Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor α and γ and reduce insulin resistance

Journal of Biological Chemistry

Volumn 279, Issue 32, 2004, Pages 33456-33462

  Yajima, Hiroaki ^a   Ikeshima, Emiko ^a   Shiraki, Maho ^a   Kanaya, Tomoka ^a   Fujiwara, Daisuke ^a   Odai, Hideharu ^a   Tsuboyama Kasaoka, Nobuyo ^b   Ezaki, Osamu ^b   Oikawa, Shinichi ^c   Kondo, Keiji ^a  

^a KIRIN BREWERY CO LTD   (Japan)

^b NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; DRUG PRODUCTS; FATTY ACIDS; GLUCOSE; LIPIDS; OXIDATION; PATIENT TREATMENT; SENSORS;

ADIPOCYTES; HOMOLOGS; RECEPTORS;

BIOCHEMISTRY;

2,4 THIAZOLIDINEDIONE DERIVATIVE; FATTY ACID; FIBRIC ACID DERIVATIVE; GLUCOSE; HEMOGLOBIN A1C; HUMULUS LUPULUS EXTRACT; ISOCOHUMULONE; ISOHUMULONE; NATURAL PRODUCT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PLACEBO; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADOLESCENT; ADULT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEER; BIOSENSOR; CARBOHYDRATE METABOLISM; CELL SIZE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; EXPERIMENTAL DIABETES MELLITUS; FAT INTAKE; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HOPS; HUMAN; HUMULUS LUPULUS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LIPID DIET; LIVER METABOLISM; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR UPREGULATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

AGED; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CYCLOPENTANES; DIABETES MELLITUS, TYPE 2; DIETARY FATS; DOUBLE-BLIND METHOD; FATTY ACIDS, NONESTERIFIED; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HUMULUS; INSULIN RESISTANCE; LIPOPROTEIN LIPASE; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PILOT PROJECTS; PLACEBOS; PLANT EXTRACTS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE PROTEINS; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TRANSFECTION; TRIGLYCERIDES; WEIGHT GAIN;

ANIMALIA; HUMULUS; HUMULUS LUPULUS;

EID: 4043145033     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403456200     Document Type: Article

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