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Volumn 8, Issue AUG, 2018, Pages

Plasticity of type I interferon-mediated responses in cancer therapy: From anti-tumor immunity to resistance

Author keywords

Cancer immunotherapy; Immune responses; Interferons; Resistance mechanisms; Tumor microenvironment

Indexed keywords

IMMUNOLOGICAL ANTINEOPLASTIC AGENT; INTERFERON; INTERFERON RECEPTOR; JANUS KINASE; MICRORNA; ONCOLYTIC VIRUS; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING;

EID: 85051851989     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2018.00322     Document Type: Review
Times cited : (139)

References (149)
  • 1
    • 85040827444 scopus 로고    scopus 로고
    • Tumour heterogeneity and resistance to cancer therapies
    • Dagogo-Jack I, Shaw AT. Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol. (2017) 15:81-94. doi: 10.1038/nrclinonc.2017.166
    • (2017) Nat Rev Clin Oncol , vol.15 , pp. 81-94
    • Dagogo-Jack, I.1    Shaw, A.T.2
  • 2
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: impact, heterogeneity, and uncertainty
    • Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 21:283-96. doi: 10.1016/j.ccr.2012.03.003
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 3
    • 33750321707 scopus 로고    scopus 로고
    • Interferons, immunity and cancer immunoediting
    • Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol. (2006) 6:836. doi: 10.1038/nri1961
    • (2006) Nat Rev Immunol , vol.6 , pp. 836
    • Dunn, G.P.1    Koebel, C.M.2    Schreiber, R.D.3
  • 5
    • 84959531327 scopus 로고    scopus 로고
    • Antitumour actions of interferons: implications for cancer therapy
    • Parker BS, Rautela J, Hertzog PJ. Antitumour actions of interferons: implications for cancer therapy. Nat Rev Cancer (2016) 16:131. doi: 10.1038/nrc.2016.14
    • (2016) Nat Rev Cancer , vol.16 , pp. 131
    • Parker, B.S.1    Rautela, J.2    Hertzog, P.J.3
  • 7
    • 77951496704 scopus 로고    scopus 로고
    • Interferon-a as angiogenesis inhibitor: learning from tumor models
    • Indraccolo S. Interferon-a as angiogenesis inhibitor: learning from tumor models. Autoimmunity (2010) 43:244-7. doi: 10.3109/08916930903510963
    • (2010) Autoimmunity , vol.43 , pp. 244-247
    • Indraccolo, S.1
  • 8
    • 85019977333 scopus 로고    scopus 로고
    • Type I interferon in chronic virus infection and cancer
    • Snell LM, McGaha TL, Brooks DG. Type I interferon in chronic virus infection and cancer. Trends Immunol. (2017) 38:542-57. doi: 10.1016/j.it.2017.05.005
    • (2017) Trends Immunol , vol.38 , pp. 542-557
    • Snell, L.M.1    McGaha, T.L.2    Brooks, D.G.3
  • 9
    • 85030226954 scopus 로고    scopus 로고
    • Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy
    • Medrano RF, Hunger A, Mendonça SA, Barbuto JAM, Strauss BE. Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy. Oncotarget (2017) 8:71249. doi: 10.18632/oncotarget.19531
    • (2017) Oncotarget , vol.8 , pp. 71249
    • Medrano, R.F.1    Hunger, A.2    Mendonça, S.A.3    Barbuto, J.A.M.4    Strauss, B.E.5
  • 10
    • 85015800274 scopus 로고    scopus 로고
    • Regulation of type I interferon signaling in immunity and inflammation: a comprehensive review
    • Chen K, Liu J, Cao X. Regulation of type I interferon signaling in immunity and inflammation: a comprehensive review. J Autoimmun. (2017) 83:1-11. doi: 10.1016/j.jaut.2017.03.008
    • (2017) J Autoimmun , vol.83 , pp. 1-11
    • Chen, K.1    Liu, J.2    Cao, X.3
  • 12
    • 84881235615 scopus 로고    scopus 로고
    • Fine tuning type I interferon responses
    • Hertzog PJ, Williams BR. Fine tuning type I interferon responses. Cytokine Growth Factor Rev. (2013) 24:217-25. doi: 10.1016/j.cytogfr.2013.04.002
    • (2013) Cytokine Growth Factor Rev , vol.24 , pp. 217-225
    • Hertzog, P.J.1    Williams, B.R.2
  • 13
    • 84893075305 scopus 로고    scopus 로고
    • Regulation of type I interferon responses
    • Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nat Rev Immunol. (2014) 14:36. doi: 10.1038/nri3581
    • (2014) Nat Rev Immunol , vol.14 , pp. 36
    • Ivashkiv, L.B.1    Donlin, L.T.2
  • 14
    • 84893934506 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA by cGAS and other STING-dependent sensors
    • Bhat N, Fitzgerald KA. Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur. J. Immunol. (2014) 44:634-40. doi: 10.1002/eji.201344127
    • (2014) Eur. J. Immunol , vol.44 , pp. 634-640
    • Bhat, N.1    Fitzgerald, K.A.2
  • 15
    • 84912128872 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
    • Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity (2014) 41:843-52. doi: 10.1016/j.immuni.2014.10.019
    • (2014) Immunity , vol.41 , pp. 843-852
    • Deng, L.1    Liang, H.2    Xu, M.3    Yang, X.4    Burnette, B.5    Arina, A.6
  • 16
    • 84929165945 scopus 로고    scopus 로고
    • NF-κB and IRF pathways: cross-regulation on target genes promoter level
    • Iwanaszko M, Kimmel M. NF-κB and IRF pathways: cross-regulation on target genes promoter level. BMC Genomics (2015) 16:307. doi: 10.1186/s12864-015-1511-7
    • (2015) BMC Genomics , vol.16 , pp. 307
    • Iwanaszko, M.1    Kimmel, M.2
  • 17
    • 33750527563 scopus 로고    scopus 로고
    • Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages
    • Solis M, Goubau D, Romieu-Mourez R, Genin P, Civas A, Hiscott J. Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. Biochem Pharmacol. (2006) 72:1469-76. doi: 10.1016/j.bcp.2006.06.002
    • (2006) Biochem Pharmacol , vol.72 , pp. 1469-1476
    • Solis, M.1    Goubau, D.2    Romieu-Mourez, R.3    Genin, P.4    Civas, A.5    Hiscott, J.6
  • 18
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha
    • Schindler C, Fu X-Y, Improta T, Aebersold R, Darnell JE. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci USA. (1992) 89:7836-9. doi: 10.1073/pnas.89.16.7836
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.-Y.2    Improta, T.3    Aebersold, R.4    Darnell, J.E.5
  • 19
    • 67249144899 scopus 로고    scopus 로고
    • Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
    • Cheon H, Stark GR. Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci USA. (2009) 106:9373-8. doi: 10.1073/pnas.0903487106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9373-9378
    • Cheon, H.1    Stark, G.R.2
  • 20
    • 82955187705 scopus 로고    scopus 로고
    • Interferon-stimulated genes and their antiviral effector functions
    • Schoggins JW, Rice CM. Interferon-stimulated genes and their antiviral effector functions. Curr Opin Virol. (2011) 1:519-25. doi: 10.1016/j.coviro.2011.10.008
    • (2011) Curr Opin Virol , vol.1 , pp. 519-525
    • Schoggins, J.W.1    Rice, C.M.2
  • 21
    • 84899755904 scopus 로고    scopus 로고
    • Interferons and their stimulated genes in the tumor microenvironment
    • Cheon H, Borden EC, Stark GR. Interferons and their stimulated genes in the tumor microenvironment. Semin Oncol. (2014) 41:156-73. doi: 10.1053/j.seminoncol.2014.02.002
    • (2014) Semin Oncol , vol.41 , pp. 156-173
    • Cheon, H.1    Borden, E.C.2    Stark, G.R.3
  • 22
    • 84991407906 scopus 로고    scopus 로고
    • Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma
    • Mastorci K, Montico B, Faè DA, Sigalotti L, Ponzoni M, Inghirami G, et al. Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma. Oncotarget (2016) 7:41913. doi: 10.18632/oncotarget.9630
    • (2016) Oncotarget , vol.7 , pp. 41913
    • Mastorci, K.1    Montico, B.2    Faè, D.A.3    Sigalotti, L.4    Ponzoni, M.5    Inghirami, G.6
  • 23
    • 84946720236 scopus 로고    scopus 로고
    • Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
    • Wilmes S, Beutel O, Li Z, Francois-Newton V, Richter CP, Janning D, et al. Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling. J Cell Biol. (2015) 209:579-93. doi: 10.1083/jcb.201412049
    • (2015) J Cell Biol , vol.209 , pp. 579-593
    • Wilmes, S.1    Beutel, O.2    Li, Z.3    Francois-Newton, V.4    Richter, C.P.5    Janning, D.6
  • 24
    • 0037155882 scopus 로고    scopus 로고
    • UBP43 (USP18) specifically removes ISG15 from conjugated proteins
    • Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang D-E. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J Biol Chem. (2002) 277:9976-81. doi: 10.1074/jbc.M109078200
    • (2002) J Biol Chem , vol.277 , pp. 9976-9981
    • Malakhov, M.P.1    Malakhova, O.A.2    Kim, K.I.3    Ritchie, K.J.4    Zhang, D.-E.5
  • 25
    • 77951991690 scopus 로고    scopus 로고
    • Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification
    • Shi HX, Yang K, Liu X, Liu XY, Wei B, Shan YF, et al. Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification. Mol Cell Biol. (2010) 30:2424-36. doi: 10.1128/MCB.01466-09
    • (2010) Mol Cell Biol , vol.30 , pp. 2424-2436
    • Shi, H.X.1    Yang, K.2    Liu, X.3    Liu, X.Y.4    Wei, B.5    Shan, Y.F.6
  • 26
    • 0018569985 scopus 로고
    • Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma 2
    • Slone HB, Peters LJ, Milas L. Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma 2. J Natl Cancer Inst. (1979) 63:1229-35. Google Scholar
    • (1979) J Natl Cancer Inst , vol.63 , pp. 1229-1235
    • Slone, H.B.1    Peters, L.J.2    Milas, L.3
  • 27
    • 79953295544 scopus 로고    scopus 로고
    • The efficacy of radiotherapy relies upon induction of type I interferon-dependent innate and adaptive immunity
    • Burnette BC, Liang H, Lee Y, Chlewicki L, Khodarev NN, Weichselbaum RR, et al. The efficacy of radiotherapy relies upon induction of type I interferon-dependent innate and adaptive immunity. Cancer Res. (2011) 71:2488-96. doi: 10.1158/0008-5472.CAN-10-2820
    • (2011) Cancer Res , vol.71 , pp. 2488-2496
    • Burnette, B.C.1    Liang, H.2    Lee, Y.3    Chlewicki, L.4    Khodarev, N.N.5    Weichselbaum, R.R.6
  • 28
    • 84894489353 scopus 로고    scopus 로고
    • Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8+ T cells
    • Lim JY, Gerber SA, Murphy SP, Lord EM. Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8+ T cells. Cancer Immunol Immunother. (2014) 63:259-71. doi: 10.1007/s00262-013-1506-7
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 259-271
    • Lim, J.Y.1    Gerber, S.A.2    Murphy, S.P.3    Lord, E.M.4
  • 29
    • 84937640449 scopus 로고    scopus 로고
    • The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant
    • Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev. (2015) 41:503-10. doi: 10.1016/j.ctrv.2015.03.011
    • (2015) Cancer Treat Rev , vol.41 , pp. 503-510
    • Reynders, K.1    Illidge, T.2    Siva, S.3    Chang, J.Y.4    De Ruysscher, D.5
  • 30
    • 29144530630 scopus 로고    scopus 로고
    • Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
    • Casares N, Pequignot MO, Tesniere A, Ghiringhelli F, Roux S, Chaput N, et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med. (2005) 202:1691-701. doi: 10.1084/jem.20050915
    • (2005) J Exp Med , vol.202 , pp. 1691-1701
    • Casares, N.1    Pequignot, M.O.2    Tesniere, A.3    Ghiringhelli, F.4    Roux, S.5    Chaput, N.6
  • 31
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med. (2007) 13:1050-9. doi: 10.1038/nm1622
    • (2007) Nat Med , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3    Obeid, M.4    Ortiz, C.5    Criollo, A.6
  • 32
    • 79952390627 scopus 로고    scopus 로고
    • Immune parameters affecting the efficacy of chemotherapeutic regimens
    • Zitvogel L, Kepp O, Kroemer G. Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol. (2011) 8:151-60. doi: 10.1038/nrclinonc.2010.223
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 151-160
    • Zitvogel, L.1    Kepp, O.2    Kroemer, G.3
  • 33
  • 34
    • 84913586780 scopus 로고    scopus 로고
    • Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
    • Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. (2014) 20:1301-9. doi: 10.1038/nm.3708
    • (2014) Nat Med , vol.20 , pp. 1301-1309
    • Sistigu, A.1    Yamazaki, T.2    Vacchelli, E.3    Chaba, K.4    Enot, D.P.5    Adam, J.6
  • 35
    • 23444462074 scopus 로고
    • Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia
    • Leukemia ICSGoCM. Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med. (1994) 1994:820-5. Google Scholar
    • (1994) N Engl J Med , vol.1994 , pp. 820-825
    • Leukemia, I.C.S.G.C.M.1
  • 36
    • 84954390395 scopus 로고    scopus 로고
    • Discontinuation of alpha-interferon treatment in patients with chronic myeloid leukemia in long-lasting complete molecular response
    • Latagliata R, Romano A, Mancini M, Breccia M, Carmosino I, Vozella F, et al. Discontinuation of alpha-interferon treatment in patients with chronic myeloid leukemia in long-lasting complete molecular response. Leuk Lymphoma. (2016) 57:99-102. doi: 10.3109/10428194.2015.1043548
    • (2016) Leuk Lymphoma , vol.57 , pp. 99-102
    • Latagliata, R.1    Romano, A.2    Mancini, M.3    Breccia, M.4    Carmosino, I.5    Vozella, F.6
  • 37
    • 80053130415 scopus 로고    scopus 로고
    • Combination of pegylated IFN-a2b with imatinib increases molecular response rates in patients with low-or intermediate-risk chronic myeloid leukemia
    • Simonsson B, Gedde-Dahl T, Markevärn B, Remes K, Stentoft J, Almqvist A, et al. Combination of pegylated IFN-a2b with imatinib increases molecular response rates in patients with low-or intermediate-risk chronic myeloid leukemia. Blood (2011) 118:3228-35. doi: 10.1182/blood-2011-02-336685
    • (2011) Blood , vol.118 , pp. 3228-3235
    • Simonsson, B.1    Gedde-Dahl, T.2    Markevärn, B.3    Remes, K.4    Stentoft, J.5    Almqvist, A.6
  • 38
    • 77956996657 scopus 로고    scopus 로고
    • Molecular responses of the Spirit phase III trial of the French CML Group comparing imatinib 400 mg to higher dose imatinib or combination with interferon or cytarabine for the treatment of newly diagnosed chronic phase (cp) chronic myeloid leukaemia (CML) patients
    • Rousselot P, Preudhomme C, Guilhot J, Dubruille V, Lamy T, Delain M, et al. Molecular responses of the Spirit phase III trial of the French CML Group comparing imatinib 400 mg to higher dose imatinib or combination with interferon or cytarabine for the treatment of newly diagnosed chronic phase (cp) chronic myeloid leukaemia (CML) patients. Haematologica (2009) 94:441
    • (2009) Haematologica , vol.94 , pp. 441
    • Rousselot, P.1    Preudhomme, C.2    Guilhot, J.3    Dubruille, V.4    Lamy, T.5    Delain, M.6
  • 39
    • 77950496740 scopus 로고    scopus 로고
    • Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia
    • Burchert A, Müller MC, Kostrewa P, Erben P, Bostel T, Liebler S, et al. Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia. J Clin Oncol. (2010) 28:1429-35. doi: 10.1200/JCO.2009.25.5075
    • (2010) J Clin Oncol , vol.28 , pp. 1429-1435
    • Burchert, A.1    Müller, M.C.2    Kostrewa, P.3    Erben, P.4    Bostel, T.5    Liebler, S.6
  • 40
    • 84957579051 scopus 로고    scopus 로고
    • Loss of host type-I IFN signaling accelerates metastasis and impairs NK-cell antitumor function in multiple models of breast cancer
    • Rautela J, Baschuk N, Slaney CY, Jayatilleke KM, Xiao K, Bidwell BN, et al. Loss of host type-I IFN signaling accelerates metastasis and impairs NK-cell antitumor function in multiple models of breast cancer. Cancer Immunol. Res. (2015) 3:1207-17. doi: 10.1158/2326-6066.CIR-15-0065
    • (2015) Cancer Immunol. Res , vol.3 , pp. 1207-1217
    • Rautela, J.1    Baschuk, N.2    Slaney, C.Y.3    Jayatilleke, K.M.4    Xiao, K.5    Bidwell, B.N.6
  • 41
    • 84883291555 scopus 로고    scopus 로고
    • The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone
    • Slaney CY, Möller A, Hertzog PJ, Parker BS. The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone. Oncoimmunology (2013) 2:e22339. doi: 10.4161/onci.22339
    • (2013) Oncoimmunology , vol.2
    • Slaney, C.Y.1    Möller, A.2    Hertzog, P.J.3    Parker, B.S.4
  • 42
    • 84955181012 scopus 로고    scopus 로고
    • Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer
    • Legrier M-E, Bièche I, Gaston J, Beurdeley A, Yvonnet V, Déas O, et al. Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer. Br J Cancer (2016) 114:177. doi: 10.1038/bjc.2015.398
    • (2016) Br J Cancer , vol.114 , pp. 177
    • Legrier, M.-E.1    Bièche, I.2    Gaston, J.3    Beurdeley, A.4    Yvonnet, V.5    Déas, O.6
  • 43
    • 67449098967 scopus 로고    scopus 로고
    • Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: long-term follow-up of a phase II study
    • Recchia F, Sica G, Candeloro G, Necozione S, Bisegna R, Bratta M, et al. Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: long-term follow-up of a phase II study. Oncol Rep. (2009) 21:1011-6. doi: 10.3892/or_00000317
    • (2009) Oncol Rep , vol.21 , pp. 1011-1016
    • Recchia, F.1    Sica, G.2    Candeloro, G.3    Necozione, S.4    Bisegna, R.5    Bratta, M.6
  • 44
    • 84890417671 scopus 로고    scopus 로고
    • Severe adverse events from the treatment of advanced melanoma: a systematic review of severe side effects associated with ipilimumab, vemurafenib, interferon alfa-2b, dacarbazine and interleukin-2
    • Ma C, Armstrong AW. Severe adverse events from the treatment of advanced melanoma: a systematic review of severe side effects associated with ipilimumab, vemurafenib, interferon alfa-2b, dacarbazine and interleukin-2. J Dermatol Treat. (2014) 25:401-8. doi: 10.3109/09546634.2013.813897
    • (2014) J Dermatol Treat , vol.25 , pp. 401-408
    • Ma, C.1    Armstrong, A.W.2
  • 45
    • 14644393659 scopus 로고    scopus 로고
    • Neuropsychiatric adverse effects of interferon-a
    • Raison CL, Demetrashvili M, Capuron L, Miller AH. Neuropsychiatric adverse effects of interferon-a. CNS Drugs (2005) 19:105-23. doi: 10.2165/00023210-200519020-00002
    • (2005) CNS Drugs , vol.19 , pp. 105-123
    • Raison, C.L.1    Demetrashvili, M.2    Capuron, L.3    Miller, A.H.4
  • 46
    • 0029912760 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of recombinant human interferon-β in healthy male volunteers
    • Salmon P, Le Cotonnec JY, Galazka A, Abdul-Ahad A, Darragh A. Pharmacokinetics and pharmacodynamics of recombinant human interferon-β in healthy male volunteers. J Interf Cytokine Res. (1996) 16:759-64. doi: 10.1089/jir.1996.16.759
    • (1996) J Interf Cytokine Res , vol.16 , pp. 759-764
    • Salmon, P.1    Le Cotonnec, J.Y.2    Galazka, A.3    Abdul-Ahad, A.4    Darragh, A.5
  • 47
    • 84963865285 scopus 로고    scopus 로고
    • Half-life extended biotherapeutics
    • Kontermann RE. Half-life extended biotherapeutics. Expert Opin Biol Ther. (2016) 16:903-15. doi: 10.1517/14712598.2016.1165661
    • (2016) Expert Opin Biol Ther , vol.16 , pp. 903-915
    • Kontermann, R.E.1
  • 48
    • 84924766920 scopus 로고    scopus 로고
    • PEGylation improves the pharmacokinetic properties and ability of interferon gamma to inhibit growth of a human tumor xenograft in athymic mice
    • Fam CM, Eisenberg SP, Carlson SJ, Chlipala EA, Cox GN, Rosendahl MS. PEGylation improves the pharmacokinetic properties and ability of interferon gamma to inhibit growth of a human tumor xenograft in athymic mice. J Interfer Cytokine Res. (2014) 34:759-68. doi: 10.1089/jir.2013.0067
    • (2014) J Interfer Cytokine Res , vol.34 , pp. 759-768
    • Fam, C.M.1    Eisenberg, S.P.2    Carlson, S.J.3    Chlipala, E.A.4    Cox, G.N.5    Rosendahl, M.S.6
  • 49
    • 84892575481 scopus 로고    scopus 로고
    • Pegylated interferon-a2a inhibits proliferation of human liver cancer cells in vitro and in vivo
    • Kusano H, Akiba J, Ogasawara S, Sanada S, Yasumoto M, Nakayama M, et al. Pegylated interferon-a2a inhibits proliferation of human liver cancer cells in vitro and in vivo. PloS ONE (2013) 8:e83195. doi: 10.1371/journal.pone.0083195
    • (2013) PloS ONE , vol.8
    • Kusano, H.1    Akiba, J.2    Ogasawara, S.3    Sanada, S.4    Yasumoto, M.5    Nakayama, M.6
  • 50
    • 85018633034 scopus 로고    scopus 로고
    • Novel pegylated interferon-β as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer
    • Iwamura T, Narumi H, Suzuki T, Yanai H, Mori K, Yamashita K, et al. Novel pegylated interferon-β as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer. Cancer Sci. (2017) 108:581-9. doi: 10.1111/cas.13176
    • (2017) Cancer Sci , vol.108 , pp. 581-589
    • Iwamura, T.1    Narumi, H.2    Suzuki, T.3    Yanai, H.4    Mori, K.5    Yamashita, K.6
  • 51
    • 46749103710 scopus 로고    scopus 로고
    • Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial
    • Eggermont AM, Suciu S, Santinami M, Testori A, Kruit WH, Marsden J, et al. Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial. Lancet. (2008) 372:117-26. doi: 10.1016/S0140-6736(08)61033-8
    • (2008) Lancet , vol.372 , pp. 117-126
    • Eggermont, A.M.1    Suciu, S.2    Santinami, M.3    Testori, A.4    Kruit, W.H.5    Marsden, J.6
  • 52
    • 84985031905 scopus 로고    scopus 로고
    • Adjuvant treatment with pegylated interferon a-2a versus low-dose interferon a-2a in patients with high-risk melanoma: a randomized phase III DeCOG trial
    • Eigentler T, Gutzmer R, Hauschild A, Heinzerling L, Schadendorf D, Nashan D, et al. Adjuvant treatment with pegylated interferon a-2a versus low-dose interferon a-2a in patients with high-risk melanoma: a randomized phase III DeCOG trial. Ann Oncol. (2016) 27:1625-32. doi: 10.1093/annonc/mdw225
    • (2016) Ann Oncol , vol.27 , pp. 1625-1632
    • Eigentler, T.1    Gutzmer, R.2    Hauschild, A.3    Heinzerling, L.4    Schadendorf, D.5    Nashan, D.6
  • 53
    • 84902596900 scopus 로고    scopus 로고
    • Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-a activates immunity and inhibits breast cancer progression
    • Escobar G, Gentner B, Naldini L, Mazzieri R. Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-a activates immunity and inhibits breast cancer progression. Oncoimmunology (2014) 3:e28696. doi: 10.4161/onci.28696
    • (2014) Oncoimmunology , vol.3
    • Escobar, G.1    Gentner, B.2    Naldini, L.3    Mazzieri, R.4
  • 55
    • 52949148222 scopus 로고    scopus 로고
    • Tumor-targeted interferon-a delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
    • De Palma M, Mazzieri R, Politi LS, Pucci F, Zonari E, Sitia G, et al. Tumor-targeted interferon-a delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell (2008) 14:299-311. doi: 10.1016/j.ccr.2008.09.004
    • (2008) Cancer Cell , vol.14 , pp. 299-311
    • De Palma, M.1    Mazzieri, R.2    Politi, L.S.3    Pucci, F.4    Zonari, E.5    Sitia, G.6
  • 56
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer (2012) 12:252. doi: 10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , pp. 252
    • Pardoll, D.M.1
  • 57
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science (2015) 348:56-61. doi: 10.1126/science.aaa8172
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 58
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, Hodi FS, Hwu W-J, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. (2013) 2013:134-44. doi: 10.1056/NEJMoa1305133
    • (2013) N Engl J Med , vol.2013 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.-J.5    Kefford, R.6
  • 59
    • 84990849572 scopus 로고    scopus 로고
    • Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy
    • Gao J, Shi LZ, Zhao H, Chen J, Xiong L, He Q, et al. Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy. Cell (2016) 167:397-404. e9. doi: 10.1016/j.cell.2016.08.069
    • (2016) Cell , vol.167 , pp. 397-404
    • Gao, J.1    Shi, L.Z.2    Zhao, H.3    Chen, J.4    Xiong, L.5    He, Q.6
  • 61
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo S-R, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity (2014) 41:830-42. doi: 10.1016/j.immuni.2014.10.017
    • (2014) Immunity , vol.41 , pp. 830-842
    • Woo, S.-R.1    Fuertes, M.B.2    Corrales, L.3    Spranger, S.4    Furdyna, M.J.5    Leung, M.Y.6
  • 62
    • 85014216230 scopus 로고    scopus 로고
    • New development in CAR-T cell therapy
    • Wang Z, Wu Z, Liu Y, Han W. New development in CAR-T cell therapy. J Hematol Oncol. (2017) 10:53. doi: 10.1186/s13045-017-0423-1
    • (2017) J Hematol Oncol , vol.10 , pp. 53
    • Wang, Z.1    Wu, Z.2    Liu, Y.3    Han, W.4
  • 63
    • 84975172606 scopus 로고    scopus 로고
    • Durable remissions in children with relapsed/refractory ALL treated with T cells engineered with a CD19-targeted chimeric antigen receptor (CTL019)
    • Grupp SA, Maude SL, Shaw PA, Aplenc R, Barrett DM, Callahan C, et al. Durable remissions in children with relapsed/refractory ALL treated with T cells engineered with a CD19-targeted chimeric antigen receptor (CTL019). Am Soc Hematol. (2015) 126:681. Google Scholar
    • (2015) Am Soc Hematol , vol.126 , pp. 681
    • Grupp, S.A.1    Maude, S.L.2    Shaw, P.A.3    Aplenc, R.4    Barrett, D.M.5    Callahan, C.6
  • 64
    • 85012931658 scopus 로고    scopus 로고
    • Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment
    • Katlinski KV, Gui J, Katlinskaya YV, Ortiz A, Chakraborty R, Bhattacharya S, et al. Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment. Cancer Cell. (2017) 31:194-207. doi: 10.1016/j.ccell.2017.01.004
    • (2017) Cancer Cell , vol.31 , pp. 194-207
    • Katlinski, K.V.1    Gui, J.2    Katlinskaya, Y.V.3    Ortiz, A.4    Chakraborty, R.5    Bhattacharya, S.6
  • 66
    • 85042772277 scopus 로고    scopus 로고
    • Oncorine, the world first oncolytic virus medicine and its update in China
    • Liang M. Oncorine, the world first oncolytic virus medicine and its update in China. Curr Cancer Drug Targets (2017) 18:171-6. doi: 10.2174/1568009618666171129221503
    • (2017) Curr Cancer Drug Targets , vol.18 , pp. 171-176
    • Liang, M.1
  • 67
    • 84997848610 scopus 로고    scopus 로고
    • Into the clinic: talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy
    • Rehman H, Silk AW, Kane MP, Kaufman HL. Into the clinic: talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy. J Immunother Cancer (2016) 4:53. doi: 10.1186/s40425-016-0158-5
    • (2016) J Immunother Cancer , vol.4 , pp. 53
    • Rehman, H.1    Silk, A.W.2    Kane, M.P.3    Kaufman, H.L.4
  • 68
    • 33845336115 scopus 로고    scopus 로고
    • A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor
    • Hu JC, Coffin RS, Davis CJ, Graham NJ, Groves N, Guest PJ, et al. A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor. Clin Cancer Res. (2006) 12:6737-47. doi: 10.1158/1078-0432.CCR-06-0759
    • (2006) Clin Cancer Res , vol.12 , pp. 6737-6747
    • Hu, J.C.1    Coffin, R.S.2    Davis, C.J.3    Graham, N.J.4    Groves, N.5    Guest, P.J.6
  • 69
    • 85029611725 scopus 로고    scopus 로고
    • Durable response rate as an endpoint in cancer immunotherapy: insights from oncolytic virus clinical trials
    • Kaufman HL, Andtbacka RH, Collichio FA, Wolf M, Zhao Z, Shilkrut M, et al. Durable response rate as an endpoint in cancer immunotherapy: insights from oncolytic virus clinical trials. J Immunother Cancer (2017) 5:72. doi: 10.1186/s40425-017-0276-8
    • (2017) J Immunother Cancer , vol.5 , pp. 72
    • Kaufman, H.L.1    Andtbacka, R.H.2    Collichio, F.A.3    Wolf, M.4    Zhao, Z.5    Shilkrut, M.6
  • 70
    • 28444480639 scopus 로고    scopus 로고
    • The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma
    • Hummel JL, Safroneeva E, Mossman KL. The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma. Mole Ther. (2005) 12:1101-10. doi: 10.1016/j.ymthe.2005.07.533
    • (2005) Mole Ther , vol.12 , pp. 1101-1110
    • Hummel, J.L.1    Safroneeva, E.2    Mossman, K.L.3
  • 71
    • 77954736379 scopus 로고    scopus 로고
    • Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death
    • Zhang Kx, Matsui Y, Hadaschik BA, Lee C, Jia W, Bell JC, et al. Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. Int J Cancer (2010) 127:830-8. doi: 10.1002/ijc.25088
    • (2010) Int J Cancer , vol.127 , pp. 830-838
    • Zhang, K.1    Matsui, Y.2    Hadaschik, B.A.3    Lee, C.4    Jia, W.5    Bell, J.C.6
  • 72
    • 83355170536 scopus 로고    scopus 로고
    • Epigenetic silencing of IRF7 and/or IRF5 in lung cancer cells leads to increased sensitivity to oncolytic viruses
    • Li Q, Tainsky MA. Epigenetic silencing of IRF7 and/or IRF5 in lung cancer cells leads to increased sensitivity to oncolytic viruses. PLoS ONE (2011) 6:e28683. doi: 10.1371/journal.pone.0028683
    • (2011) PLoS ONE , vol.6
    • Li, Q.1    Tainsky, M.A.2
  • 73
    • 3042859189 scopus 로고    scopus 로고
    • Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors
    • Wagner TC, Velichko S, Chesney SK, Biroc S, Harde D, Vogel D, et al. Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors. Int J Cancer (2004) 111:32-42. doi: 10.1002/ijc.20236
    • (2004) Int J Cancer , vol.111 , pp. 32-42
    • Wagner, T.C.1    Velichko, S.2    Chesney, S.K.3    Biroc, S.4    Harde, D.5    Vogel, D.6
  • 74
    • 80053632555 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis
    • Zheng H, Qian J, Carbone CJ, Leu NA, Baker DP, Fuchs SY. Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis. Blood (2011) 118:4003-6. doi: 10.1182/blood-2011-06-359745
    • (2011) Blood , vol.118 , pp. 4003-4006
    • Zheng, H.1    Qian, J.2    Carbone, C.J.3    Leu, N.A.4    Baker, D.P.5    Fuchs, S.Y.6
  • 75
    • 84883741732 scopus 로고    scopus 로고
    • Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses
    • Bhattacharya S, HuangFu W-C, Dong G, Qian J, Baker DP, Karar J, et al. Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses. Oncogene (2013) 32:4214-21. doi: 10.1038/onc.2012.439
    • (2013) Oncogene , vol.32 , pp. 4214-4221
    • Bhattacharya, S.1    HuangFu, W.-C.2    Dong, G.3    Qian, J.4    Baker, D.P.5    Karar, J.6
  • 76
    • 84855769864 scopus 로고    scopus 로고
    • Inflammatory signaling compromises cell responses to interferon alpha
    • HuangFu W-C, Qian J, Liu C, Liu J, Lokshin AE, Baker DP, et al. Inflammatory signaling compromises cell responses to interferon alpha. Oncogene (2012) 31:161-72. doi: 10.1038/onc.2011.221
    • (2012) Oncogene , vol.31 , pp. 161-172
    • HuangFu, W.-C.1    Qian, J.2    Liu, C.3    Liu, J.4    Lokshin, A.E.5    Baker, D.P.6
  • 77
    • 58249084172 scopus 로고    scopus 로고
    • Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor
    • Liu J, HuangFu W-C, Kumar KS, Qian J, Casey JP, Hamanaka RB, et al. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe (2009) 5:72-83. doi: 10.1016/j.chom.2008.11.008
    • (2009) Cell Host Microbe , vol.5 , pp. 72-83
    • Liu, J.1    HuangFu, W.-C.2    Kumar, K.S.3    Qian, J.4    Casey, J.P.5    Hamanaka, R.B.6
  • 78
  • 79
    • 84963545903 scopus 로고    scopus 로고
    • Suppression of type I interferon signaling overcomes oncogene-induced senescence and mediates melanoma development and progression
    • Katlinskaya YV, Katlinski KV, Yu Q, Ortiz A, Beiting DP, Brice A, et al. Suppression of type I interferon signaling overcomes oncogene-induced senescence and mediates melanoma development and progression. Cell Rep. (2016) 15:171-80. doi: 10.1016/j.celrep.2016.03.006
    • (2016) Cell Rep , vol.15 , pp. 171-180
    • Katlinskaya, Y.V.1    Katlinski, K.V.2    Yu, Q.3    Ortiz, A.4    Beiting, D.P.5    Brice, A.6
  • 80
    • 85020433706 scopus 로고    scopus 로고
    • Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells
    • Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, et al. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. (2017) 10:eaah7177. doi: 10.1126/scisignal.aah7177
    • (2017) Sci Signal , vol.10
    • Rodvold, J.J.1    Chiu, K.T.2    Hiramatsu, N.3    Nussbacher, J.K.4    Galimberti, V.5    Mahadevan, N.R.6
  • 81
    • 78650192268 scopus 로고    scopus 로고
    • Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-a
    • Tomita S, Ishibashi K, Hashimoto K, Sugino T, Yanagida T, Kushida N, et al. Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-a. Cancer Sci. (2011) 102:57-63. doi: 10.1111/j.1349-7006.2010.01751.x
    • (2011) Cancer Sci , vol.102 , pp. 57-63
    • Tomita, S.1    Ishibashi, K.2    Hashimoto, K.3    Sugino, T.4    Yanagida, T.5    Kushida, N.6
  • 82
    • 34250347991 scopus 로고    scopus 로고
    • SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells
    • Zitzmann K, Brand S, De Toni EN, Baehs S, Göke B, Meinecke J, et al. SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells. Cancer Res. (2007) 67:5025-32. doi: 10.1158/0008-5472.CAN-06-2575
    • (2007) Cancer Res , vol.67 , pp. 5025-5032
    • Zitzmann, K.1    Brand, S.2    De Toni, E.N.3    Baehs, S.4    Göke, B.5    Meinecke, J.6
  • 83
    • 0842328525 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling-1 is constitutively expressed in chronic myeloid leukemia and correlates with poor cytogenetic response to interferon-alpha
    • Roman-Gomez J, Jimenez-Velasco A, Castillejo JA, Cervantes F, Barrios M, Colomer D, et al. The suppressor of cytokine signaling-1 is constitutively expressed in chronic myeloid leukemia and correlates with poor cytogenetic response to interferon-alpha. Haematologica (2004) 89:42-8
    • (2004) Haematologica , vol.89 , pp. 42-48
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Castillejo, J.A.3    Cervantes, F.4    Barrios, M.5    Colomer, D.6
  • 85
    • 17144365840 scopus 로고    scopus 로고
    • IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression
    • Dunn GP, Sheehan KC, Old LJ, Schreiber RD. IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression. Cancer Res. (2005) 65:3447-53. doi: 10.1158/0008-5472.CAN-04-4316
    • (2005) Cancer Res , vol.65 , pp. 3447-3453
    • Dunn, G.P.1    Sheehan, K.C.2    Old, L.J.3    Schreiber, R.D.4
  • 87
    • 13844311013 scopus 로고    scopus 로고
    • Reduction in p48-ISGF?. levels confers resistance to interferon-a2a in MHCC97 cells
    • Wu W-Z, Sun H-C, Gao Y-Q, Li Y, Wang L, Zhou K, et al. Reduction in p48-ISGF? levels confers resistance to interferon-a2a in MHCC97 cells. Oncology (2004) 67:428-40. doi: 10.1159/000082928
    • (2004) Oncology , vol.67 , pp. 428-440
    • Wu, W.-Z.1    Sun, H.-C.2    Gao, Y.-Q.3    Li, Y.4    Wang, L.5    Zhou, K.6
  • 88
    • 0034584605 scopus 로고    scopus 로고
    • Chronic myeloid leukemia cells resistant to interferon-a lack STAT1 expression
    • Landolfo S, Guarini A, Riera L, Gariglio M, Gribaudo G, Cignetti A, et al. Chronic myeloid leukemia cells resistant to interferon-a lack STAT1 expression. Hematol J. (2000) 1:14. doi: 10.1038/sj.thj.6200004
    • (2000) Hematol J , vol.1 , pp. 14
    • Landolfo, S.1    Guarini, A.2    Riera, L.3    Gariglio, M.4    Gribaudo, G.5    Cignetti, A.6
  • 90
    • 34347259954 scopus 로고    scopus 로고
    • Defective Jak-Stat activation in renal cell carcinoma is associated with interferon-a resistance
    • Shang D, Liu Y, Ito N, Kamoto T, Ogawa O. Defective Jak-Stat activation in renal cell carcinoma is associated with interferon-a resistance. Cancer Sci. (2007) 98:1259-64. doi: 10.1111/j.1349-7006.2007.00526.x
    • (2007) Cancer Sci , vol.98 , pp. 1259-1264
    • Shang, D.1    Liu, Y.2    Ito, N.3    Kamoto, T.4    Ogawa, O.5
  • 91
    • 84864654660 scopus 로고    scopus 로고
    • Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
    • Bidwell BN, Slaney CY, Withana NP, Forster S, Cao Y, Loi S, et al. Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat Med. (2012) 18:1224-31. doi: 10.1038/nm.2830
    • (2012) Nat Med , vol.18 , pp. 1224-1231
    • Bidwell, B.N.1    Slaney, C.Y.2    Withana, N.P.3    Forster, S.4    Cao, Y.5    Loi, S.6
  • 92
    • 85018171209 scopus 로고    scopus 로고
    • Overexpression of interferon regulatory factor 7 (IRF7) reduces bone metastasis of prostate cancer cells in mice
    • Zhao Y, Chen W, Zhu W, Meng H, Chen J, Zhang J. Overexpression of interferon regulatory factor 7 (IRF7) reduces bone metastasis of prostate cancer cells in mice. Oncol Res Featur Preclin Clin Cancer Ther. (2017) 25:511-22. doi: 10.3727/096504016X14756226781802
    • (2017) Oncol Res Featur Preclin Clin Cancer Ther , vol.25 , pp. 511-522
    • Zhao, Y.1    Chen, W.2    Zhu, W.3    Meng, H.4    Chen, J.5    Zhang, J.6
  • 93
    • 80155157544 scopus 로고    scopus 로고
    • Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis
    • Bi X, Hameed M, Mirani N, Pimenta EM, Anari J, Barnes BJ. Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis. Breast Cancer Res. (2011) 13:R111. doi: 10.1186/bcr3053
    • (2011) Breast Cancer Res , vol.13 , pp. R111
    • Bi, X.1    Hameed, M.2    Mirani, N.3    Pimenta, E.M.4    Anari, J.5    Barnes, B.J.6
  • 94
    • 78149469070 scopus 로고    scopus 로고
    • MicroRNA-21 induces resistance to the anti-tumour effect of interferon-a/5-fluorouracil in hepatocellular carcinoma cells
    • Tomimaru Y, Eguchi H, Nagano H, Wada H, Tomokuni A, Kobayashi S, et al. MicroRNA-21 induces resistance to the anti-tumour effect of interferon-a/5-fluorouracil in hepatocellular carcinoma cells. Br J Cancer (2010) 103:1617-26. doi: 10.1038/sj.bjc.6605958
    • (2010) Br J Cancer , vol.103 , pp. 1617-1626
    • Tomimaru, Y.1    Eguchi, H.2    Nagano, H.3    Wada, H.4    Tomokuni, A.5    Kobayashi, S.6
  • 95
    • 80555122819 scopus 로고    scopus 로고
    • miR-146a suppresses the sensitivity to interferon-a in hepatocellular carcinoma cells
    • Tomokuni A, Eguchi H, Tomimaru Y, Wada H, Kawamoto K, Kobayashi S, et al. miR-146a suppresses the sensitivity to interferon-a in hepatocellular carcinoma cells. Biochem Biophys Res Commun. (2011) 414:675-80. doi: 10.1016/j.bbrc.2011.09.124
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 675-680
    • Tomokuni, A.1    Eguchi, H.2    Tomimaru, Y.3    Wada, H.4    Kawamoto, K.5    Kobayashi, S.6
  • 96
    • 77956995581 scopus 로고    scopus 로고
    • Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin
    • Pogribny IP, Filkowski JN, Tryndyak VP, Golubov A, Shpyleva SI, Kovalchuk O. Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. Int J Cancer (2010) 127:1785-94. doi: 10.1002/ijc.25191
    • (2010) Int J Cancer , vol.127 , pp. 1785-1794
    • Pogribny, I.P.1    Filkowski, J.N.2    Tryndyak, V.P.3    Golubov, A.4    Shpyleva, S.I.5    Kovalchuk, O.6
  • 99
    • 85037334618 scopus 로고    scopus 로고
    • Impaired HLA Class I Antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer
    • Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, et al. Impaired HLA Class I Antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer. Cancer Discov. (2017) 7:1420-35. doi: 10.1158/2159-8290.CD-17-0593
    • (2017) Cancer Discov , vol.7 , pp. 1420-1435
    • Gettinger, S.1    Choi, J.2    Hastings, K.3    Truini, A.4    Datar, I.5    Sowell, R.6
  • 100
    • 54949096928 scopus 로고    scopus 로고
    • Inhibition of the IFN-β response in hepatocellular carcinoma by alternative spliced isoform of IFN regulatory factor-3
    • Marozin S, Altomonte J, Stadler F, Thasler WE, Schmid RM, Ebert O. Inhibition of the IFN-β response in hepatocellular carcinoma by alternative spliced isoform of IFN regulatory factor-3. Mol Ther. (2008) 16:1789-97. doi: 10.1038/mt.2008.201
    • (2008) Mol Ther , vol.16 , pp. 1789-1797
    • Marozin, S.1    Altomonte, J.2    Stadler, F.3    Thasler, W.E.4    Schmid, R.M.5    Ebert, O.6
  • 101
    • 84857966784 scopus 로고    scopus 로고
    • Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
    • Murphy AM, Besmer DM, Moerdyk-Schauwecker M, Moestl N, Ornelles DA, Mukherjee P, et al. Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. J Virol. (2012) 86:3073-87. doi: 10.1128/JVI.05640-11
    • (2012) J Virol , vol.86 , pp. 3073-3087
    • Murphy, A.M.1    Besmer, D.M.2    Moerdyk-Schauwecker, M.3    Moestl, N.4    Ornelles, D.A.5    Mukherjee, P.6
  • 102
    • 84872192098 scopus 로고    scopus 로고
    • Resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus: role of type I interferon signaling
    • Moerdyk-Schauwecker M, Shah NR, Murphy AM, Hastie E, Mukherjee P, Grdzelishvili VZ. Resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus: role of type I interferon signaling. Virology (2013) 436:221-34. doi: 10.1016/j.virol.2012.11.014
    • (2013) Virology , vol.436 , pp. 221-234
    • Moerdyk-Schauwecker, M.1    Shah, N.R.2    Murphy, A.M.3    Hastie, E.4    Mukherjee, P.5    Grdzelishvili, V.Z.6
  • 103
    • 74949142894 scopus 로고    scopus 로고
    • Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-β for use in malignant pleural mesothelioma: heterogeneity in interferon responsiveness defines potential efficacy
    • Saloura V, Wang LCS, Fridlender ZG, Sun J, Cheng G, Kapoor V, et al. Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-β for use in malignant pleural mesothelioma: heterogeneity in interferon responsiveness defines potential efficacy. Hum Gene Ther. (2009) 21:51-64. doi: 10.1089/hum.2009.088
    • (2009) Hum Gene Ther , vol.21 , pp. 51-64
    • Saloura, V.1    Wang, L.C.S.2    Fridlender, Z.G.3    Sun, J.4    Cheng, G.5    Kapoor, V.6
  • 104
    • 80052475970 scopus 로고    scopus 로고
    • Vesicular stomatitis virus has extensive oncolytic activity against human sarcomas: rare resistance is overcome by blocking interferon pathways
    • Paglino JC, van den Pol AN. Vesicular stomatitis virus has extensive oncolytic activity against human sarcomas: rare resistance is overcome by blocking interferon pathways. J Virol. (2011) 85:9346-58. doi: 10.1128/JVI.00723-11
    • (2011) J Virol , vol.85 , pp. 9346-9358
    • Paglino, J.C.1    van den Pol, A.N.2
  • 105
    • 84962226736 scopus 로고    scopus 로고
    • Increased VSV oncolytic sensitivity in tumor cells by down-regulation of Mx1 gene expression
    • Guo B, Hu B, Zhao L, Wu K, Wu Y, Liu H. Increased VSV oncolytic sensitivity in tumor cells by down-regulation of Mx1 gene expression. Int J Clin Exp Med. (2016) 9:3746-51. Google Scholar
    • (2016) Int J Clin Exp Med , vol.9 , pp. 3746-3751
    • Guo, B.1    Hu, B.2    Zhao, L.3    Wu, K.4    Wu, Y.5    Liu, H.6
  • 106
    • 70249130819 scopus 로고    scopus 로고
    • PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses
    • Sobol P, Hummel J, Rodrigues R, Mossman K. PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses. Gene Ther. (2009) 16:1077-87. doi: 10.1038/gt.2009.68
    • (2009) Gene Ther , vol.16 , pp. 1077-1087
    • Sobol, P.1    Hummel, J.2    Rodrigues, R.3    Mossman, K.4
  • 107
    • 85001996779 scopus 로고    scopus 로고
    • Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
    • Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, et al. Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade. Cell (2016) 167:1540-54. e12. doi: 10.1016/j.cell.2016.11.022
    • (2016) Cell , vol.167 , pp. 1540-1554
    • Benci, J.L.1    Xu, B.2    Qiu, Y.3    Wu, T.J.4    Dada, H.5    Twyman-Saint Victor, C.6
  • 108
    • 85028320126 scopus 로고    scopus 로고
    • PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity
    • Gato-Ca-as M, Zuazo M, Arasanz H, Iba-ez-Vea M, Lorenzo L, Fernandez-Hinojal G, et al. PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity. Cell Rep. (2017) 20:1818-29. doi: 10.1016/j.celrep.2017.07.075
    • (2017) Cell Rep , vol.20 , pp. 1818-1829
    • Gato-Ca-as, M.1    Zuazo, M.2    Arasanz, H.3    Iba-ez-Vea, M.4    Lorenzo, L.5    Fernandez-Hinojal, G.6
  • 109
    • 84926525215 scopus 로고    scopus 로고
    • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
    • Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature (2015) 520:373-7. doi: 10.1038/nature14292
    • (2015) Nature , vol.520 , pp. 373-377
    • Twyman-Saint Victor, C.1    Rech, A.J.2    Maity, A.3    Rengan, R.4    Pauken, K.E.5    Stelekati, E.6
  • 110
    • 79952767536 scopus 로고    scopus 로고
    • IFN-a directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
    • Terawaki S, Chikuma S, Shibayama S, Hayashi T, Yoshida T, Okazaki T, et al. IFN-a directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. J Immunol. (2011) 186:2772-9. doi: 10.4049/jimmunol.1003208
    • (2011) J Immunol , vol.186 , pp. 2772-2779
    • Terawaki, S.1    Chikuma, S.2    Shibayama, S.3    Hayashi, T.4    Yoshida, T.5    Okazaki, T.6
  • 111
    • 1242319531 scopus 로고    scopus 로고
    • STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells
    • Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR. STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci USA. (2004) 101:1714-9. doi: 10.1073/pnas.0308102100
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1714-1719
    • Khodarev, N.N.1    Beckett, M.2    Labay, E.3    Darga, T.4    Roizman, B.5    Weichselbaum, R.R.6
  • 112
    • 35148879113 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells
    • Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, et al. Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res. (2007) 67:9214-20. doi: 10.1158/0008-5472.CAN-07-1019
    • (2007) Cancer Res , vol.67 , pp. 9214-9220
    • Khodarev, N.N.1    Minn, A.J.2    Efimova, E.V.3    Darga, T.E.4    Labay, E.5    Beckett, M.6
  • 113
    • 34248545443 scopus 로고    scopus 로고
    • Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation
    • Tsai MH, Cook JA, Chandramouli GV, DeGraff W, Yan H, Zhao S, et al. Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation. Cancer Res. (2007) 67:3845-52. doi: 10.1158/0008-5472.CAN-06-4250
    • (2007) Cancer Res , vol.67 , pp. 3845-3852
    • Tsai, M.H.1    Cook, J.A.2    Chandramouli, G.V.3    DeGraff, W.4    Yan, H.5    Zhao, S.6
  • 114
    • 57449088412 scopus 로고    scopus 로고
    • An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
    • Weichselbaum RR, Ishwaran H, Yoon T, Nuyten DS, Baker SW, Khodarev N, et al. An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer. Proc Natl Acad Sci USA. (2008) 105:18490-5. doi: 10.1073/pnas.0809242105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18490-18495
    • Weichselbaum, R.R.1    Ishwaran, H.2    Yoon, T.3    Nuyten, D.S.4    Baker, S.W.5    Khodarev, N.6
  • 115
    • 84855368868 scopus 로고    scopus 로고
    • Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner
    • Duarte CW, Willey CD, Zhi D, Cui X, Harris JJ, Vaughan LK, et al. Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner. PLoS ONE (2012) 7:e29653. doi: 10.1371/journal.pone.0029653
    • (2012) PLoS ONE , vol.7
    • Duarte, C.W.1    Willey, C.D.2    Zhi, D.3    Cui, X.4    Harris, J.J.5    Vaughan, L.K.6
  • 116
    • 84885869823 scopus 로고    scopus 로고
    • IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
    • Cheon H, Holvey-Bates EG, Schoggins JW, Forster S, Hertzog P, Imanaka N, et al. IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. EMBO J. (2013) 32:2751-63. doi: 10.1038/emboj.2013.203
    • (2013) EMBO J , vol.32 , pp. 2751-2763
    • Cheon, H.1    Holvey-Bates, E.G.2    Schoggins, J.W.3    Forster, S.4    Hertzog, P.5    Imanaka, N.6
  • 117
    • 24944521677 scopus 로고    scopus 로고
    • Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles
    • Rickardson L, Fryknäs M, Dhar S, Lövborg H, Gullbo J, Rydåker M, et al. Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles. Br J Cancer (2005) 93:483-92. doi: 10.1038/sj.bjc.6602699
    • (2005) Br J Cancer , vol.93 , pp. 483-492
    • Rickardson, L.1    Fryknäs, M.2    Dhar, S.3    Lövborg, H.4    Gullbo, J.5    Rydåker, M.6
  • 118
    • 85014578201 scopus 로고    scopus 로고
    • CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response
    • Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, et al. CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response. Cell Rep. (2017) 18:2373-86. doi: 10.1016/j.celrep.2017.02.037
    • (2017) Cell Rep , vol.18 , pp. 2373-2386
    • Qadir, A.S.1    Ceppi, P.2    Brockway, S.3    Law, C.4    Mu, L.5    Khodarev, N.N.6
  • 120
    • 84958559501 scopus 로고    scopus 로고
    • Cancer stem cells: radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments
    • Krause M, Dubrovska A, Linge A, Baumann M. Cancer stem cells: radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments. Adv Drug Deliv Rev. (2017) 109:63-73. doi: 10.1016/j.addr.2016.02.002
    • (2017) Adv Drug Deliv Rev , vol.109 , pp. 63-73
    • Krause, M.1    Dubrovska, A.2    Linge, A.3    Baumann, M.4
  • 122
    • 85046825668 scopus 로고    scopus 로고
    • Signalling mechanism (s) of epithelial-mesenchymal transition and cancer stem cells in tumour therapeutic resistance
    • Zhihong C, Yijing C, Yichen L, Haobin H, Hui L. Signalling mechanism (s) of epithelial-mesenchymal transition and cancer stem cells in tumour therapeutic resistance. Clin Chim Acta (2018) 483:156-63. doi: 10.1016/j.cca.2018.04.033
    • (2018) Clin Chim Acta , vol.483 , pp. 156-163
    • Zhihong, C.1    Yijing, C.2    Yichen, L.3    Haobin, H.4    Hui, L.5
  • 123
    • 84908275360 scopus 로고    scopus 로고
    • Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
    • Boelens MC, Wu TJ, Nabet BY, Xu B, Qiu Y, Yoon T, et al. Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell (2014) 159:499-513. doi: 10.1016/j.cell.2014.09.051
    • (2014) Cell , vol.159 , pp. 499-513
    • Boelens, M.C.1    Wu, T.J.2    Nabet, B.Y.3    Xu, B.4    Qiu, Y.5    Yoon, T.6
  • 124
    • 85039755329 scopus 로고    scopus 로고
    • Interferon-beta represses cancer stem cell properties in triple-negative breast cancer
    • Doherty MR, Cheon H, Junk DJ, Vinayak S, Varadan V, Telli ML, et al. Interferon-beta represses cancer stem cell properties in triple-negative breast cancer. Proc Natl Acad Sci USA. (2017) 114:13792-7. doi: 10.1073/pnas.1713728114
    • (2017) Proc Natl Acad Sci USA , vol.114 , pp. 13792-13797
    • Doherty, M.R.1    Cheon, H.2    Junk, D.J.3    Vinayak, S.4    Varadan, V.5    Telli, M.L.6
  • 125
    • 84998636529 scopus 로고    scopus 로고
    • Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents
    • Gaston J, Cheradame L, Yvonnet V, Deas O, Poupon M-F, Judde J-G, et al. Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents. Oncotarget (2016) 7:77205. doi: 10.18632/oncotarget.12858
    • (2016) Oncotarget , vol.7 , pp. 77205
    • Gaston, J.1    Cheradame, L.2    Yvonnet, V.3    Deas, O.4    Poupon, M.-F.5    Judde, J.-G.6
  • 126
    • 84947217032 scopus 로고    scopus 로고
    • Molecular pathways: targeting the stimulator of interferon genes (STING) in the immunotherapy of cancer
    • Corrales L, Gajewski TF. Molecular pathways: targeting the stimulator of interferon genes (STING) in the immunotherapy of cancer. Clin Cancer Res. (2015) 21:4774-9. doi: 10.1158/1078-0432.CCR-15-1362
    • (2015) Clin Cancer Res , vol.21 , pp. 4774-4779
    • Corrales, L.1    Gajewski, T.F.2
  • 127
    • 84929705879 scopus 로고    scopus 로고
    • Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
    • Corrales L, Glickman LH, McWhirter SM, Kanne DB, Sivick KE, Katibah GE, et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. (2015) 11:1018-30. doi: 10.1016/j.celrep.2015.04.031
    • (2015) Cell Rep , vol.11 , pp. 1018-1030
    • Corrales, L.1    Glickman, L.H.2    McWhirter, S.M.3    Kanne, D.B.4    Sivick, K.E.5    Katibah, G.E.6
  • 128
    • 85020641723 scopus 로고    scopus 로고
    • A STING agonist given with OX40 receptor and PD-L1 modulators primes immunity and reduces tumor growth in tolerized mice
    • Foote JB, Kok M, Leatherman JM, Armstrong TD, Marcinkowski BC, Ojalvo LS, et al. A STING agonist given with OX40 receptor and PD-L1 modulators primes immunity and reduces tumor growth in tolerized mice. Cancer Immunol Res. (2017) 5:468-79. doi: 10.1158/2326-6066.CIR-16-0284
    • (2017) Cancer Immunol Res , vol.5 , pp. 468-479
    • Foote, J.B.1    Kok, M.2    Leatherman, J.M.3    Armstrong, T.D.4    Marcinkowski, B.C.5    Ojalvo, L.S.6
  • 129
    • 85017389955 scopus 로고    scopus 로고
    • Induction of tumor regression by intratumoral STING agonists combined with anti-programmed death-L1 blocking antibody in a preclinical squamous cell carcinoma model
    • Gadkaree SK, Fu J, Sen R, Korrer MJ, Allen C, Kim YJ. Induction of tumor regression by intratumoral STING agonists combined with anti-programmed death-L1 blocking antibody in a preclinical squamous cell carcinoma model. Head Neck (2017) 39:1086-94. doi: 10.1002/hed.24704
    • (2017) Head Neck , vol.39 , pp. 1086-1094
    • Gadkaree, S.K.1    Fu, J.2    Sen, R.3    Korrer, M.J.4    Allen, C.5    Kim, Y.J.6
  • 130
    • 84890128532 scopus 로고    scopus 로고
    • STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo
    • Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, et al. STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo. Int J Cancer (2014) 134:997-1007. doi: 10.1002/ijc.28429
    • (2014) Int J Cancer , vol.134 , pp. 997-1007
    • Spitzner, M.1    Roesler, B.2    Bielfeld, C.3    Emons, G.4    Gaedcke, J.5    Wolff, H.A.6
  • 131
    • 79955000497 scopus 로고    scopus 로고
    • Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation
    • Ashizawa T, Miyata H, Ishii H, Oshita C, Matsuno K, Masuda Y, et al. Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. Int J Oncol. (2011) 38:1245-52. doi: 10.3892/ijo.2011.957
    • (2011) Int J Oncol , vol.38 , pp. 1245-1252
    • Ashizawa, T.1    Miyata, H.2    Ishii, H.3    Oshita, C.4    Matsuno, K.5    Masuda, Y.6
  • 132
    • 84942941353 scopus 로고    scopus 로고
    • Phase I study of OPB-31121, an oral STAT3 inhibitor, in patients with advanced solid tumors
    • Oh DY, Lee SH, Han SW, Kim MJ, Kim TM, Kim TY, et al. Phase I study of OPB-31121, an oral STAT3 inhibitor, in patients with advanced solid tumors. Cancer Res Treat. (2015) 47:607. doi: 10.4143/crt.2014.249
    • (2015) Cancer Res Treat , vol.47 , pp. 607
    • Oh, D.Y.1    Lee, S.H.2    Han, S.W.3    Kim, M.J.4    Kim, T.M.5    Kim, T.Y.6
  • 133
    • 77953208379 scopus 로고    scopus 로고
    • Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis
    • Mesa RA. Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis. IDrugs (2010) 13:394-403
    • (2010) IDrugs , vol.13 , pp. 394-403
    • Mesa, R.A.1
  • 134
    • 84910144414 scopus 로고    scopus 로고
    • Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC
    • Hu Y, Hong Y, Xu Y, Liu P, Guo D-H, Chen Y. Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC. Apoptosis (2014) 19:1627-36. doi: 10.1007/s10495-014-1030-z
    • (2014) Apoptosis , vol.19 , pp. 1627-1636
    • Hu, Y.1    Hong, Y.2    Xu, Y.3    Liu, P.4    Guo, D.-H.5    Chen, Y.6
  • 135
    • 85051872834 scopus 로고    scopus 로고
    • Transient inhibition of the JAK1/3-STAT5 pathway by ruxolitinib is insufficient to produce clinical benefit in patients with indolent adult T-cell leukemia
    • Dubois S, Miljkovic MD, Fleisher T, Hsu J, Waldmann TA, Conlon KC. Transient inhibition of the JAK1/3-STAT5 pathway by ruxolitinib is insufficient to produce clinical benefit in patients with indolent adult T-cell leukemia. Am Soc Hematol. (2017) 130:3840. Google Scholar
    • (2017) Am Soc Hematol , vol.130 , pp. 3840
    • Dubois, S.1    Miljkovic, M.D.2    Fleisher, T.3    Hsu, J.4    Waldmann, T.A.5    Conlon, K.C.6
  • 136
    • 84861216420 scopus 로고    scopus 로고
    • Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia
    • Eghtedar A, Verstovsek S, Estrov Z, Burger J, Cortes J, Bivins C, et al. Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia. Blood (2012) 119:4614-8. doi: 10.1182/blood-2011-12-400051
    • (2012) Blood , vol.119 , pp. 4614-4618
    • Eghtedar, A.1    Verstovsek, S.2    Estrov, Z.3    Burger, J.4    Cortes, J.5    Bivins, C.6
  • 137
    • 85047954913 scopus 로고    scopus 로고
    • JAK2 inhibitor SAR302503 abrogates PD-L1 expression and targets therapy resistant non-small cell lung cancers
    • Pitroda S, Stack M, Liu GF, Song SS, Chen L, Liang H, et al. JAK2 inhibitor SAR302503 abrogates PD-L1 expression and targets therapy resistant non-small cell lung cancers. Mol Cancer Ther. (2018) 17:732-9. doi: 10.1158/1535-7163.MCT-17-0667
    • (2018) Mol Cancer Ther , vol.17 , pp. 732-739
    • Pitroda, S.1    Stack, M.2    Liu, G.F.3    Song, S.S.4    Chen, L.5    Liang, H.6
  • 138
    • 85031741003 scopus 로고    scopus 로고
    • 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells
    • Wonganan O, He YJ, Shen XF, Wongkrajang K, Suksamrarn A, Zhang GL, et al. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicol Appl Pharmacol. (2017) 336:31-9. doi: 10.1016/j.taap.2017.10.004
    • (2017) Toxicol Appl Pharmacol , vol.336 , pp. 31-39
    • Wonganan, O.1    He, Y.J.2    Shen, X.F.3    Wongkrajang, K.4    Suksamrarn, A.5    Zhang, G.L.6
  • 139
    • 85041491182 scopus 로고    scopus 로고
    • Evidence for the ISG15-specific deubiquitinase USP18 as an antineoplastic target
    • Mustachio LM, Lu Y, Kawakami M, Roszik J, Freemantle SJ, Liu X, et al. Evidence for the ISG15-specific deubiquitinase USP18 as an antineoplastic target. Cancer Res. (2018) 78:587-92. doi: 10.1158/0008-5472.CAN-17-1752
    • (2018) Cancer Res , vol.78 , pp. 587-592
    • Mustachio, L.M.1    Lu, Y.2    Kawakami, M.3    Roszik, J.4    Freemantle, S.J.5    Liu, X.6
  • 140
    • 84862824416 scopus 로고    scopus 로고
    • LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism
    • Zhao W, Qi J, Wang L, Zhang M, Wang P, Gao C. LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism. FEBS Lett. (2012) 586:705-10. doi: 10.1016/j.febslet.2012.01.016
    • (2012) FEBS Lett , vol.586 , pp. 705-710
    • Zhao, W.1    Qi, J.2    Wang, L.3    Zhang, M.4    Wang, P.5    Gao, C.6
  • 142
    • 84941350329 scopus 로고    scopus 로고
    • Fine tuning of a type 1 interferon antagonist
    • Urin V, Levin D, Sharma N, Harari D, Schreiber G. Fine tuning of a type 1 interferon antagonist. PloS ONE (2015) 10:e0130797. doi: 10.1371/journal.pone.0130797
    • (2015) PloS ONE , vol.10
    • Urin, V.1    Levin, D.2    Sharma, N.3    Harari, D.4    Schreiber, G.5
  • 143
    • 85018399028 scopus 로고    scopus 로고
    • Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances
    • Simpson GR, Relph K, Harrington K, Melcher A, Pandha H. Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances. Oncolyt. Virother. (2016) 5:1. doi: 10.2147/OV.S66083
    • (2016) Oncolyt. Virother , vol.5 , pp. 1
    • Simpson, G.R.1    Relph, K.2    Harrington, K.3    Melcher, A.4    Pandha, H.5
  • 144
    • 84969174600 scopus 로고    scopus 로고
    • STAT1 and NF-κB inhibitors diminish basal interferon-stimulated gene expression and improve the productive infection of oncolytic HSV in MPNST cells
    • Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA. STAT1 and NF-κB inhibitors diminish basal interferon-stimulated gene expression and improve the productive infection of oncolytic HSV in MPNST cells. Mol Cancer Res. (2016) 14:482-92. doi: 10.1158/1541-7786.MCR-15-0427
    • (2016) Mol Cancer Res , vol.14 , pp. 482-492
    • Jackson, J.D.1    Markert, J.M.2    Li, L.3    Carroll, S.L.4    Cassady, K.A.5
  • 146
    • 85026323890 scopus 로고    scopus 로고
    • Ruxolitinib and polycation combination treatment overcomes multiple mechanisms of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
    • Felt SA, Droby GN, Grdzelishvili VZ. Ruxolitinib and polycation combination treatment overcomes multiple mechanisms of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. J Virol. (2017) 91:e00461-17. doi: 10.1128/JVI.00461-17
    • (2017) J Virol , vol.91
    • Felt, S.A.1    Droby, G.N.2    Grdzelishvili, V.Z.3
  • 147
    • 85006138340 scopus 로고    scopus 로고
    • Combination of the oral histone deacetylase inhibitor resminostat with oncolytic measles vaccine virus as a new option for epi-virotherapeutic treatment of hepatocellular carcinoma
    • Ruf B, Berchtold S, Venturelli S, Burkard M, Smirnow I, Prenzel T, et al. Combination of the oral histone deacetylase inhibitor resminostat with oncolytic measles vaccine virus as a new option for epi-virotherapeutic treatment of hepatocellular carcinoma. Mol Ther Oncolyt. (2015) 2:15019. doi: 10.1038/mto.2015.19
    • (2015) Mol Ther Oncolyt , vol.2 , pp. 15019
    • Ruf, B.1    Berchtold, S.2    Venturelli, S.3    Burkard, M.4    Smirnow, I.5    Prenzel, T.6
  • 148
    • 84937694462 scopus 로고    scopus 로고
    • Interferon beta and interferon alpha 2a differentially protect head and neck cancer cells from vesicular stomatitis virus-induced oncolysis
    • Westcott MM, Liu J, Rajani K, D'Agostino R, Lyles DS, Porosnicu M. Interferon beta and interferon alpha 2a differentially protect head and neck cancer cells from vesicular stomatitis virus-induced oncolysis. J Virol. (2015) 89:7944-54. doi: 10.1128/JVI.00757-15
    • (2015) J Virol , vol.89 , pp. 7944-7954
    • Westcott, M.M.1    Liu, J.2    Rajani, K.3    D'Agostino, R.4    Lyles, D.S.5    Porosnicu, M.6
  • 149
    • 85014004127 scopus 로고    scopus 로고
    • Suppression of type I IFN signaling in tumors mediates resistance to anti-PD-1 treatment that can be overcome by radiotherapy
    • Wang X, Schoenhals JE, Li A, Valdecanas DR, Ye H, Zang F, et al. Suppression of type I IFN signaling in tumors mediates resistance to anti-PD-1 treatment that can be overcome by radiotherapy. Cancer Res. (2017) 77:839-50. doi: 10.1158/0008-5472.CAN-15-3142
    • (2017) Cancer Res , vol.77 , pp. 839-850
    • Wang, X.1    Schoenhals, J.E.2    Li, A.3    Valdecanas, D.R.4    Ye, H.5    Zang, F.6


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