메뉴 건너뛰기




Volumn 1736, Issue 1, 2005, Pages 51-60

Isohumulones modulate blood lipid status through the activation of PPARα

Author keywords

Atherosclerosis; Beer; Fatty acid oxidation; Hop; Isohumulone; Liver; Microarray; Nutrigenomics; PPAR ; Triglyceride

Indexed keywords

FENOFIBRATE; HUMULUS LUPULUS EXTRACT; ISOADHUMULONE; ISOCOHUMULONE; ISOHUMULONE; ISOMERIZED HOP EXTRACT; KETONE DERIVATIVE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCLASSIFIED DRUG;

EID: 23944508265     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2005.06.008     Document Type: Article
Times cited : (39)

References (42)
  • 3
    • 0034713444 scopus 로고    scopus 로고
    • Roles of PPARs in health and disease
    • S. Kersten, B. Desvergne, and W. Wahli Roles of PPARs in health and disease Nature 405 2000 421 424
    • (2000) Nature , vol.405 , pp. 421-424
    • Kersten, S.1    Desvergne, B.2    Wahli, W.3
  • 4
    • 0034939632 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system
    • J.K. Reddy, and T. Hashimoto Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system Annu. Rev. Nutr. 21 2001 193 230
    • (2001) Annu. Rev. Nutr. , vol.21 , pp. 193-230
    • Reddy, J.K.1    Hashimoto, T.2
  • 6
    • 0842263981 scopus 로고    scopus 로고
    • The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity
    • P. Ferre The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity Diabetes 53 Suppl. 1 2004 S43 S50
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Ferre, P.1
  • 7
    • 0036959260 scopus 로고    scopus 로고
    • Update on fenofibrate
    • D.R. Guay Update on fenofibrate Cardiovasc. Drug Rev. 20 2002 281 302
    • (2002) Cardiovasc. Drug Rev. , vol.20 , pp. 281-302
    • Guay, D.R.1
  • 9
    • 0037025390 scopus 로고    scopus 로고
    • WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice
    • C.J. Chou, M. Haluzik, C. Gregory, K.R. Dietz, C. Vinson, O. Gavrilova, and M.L. Reitman WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice J. Biol. Chem. 277 2002 24484 24489
    • (2002) J. Biol. Chem. , vol.277 , pp. 24484-24489
    • Chou, C.J.1    Haluzik, M.2    Gregory, C.3    Dietz, K.R.4    Vinson, C.5    Gavrilova, O.6    Reitman, M.L.7
  • 11
    • 0031724132 scopus 로고    scopus 로고
    • Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes
    • J. Minamikawa, S. Tanaka, M. Yamauchi, D. Inoue, and H. Koshiyama Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes J. Clin. Endocrinol. Metab. 83 1998 1818 1820
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1818-1820
    • Minamikawa, J.1    Tanaka, S.2    Yamauchi, M.3    Inoue, D.4    Koshiyama, H.5
  • 12
    • 0034920087 scopus 로고    scopus 로고
    • Rapid communication: Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes
    • H. Koshiyama, D. Shimono, N. Kuwamura, J. Minamikawa, and Y. Nakamura Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes J. Clin. Endocrinol. Metab. 86 2001 3452 3456
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3452-3456
    • Koshiyama, H.1    Shimono, D.2    Kuwamura, N.3    Minamikawa, J.4    Nakamura, Y.5
  • 13
    • 4043145033 scopus 로고    scopus 로고
    • Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated Receptor {alpha} and {gamma} and reduce insulin resistance
    • H. Yajima, E. Ikeshima, M. Shiraki, T. Kanaya, D. Fujiwara, H. Odai, N. Tsuboyama-Kasaoka, O. Ezaki, S. Oikawa, and K. Kondo Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated Receptor {alpha} and {gamma} and reduce insulin resistance J. Biol. Chem. 279 2004 33456 33462
    • (2004) J. Biol. Chem. , vol.279 , pp. 33456-33462
    • Yajima, H.1    Ikeshima, E.2    Shiraki, M.3    Kanaya, T.4    Fujiwara, D.5    Odai, H.6    Tsuboyama-Kasaoka, N.7    Ezaki, O.8    Oikawa, S.9    Kondo, K.10
  • 14
    • 23044517297 scopus 로고    scopus 로고
    • Dietary isohumulones, the bitter components of beer, raise plasama HDL cholesterol levels and reduce liver cholesterol and triglyceride contents similar to PPAR {alpha} activations in C57BL/6 mice
    • Y. Miura, M. Hosono, C. Oyamada, S. Oikawa, and K. Kondo Dietary isohumulones, the bitter components of beer, raise plasama HDL cholesterol levels and reduce liver cholesterol and triglyceride contents similar to PPAR {alpha} activations in C57BL/6 mice Br. J. Nutr. 93 2005 559 567
    • (2005) Br. J. Nutr. , vol.93 , pp. 559-567
    • Miura, Y.1    Hosono, M.2    Oyamada, C.3    Oikawa, S.4    Kondo, K.5
  • 15
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • S. Rozen, and H. Skaletsky Primer3 on the WWW for general users and for biologist programmers Methods Mol. Biol. 132 2000 365 386
    • (2000) Methods Mol. Biol. , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 17
    • 0025778925 scopus 로고
    • 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO
    • J. Laborda 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO Nucleic Acids Res. 19 1991 3998
    • (1991) Nucleic Acids Res. , vol.19 , pp. 3998
    • Laborda, J.1
  • 18
    • 0035184941 scopus 로고    scopus 로고
    • Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis
    • M. Cherkaoui-Malki, K. Meyer, W.Q. Cao, N. Latruffe, A.V. Yeldandi, M.S. Rao, C.A. Bradfield, and J.K. Reddy Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis Gene Expr. 9 2001 291 304
    • (2001) Gene Expr. , vol.9 , pp. 291-304
    • Cherkaoui-Malki, M.1    Meyer, K.2    Cao, W.Q.3    Latruffe, N.4    Yeldandi, A.V.5    Rao, M.S.6    Bradfield, C.A.7    Reddy, J.K.8
  • 19
    • 0036289332 scopus 로고    scopus 로고
    • Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor alpha agonists
    • K. Yamazaki, J. Kuromitsu, and I. Tanaka Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor alpha agonists Biochem. Biophys. Res. Commun. 290 2002 1114 1122
    • (2002) Biochem. Biophys. Res. Commun. , vol.290 , pp. 1114-1122
    • Yamazaki, K.1    Kuromitsu, J.2    Tanaka, I.3
  • 21
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation
    • K. Schoonjans, B. Staels, and J. Auwerx The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation Biochim. Biophys. Acta 1302 1996 93 109
    • (1996) Biochim. Biophys. Acta , vol.1302 , pp. 93-109
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 23
    • 0030849408 scopus 로고    scopus 로고
    • A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans
    • Y.M. Heng, C.S. Kuo, P.S. Jones, R. Savory, R.M. Schulz, S.R. Tomlinson, T.J. Gray, and D.R. Bell A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans Biochem. J. 325 Pt 3 1997 741 749
    • (1997) Biochem. J. , vol.325 , Issue.PART 3 , pp. 741-749
    • Heng, Y.M.1    Kuo, C.S.2    Jones, P.S.3    Savory, R.4    Schulz, R.M.5    Tomlinson, S.R.6    Gray, T.J.7    Bell, D.R.8
  • 25
    • 0033618161 scopus 로고    scopus 로고
    • Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes
    • B.V. Geisbrecht, D. Zhang, H. Schulz, and S.J. Gould Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes J. Biol. Chem. 274 1999 21797 21803
    • (1999) J. Biol. Chem. , vol.274 , pp. 21797-21803
    • Geisbrecht, B.V.1    Zhang, D.2    Schulz, H.3    Gould, S.J.4
  • 26
    • 0033025523 scopus 로고    scopus 로고
    • Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/l-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism
    • C. Qi, Y. Zhu, J. Pan, N. Usuda, N. Maeda, A.V. Yeldandi, M.S. Rao, T. Hashimoto, and J.K. Reddy Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/l-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism J. Biol. Chem. 274 1999 15775 15780
    • (1999) J. Biol. Chem. , vol.274 , pp. 15775-15780
    • Qi, C.1    Zhu, Y.2    Pan, J.3    Usuda, N.4    Maeda, N.5    Yeldandi, A.V.6    Rao, M.S.7    Hashimoto, T.8    Reddy, J.K.9
  • 28
    • 0027770698 scopus 로고
    • Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene
    • B.D. Gelb Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene Genomics 18 1993 651 655
    • (1993) Genomics , vol.18 , pp. 651-655
    • Gelb, B.D.1
  • 29
    • 0031049167 scopus 로고    scopus 로고
    • Cloning and characterization of murine carnitine acetyltransferase: Evidence for a requirement during cell cycle progression
    • S. Brunner, K. Kramar, D.T. Denhardt, and R. Hofbauer Cloning and characterization of murine carnitine acetyltransferase: evidence for a requirement during cell cycle progression Biochem. J. 322 Pt 2 1997 403 410
    • (1997) Biochem. J. , vol.322 , Issue.PART 2 , pp. 403-410
    • Brunner, S.1    Kramar, K.2    Denhardt, D.T.3    Hofbauer, R.4
  • 30
    • 0027424775 scopus 로고
    • Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase
    • W. Stoffel, M. Duker, and K. Hofmann Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase FEBS Lett. 333 1993 119 122
    • (1993) FEBS Lett. , vol.333 , pp. 119-122
    • Stoffel, W.1    Duker, M.2    Hofmann, K.3
  • 31
    • 0036321931 scopus 로고    scopus 로고
    • Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?
    • R.A. Coleman, T.M. Lewin, C.G. Van Horn, and M.R. Gonzalez-Baro Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways? J. Nutr. 132 2002 2123 2126
    • (2002) J. Nutr. , vol.132 , pp. 2123-2126
    • Coleman, R.A.1    Lewin, T.M.2    Van Horn, C.G.3    Gonzalez-Baro, M.R.4
  • 32
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • S.S. Lee, T. Pineau, J. Drago, E.J. Lee, J.W. Owens, D.L. Kroetz, P.M. Fernandez-Salguero, H. Westphal, and F.J. Gonzalez Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators Mol. Cell. Biol. 15 1995 3012 3022
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzalez, F.J.9
  • 33
    • 0035914298 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: Studies with congenic mouse lines
    • T.E. Akiyama, C.J. Nicol, C. Fievet, B. Staels, J.M. Ward, J. Auwerx, S.S. Lee, F.J. Gonzalez, and J.M. Peters Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines J. Biol. Chem. 276 2001 39088 39093
    • (2001) J. Biol. Chem. , vol.276 , pp. 39088-39093
    • Akiyama, T.E.1    Nicol, C.J.2    Fievet, C.3    Staels, B.4    Ward, J.M.5    Auwerx, J.6    Lee, S.S.7    Gonzalez, F.J.8    Peters, J.M.9
  • 34
    • 0033623539 scopus 로고    scopus 로고
    • Differential effects of PPARalpha activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver
    • K. Motojima Differential effects of PPARalpha activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver Int. J. Biochem. Cell Biol. 32 2000 1085 1092
    • (2000) Int. J. Biochem. Cell Biol. , vol.32 , pp. 1085-1092
    • Motojima, K.1
  • 35
    • 0026671184 scopus 로고
    • Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone
    • S.S. Sundseth, and D.J. Waxman Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone J. Biol. Chem. 267 1992 3915 3921
    • (1992) J. Biol. Chem. , vol.267 , pp. 3915-3921
    • Sundseth, S.S.1    Waxman, D.J.2
  • 39
    • 0035808410 scopus 로고    scopus 로고
    • The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. a novel mechanism for the development of ethanol-induced fatty liver
    • A. Galli, J. Pinaire, M. Fischer, R. Dorris, and D.W. Crabb The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver J. Biol. Chem. 276 2001 68 75
    • (2001) J. Biol. Chem. , vol.276 , pp. 68-75
    • Galli, A.1    Pinaire, J.2    Fischer, M.3    Dorris, R.4    Crabb, D.W.5
  • 40
    • 0042847330 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice
    • M. Fischer, M. You, M. Matsumoto, and D.W. Crabb Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice J. Biol. Chem. 278 2003 27997 28004
    • (2003) J. Biol. Chem. , vol.278 , pp. 27997-28004
    • Fischer, M.1    You, M.2    Matsumoto, M.3    Crabb, D.W.4
  • 41
    • 0034989967 scopus 로고    scopus 로고
    • Effect of fenofibrate on fatty liver in rats treated with alcohol
    • M. Tsutsumi, and S. Takase Effect of fenofibrate on fatty liver in rats treated with alcohol Alcohol., Clin. Exp. Res. 25 2001 75S 79S
    • (2001) Alcohol., Clin. Exp. Res. , vol.25
    • Tsutsumi, M.1    Takase, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.