-
1
-
-
79960614571
-
-
US Department of Health and Human Services, CDC, Atlanta, GA, USA
-
CDC: National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States, 2007. US Department of Health and Human Services, CDC, Atlanta, GA, USA (2008).
-
(2008)
CDC: National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States, 2007
-
-
-
2
-
-
58149090676
-
The role of incretins in glucose homeostasis and diabetes treatment
-
Kim W, Egan JM: The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev (2008) 60(4):470-512.
-
(2008)
Pharmacol Rev
, vol.60
, Issue.4
, pp. 470-512
-
-
Kim, W.1
Egan, J.M.2
-
3
-
-
68949159829
-
Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors
-
Verspohl EJ: Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacol Ther (2009) 124(1):113-138.
-
(2009)
Pharmacol Ther
, vol.124
, Issue.1
, pp. 113-138
-
-
Verspohl, E.J.1
-
4
-
-
47649095004
-
Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes
-
Gautier JF, Choukem SP, Girard J: Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes Metab (2008) 34(Suppl 2):S65-S72.
-
(2008)
Diabetes Metab
, vol.34
, Issue.SUPPL. 2
-
-
Gautier, J.F.1
Choukem, S.P.2
Girard, J.3
-
5
-
-
38049129559
-
Enteroendocrine cells: A site of 'taste' in gastrointestinal chemosensing
-
Sternini C, Anselmi L, Rozengurt E: Enteroendocrine cells: A site of 'taste' in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes (2008) 15(1):73-78.
-
(2008)
Curr Opin Endocrinol Diabetes Obes
, vol.15
, Issue.1
, pp. 73-78
-
-
Sternini, C.1
Anselmi, L.2
Rozengurt, E.3
-
6
-
-
42249094149
-
Taste cells of the gut and gastrointestinal chemosensation
-
Egan JM, Margolskee RF: Taste cells of the gut and gastrointestinal chemosensation. Mol Interv (2008) 8(2):78-81.
-
(2008)
Mol Interv
, vol.8
, Issue.2
, pp. 78-81
-
-
Egan, J.M.1
Margolskee, R.F.2
-
7
-
-
0014811685
-
Further purification of a polypeptide demonstrating enterogastrone activity
-
Brown JC, Mutt V, Pederson RA: Further purification of a polypeptide demonstrating enterogastrone activity. J Physiol (1970) 209(1):57-64.
-
(1970)
J Physiol
, vol.209
, Issue.1
, pp. 57-64
-
-
Brown, J.C.1
Mutt, V.2
Pederson, R.A.3
-
8
-
-
0022389280
-
Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets
-
Schmidt WE, Siegel EG, Creutzfeldt W: Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia (1985) 28(9): 704-707.
-
(1985)
Diabetologia
, vol.28
, Issue.9
, pp. 704-707
-
-
Schmidt, W.E.1
Siegel, E.G.2
Creutzfeldt, W.3
-
9
-
-
67849124833
-
Intestinal cholecystokinin controls glucose production through a neuronal network
-
Cheung GW, Kokorovic A, Lam CK, Chari M, Lam TK: Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab (2009) 10(2):99-109.
-
(2009)
Cell Metab
, vol.10
, Issue.2
, pp. 99-109
-
-
Cheung, G.W.1
Kokorovic, A.2
Lam, C.K.3
Chari, M.4
Lam, T.K.5
-
10
-
-
0023787492
-
Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion
-
Zawalich WS: Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism (1988) 37(8):778-781.
-
(1988)
Metabolism
, vol.37
, Issue.8
, pp. 778-781
-
-
Zawalich, W.S.1
-
11
-
-
34248223285
-
Biology of incretins: GLP-1 and GIP
-
Baggio LL, Drucker DJ: Biology of incretins: GLP-1 and GIP. Gastroenterology (2007) 132(6):2131-2157.
-
(2007)
Gastroenterology
, vol.132
, Issue.6
, pp. 2131-2157
-
-
Baggio, L.L.1
Drucker, D.J.2
-
12
-
-
45249117904
-
Modulation of taste sensitivity by GLP-1 signaling
-
Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, Jang HJ, Mattson MP, Drucker DJ, Egan JM, Munger SD: Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 106(1):455-463.
-
(2008)
J Neurochem
, vol.106
, Issue.1
, pp. 455-463
-
-
Shin, Y.K.1
Martin, B.2
Golden, E.3
Dotson, C.D.4
Maudsley, S.5
Kim, W.6
Jang, H.J.7
Mattson, M.P.8
Drucker, D.J.9
Egan, J.M.10
Munger, S.D.11
-
13
-
-
39849096147
-
Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae
-
Feng XH, Liu XM, Zhou LH, Wang J, Liu GD: Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae. Acta Histochem (2007) 110(2):151-154.
-
(2007)
Acta Histochem
, vol.110
, Issue.2
, pp. 151-154
-
-
Feng, X.H.1
Liu, X.M.2
Zhou, L.H.3
Wang, J.4
Liu, G.D.5
-
14
-
-
65249188272
-
Modulation of taste sensitivity by GLP-1 signaling in taste buds
-
Martin B, Dotson CD, Shin YK, Ji S, Drucker DJ, Maudsley S, Munger SD: Modulation of taste sensitivity by GLP-1 signaling in taste buds. Ann N Y Acad Sci (2009) 1170:98-101.
-
(2009)
Ann N y Acad Sci
, vol.1170
, pp. 98-101
-
-
Martin, B.1
Dotson, C.D.2
Shin, Y.K.3
Ji, S.4
Drucker, D.J.5
Maudsley, S.6
Munger, S.D.7
-
15
-
-
33847758675
-
Glucagon-like peptide 1: Continued advances, new targets and expanding promise as a model therapeutic
-
Aulinger B, D'Alessio D: Glucagon-like peptide 1: Continued advances, new targets and expanding promise as a model therapeutic. Curr Opin Endocrinol Diabetes Obes (2007) 14(1): 68-73.
-
(2007)
Curr Opin Endocrinol Diabetes Obes
, vol.14
, Issue.1
, pp. 68-73
-
-
Aulinger, B.1
D'Alessio, D.2
-
16
-
-
34748898831
-
Glucagonlike peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
-
Vahl TP, Tauchi M, Durler TS, Elfers EE, Fernandes TM, Bitner RD, Ellis KS, Woods SC, Seeley RJ, Herman JP, D'Alessio DA: Glucagonlike peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology (2007) 148(10):4965-4973.
-
(2007)
Endocrinology
, vol.148
, Issue.10
, pp. 4965-4973
-
-
Vahl, T.P.1
Tauchi, M.2
Durler, T.S.3
Elfers, E.E.4
Fernandes, T.M.5
Bitner, R.D.6
Ellis, K.S.7
Woods, S.C.8
Seeley, R.J.9
Herman, J.P.10
D'Alessio, D.A.11
-
17
-
-
33644618433
-
The biology of incretin hormones
-
Drucker DJ: The biology of incretin hormones. Cell Metab (2006) 3(3):153-165.
-
(2006)
Cell Metab
, vol.3
, Issue.3
, pp. 153-165
-
-
Drucker, D.J.1
-
18
-
-
34547586659
-
Reduced incretin effect in type 2 diabetes: Cause or consequence of the diabetic state?
-
Knop FK, Vilsboll T, Højberg PV, Larsen S, Madsbad S, Volund A, Holst JJ, Krarup T: Reduced incretin effect in type 2 diabetes: Cause or consequence of the diabetic state? Diabetes (2007) 56(8):1951-1959.
-
(2007)
Diabetes
, vol.56
, Issue.8
, pp. 1951-1959
-
-
Knop, F.K.1
Vilsboll, T.2
Højberg, P.V.3
Larsen, S.4
Madsbad, S.5
Volund, A.6
Holst, J.J.7
Krarup, T.8
-
19
-
-
0022617246
-
Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
-
Nauck M, Stöckmann F, Ebert R, Creutzfeldt W: Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia (1986) 29(1):46-52.
-
(1986)
Diabetologia
, vol.29
, Issue.1
, pp. 46-52
-
-
Nauck, M.1
Stöckmann, F.2
Ebert, R.3
Creutzfeldt, W.4
-
20
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
-
Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W: Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest (1993) 91(1):301-307.
-
(1993)
J Clin Invest
, vol.91
, Issue.1
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Orskov, C.3
Holst, J.J.4
Ebert, R.5
Creutzfeldt, W.6
-
21
-
-
0030068620
-
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagonlike peptide-1 (GLP-1)-( 7- 36) amide in type 2 (noninsulindependent) diabetic patients
-
Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA: Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagonlike peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulindependent) diabetic patients. J Clin Endocrinol Metab (1996) 81(1):327-332.
-
(1996)
J Clin Endocrinol Metab
, vol.81
, Issue.1
, pp. 327-332
-
-
Willms, B.1
Werner, J.2
Holst, J.J.3
Orskov, C.4
Creutzfeldt, W.5
Nauck, M.A.6
-
22
-
-
0026648961
-
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
-
Eng J, Kleinman WA, Singh L, Singh G, Raufman JP: Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem (1992) 267(11):7402-7405.
-
(1992)
J Biol Chem
, vol.267
, Issue.11
, pp. 7402-7405
-
-
Eng, J.1
Kleinman, W.A.2
Singh, L.3
Singh, G.4
Raufman, J.P.5
-
23
-
-
0034108646
-
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
-
Knudsen LB, Nielsen PF, Huusfeldt PO, Johansen NL, Madsen K, Pedersen FZ, Thogersen H, Wilken M, Agersø H: Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem (2000) 43(9):1664-1669.
-
(2000)
J Med Chem
, vol.43
, Issue.9
, pp. 1664-1669
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
Johansen, N.L.4
Madsen, K.5
Pedersen, F.Z.6
Thogersen, H.7
Wilken, M.8
Agersø, H.9
-
24
-
-
0029118049
-
Degradation of glucosedependent insulinotropic polypeptide and truncated glucagonlike peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
-
Kieffer TJ, McIntosh CH, Pederson RA: Degradation of glucosedependent insulinotropic polypeptide and truncated glucagonlike peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology (1995) 136(8):3585-3596.
-
(1995)
Endocrinology
, vol.136
, Issue.8
, pp. 3585-3596
-
-
Kieffer, T.J.1
McIntosh, C.H.2
Pederson, R.A.3
-
25
-
-
0027215348
-
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagonlike peptide-1( 7- 36)amide, peptide histidine methionine and is responsible for their degradation in human serum
-
Mentlein R, Gallwitz B, Schmidt WE: Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagonlike peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem (1993) 214(3):829-835.
-
(1993)
Eur J Biochem
, vol.214
, Issue.3
, pp. 829-835
-
-
Mentlein, R.1
Gallwitz, B.2
Schmidt, W.E.3
-
28
-
-
33751084573
-
The receptors and cells for mammalian taste
-
Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS: The receptors and cells for mammalian taste. Nature (2006) 444(7117):288-294.
-
(2006)
Nature
, vol.444
, Issue.7117
, pp. 288-294
-
-
Chandrashekar, J.1
Hoon, M.A.2
Ryba, N.J.3
Zuker, C.S.4
-
30
-
-
65449180276
-
The receptor basis of sweet taste in mammals
-
Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany
-
Vigues S, Dotson CD, Munger SD: The receptor basis of sweet taste in mammals. In: Chemosensory Systems in Mammals, Fishes, and Insects. Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany (2009) 47:187-202.
-
(2009)
Chemosensory Systems in Mammals, Fishes, and Insects
, vol.47
, pp. 187-202
-
-
Vigues, S.1
Dotson, C.D.2
Munger, S.D.3
-
31
-
-
0035839040
-
Mammalian sweet taste receptors
-
Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS: Mammalian sweet taste receptors. Cell (2001) 106(3):381-390.
-
(2001)
Cell
, vol.106
, Issue.3
, pp. 381-390
-
-
Nelson, G.1
Hoon, M.A.2
Chandrashekar, J.3
Zhang, Y.4
Ryba, N.J.5
Zuker, C.S.6
-
32
-
-
0037007027
-
Human receptors for sweet and umami taste
-
Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E: Human receptors for sweet and umami taste. Proc Natl Acad Sci USA (2002) 99(7):4692-4696.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.7
, pp. 4692-4696
-
-
Li, X.1
Staszewski, L.2
Xu, H.3
Durick, K.4
Zoller, M.5
Adler, E.6
-
33
-
-
0344823647
-
The receptors for mammalian sweet and umami taste
-
Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS: The receptors for mammalian sweet and umami taste. Cell (2003) 115(3):255-266.
-
(2003)
Cell
, vol.115
, Issue.3
, pp. 255-266
-
-
Zhao, G.Q.1
Zhang, Y.2
Hoon, M.A.3
Chandrashekar, J.4
Erlenbach, I.5
Ryba, N.J.6
Zuker, C.S.7
-
34
-
-
0037075555
-
An amino-acid taste receptor
-
Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS: An amino-acid taste receptor. Nature (2002) 416(6877):199-202.
-
(2002)
Nature
, vol.416
, Issue.6877
, pp. 199-202
-
-
Nelson, G.1
Chandrashekar, J.2
Hoon, M.A.3
Feng, L.4
Zhao, G.5
Ryba, N.J.6
Zuker, C.S.7
-
35
-
-
65449159720
-
Mammalian bitter taste perception
-
Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany
-
Behrens M, Meyerhof W: Mammalian bitter taste perception. In: Chemosensory Systems in Mammals, Fishes, and Insects. Meyerhof W, Korsching S (Eds), Springer Berlin/Heidelberg, Berlin, Germany (2009) 47:203-220.
-
(2009)
Chemosensory Systems in Mammals, Fishes, and Insects
, vol.47
, pp. 203-220
-
-
Behrens, M.1
Meyerhof, W.2
-
36
-
-
0034677655
-
T2Rs function as bitter taste receptors
-
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ: T2Rs function as bitter taste receptors. Cell (2000) 100(6):703-711.
-
(2000)
Cell
, vol.100
, Issue.6
, pp. 703-711
-
-
Chandrashekar, J.1
Mueller, K.L.2
Hoon, M.A.3
Adler, E.4
Feng, L.5
Guo, W.6
Zuker, C.S.7
Ryba, N.J.8
-
37
-
-
77950114281
-
The molecular receptive ranges of human TAS2R bitter taste receptors
-
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M: The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses (2010) 35(2):157-170.
-
(2010)
Chem Senses
, vol.35
, Issue.2
, pp. 157-170
-
-
Meyerhof, W.1
Batram, C.2
Kuhn, C.3
Brockhoff, A.4
Chudoba, E.5
Bufe, B.6
Appendino, G.7
Behrens, M.8
-
38
-
-
33748481774
-
Taste perception and coding in the periphery
-
Sugita M: Taste perception and coding in the periphery. Cell Mol Life Sci (2006) 63(17):2000-2015.
-
(2006)
Cell Mol Life Sci
, vol.63
, Issue.17
, pp. 2000-2015
-
-
Sugita, M.1
-
39
-
-
0026718951
-
Gustducin is a taste-cell-specific G protein closely related to the transducins
-
McLaughlin SK, McKinnon PJ, Margolskee RF: Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature (1992) 357(6379):563-569.
-
(1992)
Nature
, vol.357
, Issue.6379
, pp. 563-569
-
-
McLaughlin, S.K.1
McKinnon, P.J.2
Margolskee, R.F.3
-
40
-
-
0029957779
-
Transduction of bitter and sweet taste by gustducin
-
Wong GT, Gannon KS, Margolskee RF: Transduction of bitter and sweet taste by gustducin. Nature (1996) 381(6585): 796-800.
-
(1996)
Nature
, vol.381
, Issue.6585
, pp. 796-800
-
-
Wong, G.T.1
Gannon, K.S.2
Margolskee, R.F.3
-
41
-
-
0037423367
-
Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
-
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ: Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell (2003) 112(3):293-301.
-
(2003)
Cell
, vol.112
, Issue.3
, pp. 293-301
-
-
Zhang, Y.1
Hoon, M.A.2
Chandrashekar, J.3
Mueller, K.L.4
Cook, B.5
Wu, D.6
Zuker, C.S.7
Ryba, N.J.8
-
42
-
-
0035789507
-
Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction
-
Clapp TR, Stone LM, Margolskee RF, Kinnamon SC: Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci (2001) 2:6.
-
(2001)
BMC Neurosci
, vol.2
, pp. 6
-
-
Clapp, T.R.1
Stone, L.M.2
Margolskee, R.F.3
Kinnamon, S.C.4
-
43
-
-
37549017349
-
Abnormal taste perception in mice lacking the type 3 inositol 1, 4,5- trisphosphate receptor
-
Hisatsune C, Yasumatsu K, Takahashi-Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba K: Abnormal taste perception in mice lacking the type 3 inositol 1,4,5- trisphosphate receptor. J Biol Chem (2007) 282(51):37225-37231.
-
(2007)
J Biol Chem
, vol.282
, Issue.51
, pp. 37225-37231
-
-
Hisatsune, C.1
Yasumatsu, K.2
Takahashi-Iwanaga, H.3
Ogawa, N.4
Kuroda, Y.5
Yoshida, R.6
Ninomiya, Y.7
Mikoshiba, K.8
-
44
-
-
0036830145
-
A transient receptor potential channel expressed in taste receptor cells
-
Perez CA, Huang L, Rong M, Kozak JA, Preuss AK, Zhang H, Max M, Margolskee RF: A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci (2002) 5(11): 1169-1176.
-
(2002)
Nat Neurosci
, vol.5
, Issue.11
, pp. 1169-1176
-
-
Perez, C.A.1
Huang, L.2
Rong, M.3
Kozak, J.A.4
Preuss, A.K.5
Zhang, H.6
Max, M.7
Margolskee, R.F.8
-
45
-
-
65249129179
-
Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion
-
Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I: Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One (2009) 4(4):e5106.
-
(2009)
PLoS One
, vol.4
, Issue.4
-
-
Nakagawa, Y.1
Nagasawa, M.2
Yamada, S.3
Hara, A.4
Mogami, H.5
Nikolaev, V.O.6
Lohse, M.J.7
Shigemura, N.8
Ninomiya, Y.9
Kojima, I.10
-
46
-
-
16644379784
-
Expression of the sweet receptor protein, T1R3, in the human liver and pancreas
-
Taniguchi K: Expression of the sweet receptor protein, T1R3, in the human liver and pancreas. J Vet Med Sci (2004) 66(11): 1311-1314.
-
(2004)
J Vet Med Sci
, vol.66
, Issue.11
, pp. 1311-1314
-
-
Taniguchi, K.1
-
47
-
-
72449180982
-
Sweet taste signaling functions as a hypothalamic glucose sensor
-
Ren X, Zhou L, Terwilliger R, Newton SS, de Araujo IE: Sweet taste signaling functions as a hypothalamic glucose sensor. Front Integr Neurosci (2009) 3:12.
-
(2009)
Front Integr Neurosci
, vol.3
, pp. 12
-
-
Ren, X.1
Zhou, L.2
Terwilliger, R.3
Newton, S.S.4
De Araujo, I.E.5
-
48
-
-
0041806520
-
Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration
-
Finger TE, Bottger B, Hansen A, Anderson KT, Alimohammadi H, Silver WL: Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci USA (2003) 100(15):8981-8986.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.15
, pp. 8981-8986
-
-
Finger, T.E.1
Bottger, B.2
Hansen, A.3
Anderson, K.T.4
Alimohammadi, H.5
Silver, W.L.6
-
49
-
-
52049093081
-
Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro
-
Gulbransen BD, Clapp TR, Finger TE, Kinnamon SC: Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro. J Neurophysiol (2008) 99(6):2929-2937.
-
(2008)
J Neurophysiol
, vol.99
, Issue.6
, pp. 2929-2937
-
-
Gulbransen, B.D.1
Clapp, T.R.2
Finger, T.E.3
Kinnamon, S.C.4
-
50
-
-
69549084858
-
Motile cilia of human airway epithelia are chemosensory
-
Shah AS, Ben-Shahar Y, Moninger TO, Kline JN, Welsh MJ: Motile cilia of human airway epithelia are chemosensory. Science (2009) 325(5944):1131-1134.
-
(2009)
Science
, vol.325
, Issue.5944
, pp. 1131-1134
-
-
Shah, A.S.1
Ben-Shahar, Y.2
Moninger, T.O.3
Kline, J.N.4
Welsh, M.J.5
-
51
-
-
0029908546
-
Taste receptor-like cells in the rat gut identified by expression of a-gustducin
-
Hofer D, Puschel B, Drenckhahn D: Taste receptor-like cells in the rat gut identified by expression of a-gustducin. Proc Natl Acad Sci USA (1996) 93(13):6631-6634.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.13
, pp. 6631-6634
-
-
Hofer, D.1
Puschel, B.2
Drenckhahn, D.3
-
52
-
-
0037133261
-
Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
-
Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E: Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci USA (2002) 99(4):2392-2397.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.4
, pp. 2392-2397
-
-
Wu, S.V.1
Rozengurt, N.2
Yang, M.3
Young, S.H.4
Sinnett-Smith, J.5
Rozengurt, E.6
-
53
-
-
14644415512
-
Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells
-
Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP: Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans (2005) 33 (Pt 1):302-305.
-
(2005)
Biochem Soc Trans
, vol.33
, Issue.PART 1
, pp. 302-305
-
-
Dyer, J.1
Salmon, K.S.2
Zibrik, L.3
Shirazi-Beechey, S.P.4
-
54
-
-
35448986920
-
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
-
Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M et al: Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci USA (2007) 104(38):15069-15074.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.38
, pp. 15069-15074
-
-
Jang, H.J.1
Kokrashvili, Z.2
Theodorakis, M.J.3
Carlson, O.D.4
Kim, B.J.5
Zhou, J.6
Kim, H.H.7
Xu, X.8
Chan, S.L.9
Juhaszova, M.10
Bernier, M.11
-
55
-
-
35448995622
-
T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1
-
Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP: T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci USA (2007) 104(38):15075-15080.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.38
, pp. 15075-15080
-
-
Margolskee, R.F.1
Dyer, J.2
Kokrashvili, Z.3
Salmon, K.S.4
Ilegems, E.5
Daly, K.6
Maillet, E.L.7
Ninomiya, Y.8
Mosinger, B.9
Shirazi-Beechey, S.P.10
-
56
-
-
34347236558
-
Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
-
Mace OJ, Affleck J, Patel N, Kellett GL: Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol (2007) 582(Pt 1):379-392.
-
(2007)
J Physiol
, vol.582
, Issue.PART 1
, pp. 379-392
-
-
MacE, O.J.1
Affleck, J.2
Patel, N.3
Kellett, G.L.4
-
57
-
-
33845865790
-
Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
-
Bezencon C, le Coutre J, Damak S: Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses (2007) 32(1):41-49.
-
(2007)
Chem Senses
, vol.32
, Issue.1
, pp. 41-49
-
-
Bezencon, C.1
Le Coutre, J.2
Damak, S.3
-
58
-
-
58049095069
-
Bitter taste receptors influence glucose homeostasis
-
Dotson CD, Zhang L, Xu H, Shin Y-K, Vigues S, Ott SH, Elson AET, Choi H-J, Shaw H, Egan JM, Mitchell BD et al: Bitter taste receptors influence glucose homeostasis. PLoS ONE (2008) 3(12):e3974.
-
(2008)
PLoS ONE
, vol.3
, Issue.12
-
-
Dotson, C.D.1
Zhang, L.2
Xu, H.3
Shin, Y.-K.4
Vigues, S.5
Ott, S.H.6
Elson, A.E.T.7
Choi, H.-J.8
Shaw, H.9
Egan, J.M.10
Mitchell, B.D.11
-
59
-
-
55849136194
-
SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
-
Jeon TI, Zhu B, Larson JL, Osborne TF: SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J Clin Invest (2008) 118(11):3693-3700.
-
(2008)
J Clin Invest
, vol.118
, Issue.11
, pp. 3693-3700
-
-
Jeon, T.I.1
Zhu, B.2
Larson, J.L.3
Osborne, T.F.4
-
60
-
-
33751100128
-
Colocalization of the α-subunit of gustducin with PYY and GLP-1 in L cells of human colon
-
Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E: Colocalization of the α-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol (2006) 291(5):G792-G802.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.291
, Issue.5
-
-
Rozengurt, N.1
Wu, S.V.2
Chen, M.C.3
Huang, C.4
Sternini, C.5
Rozengurt, E.6
-
61
-
-
34347371617
-
Phenotypic characterization of taste cells of the mouse small intestine
-
Sutherland K, Young RL, Cooper NJ, Horowitz M, Blackshaw LA: Phenotypic characterization of taste cells of the mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2007) 292(5):G1420-G1428.
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.292
, Issue.5
-
-
Sutherland, K.1
Young, R.L.2
Cooper, N.J.3
Horowitz, M.4
Blackshaw, L.A.5
-
62
-
-
33744969314
-
A TAS1R receptor-based explanation of sweet 'water-taste'
-
Galindo-Cuspinera V, Winnig M, Bufe B, Meyerhof W, Breslin PA: A TAS1R receptor-based explanation of sweet 'water-taste'. Nature (2006) 441(7091):354-357.
-
(2006)
Nature
, vol.441
, Issue.7091
, pp. 354-357
-
-
Galindo-Cuspinera, V.1
Winnig, M.2
Bufe, B.3
Meyerhof, W.4
Breslin, P.A.5
-
63
-
-
4644308014
-
Different functional roles of T1R subunits in the heteromeric taste receptors
-
Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X: Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci USA (2004) 101(39):14258-14263.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.39
, pp. 14258-14263
-
-
Xu, H.1
Staszewski, L.2
Tang, H.3
Adler, E.4
Zoller, M.5
Li, X.6
-
64
-
-
33749352662
-
Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: Role of L-type voltage-sensitive Ca2+ channels
-
Chen MC, Wu SV, Reeve JR Jr, Rozengurt E: Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: Role of L-type voltage-sensitive Ca2+ channels. Am J Physiol Cell Physiol (2006) 291(4):C726-C739.
-
(2006)
Am J Physiol Cell Physiol
, vol.291
, Issue.4
-
-
Chen, M.C.1
Wu, S.V.2
Reeve Jr., J.R.3
Rozengurt, E.4
-
65
-
-
67650686837
-
Bitter peptides and bitter taste receptors
-
Maehashi K, Huang L: Bitter peptides and bitter taste receptors. Cell Mol Life Sci (2009) 66(10):1661-1671.
-
(2009)
Cell Mol Life Sci
, vol.66
, Issue.10
, pp. 1661-1671
-
-
Maehashi, K.1
Huang, L.2
-
66
-
-
58149312534
-
An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine
-
Mace OJ, Lister N, Morgan E, Shepherd E, Affleck J, Helliwell P, Bronk JR, Kellett GL, Meredith D, Boyd R, Pieri M et al: An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. J Physiol (2009) 587(Pt 1):195-210.
-
(2009)
J Physiol
, vol.587
, Issue.PART 1
, pp. 195-210
-
-
MacE, O.J.1
Lister, N.2
Morgan, E.3
Shepherd, E.4
Affleck, J.5
Helliwell, P.6
Bronk, J.R.7
Kellett, G.L.8
Meredith, D.9
Boyd, R.10
Pieri, M.11
-
67
-
-
64749083079
-
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo
-
Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ: Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. Am J Physiol Endocrinol Metab (2009) 296(3):E473-E479.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
, Issue.3
-
-
Fujita, Y.1
Wideman, R.D.2
Speck, M.3
Asadi, A.4
King, D.S.5
Webber, T.D.6
Haneda, M.7
Kieffer, T.J.8
-
68
-
-
67149121867
-
Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects
-
Ma J, Bellon M, Wishart JM, Young R, Blackshaw LA, Jones KL, Horowitz M, Rayner CK: Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol Gastrointest Liver Physiol (2009) 296(4):G735-G739.
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.296
, Issue.4
-
-
Ma, J.1
Bellon, M.2
Wishart, J.M.3
Young, R.4
Blackshaw, L.A.5
Jones, K.L.6
Horowitz, M.7
Rayner, C.K.8
-
69
-
-
0347361497
-
Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes
-
Grotz VL, Henry RR, McGill JB, Prince MJ, Shamoon H, Trout JR, Pi-Sunyer FX: Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes. J Am Diet Assoc (2003) 103(12):1607-1612.
-
(2003)
J Am Diet Assoc
, vol.103
, Issue.12
, pp. 1607-1612
-
-
Grotz, V.L.1
Henry, R.R.2
McGill, J.B.3
Prince, M.J.4
Shamoon, H.5
Trout, J.R.6
Pi-Sunyer, F.X.7
-
70
-
-
73249117478
-
Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet α-cells but not of intestinal L-cells
-
Hayashi Y, Yamamoto M, Mizoguchi H, Watanabe C, Ito R, Yamamoto S, Sun XY, Murata Y: Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet α-cells but not of intestinal L-cells. Mol Endocrinol (2009) 23(12):1990-1999.
-
(2009)
Mol Endocrinol
, vol.23
, Issue.12
, pp. 1990-1999
-
-
Hayashi, Y.1
Yamamoto, M.2
Mizoguchi, H.3
Watanabe, C.4
Ito, R.5
Yamamoto, S.6
Sun, X.Y.7
Murata, Y.8
-
71
-
-
0029958404
-
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
-
Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL, Drucker DJ: Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med (1996) 2(11):1254-1258.
-
(1996)
Nat Med
, vol.2
, Issue.11
, pp. 1254-1258
-
-
Scrocchi, L.A.1
Brown, T.J.2
MacLusky, N.3
Brubaker, P.L.4
Auerbach, A.B.5
Joyner, A.L.6
Drucker, D.J.7
-
72
-
-
0036679173
-
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
-
Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, Steiner DF: Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci USA (2002) 99(16):10293-10298.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.16
, pp. 10293-10298
-
-
Zhu, X.1
Zhou, A.2
Dey, A.3
Norrbom, C.4
Carroll, R.5
Zhang, C.6
Laurent, V.7
Lindberg, I.8
Ugleholdt, R.9
Holst, J.J.10
Steiner, D.F.11
-
73
-
-
1442274636
-
Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1
-
Ugleholdt R, Zhu X, Deacon CF, Orskov C, Steiner DF, Holst JJ: Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology (2004) 145(3): 1349-1355.
-
(2004)
Endocrinology
, vol.145
, Issue.3
, pp. 1349-1355
-
-
Ugleholdt, R.1
Zhu, X.2
Deacon, C.F.3
Orskov, C.4
Steiner, D.F.5
Holst, J.J.6
-
74
-
-
27644568166
-
Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli
-
Nie Y, Vigues S, Hobbs JR, Conn GL, Munger SD: Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr Biol (2005) 15(21): 1948-1952.
-
(2005)
Curr Biol
, vol.15
, Issue.21
, pp. 1948-1952
-
-
Nie, Y.1
Vigues, S.2
Hobbs, J.R.3
Conn, G.L.4
Munger, S.D.5
-
75
-
-
44949101443
-
Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR
-
Assadi-Porter FM, Tonelli M, Maillet E, Hallenga K, Benard O, Max M, Markley JL: Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR. J Am Chem Soc (2008) 130(23): 7212-7213.
-
(2008)
J Am Chem Soc
, vol.130
, Issue.23
, pp. 7212-7213
-
-
Assadi-Porter, F.M.1
Tonelli, M.2
Maillet, E.3
Hallenga, K.4
Benard, O.5
Max, M.6
Markley, J.L.7
-
76
-
-
77950160403
-
-
Senomyx Inc , US-07476399
-
Senomyx Inc (Tachdjian C, Li X, Qi M, Rinnova M, Servant G, Zoller M): Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof. US-07476399 (2009).
-
(2009)
Flavors, Flavor Modifiers, Tastants, Taste Enhancers, Umami or Sweet Tastants, And/or Enhancers and Use Thereof
-
-
Tachdjian, C.1
Li, X.2
Qi, M.3
Rinnova, M.4
Servant, G.5
Zoller, M.6
-
77
-
-
77950145813
-
-
Senomyx Inc, US-07407765
-
Senomyx Inc (Li X, Xu H, Tang H, Li Q): Human T2R receptors for acetaminophen ranitidine, strychnine and denatomium and related assays for identifying human bitter taste modulators. US-07407765 (2008).
-
(2008)
Human T2R Receptors for Acetaminophen Ranitidine, Strychnine and Denatomium and Related Assays for Identifying Human Bitter Taste Modulators
-
-
Li, X.1
Xu, H.2
Tang, H.3
Li, Q.4
-
78
-
-
77950101925
-
-
Senomyx Inc , US-07419791
-
Senomyx Inc (Adler J, Li X, Staszewski L, Xu H, Echeverri F): Methods of screening compounds using a T1R3 heterooligomeric taste receptor. US-07419791 (2008).
-
(2008)
Methods of Screening Compounds Using A T1R3 Heterooligomeric Taste Receptor
-
-
Adler, J.1
Li, X.2
Staszewski, L.3
Xu, H.4
Echeverri, F.5
-
79
-
-
77949531914
-
Molecular mechanism of the sweet taste enhancers
-
Zhang F, Klebansky B, Fine RM, Liu H, Xu H, Servant G, Zoller M, Tachdjian C, Li X: Molecular mechanism of the sweet taste enhancers. Proc Natl Acad Sci USA 107(10):4752-4757.
-
Proc Natl Acad Sci USA
, vol.107
, Issue.10
, pp. 4752-4757
-
-
Zhang, F.1
Klebansky, B.2
Fine, R.M.3
Liu, H.4
Xu, H.5
Servant, G.6
Zoller, M.7
Tachdjian, C.8
Li, X.9
-
80
-
-
77949529410
-
Positive allosteric modulators of the human sweet taste receptor enhance sweet taste
-
Servant G, Tachdjian C, Tang XQ, Werner S, Zhang F, Li X, Kamdar P, Petrovic G, Ditschun T, Java A, Brust P et al: Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. Proc Natl Acad Sci USA 107(10):4746-4751.
-
Proc Natl Acad Sci USA
, vol.107
, Issue.10
, pp. 4746-4751
-
-
Servant, G.1
Tachdjian, C.2
Tang, X.Q.3
Werner, S.4
Zhang, F.5
Li, X.6
Kamdar, P.7
Petrovic, G.8
Ditschun, T.9
Java, A.10
Brust, P.11
-
81
-
-
26644458124
-
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3
-
Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF: Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem (2005) 280(40):34296-34305.
-
(2005)
J Biol Chem
, vol.280
, Issue.40
, pp. 34296-34305
-
-
Jiang, P.1
Cui, M.2
Zhao, B.3
Snyder, L.A.4
Benard, L.M.5
Osman, R.6
Max, M.7
Margolskee, R.F.8
-
82
-
-
36749099088
-
The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor
-
Winnig M, Bufe B, Kratochwil NA, Slack JP, Meyerhof W: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. BMC Struct Biol (2007) 7:66.
-
(2007)
BMC Struct Biol
, vol.7
, pp. 66
-
-
Winnig, M.1
Bufe, B.2
Kratochwil, N.A.3
Slack, J.P.4
Meyerhof, W.5
-
83
-
-
26444538550
-
Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor
-
Winnig M, Bufe B, Meyerhof W: Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci (2005) 6(1):22.
-
(2005)
BMC Neurosci
, vol.6
, Issue.1
, pp. 22
-
-
Winnig, M.1
Bufe, B.2
Meyerhof, W.3
|