메뉴 건너뛰기




Volumn 11, Issue 4, 2010, Pages 447-454

T1R and T2R receptors: The modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus

Author keywords

Bitter; Enteroendocrine cell; Glucagon like peptide 1; Glucose dependent insulinotropic peptide; Sweet; Taste

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; INCRETIN; INSULIN; NUCLEAR PROTEIN; T1R RECEPTOR; T2R RECEPTOR; UNCLASSIFIED DRUG;

EID: 77950112427     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (35)

References (83)
  • 2
    • 58149090676 scopus 로고    scopus 로고
    • The role of incretins in glucose homeostasis and diabetes treatment
    • Kim W, Egan JM: The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev (2008) 60(4):470-512.
    • (2008) Pharmacol Rev , vol.60 , Issue.4 , pp. 470-512
    • Kim, W.1    Egan, J.M.2
  • 3
    • 68949159829 scopus 로고    scopus 로고
    • Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors
    • Verspohl EJ: Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacol Ther (2009) 124(1):113-138.
    • (2009) Pharmacol Ther , vol.124 , Issue.1 , pp. 113-138
    • Verspohl, E.J.1
  • 4
    • 47649095004 scopus 로고    scopus 로고
    • Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes
    • Gautier JF, Choukem SP, Girard J: Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes Metab (2008) 34(Suppl 2):S65-S72.
    • (2008) Diabetes Metab , vol.34 , Issue.SUPPL. 2
    • Gautier, J.F.1    Choukem, S.P.2    Girard, J.3
  • 5
    • 38049129559 scopus 로고    scopus 로고
    • Enteroendocrine cells: A site of 'taste' in gastrointestinal chemosensing
    • Sternini C, Anselmi L, Rozengurt E: Enteroendocrine cells: A site of 'taste' in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes (2008) 15(1):73-78.
    • (2008) Curr Opin Endocrinol Diabetes Obes , vol.15 , Issue.1 , pp. 73-78
    • Sternini, C.1    Anselmi, L.2    Rozengurt, E.3
  • 6
    • 42249094149 scopus 로고    scopus 로고
    • Taste cells of the gut and gastrointestinal chemosensation
    • Egan JM, Margolskee RF: Taste cells of the gut and gastrointestinal chemosensation. Mol Interv (2008) 8(2):78-81.
    • (2008) Mol Interv , vol.8 , Issue.2 , pp. 78-81
    • Egan, J.M.1    Margolskee, R.F.2
  • 7
    • 0014811685 scopus 로고
    • Further purification of a polypeptide demonstrating enterogastrone activity
    • Brown JC, Mutt V, Pederson RA: Further purification of a polypeptide demonstrating enterogastrone activity. J Physiol (1970) 209(1):57-64.
    • (1970) J Physiol , vol.209 , Issue.1 , pp. 57-64
    • Brown, J.C.1    Mutt, V.2    Pederson, R.A.3
  • 8
    • 0022389280 scopus 로고
    • Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets
    • Schmidt WE, Siegel EG, Creutzfeldt W: Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia (1985) 28(9): 704-707.
    • (1985) Diabetologia , vol.28 , Issue.9 , pp. 704-707
    • Schmidt, W.E.1    Siegel, E.G.2    Creutzfeldt, W.3
  • 9
    • 67849124833 scopus 로고    scopus 로고
    • Intestinal cholecystokinin controls glucose production through a neuronal network
    • Cheung GW, Kokorovic A, Lam CK, Chari M, Lam TK: Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab (2009) 10(2):99-109.
    • (2009) Cell Metab , vol.10 , Issue.2 , pp. 99-109
    • Cheung, G.W.1    Kokorovic, A.2    Lam, C.K.3    Chari, M.4    Lam, T.K.5
  • 10
    • 0023787492 scopus 로고
    • Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion
    • Zawalich WS: Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism (1988) 37(8):778-781.
    • (1988) Metabolism , vol.37 , Issue.8 , pp. 778-781
    • Zawalich, W.S.1
  • 11
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ: Biology of incretins: GLP-1 and GIP. Gastroenterology (2007) 132(6):2131-2157.
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 13
    • 39849096147 scopus 로고    scopus 로고
    • Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae
    • Feng XH, Liu XM, Zhou LH, Wang J, Liu GD: Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae. Acta Histochem (2007) 110(2):151-154.
    • (2007) Acta Histochem , vol.110 , Issue.2 , pp. 151-154
    • Feng, X.H.1    Liu, X.M.2    Zhou, L.H.3    Wang, J.4    Liu, G.D.5
  • 15
    • 33847758675 scopus 로고    scopus 로고
    • Glucagon-like peptide 1: Continued advances, new targets and expanding promise as a model therapeutic
    • Aulinger B, D'Alessio D: Glucagon-like peptide 1: Continued advances, new targets and expanding promise as a model therapeutic. Curr Opin Endocrinol Diabetes Obes (2007) 14(1): 68-73.
    • (2007) Curr Opin Endocrinol Diabetes Obes , vol.14 , Issue.1 , pp. 68-73
    • Aulinger, B.1    D'Alessio, D.2
  • 17
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ: The biology of incretin hormones. Cell Metab (2006) 3(3):153-165.
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 153-165
    • Drucker, D.J.1
  • 19
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stöckmann F, Ebert R, Creutzfeldt W: Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia (1986) 29(1):46-52.
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stöckmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 20
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W: Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest (1993) 91(1):301-307.
    • (1993) J Clin Invest , vol.91 , Issue.1 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 21
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagonlike peptide-1 (GLP-1)-( 7- 36) amide in type 2 (noninsulindependent) diabetic patients
    • Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA: Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagonlike peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulindependent) diabetic patients. J Clin Endocrinol Metab (1996) 81(1):327-332.
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.1 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3    Orskov, C.4    Creutzfeldt, W.5    Nauck, M.A.6
  • 22
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP: Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem (1992) 267(11):7402-7405.
    • (1992) J Biol Chem , vol.267 , Issue.11 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 24
    • 0029118049 scopus 로고
    • Degradation of glucosedependent insulinotropic polypeptide and truncated glucagonlike peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA: Degradation of glucosedependent insulinotropic polypeptide and truncated glucagonlike peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology (1995) 136(8):3585-3596.
    • (1995) Endocrinology , vol.136 , Issue.8 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 25
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagonlike peptide-1( 7- 36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE: Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagonlike peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem (1993) 214(3):829-835.
    • (1993) Eur J Biochem , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 28
    • 33751084573 scopus 로고    scopus 로고
    • The receptors and cells for mammalian taste
    • Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS: The receptors and cells for mammalian taste. Nature (2006) 444(7117):288-294.
    • (2006) Nature , vol.444 , Issue.7117 , pp. 288-294
    • Chandrashekar, J.1    Hoon, M.A.2    Ryba, N.J.3    Zuker, C.S.4
  • 30
    • 65449180276 scopus 로고    scopus 로고
    • The receptor basis of sweet taste in mammals
    • Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany
    • Vigues S, Dotson CD, Munger SD: The receptor basis of sweet taste in mammals. In: Chemosensory Systems in Mammals, Fishes, and Insects. Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany (2009) 47:187-202.
    • (2009) Chemosensory Systems in Mammals, Fishes, and Insects , vol.47 , pp. 187-202
    • Vigues, S.1    Dotson, C.D.2    Munger, S.D.3
  • 35
    • 65449159720 scopus 로고    scopus 로고
    • Mammalian bitter taste perception
    • Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany
    • Behrens M, Meyerhof W: Mammalian bitter taste perception. In: Chemosensory Systems in Mammals, Fishes, and Insects. Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany (2009) 47:203-220.
    • (2009) Chemosensory Systems in Mammals, Fishes, and Insects , vol.47 , pp. 203-220
    • Behrens, M.1    Meyerhof, W.2
  • 38
    • 33748481774 scopus 로고    scopus 로고
    • Taste perception and coding in the periphery
    • Sugita M: Taste perception and coding in the periphery. Cell Mol Life Sci (2006) 63(17):2000-2015.
    • (2006) Cell Mol Life Sci , vol.63 , Issue.17 , pp. 2000-2015
    • Sugita, M.1
  • 39
    • 0026718951 scopus 로고
    • Gustducin is a taste-cell-specific G protein closely related to the transducins
    • McLaughlin SK, McKinnon PJ, Margolskee RF: Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature (1992) 357(6379):563-569.
    • (1992) Nature , vol.357 , Issue.6379 , pp. 563-569
    • McLaughlin, S.K.1    McKinnon, P.J.2    Margolskee, R.F.3
  • 40
    • 0029957779 scopus 로고    scopus 로고
    • Transduction of bitter and sweet taste by gustducin
    • Wong GT, Gannon KS, Margolskee RF: Transduction of bitter and sweet taste by gustducin. Nature (1996) 381(6585): 796-800.
    • (1996) Nature , vol.381 , Issue.6585 , pp. 796-800
    • Wong, G.T.1    Gannon, K.S.2    Margolskee, R.F.3
  • 41
    • 0037423367 scopus 로고    scopus 로고
    • Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
    • Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ: Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell (2003) 112(3):293-301.
    • (2003) Cell , vol.112 , Issue.3 , pp. 293-301
    • Zhang, Y.1    Hoon, M.A.2    Chandrashekar, J.3    Mueller, K.L.4    Cook, B.5    Wu, D.6    Zuker, C.S.7    Ryba, N.J.8
  • 42
    • 0035789507 scopus 로고    scopus 로고
    • Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction
    • Clapp TR, Stone LM, Margolskee RF, Kinnamon SC: Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci (2001) 2:6.
    • (2001) BMC Neurosci , vol.2 , pp. 6
    • Clapp, T.R.1    Stone, L.M.2    Margolskee, R.F.3    Kinnamon, S.C.4
  • 46
    • 16644379784 scopus 로고    scopus 로고
    • Expression of the sweet receptor protein, T1R3, in the human liver and pancreas
    • Taniguchi K: Expression of the sweet receptor protein, T1R3, in the human liver and pancreas. J Vet Med Sci (2004) 66(11): 1311-1314.
    • (2004) J Vet Med Sci , vol.66 , Issue.11 , pp. 1311-1314
    • Taniguchi, K.1
  • 49
    • 52049093081 scopus 로고    scopus 로고
    • Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro
    • Gulbransen BD, Clapp TR, Finger TE, Kinnamon SC: Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro. J Neurophysiol (2008) 99(6):2929-2937.
    • (2008) J Neurophysiol , vol.99 , Issue.6 , pp. 2929-2937
    • Gulbransen, B.D.1    Clapp, T.R.2    Finger, T.E.3    Kinnamon, S.C.4
  • 50
  • 51
    • 0029908546 scopus 로고    scopus 로고
    • Taste receptor-like cells in the rat gut identified by expression of a-gustducin
    • Hofer D, Puschel B, Drenckhahn D: Taste receptor-like cells in the rat gut identified by expression of a-gustducin. Proc Natl Acad Sci USA (1996) 93(13):6631-6634.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.13 , pp. 6631-6634
    • Hofer, D.1    Puschel, B.2    Drenckhahn, D.3
  • 52
    • 0037133261 scopus 로고    scopus 로고
    • Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
    • Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E: Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci USA (2002) 99(4):2392-2397.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.4 , pp. 2392-2397
    • Wu, S.V.1    Rozengurt, N.2    Yang, M.3    Young, S.H.4    Sinnett-Smith, J.5    Rozengurt, E.6
  • 53
    • 14644415512 scopus 로고    scopus 로고
    • Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells
    • Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP: Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans (2005) 33 (Pt 1):302-305.
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 1 , pp. 302-305
    • Dyer, J.1    Salmon, K.S.2    Zibrik, L.3    Shirazi-Beechey, S.P.4
  • 56
    • 34347236558 scopus 로고    scopus 로고
    • Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
    • Mace OJ, Affleck J, Patel N, Kellett GL: Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol (2007) 582(Pt 1):379-392.
    • (2007) J Physiol , vol.582 , Issue.PART 1 , pp. 379-392
    • MacE, O.J.1    Affleck, J.2    Patel, N.3    Kellett, G.L.4
  • 57
    • 33845865790 scopus 로고    scopus 로고
    • Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
    • Bezencon C, le Coutre J, Damak S: Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses (2007) 32(1):41-49.
    • (2007) Chem Senses , vol.32 , Issue.1 , pp. 41-49
    • Bezencon, C.1    Le Coutre, J.2    Damak, S.3
  • 59
    • 55849136194 scopus 로고    scopus 로고
    • SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
    • Jeon TI, Zhu B, Larson JL, Osborne TF: SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J Clin Invest (2008) 118(11):3693-3700.
    • (2008) J Clin Invest , vol.118 , Issue.11 , pp. 3693-3700
    • Jeon, T.I.1    Zhu, B.2    Larson, J.L.3    Osborne, T.F.4
  • 63
    • 4644308014 scopus 로고    scopus 로고
    • Different functional roles of T1R subunits in the heteromeric taste receptors
    • Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X: Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci USA (2004) 101(39):14258-14263.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.39 , pp. 14258-14263
    • Xu, H.1    Staszewski, L.2    Tang, H.3    Adler, E.4    Zoller, M.5    Li, X.6
  • 64
    • 33749352662 scopus 로고    scopus 로고
    • Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: Role of L-type voltage-sensitive Ca2+ channels
    • Chen MC, Wu SV, Reeve JR Jr, Rozengurt E: Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: Role of L-type voltage-sensitive Ca2+ channels. Am J Physiol Cell Physiol (2006) 291(4):C726-C739.
    • (2006) Am J Physiol Cell Physiol , vol.291 , Issue.4
    • Chen, M.C.1    Wu, S.V.2    Reeve Jr., J.R.3    Rozengurt, E.4
  • 65
    • 67650686837 scopus 로고    scopus 로고
    • Bitter peptides and bitter taste receptors
    • Maehashi K, Huang L: Bitter peptides and bitter taste receptors. Cell Mol Life Sci (2009) 66(10):1661-1671.
    • (2009) Cell Mol Life Sci , vol.66 , Issue.10 , pp. 1661-1671
    • Maehashi, K.1    Huang, L.2
  • 70
    • 73249117478 scopus 로고    scopus 로고
    • Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet α-cells but not of intestinal L-cells
    • Hayashi Y, Yamamoto M, Mizoguchi H, Watanabe C, Ito R, Yamamoto S, Sun XY, Murata Y: Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet α-cells but not of intestinal L-cells. Mol Endocrinol (2009) 23(12):1990-1999.
    • (2009) Mol Endocrinol , vol.23 , Issue.12 , pp. 1990-1999
    • Hayashi, Y.1    Yamamoto, M.2    Mizoguchi, H.3    Watanabe, C.4    Ito, R.5    Yamamoto, S.6    Sun, X.Y.7    Murata, Y.8
  • 71
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL, Drucker DJ: Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med (1996) 2(11):1254-1258.
    • (1996) Nat Med , vol.2 , Issue.11 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    MacLusky, N.3    Brubaker, P.L.4    Auerbach, A.B.5    Joyner, A.L.6    Drucker, D.J.7
  • 73
    • 1442274636 scopus 로고    scopus 로고
    • Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1
    • Ugleholdt R, Zhu X, Deacon CF, Orskov C, Steiner DF, Holst JJ: Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology (2004) 145(3): 1349-1355.
    • (2004) Endocrinology , vol.145 , Issue.3 , pp. 1349-1355
    • Ugleholdt, R.1    Zhu, X.2    Deacon, C.F.3    Orskov, C.4    Steiner, D.F.5    Holst, J.J.6
  • 74
    • 27644568166 scopus 로고    scopus 로고
    • Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli
    • Nie Y, Vigues S, Hobbs JR, Conn GL, Munger SD: Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr Biol (2005) 15(21): 1948-1952.
    • (2005) Curr Biol , vol.15 , Issue.21 , pp. 1948-1952
    • Nie, Y.1    Vigues, S.2    Hobbs, J.R.3    Conn, G.L.4    Munger, S.D.5
  • 75
    • 44949101443 scopus 로고    scopus 로고
    • Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR
    • Assadi-Porter FM, Tonelli M, Maillet E, Hallenga K, Benard O, Max M, Markley JL: Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR. J Am Chem Soc (2008) 130(23): 7212-7213.
    • (2008) J Am Chem Soc , vol.130 , Issue.23 , pp. 7212-7213
    • Assadi-Porter, F.M.1    Tonelli, M.2    Maillet, E.3    Hallenga, K.4    Benard, O.5    Max, M.6    Markley, J.L.7
  • 81
    • 26644458124 scopus 로고    scopus 로고
    • Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3
    • Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF: Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem (2005) 280(40):34296-34305.
    • (2005) J Biol Chem , vol.280 , Issue.40 , pp. 34296-34305
    • Jiang, P.1    Cui, M.2    Zhao, B.3    Snyder, L.A.4    Benard, L.M.5    Osman, R.6    Max, M.7    Margolskee, R.F.8
  • 82
    • 36749099088 scopus 로고    scopus 로고
    • The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor
    • Winnig M, Bufe B, Kratochwil NA, Slack JP, Meyerhof W: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. BMC Struct Biol (2007) 7:66.
    • (2007) BMC Struct Biol , vol.7 , pp. 66
    • Winnig, M.1    Bufe, B.2    Kratochwil, N.A.3    Slack, J.P.4    Meyerhof, W.5
  • 83
    • 26444538550 scopus 로고    scopus 로고
    • Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor
    • Winnig M, Bufe B, Meyerhof W: Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci (2005) 6(1):22.
    • (2005) BMC Neurosci , vol.6 , Issue.1 , pp. 22
    • Winnig, M.1    Bufe, B.2    Meyerhof, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.