunes, A. Groen, E. Bindels, J. Jonkers, P. Krimpenfort, R. Meuwissen, et al. 2007. Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues. Physiol. Genomics. 31:32-41. http://dx.doi.org/10.1152/physiolgenomics.00019.2007
    • (2007) Physiol. Genomics , vol.31 , pp. 32-41
    • Hameyer, D.1    Loonstra, A.2    Eshkind, L.3    Schmitt, S.4    Antunes, C.5    Groen, A.6    Bindels, E.7    Jonkers, J.8    Krimpenfort, P.9    Meuwissen, R.10
  • 19
    • 4444221709 scopus 로고    scopus 로고
    • T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
    • Jackson, S.H., S. Devadas, J. Kwon, L.A. Pinto, and M.S. Williams. 2004. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat. Immunol. 5:818-827. http://dx.doi.org/10.1038/ni1096
    • (2004) Nat. Immunol. , vol.5 , pp. 818-827
    • Jackson, S.H.1    Devadas, S.2    Kwon, J.3    Pinto, L.A.4    Williams, M.S.5
  • 20
    • 34548617735 scopus 로고    scopus 로고
    • Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
    • Lambert, A.J., H.M. Boysen, J.A. Buckingham, T. Yang, A. Podlutsky, S.N. Austad, T.H. Kunz, R. Buffenstein, and M.D. Brand. 2007. Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell. 6:607-618. http://dx.doi.org/10.1111/j.1474-9726.2007.00312.x
    • (2007) Aging Cell , vol.6 , pp. 607-618
    • Lambert, A.J.1    Boysen, H.M.2    Buckingham, J.A.3    Yang, T.4    Podlutsky, A.5    Austad, S.N.6    Kunz, T.H.7    Buffenstein, R.8    Brand, M.D.9
  • 22
    • 33750926794 scopus 로고    scopus 로고
    • Role of Nox family NADPH oxidases in host defense
    • Leto, T.L., and M. Geiszt. 2006. Role of Nox family NADPH oxidases in host defense. Antioxid. Redox Signal. 8:1549-1561. http://dx.doi.org/10.1089/ars.2006.8.1549
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 1549-1561
    • Leto, T.L.1    Geiszt, M.2
  • 24
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin, M.T., and M.F. Beal. 2006. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 443:787-795. http://dx.doi.org/10.1038/nature05292
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 25
    • 0029164695 scopus 로고
    • IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase
    • Los, M., H. Schenk, K. Hexel, P.A. Baeuerle, W. Dröge, and K. Schulze-Osthoff. 1995. IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. EMBO J. 14:3731-3740.
    • (1995) EMBO J. , vol.14 , pp. 3731-3740
    • Los, M.1    Schenk, H.2    Hexel, K.3    Baeuerle, P.A.4    Dröge, W.5    Schulze-Osthoff, K.6
  • 26
    • 84875494365 scopus 로고    scopus 로고
    • Metabolic regulation of T lymphocytes
    • MacIver, N.J., R.D. Michalek, and J.C. Rathmell. 2013. Metabolic regulation of T lymphocytes. Annu. Rev. Immunol. 31:259-283. http://dx.doi.org/10.1146/annurev-immunol-032712-095956
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 259-283
    • MacIver, N.J.1    Michalek, R.D.2    Rathmell, J.C.3
  • 27
    • 18144452679 scopus 로고    scopus 로고
    • Oxy radicals, lipid peroxidation and DNA damage
    • Marnett, L.J. 2002. Oxy radicals, lipid peroxidation and DNA damage. Toxicology. 181-182:219-222. http://dx.doi.org/10.1016/S0300-483X(02)00448-1
    • (2002) Toxicology , vol.181-182 , pp. 219-222
    • Marnett, L.J.1
  • 28
    • 78751700887 scopus 로고    scopus 로고
    • Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress
    • Mougiakakos, D., C.C. Johansson, R. Jitschin, M. Böttcher, and R. Kiessling. 2011. Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress. Blood. 117:857-861. http://dx.doi.org/10.1182/blood-2010-09-307041
    • (2011) Blood , vol.117 , pp. 857-861
    • Mougiakakos, D.1    Johansson, C.C.2    Jitschin, R.3    Böttcher, M.4    Kiessling, R.5
  • 29
    • 0031729039 scopus 로고    scopus 로고
    • Vitamin E and selenium deficiency induces expression of the ubiquinone-dependent antioxidant system at the plasma membrane
    • Navarro, F., P. Navas, J.R. Burgess, R.I. Bello, R. De Cabo, A. Arroyo, and J.M. Villalba. 1998. Vitamin E and selenium deficiency induces expression of the ubiquinone-dependent antioxidant system at the plasma membrane. FASEB J. 12:1665-1673.
    • (1998) FASEB J. , vol.12 , pp. 1665-1673
    • Navarro, F.1    Navas, P.2    Burgess, J.R.3    Bello, R.I.4    De Cabo, R.5    Arroyo, A.6    Villalba, J.M.7
  • 30
    • 0842304221 scopus 로고    scopus 로고
    • Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4
    • Newton, K., X. Sun, and V.M. Dixit. 2004. Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol. Cell. Biol. 24:1464-1469. http://dx.doi.org/10.1128/MCB.24.4.1464-1469.2004
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1464-1469
    • Newton, K.1    Sun, X.2    Dixit, V.M.3
  • 31
    • 0021984463 scopus 로고
    • Oxidation of lipids. VIII. Synergistic inhibition of oxidation of phosphatidylcholine liposome in aqueous dispersion by vitamin E and vitamin C
    • Niki, E., A. Kawakami, Y. Yamamoto, and Y. Kamiya. 1985. Oxidation of lipids. VIII. Synergistic inhibition of oxidation of phosphatidylcholine liposome in aqueous dispersion by vitamin E and vitamin C. Bull. Chem. Soc. Jpn. 58:1971-1975. http://dx.doi.org/10.1246/bcsj.58.1971
    • (1985) Bull. Chem. Soc. Jpn. , vol.58 , pp. 1971-1975
    • Niki, E.1    Kawakami, A.2    Yamamoto, Y.3    Kamiya, Y.4
  • 32
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce, E.L., and E.J. Pearce. 2013. Metabolic pathways in immune cell activation and quiescence. Immunity. 38:633-643. http://dx.doi.org/10.1016/j.immuni.2013.04.005
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 33
    • 0024307348 scopus 로고
    • Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    • Pircher, H., K. Bürki, R. Lang, H. Hengartner, and R.M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature. 342:559-561. http://dx.doi.org/10.1038/342559a0
    • (1989) Nature , vol.342 , pp. 559-561
    • Pircher, H.1    Bürki, K.2    Lang, R.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 34
    • 0030986358 scopus 로고    scopus 로고
    • A critical role for neutralizing-antibodyproducing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers
    • Planz, O., S. Ehl, E. Furrer, E. Horvath, M.A. Bründler, H. Hengartner, and R.M. Zinkernagel. 1997. A critical role for neutralizing-antibodyproducing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers. Proc. Natl. Acad. Sci. USA. 94:6874-6879. http://dx.doi.org/10.1073/pnas.94.13.6874
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6874-6879
    • Planz, O.1    Ehl, S.2    Furrer, E.3    Horvath, E.4    Bründler, M.A.5    Hengartner, H.6    Zinkernagel, R.M.7
  • 35
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • Ray, P.D., B.-W. Huang, and Y. Tsuji. 2012. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell. Signal. 24:981-990. http://dx.doi.org/10.1016/j.cellsig.2012.01.008
    • (2012) Cell. Signal. , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.-W.2    Tsuji, Y.3
  • 36
    • 0030849637 scopus 로고    scopus 로고
    • Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses
    • Rooke, R., C. Waltzinger, C. Benoist, and D. Mathis. 1997. Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity. 7:123-134. http://dx.doi.org/10.1016/S1074-7613(00)80515-4
    • (1997) Immunity , vol.7 , pp. 123-134
    • Rooke, R.1    Waltzinger, C.2    Benoist, C.3    Mathis, D.4
  • 37
    • 0028287639 scopus 로고
    • Reduction of HDL-and LDL-associated cholesterylester and phospholipid hydroperoxides by phospholipid hydroperoxide glutathione peroxidase and Ebselen (PZ 51)
    • Sattler, W., M. Maiorino, and R. Stocker. 1994. Reduction of HDL-and LDL-associated cholesterylester and phospholipid hydroperoxides by phospholipid hydroperoxide glutathione peroxidase and Ebselen (PZ 51). Arch. Biochem. Biophys. 309:214-221. http://dx.doi.org/10.1006/abbi.1994.1105
    • (1994) Arch. Biochem. Biophys. , vol.309 , pp. 214-221
    • Sattler, W.1    Maiorino, M.2    Stocker, R.3
  • 39
    • 50049133588 scopus 로고    scopus 로고
    • Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death
    • Seiler, A., M. Schneider, H. Förster, S. Roth, E.K. Wirth, C. Culmsee, N. Plesnila, E. Kremmer, O. Rådmark, W. Wurst, et al. 2008. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death. Cell Metab. 8:237-248. http://dx.doi.org/10.1016/j.cmet.2008.07.005
    • (2008) Cell Metab. , vol.8 , pp. 237-248
    • Seiler, A.1    Schneider, M.2    Förster, H.3    Roth, S.4    Wirth, E.K.5    Culmsee, C.6    Plesnila, N.7    Kremmer, E.8    Rådmark, O.9    Wurst, W.10
  • 40
    • 0033451199 scopus 로고    scopus 로고
    • Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
    • Selin, L.K., M.Y. Lin, K.A. Kraemer, D.M. Pardoll, J.P. Schneck, S.M. Varga, P.A. Santolucito, A.K. Pinto, and R.M. Welsh. 1999. Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. Immunity. 11:733-742. http://dx.doi.org/10.1016/S1074-7613(00)80147-8
    • (1999) Immunity , vol.11 , pp. 733-742
    • Selin, L.K.1    Lin, M.Y.2    Kraemer, K.A.3    Pardoll, D.M.4    Schneck, J.P.5    Varga, S.M.6    Santolucito, P.A.7    Pinto, A.K.8    Welsh, R.M.9
  • 43
    • 0029844659 scopus 로고    scopus 로고
    • Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein
    • Sun, D., and C.D. Funk. 1996. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J. Biol. Chem. 271:24055-24062. http://dx.doi.org/10.1074/jbc.271.39.24055
    • (1996) J. Biol. Chem. , vol.271 , pp. 24055-24062
    • Sun, D.1    Funk, C.D.2
  • 44
    • 0030873556 scopus 로고    scopus 로고
    • Differential requirements for survival and proliferation of CD8 naïve or memory T cells
    • Tanchot, C., F.A. Lemonnier, B. Pérarnau, A.A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science. 276:2057-2062. http://dx.doi.org/10.1126/science.276.5321.2057
    • (1997) Science , vol.276 , pp. 2057-2062
    • Tanchot, C.1    Lemonnier, F.A.2    Pérarnau, B.3    Freitas, A.A.4    Rocha, B.5
  • 45
    • 0015436711 scopus 로고
    • Vitamin E and free radical peroxidation of lipids
    • Tappel, A.L. 1972. Vitamin E and free radical peroxidation of lipids. Ann. N. Y. Acad. Sci. 203:12-28. http://dx.doi.org/10.1111/j.1749-6632.1972.tb27851.x
    • (1972) Ann. N. Y. Acad. Sci. , vol.203 , pp. 12-28
    • Tappel, A.L.1
  • 46
    • 0025060737 scopus 로고
    • Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides
    • Thomas, J.P., M. Maiorino, F. Ursini, and A.W. Girotti. 1990. Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. J. Biol. Chem. 265:454-461.
    • (1990) J. Biol. Chem. , vol.265 , pp. 454-461
    • Thomas, J.P.1    Maiorino, M.2    Ursini, F.3    Girotti, A.W.4
  • 47
    • 0028900690 scopus 로고
    • Persistent oxidative stress in cancer
    • Toyokuni, S., K. Okamoto, J. Yodoi, and H. Hiai. 1995. Persistent oxidative stress in cancer. FEBS Lett. 358:1-3. http://dx.doi.org/10.1016/0014-5793(94)01368-B
    • (1995) FEBS Lett. , vol.358 , pp. 1-3
    • Toyokuni, S.1    Okamoto, K.2    Yodoi, J.3    Hiai, H.4
  • 50
    • 84866562625 scopus 로고    scopus 로고
    • Metabolic checkpoints in activated T cells
    • Wang, R., and D.R. Green. 2012. Metabolic checkpoints in activated T cells. Nat. Immunol. 13:907-915. http://dx.doi.org/10.1038/ni.2386
    • (2012) Nat. Immunol. , vol.13 , pp. 907-915
    • Wang, R.1    Green, D.R.2
  • 51
    • 42249088093 scopus 로고    scopus 로고
    • Reconciling the chemistry and biology of reactive oxygen species
    • Winterbourn, C.C. 2008. Reconciling the chemistry and biology of reactive oxygen species. Nat. Chem. Biol. 4:278-286. http://dx.doi.org/10.1038/nchembio.85
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 278-286
    • Winterbourn, C.C.1
  • 54
    • 0037441379 scopus 로고    scopus 로고
    • The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults
    • Yant, L.J., Q. Ran, L. Rao, H. Van Remmen, T. Shibatani, J.G. Belter, L. Motta, A. Richardson, and T.A. Prolla. 2003. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic. Biol. Med. 34:496-502. http://dx.doi.org/10.1016/S0891-5849(02)01360-6
    • (2003) Free Radic. Biol. Med. , vol.34 , pp. 496-502
    • Yant, L.J.1    Ran, Q.2    Rao, L.3    Van Remmen, H.4    Shibatani, T.5    Belter, J.G.6    Motta, L.7    Richardson, A.8    Prolla, T.A.9
  • 55
    • 33745812415 scopus 로고    scopus 로고
    • Electron transport complex I is required for CD8+ T cell function
    • Yi, J.S., B.C. Holbrook, R.D. Michalek, N.G. Laniewski, and J.M. Grayson. 2006. Electron transport complex I is required for CD8+ T cell function. J. Immunol. 177:852-862. http://dx.doi.org/10.4049/jimmunol.177.2.852
    • (2006) J. Immunol. , vol.177 , pp. 852-862
    • Yi, J.S.1    Holbrook, B.C.2    Michalek, R.D.3    Laniewski, N.G.4    Grayson, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.