-
1
-
-
79958043675
-
-
Vintage 2009 Populations Available from
-
Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, et al. SEER Cancer Statistics Review, 1975-2009. (Vintage 2009 Populations). 2012. Available from http://seer.cancer.gov/ csr/19752009pops09/.
-
(2012)
SEER Cancer Statistics Review 1975- 2009
-
-
Howlader, N.1
Noone, A.M.2
Krapcho, M.3
Neyman, N.4
Aminou, R.5
Altekruse, S.F.6
-
2
-
-
69949095926
-
A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
-
Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, et al. A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res. 2009;15:5591-5598
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5591-5598
-
-
Weber, J.1
Thompson, J.A.2
Hamid, O.3
Minor, D.4
Amin, A.5
Ron, I.6
-
3
-
-
84856739604
-
Ipilimumab in pretreated patients with metastatic uveal melanoma: Safety and clinical efficacy
-
Danielli R, Ridolfi R, Chiarion-Sileni V, et al. Ipilimumab in pretreated patients with metastatic uveal melanoma: Safety and clinical efficacy. Cancer Immunol Immunother. 2012;61:41-48
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 41-48
-
-
Danielli, R.1
Ridolfi, R.2
Chiarion-Sileni, V.3
-
4
-
-
79953784382
-
Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy
-
Di Giacomo AM, Danielli R, Calabro L, Bertocci E, Nannicini C, Giannarelli D, et al. Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy). Cancer immunol. Immunother. 2011;60:467-477
-
(2011)
Cancer immunol. Immunother
, vol.60
, pp. 467-477
-
-
Di Giacomo, A.M.1
Danielli, R.2
Calabro, L.3
Bertocci, E.4
Nannicini, C.5
Giannarelli, D.6
-
5
-
-
82155168544
-
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
-
Hamid O, Schmidt H, Nissan A, Ridolfi L, Aamdal S, Hansson J, et al. A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med. 2011;9:204
-
(2011)
J Transl Med
, vol.9
, pp. 204
-
-
Hamid, O.1
Schmidt, H.2
Nissan, A.3
Ridolfi, L.4
Aamdal, S.5
Hansson, J.6
-
6
-
-
79955581263
-
A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naive patients with advanced melanoma
-
Hersh EM, O'Day SJ, Powderly J, Khan KD, Pavlick AC, Cranmer LD, et al. A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naive patients with advanced melanoma. Invest New Drugs. 2011;29:489-498
-
(2011)
Invest New Drugs
, vol.29
, pp. 489-498
-
-
Hersh, E.M.1
O'Day, S.J.2
Powderly, J.3
Khan, K.D.4
Pavlick, A.C.5
Cranmer, L.D.6
-
7
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711-723
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
8
-
-
77955256254
-
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: A multicenter singlearm phase II study
-
O'Day SJ, Maio M, Chiarion-Sileni V, Gajewski TF, Pehamberger H, Bondarenko IN, et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: A multicenter singlearm phase II study. Ann Oncol. 2010;21:1712-1717
-
(2010)
Ann Oncol
, vol.21
, pp. 1712-1717
-
-
O'Day, S.J.1
Maio, M.2
Chiarion-Sileni, V.3
Gajewski, T.F.4
Pehamberger, H.5
Bondarenko, I.N.6
-
9
-
-
58049202334
-
Phase I/II study of ipilimumab for patients with metastatic melanoma
-
Weber JS, O'Day S, Urba W, Powderly J, Nichol G, Yellin M, et al. Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol. 2008;26:5950-5956
-
(2008)
J Clin Oncol
, vol.26
, pp. 5950-5956
-
-
Weber, J.S.1
O'Day, S.2
Urba, W.3
Powderly, J.4
Nichol, G.5
Yellin, M.6
-
10
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
-
Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010;11:155-164
-
(2010)
Lancet Oncol
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
Negrier, S.4
Lutzky, J.5
Thomas, L.6
-
11
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364:2507-2516
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
-
12
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363:809-819
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
Sosman, J.A.6
-
13
-
-
84863116743
-
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
-
Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012;366:707-714
-
(2012)
N Engl J Med
, vol.366
, pp. 707-714
-
-
Sosman, J.A.1
Kim, K.B.2
Schuchter, L.3
Gonzalez, R.4
Pavlick, A.C.5
Weber, J.S.6
-
14
-
-
33644970827
-
Randomized dose-escalation study evaluating peginterferon alfa-2a in patients with metastatic malignant melanoma
-
Dummer R, Garbe C, Thompson JA, Eggermont AM, Yoo K, Maier T, et al. Randomized dose-escalation study evaluating peginterferon alfa-2a in patients with metastatic malignant melanoma. J Clin Oncol. 2006;24:1188-1194
-
(2006)
J Clin Oncol
, vol.24
, pp. 1188-1194
-
-
Dummer, R.1
Garbe, C.2
Thompson, J.A.3
Eggermont, A.M.4
Yoo, K.5
Maier, T.6
-
15
-
-
46749103710
-
Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: Final results of EORTC 18991, a randomised phase III trial
-
Eggermont AM, Suciu S, Santinami M, Testori A, Kruit WH, Marsden J, et al. Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: Final results of EORTC 18991, a randomised phase III trial. Lancet. 2008;372:117-126
-
(2008)
Lancet
, vol.372
, pp. 117-126
-
-
Eggermont, A.M.1
Suciu, S.2
Santinami, M.3
Testori, A.4
Kruit, W.H.5
Marsden, J.6
-
16
-
-
44849131339
-
Adjuvant low-dose interferon {alpha}2a with or without dacarbazine compared with surgery alone: A prospective-randomized phase III DeCOG trial in melanoma patients with regional lymph node metastasis
-
Garbe C, Radny P, Linse R, Dummer R, Gutzmer R, Ulrich J, et al. Adjuvant low-dose interferon {alpha}2a with or without dacarbazine compared with surgery alone: A prospective-randomized phase III DeCOG trial in melanoma patients with regional lymph node metastasis. Ann Oncol. 2008;19:1195-1201
-
(2008)
Ann Oncol
, vol.19
, pp. 1195-1201
-
-
Garbe, C.1
Radny, P.2
Linse, R.3
Dummer, R.4
Gutzmer, R.5
Ulrich, J.6
-
17
-
-
79151485188
-
Two different durations of adjuvant therapy with intermediate-dose interferon alfa-2b in patients with high-risk melanoma (Nordic IFN trial): A randomised phase 3 trial
-
Hansson J, Aamdal S, Bastholt L, Brandberg Y, Hernberg M, Nilsson B, et al. Two different durations of adjuvant therapy with intermediate-dose interferon alfa-2b in patients with high-risk melanoma (Nordic IFN trial): A randomised phase 3 trial. Lancet Oncol. 2011;12:144-152
-
(2011)
Lancet Oncol
, vol.12
, pp. 144-152
-
-
Hansson, J.1
Aamdal, S.2
Bastholt, L.3
Brandberg, Y.4
Hernberg, M.5
Nilsson, B.6
-
18
-
-
77649217618
-
Efficacy of low-dose interferon {alpha}2a 18 versus 60 months of treatment in patients with primary melanoma of >= 1.5 mm tumor thickness: Results of a randomized phase III DeCOG trial
-
Hauschild A, Weichenthal M, Rass K, Linse R, Berking C, Böttjer J, et al. Efficacy of low-dose interferon {alpha}2a 18 versus 60 months of treatment in patients with primary melanoma of >= 1.5 mm tumor thickness: Results of a randomized phase III DeCOG trial. J Clinical Oncol. 2010;28:841-846
-
(2010)
J Clinical Oncol
, vol.28
, pp. 841-846
-
-
Hauschild, A.1
Weichenthal, M.2
Rass, K.3
Linse, R.4
Berking, C.5
Böttjer, J.6
-
19
-
-
79954438231
-
Halpha b2m and sil-2r levels are biological correlates of outcome in adjuvant ifn-alpha2b treatment of patients with melanoma
-
Hofmann MA, Kiecker F, Kuchler I, Kors C, Trefzer U. Serum TNFalpha, B2M and sIL-2R levels are biological correlates of outcome in adjuvant IFN-alpha2b treatment of patients with melanoma. J Cancer Res Clin Oncol. 2011;137:455-462
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 455-462
-
-
Hofmann, M.A.1
Kiecker, F.2
Kuchler, I.3
Kors, C.4
Trefzer, U.5
Serum, T.N.6
-
20
-
-
59549100740
-
A randomized phase III trial of biochemotherapy versus interferon-alpha-2b for adjuvant therapy in patients at high risk for melanoma recurrence
-
Kim KB, Legha SS, Gonzalez R, Anderson CM, Johnson MM, Liu P, et al. A randomized phase III trial of biochemotherapy versus interferon-alpha-2b for adjuvant therapy in patients at high risk for melanoma recurrence. Melanoma Res. 2009;19:42-49
-
(2009)
Melanoma Res
, vol.19
, pp. 42-49
-
-
Kim, K.B.1
Legha, S.S.2
Gonzalez, R.3
Anderson, C.M.4
Johnson, M.M.5
Liu, P.6
-
21
-
-
79958797459
-
A randomised phase II trial of 1 month versus 1 year of adjuvant high-dose interferon alpha-2b in high-risk acral melanoma patients
-
Mao L, Si L, Chi Z, Cui C, Sheng X, Li S, et al. A randomised phase II trial of 1 month versus 1 year of adjuvant high-dose interferon alpha-2b in high-risk acral melanoma patients. Eur J Cancer. 2011; 47:1498-1503
-
(2011)
Eur J Cancer
, vol.47
, pp. 1498-1503
-
-
Mao, L.1
Si, L.2
Chi, Z.3
Cui, C.4
Sheng, X.5
Li, S.6
-
22
-
-
60849108348
-
Randomized phase III study of 1 month versus 1 year of adjuvant high-dose interferon alfa-2b in patients with resected high-risk melanoma
-
Pectasides D, Dafni U, Bafaloukos D, Skarlos D, Polyzos A, Tsoutsos D, et al. Randomized phase III study of 1 month versus 1 year of adjuvant high-dose interferon alfa-2b in patients with resected high-risk melanoma. J Clin Oncol. 2009;27:939-944
-
(2009)
J Clin Oncol
, vol.27
, pp. 939-944
-
-
Pectasides, D.1
Dafni, U.2
Bafaloukos, D.3
Skarlos, D.4
Polyzos, A.5
Tsoutsos, D.6
-
23
-
-
1842562211
-
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: A phase III study
-
Avril MF, Aamdal S, Grob JJ, Hauschild A, Mohr P, Bonerandi JJ, et al. Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: A phase III study. J Clin Oncol. 2004;22:1118- 1125
-
(2004)
J Clin Oncol
, vol.22
, pp. 1118-1125
-
-
Avril, M.F.1
Aamdal, S.2
Grob, J.J.3
Hauschild, A.4
Mohr, P.5
Bonerandi, J.J.6
-
24
-
-
79953324540
-
Phase 3 study of docosahexaenoic acid-paclitaxel versus dacarbazine in patients with metastatic malignant melanoma
-
Bedikian AY, DeConti RC, Conry R, Agarwala S, Papadopoulos N, Kim KB, et al. Phase 3 study of docosahexaenoic acid-paclitaxel versus dacarbazine in patients with metastatic malignant melanoma. Ann Oncol. 2011;22:787-793
-
(2011)
Ann Oncol
, vol.22
, pp. 787-793
-
-
Bedikian, A.Y.1
DeConti, R.C.2
Conry, R.3
Agarwala, S.4
Papadopoulos, N.5
Kim, K.B.6
-
25
-
-
0032858487
-
Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma
-
Chapman PB, Einhorn LH, Meyers ML, Saxman S, Destro AN, Panageas KS, et al. Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol. 1999;17:2745-2751
-
(1999)
J Clin Oncol
, vol.17
, pp. 2745-2751
-
-
Chapman, P.B.1
Einhorn, L.H.2
Meyers, M.L.3
Saxman, S.4
Destro, A.N.5
Panageas, K.S.6
-
26
-
-
0031805725
-
Phase III trial of dacarbazine versus dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: An Eastern Cooperative Oncology Group study
-
Falkson CI, Ibrahim J, Kirkwood JM, Coates AS, Atkins MB, Blum RH. Phase III trial of dacarbazine versus dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: An Eastern Cooperative Oncology Group study. J Clin Oncol. 1998;16:1743-1751
-
(1998)
J Clin Oncol
, vol.16
, pp. 1743-1751
-
-
Falkson, C.I.1
Ibrahim, J.2
Kirkwood, J.M.3
Coates, A.S.4
Atkins, M.B.5
Blum, R.H.6
-
27
-
-
34848865621
-
Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage IV melanoma
-
Middleton M, Hauschild A, Thomson D, Anderson R, Burdette- Radoux S, Gehlsen K, et al. Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage IV melanoma. Ann Oncol. 2007;18:1691-1697
-
(2007)
Ann Oncol
, vol.18
, pp. 1691-1697
-
-
Middleton, M.1
Hauschild, A.2
Thomson, D.3
Anderson, R.4
Burdette- Radoux, S.5
Gehlsen, K.6
-
28
-
-
0033989205
-
Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma
-
Middleton MR, Grob JJ, Aaronson N, Fierlbeck G, Tilgen W, Seiter S, et al. Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol. 2000;18:158-166
-
(2000)
J Clin Oncol
, vol.18
, pp. 158-166
-
-
Middleton, M.R.1
Grob, J.J.2
Aaronson, N.3
Fierlbeck, G.4
Tilgen, W.5
Seiter, S.6
-
29
-
-
79958783120
-
Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: Final results of a randomised phase III study (EORTC 18032
-
Patel PM, Suciu S, Mortier L, Fierlbeck G, Tilgen W, Seiter S, et al. Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: Final results of a randomised phase III study (EORTC 18032). Eur J Cancer. 2011;47:1476-1483
-
(2011)
Eur J Cancer
, vol.47
, pp. 1476-1483
-
-
Patel, P.M.1
Suciu, S.2
Mortier, L.3
Fierlbeck, G.4
Tilgen, W.5
Seiter, S.6
-
30
-
-
33645325115
-
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: A randomized phase III trial of the DC study group of the DeCOG
-
Schadendorf D, Ugurel S, Schuler-Thurner B, Nestle FO, Enk A, Bröcker EB, et al. Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: A randomized phase III trial of the DC study group of the DeCOG. Ann Oncol. 2006;17:563-570
-
(2006)
Ann Oncol
, vol.17
, pp. 563-570
-
-
Schadendorf, D.1
Ugurel, S.2
Schuler-Thurner, B.3
Nestle, F.O.4
Enk, A.5
Bröcker, E.B.6
-
31
-
-
0033024863
-
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
-
Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993. J Clin Oncol. 1999;17:2105-2116
-
(1999)
J Clin Oncol
, vol.17
, pp. 2105-2116
-
-
Atkins, M.B.1
Lotze, M.T.2
Dutcher, J.P.3
Fisher, R.I.4
Weiss, G.5
Margolin, K.6
-
32
-
-
0027524697
-
Randomized phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon alfa-2a in patients with advanced melanoma
-
Sparano JA, Fisher RI, Sunderland M, Margolin K, Ernest ML, Sznol M, et al. Randomized phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon alfa-2a in patients with advanced melanoma. J Clin Oncol. 1993;11:1969-1977
-
(1993)
J Clin Oncol
, vol.11
, pp. 1969-1977
-
-
Sparano, J.A.1
Fisher, R.I.2
Sunderland, M.3
Margolin, K.4
Ernest, M.L.5
Sznol, M.6
-
33
-
-
34548543781
-
Durable complete responses with high-dose bolus interleukin-2 in patients with metastatic melanoma who have experienced progression after biochemotherapy
-
Tarhini AA, Kirkwood JM, Gooding WE, Cai C, Agarwala SS. Durable complete responses with high-dose bolus interleukin-2 in patients with metastatic melanoma who have experienced progression after biochemotherapy. J Clin Oncol. 2007;25:3802-3807
-
(2007)
J Clin Oncol
, vol.25
, pp. 3802-3807
-
-
Tarhini, A.A.1
Kirkwood, J.M.2
Gooding, W.E.3
Cai, C.4
Agarwala, S.S.5
-
34
-
-
78650428877
-
Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma
-
Berman D, Parker SM, Siegel J, Chasalow SD, Weber J, Galbraith S, et al. Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun. 2010;10:11
-
(2010)
Cancer Immun
, vol.10
, pp. 11
-
-
Berman, D.1
Parker, S.M.2
Siegel, J.3
Chasalow, S.D.4
Weber, J.5
Galbraith, S.6
-
36
-
-
67650848410
-
Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immune-related colitis
-
Minor DR, Chin K, Kashani-Sabet M. Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immune-related colitis. Cancer Biother Radiopharm. 2009;24:321-325
-
(2009)
Cancer Biother Radiopharm
, vol.24
, pp. 321-325
-
-
Minor, D.R.1
Chin, K.2
Kashani-Sabet, M.3
-
37
-
-
70350244517
-
Cytotoxic Tlymphocyte- Associated antigen 4 antibody-induced colitis and its management with infliximab
-
Johnston RL, Lutzky J, Chodhry A, Barkin JS. Cytotoxic Tlymphocyte- Associated antigen 4 antibody-induced colitis and its management with infliximab. Dig Dis Sci. 2009;54:2538-2540
-
(2009)
Dig Dis Sci
, vol.54
, pp. 2538-2540
-
-
Johnston, R.L.1
Lutzky, J.2
Chodhry, A.3
Barkin, J.S.4
-
38
-
-
84862908526
-
RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors
-
Oberholzer PA, Kee D, Dziunycz P, Sucker A, Kamsukom N, Jones R, et al. RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors. J Clin Oncol. 2012;30:316-312
-
(2012)
J Clin Oncol
, vol.30
, pp. 316-312
-
-
Oberholzer, P.A.1
Kee, D.2
Dziunycz, P.3
Sucker, A.4
Kamsukom, N.5
Jones, R.6
-
39
-
-
84862908097
-
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
-
Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med. 2012;366:207-215
-
(2012)
N Engl J Med
, vol.366
, pp. 207-215
-
-
Su, F.1
Viros, A.2
Milagre, C.3
Trunzer, K.4
Bollag, G.5
Spleiss, O.6
-
40
-
-
84855435059
-
Skin tumors induced by sorafenib; paradoxic rasraf pathway activation and oncogenic mutations of hras tp53 and tgfbr1
-
Arnault JP, Mateus C, Escudier B, Tomasic G, Wechsler J, Hollville E, et al. Skin tumors induced by sorafenib; paradoxic RASRAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1. Clin Cancer Res. 2012;18:263-272
-
(2012)
Clin Cancer Res
, vol.18
, pp. 263-272
-
-
Arnault, J.P.1
Mateus, C.2
Escudier, B.3
Tomasic, G.4
Wechsler, J.5
Hollville, E.6
-
41
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature. 2010;464:431-435
-
(2010)
Nature
, vol.464
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
Brandhuber, B.J.4
Anderson, D.J.5
Alvarado, R.6
-
42
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 2010;464:427-430
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
43
-
-
77949354563
-
PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells
-
Halaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, et al. PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells. Pigment Cell Melanoma Res. 2010;23:190-200
-
(2010)
Pigment Cell Melanoma Res
, vol.23
, pp. 190-200
-
-
Halaban, R.1
Zhang, W.2
Bacchiocchi, A.3
Cheng, E.4
Parisi, F.5
Ariyan, S.6
-
44
-
-
39749104201
-
Practical guidelines for the management of interferon- Alpha-2b side effects in patients receiving adjuvant treatment for melanoma: Expert opinion
-
Hauschild A, Gogas H, Tarhini A, Middleton MR, Testori A, Dréno B, et al. Practical guidelines for the management of interferon- Alpha-2b side effects in patients receiving adjuvant treatment for melanoma: Expert opinion. Cancer. 2008;112:982-994
-
(2008)
Cancer
, vol.112
, pp. 982-994
-
-
Hauschild, A.1
Gogas, H.2
Tarhini, A.3
Middleton, M.R.4
Testori, A.5
Dréno, B.6
-
45
-
-
84863986611
-
Side effects in melanoma patients receiving adjuvant interferon alfa-2b therapy: A nurse's perspective
-
Rubin KM, Vona K, Madden K, McGettigan S, Braun IM. Side effects in melanoma patients receiving adjuvant interferon alfa-2b therapy: A nurse's perspective. Support Care Cancer. 2012;20:1601-1611
-
(2012)
Support Care Cancer
, vol.20
, pp. 1601-1611
-
-
Rubin, K.M.1
Vona, K.2
Madden, K.3
McGettigan, S.4
Braun, I.M.5
-
46
-
-
78649682500
-
Dose-dependent development of depressive symptoms during adjuvant interferon-{alpha} treatment of patients with malignant melanoma
-
Friebe A, Horn M, Schmidt F, Janssen G, Schmid-Wendtner MH, Volkenandt M, et al. Dose-dependent development of depressive symptoms during adjuvant interferon-{alpha} treatment of patients with malignant melanoma. Psychosomatics. 2010;51:466-473
-
(2010)
Psychosomatics
, vol.51
, pp. 466-473
-
-
Friebe, A.1
Horn, M.2
Schmidt, F.3
Janssen, G.4
Schmid-Wendtner, M.H.5
Volkenandt, M.6
-
47
-
-
74349126816
-
Depressive mood changes and psychiatric symptoms during 12-month low-dose interferon-alpha treatment in patients with malignant melanoma: Results from the multicenter DeCOG trial
-
Heinze S, Egberts F, Rotzer S, Volkenandt M, Tilgen W, Linse R, et al. Depressive mood changes and psychiatric symptoms during 12-month low-dose interferon-alpha treatment in patients with malignant melanoma: Results from the multicenter DeCOG trial. J Immunother. 2010; 33:106-114
-
(2010)
J Immunother
, vol.33
, pp. 106-114
-
-
Heinze, S.1
Egberts, F.2
Rotzer, S.3
Volkenandt, M.4
Tilgen, W.5
Linse, R.6
-
48
-
-
73249124584
-
Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: Primary to induced disorders
-
Navines R, Gomez-Gil E, Puig S, Baeza I, De Pablo J, Martin- Santos R. Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: Primary to induced disorders. Eur J Dermatol. 2009;19:611-615
-
(2009)
Eur J Dermatol
, vol.19
, pp. 611-615
-
-
Navines, R.1
Gomez-Gil, E.2
Puig, S.3
Baeza, I.4
De Pablo, J.5
Martin- Santos, R.6
-
49
-
-
0036199336
-
Neurobehavioral effects of interferon-alpha in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions
-
Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CB, et al. Neurobehavioral effects of interferon-alpha in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology. 2002;26:643-652
-
(2002)
Neuropsychopharmacology
, vol.26
, pp. 643-652
-
-
Capuron, L.1
Gumnick, J.F.2
Musselman, D.L.3
Lawson, D.H.4
Reemsnyder, A.5
Nemeroff, C.B.6
-
50
-
-
34547794475
-
The immune-mediated alteration of serotonin and glutamate: Towards an integrated view of depression
-
Muller N, Schwarz MJ. The immune-mediated alteration of serotonin and glutamate: Towards an integrated view of depression. Mol psychiatry. 2007;12:988-1000
-
(2007)
Mol psychiatry
, vol.12
, pp. 988-1000
-
-
Muller, N.1
Schwarz, M.J.2
-
51
-
-
0035985472
-
Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
-
Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R. Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol psychiatry. 2002;7:468-473
-
(2002)
Mol psychiatry
, vol.7
, pp. 468-473
-
-
Capuron, L.1
Ravaud, A.2
Neveu, P.J.3
Miller, A.H.4
Maes, M.5
Dantzer, R.6
-
52
-
-
0025949160
-
Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS
-
Brown RR, Ozaki Y, Datta SP, Borden EC, Sondel PM, Malone DG. Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS. Adv Exp Med Biol. 1991;294:425- 435
-
(1991)
Adv Exp Med Biol
, vol.294
, pp. 425-435
-
-
Brown, R.R.1
Ozaki, Y.2
Datta, S.P.3
Borden, E.C.4
Sondel, P.M.5
Malone, D.G.6
-
53
-
-
3142664534
-
Pegylated interferon-alpha2b treatment in melanoma patients: Influence on amino acids, 5-hydroxyindolacetic acid and pteridine plasma concentrations
-
Van Gool AR, van Ojik HH, Kruit WH, Bannink M, Mulder PG, Eggermont AM, et al. Pegylated interferon-alpha2b treatment in melanoma patients: Influence on amino acids, 5-hydroxyindolacetic acid and pteridine plasma concentrations. Anticancer Drugs. 2004;15: 587-591
-
(2004)
Anticancer Drugs
, vol.15
, pp. 587-591
-
-
Van Gool, A.R.1
Van Ojik, H.H.2
Kruit, W.H.3
Bannink, M.4
Mulder, P.G.5
Eggermont, A.M.6
-
54
-
-
0028032353
-
-
Delgado PL, Price LH, Miller HL, Salomon RM, Aghajanian GK, Heninger GR, et al. Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psychiatry. 1994;51:865-874
-
(1994)
Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psychiatry
, vol.51
, pp. 865-874
-
-
Delgado, P.L.1
Price, L.H.2
Miller, H.L.3
Salomon, R.M.4
Aghajanian, G.K.5
Heninger, G.R.6
-
55
-
-
0028178126
-
5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone
-
Cowen PJ, Power AC, Ware CJ, Anderson IM. 5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone. Br J Psychiatry. 1994;164:372-379
-
(1994)
Br J Psychiatry
, vol.164
, pp. 372-379
-
-
Cowen, P.J.1
Power, A.C.2
Ware, C.J.3
Anderson, I.M.4
-
56
-
-
0028180671
-
The relationship of platelet 5-HT2 receptor indices to major depressive disorder, personality traits, and suicidal behavior
-
McBride PA, Brown RP, DeMeo M, Keilp J, Mieczkowski T, Mann JJ. The relationship of platelet 5-HT2 receptor indices to major depressive disorder, personality traits, and suicidal behavior. Biol Psychiatry. 1994;35:295-308
-
(1994)
Biol Psychiatry
, vol.35
, pp. 295-308
-
-
McBride, P.A.1
Brown, R.P.2
DeMeo, M.3
Keilp, J.4
Mieczkowski, T.5
Mann, J.J.6
-
57
-
-
0029012902
-
Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia
-
Pavol MA, Meyers CA, Rexer JL, Valentine AD, Mattis PJ, Talpaz M. Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia. Neurology. 1995;45:947-950
-
(1995)
Neurology
, vol.45
, pp. 947-950
-
-
Pavol, M.A.1
Meyers, C.A.2
Rexer, J.L.3
Valentine, A.D.4
Mattis, P.J.5
Talpaz, M.6
-
58
-
-
0025921602
-
Persistent neurotoxicity of systemically administered interferon-alpha
-
Meyers CA, Scheibel RS, Forman AD. Persistent neurotoxicity of systemically administered interferon-alpha. Neurology. 1991;41:672- 676
-
(1991)
Neurology
, vol.41
, pp. 672-676
-
-
Meyers, C.A.1
Scheibel, R.S.2
Forman, A.D.3
-
59
-
-
0031040003
-
Repeated interferon-alpha administration inhibits dopaminergic neural activity in the mouse brain
-
Shuto H, Kataoka Y, Horikawa T, Fujihara N, Oishi R. Repeated interferon-alpha administration inhibits dopaminergic neural activity in the mouse brain. Brain Res. 1997;747:348-351
-
(1997)
Brain Res
, vol.747
, pp. 348-351
-
-
Shuto, H.1
Kataoka, Y.2
Horikawa, T.3
Fujihara, N.4
Oishi, R.5
-
60
-
-
84863896049
-
Escitalopram for the prevention of peginterferon-alpha2a-associated depression in hepatitis c virus-infected patients without previous psychiatric disease: A randomized trial
-
Schaefer M, Sarkar R, Knop V, Effenberger S, Friebe A, Heinze L, et al. Escitalopram for the Prevention of Peginterferon-alpha2a-Associated Depression in Hepatitis C Virus-Infected Patients Without Previous Psychiatric Disease: A Randomized Trial. Ann Intern Med. 2012;157: 94-103
-
(2012)
Ann Intern Med
, vol.157
, pp. 94-103
-
-
Schaefer, M.1
Sarkar, R.2
Knop, V.3
Effenberger, S.4
Friebe, A.5
Heinze, L.6
-
61
-
-
18844395344
-
Prevention of interferon-alpha associated depression in psychiatric risk patients with chronic hepatitis C
-
Schaefer M, Schwaiger M, Garkisch AS, Pich M, Hinzpeter A, Uebelhack R, et al. Prevention of interferon-alpha associated depression in psychiatric risk patients with chronic hepatitis C. J Hepatol. 2005;42:793-798
-
(2005)
J Hepatol
, vol.42
, pp. 793-798
-
-
Schaefer, M.1
Schwaiger, M.2
Garkisch, A.S.3
Pich, M.4
Hinzpeter, A.5
Uebelhack, R.6
-
62
-
-
34247550405
-
Paroxetine for prevention of depressive symptoms induced by interferon-alpha and ribavirin for hepatitis C
-
Raison CL, Woolwine BJ, Demetrashvili MF, Borisov AS, Weinreib R, Staab JP, et al. Paroxetine for prevention of depressive symptoms induced by interferon-alpha and ribavirin for hepatitis C. Alimentary Pharmacol Ther. 2007;25:1163-1174
-
(2007)
Alimentary Pharmacol Ther
, vol.25
, pp. 1163-1174
-
-
Raison, C.L.1
Woolwine, B.J.2
Demetrashvili, M.F.3
Borisov, A.S.4
Weinreib, R.5
Staab, J.P.6
-
63
-
-
0035967235
-
Paroxetine for the prevention of depression induced by high-dose interferon alfa
-
Musselman DL, Lawson DH, Gumnick JF, Manatunga AK, Penna S, Goodkin RS, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N Engl J Med. 2001;344:961-966
-
(2001)
N Engl J Med
, vol.344
, pp. 961-966
-
-
Musselman, D.L.1
Lawson, D.H.2
Gumnick, J.F.3
Manatunga, A.K.4
Penna, S.5
Goodkin, R.S.6
-
64
-
-
33745045211
-
Listeria brain abscess pneumocystis pneumonia and kaposi's sarcoma after temozolomide
-
quiz following 343
-
Ganiere V, Christen G, Bally F, Guillou L, Pica A, de Ribaupierre S, et al. Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide. Nature Clin Pract Oncol. 2006;3:339- 343; quiz following 343
-
(2006)
Nature Clin Pract Oncol
, vol.3
, pp. 339-343
-
-
Ganiere, V.1
Christen, G.2
Bally, F.3
Guillou, L.4
Pica, A.5
De Ribaupierre, S.6
-
65
-
-
0027501997
-
Activity and unexpected lung toxicity of the sequential administration of two alkylating agents-dacarbazine and fotemustine-in patients with melanoma
-
Gerard B, Aamdal S, Lee SM, Leyvraz S, Lucas C, D'Incalci M, et al. Activity and unexpected lung toxicity of the sequential administration of two alkylating agents-dacarbazine and fotemustine-in patients with melanoma. Eur J Cancer. 1993;29A:711-719
-
(1993)
Eur J Cancer
, vol.29 A
, pp. 711-719
-
-
Gerard, B.1
Aamdal, S.2
Lee, S.M.3
Leyvraz, S.4
Lucas, C.5
D'Incalci, M.6
-
66
-
-
0026586976
-
Sequential administration of dacarbazine and fotemustine in patients with disseminated malignant melanoma-an effective combination with unexpected toxicity
-
Aamdal S, Gerard B, Bohman T, D'Incalci M. Sequential administration of dacarbazine and fotemustine in patients with disseminated malignant melanoma-an effective combination with unexpected toxicity. Eur J Cancer. 1992;28:447-450
-
(1992)
Eur J Cancer
, vol.28
, pp. 447-450
-
-
Aamdal, S.1
Gerard, B.2
Bohman, T.3
D'Incalci, M.4
-
67
-
-
0019507523
-
Interstitial pneumonitis associated with mitomycin C and DTIC: A case report
-
Yoon JM, Rao U, Vassilopoulos PP, Ledesma E, Mittelman A. Interstitial pneumonitis associated with mitomycin C and DTIC: A case report. Med Pediatr Oncol. 1981;9:61-67
-
(1981)
Med Pediatr Oncol
, vol.9
, pp. 61-67
-
-
Yoon, J.M.1
Rao, U.2
Vassilopoulos, P.P.3
Ledesma, E.4
Mittelman, A.5
-
69
-
-
0021287831
-
O6-alkylguanine- DNA alkyltransferase activity in normal human tissues and cells
-
Grafstrom RC, Pegg AE, Trump BF, Harris CC. O6-alkylguanine- DNA alkyltransferase activity in normal human tissues and cells. Cancer Res. 1984;44:2855-2857
-
(1984)
Cancer Res
, vol.44
, pp. 2855-2857
-
-
Grafstrom, R.C.1
Pegg, A.E.2
Trump, B.F.3
Harris, C.C.4
-
70
-
-
0022931463
-
Comparison of O6- Alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues
-
Gerson SL, Trey JE, Miller K, Berger NA. Comparison of O6- Alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis. 1986;7: 745-749
-
(1986)
Carcinogenesis
, vol.7
, pp. 745-749
-
-
Gerson, S.L.1
Trey, J.E.2
Miller, K.3
Berger, N.A.4
-
71
-
-
70149115865
-
Quantitative analysis of cytokine-induced vascular toxicity and vascular leak in the mouse brain
-
Irwan YY, Feng Y, Gach HM, Symanowski JT, McGregor JR, Veni G, et al. Quantitative analysis of cytokine-induced vascular toxicity and vascular leak in the mouse brain. J Immunol Methods. 2009;349:45-55
-
(2009)
J Immunol Methods
, vol.349
, pp. 45-55
-
-
Irwan, Y.Y.1
Feng, Y.2
Gach, H.M.3
Symanowski, J.T.4
McGregor, J.R.5
Veni, G.6
-
72
-
-
0023875966
-
Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome
-
Cotran RS, Pober JS, Gimbrone MA Jr, Springer TA, Wiebke EA, Gaspari AA, et al. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. J Immunol. 1988;140:1883-1888
-
(1988)
J Immunol
, vol.140
, pp. 1883-1888
-
-
Cotran, R.S.1
Pober, J.S.2
Gimbrone Jr., M.A.3
Springer, T.A.4
Wiebke, E.A.5
Gaspari, A.A.6
-
73
-
-
0026605238
-
Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy
-
Hibbs JB Jr, Westenfelder C, Taintor R, Vavrin Z, Kablitz C, Baranowski RL, et al. Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. J Clinl Invest. 1992;89:867-877
-
(1992)
J Clinl Invest
, vol.89
, pp. 867-877
-
-
Hibbs Jr., J.B.1
Westenfelder, C.2
Taintor, R.3
Vavrin, Z.4
Kablitz, C.5
Baranowski, R.L.6
-
74
-
-
79957922807
-
Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome
-
Samlowski WE, Kondapaneni M, Tharkar S, McGregor JR, Laubach VE, Salvemini D. Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome. J Immunother. 2011;34:419-427
-
(2011)
J Immunother
, vol.34
, pp. 419-427
-
-
Samlowski, W.E.1
Kondapaneni, M.2
Tharkar, S.3
McGregor, J.R.4
Laubach, V.E.5
Salvemini, D.6
-
75
-
-
0026586461
-
The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids
-
Palmer RM, Bridge L, Foxwell NA, Moncada S. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids. Br J Pharmacol. 1992;105:11-12
-
(1992)
Br J Pharmacol
, vol.105
, pp. 11-12
-
-
Palmer, R.M.1
Bridge, L.2
Foxwell, N.A.3
Moncada, S.4
-
76
-
-
0032475865
-
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
-
Xia Y, Tsai AL, Berka V, Zweier JL. Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem. 1998;273: 25804-25808
-
(1998)
J Biol Chem
, vol.273
, pp. 25804-25808
-
-
Xia, Y.1
Tsai, A.L.2
Berka, V.3
Zweier, J.L.4
-
77
-
-
0038714286
-
A nonpeptidyl mimic of superoxide dismutase M40403, inhibits dose-limiting hypotension associated with interleukin- 2 and increases its antitumor effects
-
Samlowski WE, Petersen R, Cuzzocrea S, Macarthur H, Burton D, McGregor JR, et al. A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin- 2 and increases its antitumor effects. Nat Med. 2003;9:750-755
-
(2003)
Nat Med
, vol.9
, pp. 750-755
-
-
Samlowski, W.E.1
Petersen, R.2
Cuzzocrea, S.3
Macarthur, H.4
Burton, D.5
McGregor, J.R.6
-
78
-
-
42649085034
-
Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice
-
Kondapaneni M, McGregor JR, Salvemini D, Laubach VE, Samlowski WE. Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice. J Immunother. 2008;31:325-333
-
(2008)
J Immunother
, vol.31
, pp. 325-333
-
-
Kondapaneni, M.1
McGregor, J.R.2
Salvemini, D.3
Laubach, V.E.4
Samlowski, W.E.5
-
80
-
-
0027980054
-
A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy
-
Pockaj BA, Yang JC, Lotze MT, Lange JR, Spencer WF, Steinberg SM, et al. A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy. J Immunother Emphasis Tumor Immunol. 1994;15:22-28
-
(1994)
J Immunother Emphasis Tumor Immunol
, vol.15
, pp. 22-28
-
-
Pockaj, B.A.1
Yang, J.C.2
Lotze, M.T.3
Lange, J.R.4
Spencer, W.F.5
Steinberg, S.M.6
-
81
-
-
84890362378
-
-
Ipilimumab Approval Letter. In: U.S EdMarch
-
Ipilimumab, approval letter. In: U.S. Food and Drug Administration CfDEaR, edMarch 25, 2011
-
(2011)
Food And Drug Administration CfDEaR
, vol.25
-
-
-
82
-
-
36849035139
-
Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): A novel strategy for the treatment of melanoma and other malignancies
-
O'Day SJ, Hamid O, Urba WJ. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): A novel strategy for the treatment of melanoma and other malignancies. Cancer. 2007;110:2614-2627
-
(2007)
Cancer
, vol.110
, pp. 2614-2627
-
-
O'Day, S.J.1
Hamid, O.2
Urba, W.J.3
-
83
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A. 2003; 100:8372-8377
-
(2003)
Proc Natl Acad Sci U S A.
, vol.100
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
Hwu, P.4
Topalian, S.L.5
Schwartzentruber, D.J.6
-
84
-
-
78651072784
-
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance
-
Pedicord VA, Montalvo W, Leiner IM, Allison JP. Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance. Proc Natl Acad Sci USA. 2011;108:266-271
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 266-271
-
-
Pedicord, V.A.1
Montalvo, W.2
Leiner, I.M.3
Allison, J.P.4
-
85
-
-
84860814226
-
-
Princeton NJ Bristol-Myers Squibb Company
-
Yervoy [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2011
-
(2011)
Yervoy [package insert].
-
-
-
86
-
-
84890361213
-
-
Vemurafenib Approval Letter. In: U.S EdAugust
-
Vemurafenib, approval letter. In: U.S. Food and Drug Administration CfDEaR, edAugust 17, 2011
-
(2011)
Food And Drug Administration CfDEaR
, vol.17
-
-
-
87
-
-
58649110598
-
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
-
Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, et al. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell. 2009;33:237-247
-
(2009)
Mol Cell
, vol.33
, pp. 237-247
-
-
Zheng, B.1
Jeong, J.H.2
Asara, J.M.3
Yuan, Y.Y.4
Granter, S.R.5
Chin, L.6
-
88
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
-
89
-
-
77954376912
-
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models
-
Yang H, Higgins B, Kolinsky K, Packman K, Go Z, Iyer R, et al. RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res. 2010;70: 5518-5527
-
(2010)
Cancer Res
, vol.70
, pp. 5518-5527
-
-
Yang, H.1
Higgins, B.2
Kolinsky, K.3
Packman, K.4
Go, Z.5
Iyer, R.6
-
90
-
-
84867020366
-
-
South San Francisco CA: Genentech USA, Inc
-
Zelboraf [package insert]. South San Francisco, CA: Genentech USA, Inc.; 2011
-
(2011)
Zelboraf [package insert
-
-
-
91
-
-
84890352083
-
-
Sylatron Approval Letter. In: U.S EdMarch
-
Sylatron, approval letter. In: U.S. Food and Drug Administration CfDEaR, edMarch 29, 2011
-
Food And Drug Administration CfDEaR
, vol.29
, pp. 2011
-
-
-
92
-
-
0037075172
-
Mechanisms of Interferon-alpha induced apoptosis in malignant cells
-
Thyrell L, Erickson S, Zhivotovsky B, Pokrovskaja K, Sangfelt O, Castro J, et al. Mechanisms of Interferon-alpha induced apoptosis in malignant cells. Oncogene. 2002;21:1251-1262
-
(2002)
Oncogene
, vol.21
, pp. 1251-1262
-
-
Thyrell, L.1
Erickson, S.2
Zhivotovsky, B.3
Pokrovskaja, K.4
Sangfelt, O.5
Castro, J.6
-
93
-
-
0030916238
-
Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines
-
Sangfelt O, Erickson S, Castro J, Heiden T, Einhorn S, Grander D. Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines. Cell Growth Differ. 1997;8:343-352
-
(1997)
Cell Growth Differ
, vol.8
, pp. 343-352
-
-
Sangfelt, O.1
Erickson, S.2
Castro, J.3
Heiden, T.4
Einhorn, S.5
Grander, D.6
-
94
-
-
0028874354
-
Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth
-
Deblandre GA, Marinx OP, Evans SS, Majjaj S, Leo O, Caput D, et al. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J Biol Chem. 1995; 270:23860-23866
-
(1995)
J Biol Chem
, vol.270
, pp. 23860-23866
-
-
Deblandre, G.A.1
Marinx, O.P.2
Evans, S.S.3
Majjaj, S.4
Leo, O.5
Caput, D.6
-
95
-
-
4644234027
-
Pegylated and conventional interferon-alpha induce comparable transcriptional responses and inhibition of tumor growth in a human melanoma SCID mouse xenotransplantation model
-
Krepler C, Certa U, Wacheck V, Jansen B, Wolff K, Pehamberger H. Pegylated and conventional interferon-alpha induce comparable transcriptional responses and inhibition of tumor growth in a human melanoma SCID mouse xenotransplantation model. J Invest Dermatol. 2004;123:664-669
-
(2004)
J Invest Dermatol
, vol.123
, pp. 664-669
-
-
Krepler, C.1
Certa, U.2
Wacheck, V.3
Jansen, B.4
Wolff, K.5
Pehamberger, H.6
-
96
-
-
84890326718
-
-
Kenilworth NJ Schering Corporation 2011
-
Sylatron [package insert]. Kenilworth, NJ: Schering Corporation 2011
-
Sylatron [package insert].
-
-
-
97
-
-
84890388420
-
-
Available from Accessed August
-
FDA Approved Drug Products - Dacarbazine. Available from http:// www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction= Search.Overview&DrugName=DACARBAZINE. Accessed August 1, 2012
-
(2012)
FDA Approved Drug Products ? Dacarbazine
, vol.1
-
-
-
98
-
-
0024313342
-
Reduced DNA damage induced in human melanoma cells by dacarbazine in the presence of deoxyribonucleosides
-
Lonn U, Lonn S, Nylen U, Winblad G. Reduced DNA damage induced in human melanoma cells by dacarbazine in the presence of deoxyribonucleosides. Cancer Res. 1989;49:2921-2924
-
(1989)
Cancer Res
, vol.49
, pp. 2921-2924
-
-
Lonn, U.1
Lonn, S.2
Nylen, U.3
Winblad, G.4
-
99
-
-
0023097887
-
Prevention of dacarbazine damage of human neoplastic cell DNA by aphidicolin
-
Lonn U, Lohn S. Prevention of dacarbazine damage of human neoplastic cell DNA by aphidicolin. Cancer Res. 1987;47:26-30
-
(1987)
Cancer Res
, vol.47
, pp. 26-30
-
-
Lonn, U.1
Lohn, S.2
-
100
-
-
0017148083
-
Effects of 5- (3,3- dimethyl-1-triazeno)imidazole-4-carboxamide and its metabolites on Novikoff hepatoma cells
-
Beal DD, Skibba JL, Whitnable KK, Bryan GT. Effects of 5-(3,3- dimethyl-1-triazeno)imidazole-4-carboxamide and its metabolites on Novikoff hepatoma cells. Cancer Res. 1976;36:2827-2831
-
(1976)
Cancer Res
, vol.36
, pp. 2827-2831
-
-
Beal, D.D.1
Skibba, J.L.2
Whitnable, K.K.3
Bryan, G.T.4
-
102
-
-
84890341167
-
-
Available from Accessed August
-
FDA Approved Drug Products - Aldesleukin. Available from http:// www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction= Search.DrugDetails.Accessed August 8, 2012
-
(2012)
FDA Approved Drug Products ? Aldesleukin
, vol.8
-
-
-
103
-
-
45949090851
-
Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages
-
Choi KS, Song EK, Yim CY. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol. 2008;83:1440-1450
-
(2008)
J Leukoc Biol
, vol.83
, pp. 1440-1450
-
-
Choi, K.S.1
Song, E.K.2
Yim, C.Y.3
-
104
-
-
0022617108
-
Lysis of human solid tumor cells by lymphokine-activated natural killer cells
-
Itoh K, Tilden AB, Balch CM. Lysis of human solid tumor cells by lymphokine-activated natural killer cells. J Immunol. 1986;136:3910- 3915
-
(1986)
J Immunol
, vol.136
, pp. 3910-3915
-
-
Itoh, K.1
Tilden, A.B.2
Balch, C.M.3
-
105
-
-
0034253395
-
Cytokines secreted by lymphokine-activated killer cells induce endogenous nitric oxide synthesis and apoptosis in DLD-1 colon cancer cells
-
Kwak JY, Han MK, Choi KS, Park IH, Park SY, Sohn MH, et al. Cytokines secreted by lymphokine-activated killer cells induce endogenous nitric oxide synthesis and apoptosis in DLD-1 colon cancer cells. Cell Immunol. 2000;203:84-94
-
(2000)
Cell Immunol
, vol.203
, pp. 84-94
-
-
Kwak, J.Y.1
Han, M.K.2
Choi, K.S.3
Park, I.H.4
Park, S.Y.5
Sohn, M.H.6
-
106
-
-
84868549488
-
Clinical-scale isolation of interleukin-2-stimulated liver natural killer cells for treatment of liver transplantation with hepatocellular carcinoma
-
Ohira M, Nishida S, Tryphonopoulos P, Tekin A, Selvaggi G, Moon J, et al. Clinical-scale isolation of interleukin-2-stimulated liver natural killer cells for treatment of liver transplantation with hepatocellular carcinoma. Cell transplant. 2012;21(7):1397-1406
-
(2012)
Cell transplant
, vol.21
, Issue.7
, pp. 1397-1406
-
-
Ohira, M.1
Nishida, S.2
Tryphonopoulos, P.3
Tekin, A.4
Selvaggi, G.5
Moon, J.6
-
107
-
-
84865799326
-
Cetuximab therapy in head and neck cancer: Immune modulation with interleukin-12 and other natural killer cell-activating cytokines
-
Luedke E, Jaime-Ramirez AC, Bhave N, Roda J, Choudhary MM, Kumar B, et al. Cetuximab therapy in head and neck cancer: Immune modulation with interleukin-12 and other natural killer cell-activating cytokines. Surgery. 2012;152:431-440
-
(2012)
Surgery
, vol.152
, pp. 431-440
-
-
Luedke, E.1
Jaime-Ramirez, A.C.2
Bhave, N.3
Roda, J.4
Choudhary, M.M.5
Kumar, B.6
-
108
-
-
84863721426
-
Radio frequency ablation combined with interleukin-2- induces an antitumor immune response to renal cell carcinoma in a murine model
-
Kroeze SG, Daenen LG, Nijkamp MW, Roodhart JM, de Gast GC, Bosch JL, et al. Radio frequency ablation combined with interleukin-2- induces an antitumor immune response to renal cell carcinoma in a murine model. J Urol. 2012;188:607-614
-
(2012)
J Urol
, vol.188
, pp. 607-614
-
-
Kroeze, S.G.1
Daenen, L.G.2
Nijkamp, M.W.3
Roodhart, J.M.4
De Gast, G.C.5
Bosch, J.L.6
-
109
-
-
0023485232
-
In vivo and in vitro activation of natural killer cells in advanced cancer patients undergoing combined recombinant interleukin-2 and LAK cell therapy
-
Phillips JH, Gemlo BT, Myers WW, Rayner AA, Lanier LL. In vivo and in vitro activation of natural killer cells in advanced cancer patients undergoing combined recombinant interleukin-2 and LAK cell therapy. J Clin Oncol. 1987;5:1933-1941
-
(1987)
J Clin Oncol
, vol.5
, pp. 1933-1941
-
-
Phillips, J.H.1
Gemlo, B.T.2
Myers, W.W.3
Rayner, A.A.4
Lanier, L.L.5
-
110
-
-
84890386619
-
-
Emeryville CA Bayer HealthCare Pharmaceuticals Inc
-
Aldesleukin [package insert]. Emeryville, CA: Bayer HealthCare Pharmaceuticals, Inc.; 2008
-
(2008)
Aldesleukin [Package Insert
-
-
|