-
1
-
-
19944427998
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
-
Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He HD, et al. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005; 48(1): 141-51.
-
(2005)
J Med Chem.
, vol.48
, Issue.1
, pp. 141-151
-
-
Kim, D.1
Wang, L.2
Beconi, M.3
Eiermann, G.J.4
Fisher, M.H.5
He, H.D.6
-
2
-
-
84873852937
-
Choosing between GLP-1 receptor agonists and DPP-4 inhibitors: A pharmacological perspective
-
PMID: 23125920
-
Brown DX, Evans M. Choosing between GLP-1 Receptor Agonists and DPP-4 Inhibitors: A Pharmacological Perspective. J Nutr Metab. 2012; 2012: 381713. doi: 10.1155/2012/381713 PMID: 23125920
-
(2012)
J Nutr Metab
, vol.2012
, pp. 381713
-
-
Brown, D.X.1
Evans, M.2
-
3
-
-
69949163754
-
Exenatide and liraglutide: Different approaches to develop GLP-1 receptor agonists (incretin mimetics) - Preclinical and clinical results
-
PMID: 19748064
-
Madsbad S. Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics) - preclinical and clinical results. Best Pract Res Clin Endocrinol Metab. 2009; 23(4): 463-77. doi: 10.1016/j.beem.2009.03.008 PMID: 19748064
-
(2009)
Best Pract Res Clin Endocrinol Metab
, vol.23
, Issue.4
, pp. 463-477
-
-
Madsbad, S.1
-
4
-
-
77957750184
-
DPP-4 inhibitors: What may be the clinical differentiators?
-
201, PMID: 20708812
-
Gerich J. DPP-4 inhibitors: what may be the clinical differentiators? Diabetes Res Clin Pract. 201; 90(2): 131-40. doi: 10.1016/j.diabres.2010.07.006 PMID: 20708812
-
Diabetes Res Clin Pract
, vol.90
, Issue.2
, pp. 131-140
-
-
Gerich, J.1
-
5
-
-
0030032123
-
Digestion and physiological properties of resistant starch in the human large bowel
-
PMID: 8695600
-
Cummings JH, Beatty ER, Kingman SM, Bingham SA, Englyst HN. Digestion and physiological properties of resistant starch in the human large bowel. Br J Nutr. 1996; 75(5): 733-47. PMID: 8695600
-
(1996)
Br J Nutr
, vol.75
, Issue.5
, pp. 733-747
-
-
Cummings, J.H.1
Beatty, E.R.2
Kingman, S.M.3
Bingham, S.A.4
Englyst, H.N.5
-
6
-
-
0023548669
-
Dietary fiber and resistant starch
-
PMID: 2825503
-
Englyst HN, Trowell H, Southgate DA, Cummings JH. Dietary fiber and resistant starch. Am J Clin Nutr. 1987; 46(6): 873-4. PMID: 2825503
-
(1987)
Am J Clin Nutr
, vol.46
, Issue.6
, pp. 873-874
-
-
Englyst, H.N.1
Trowell, H.2
Southgate, D.A.3
Cummings, J.H.4
-
7
-
-
15244348629
-
Resistant starch consumption promotes lipid oxidation
-
Higgins JA, Higbee DR, Donahoo WT, Brown IL, Bell ML, Bessesen DH. Resistant starch consumption promotes lipid oxidation. Nutr Metab (Lond). 2004; 1(1); 8.
-
(2004)
Nutr Metab (Lond)
, vol.1
, Issue.1
, pp. 8
-
-
Higgins, J.A.1
Higbee, D.R.2
Donahoo, W.T.3
Brown, I.L.4
Bell, M.L.5
Bessesen, D.H.6
-
8
-
-
33846827097
-
Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat
-
PMID: 17030963
-
Keenan MJ, Zhou J, McCutcheon KL, Raggio AM, Bateman HG, Todd E, et al. Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat. Obesity (Silver Spring). 2006; 14(9): 1523-34. PMID: 17030963
-
(2006)
Obesity (Silver Spring)
, vol.14
, Issue.9
, pp. 1523-1534
-
-
Keenan, M.J.1
Zhou, J.2
McCutcheon, K.L.3
Raggio, A.M.4
Bateman, H.G.5
Todd, E.6
-
9
-
-
84887134144
-
High fat diet partially attenuates fermentation responses in rats fed resistant starch from high-amylose maize
-
PMID: 23512798
-
Charrier JA, Martin RJ, McCutcheon KL, Raggio AM, Goldsmith F, Goita M, et al. High fat diet partially attenuates fermentation responses in rats fed resistant starch from high-amylose maize. Obesity (Silver Spring). 2013; 21(11): 2350-5. doi: 10.1002/oby.20362 PMID: 23512798
-
(2013)
Obesity (Silver Spring)
, vol.21
, Issue.11
, pp. 2350-2355
-
-
Charrier, J.A.1
Martin, R.J.2
McCutcheon, K.L.3
Raggio, A.M.4
Goldsmith, F.5
Goita, M.6
-
10
-
-
0029958404
-
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
-
PMID: 8898756
-
Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med. 1996; 2(11: 1254-58. PMID: 8898756
-
(1996)
Nat Med
, vol.2
, Issue.11
, pp. 1254-1258
-
-
Scrocchi, L.A.1
Brown, T.J.2
Maclusky, N.3
Brubaker, P.L.4
Auerbach, A.B.5
Joyner, A.L.6
-
11
-
-
33845476757
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
-
PMID: 17130197
-
Charbonnel B, Karasik A, Liu J, Wu M, Meininger G. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006; 29(12): 2638-43. PMID: 17130197
-
(2006)
Diabetes Care.
, vol.29
, Issue.12
, pp. 2638-2643
-
-
Charbonnel, B.1
Karasik, A.2
Liu, J.3
Wu, M.4
Meininger, G.5
-
12
-
-
33845489598
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
-
PMID: 17001471
-
Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006; 49(11): 2564-71. PMID: 17001471
-
(2006)
Diabetologia.
, vol.49
, Issue.11
, pp. 2564-2571
-
-
Raz, I.1
Hanefeld, M.2
Xu, L.3
Caria, C.4
Williams-Herman, D.5
Khatami, H.6
-
13
-
-
33751557143
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
-
PMID: 17157112
-
Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2006; 28(10): 1556-68. PMID: 17157112
-
(2006)
Clin Ther.
, vol.28
, Issue.10
, pp. 1556-1568
-
-
Rosenstock, J.1
Brazg, R.2
Andryuk, P.J.3
Lu, K.4
Stein, P.5
-
14
-
-
33750093045
-
Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans
-
PMID: 16960169
-
Pannacciulli N, Bunt JC, Koska J, Bogardus C, Krakoff J. Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans. Am J Clin Nutr. 2006; 84(3): 556-60. PMID: 16960169
-
(2006)
Am J Clin Nutr
, vol.84
, Issue.3
, pp. 556-560
-
-
Pannacciulli, N.1
Bunt, J.C.2
Koska, J.3
Bogardus, C.4
Krakoff, J.5
-
15
-
-
23844446798
-
Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system
-
PMID: 16112402
-
Osaka T, Endo M, Yamakawa M, Inoue S Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system. Peptides. 2005; 26(9): 1623-31. PMID: 16112402
-
(2005)
Peptides
, vol.26
, Issue.9
, pp. 1623-1631
-
-
Osaka, T.1
Endo, M.2
Yamakawa, M.3
Inoue, S.4
-
16
-
-
0034612348
-
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
-
PMID: 10823914
-
Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, et al. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci USA. 2000; 97(12): 6874-9. PMID: 10823914
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.12
, pp. 6874-6879
-
-
Marguet, D.1
Baggio, L.2
Kobayashi, T.3
Bernard, A.M.4
Pierres, M.5
Nielsen, P.F.6
-
17
-
-
0037974604
-
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
-
PMID: 12748388
-
Conarello SL, Li Z, Ronan J, Roy RS, Zhu L, Jiang G, et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci USA. 2003; 100(11): 6825-6830. PMID: 12748388
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.11
, pp. 6825-6830
-
-
Conarello, S.L.1
Li, Z.2
Ronan, J.3
Roy, R.S.4
Zhu, L.5
Jiang, G.6
-
19
-
-
79959778328
-
Long-acting glucagon-like peptide 1 receptor agonists: A review of their efficacy and tolerability
-
PMID: 21525469
-
Garber AJ. Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability. Diabetes Care. 2011; 34 Suppl 2: S279-84. doi: 10.2337/dc11-s231 PMID: 21525469
-
(2011)
Diabetes Care.
, vol.34
, pp. S279-S284
-
-
Garber, A.J.1
-
20
-
-
62349138180
-
Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients
-
PMID: 19088168
-
Boschmann M, Engeli S, Dobberstein K, Budziarek P, Strauss A, Boehnke J, et al. Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients. J Clin Endocrinol Metab. 2009; 94(3): 846-52. doi: 10.1210/jc.2008-1400 PMID: 19088168
-
(2009)
J Clin Endocrinol Metab
, vol.94
, Issue.3
, pp. 846-852
-
-
Boschmann, M.1
Engeli, S.2
Dobberstein, K.3
Budziarek, P.4
Strauss, A.5
Boehnke, J.6
-
21
-
-
84856088215
-
Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue
-
PMID: 22186413
-
Sangle GV, Lauffer LM, Grieco A, Trivedi S, Iakoubov R, Brubaker PL. Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue. Endocrinology. 2012; 153(2): 564-73. doi: 10.1210/en.2011-1732 PMID: 22186413
-
(2012)
Endocrinology
, vol.153
, Issue.2
, pp. 564-573
-
-
Sangle, G.V.1
Lauffer, L.M.2
Grieco, A.3
Trivedi, S.4
Iakoubov, R.5
Brubaker, P.L.6
|