메뉴 건너뛰기




Volumn 159, Issue 6, 2018, Pages 2495-2505

Gut microbiota: FFAR reaching effects on islets

Author keywords

[No Author keywords available]

Indexed keywords

FREE FATTY ACID RECEPTOR 2; FREE FATTY ACID RECEPTOR 3; G PROTEIN COUPLED RECEPTOR; INSULIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; FATTY ACID;

EID: 85050971004     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2018-00296     Document Type: Review
Times cited : (34)

References (84)
  • 1
    • 84990234576 scopus 로고    scopus 로고
    • Signals from the gut microbiota to distant organs in physiology and disease
    • Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat Med. 2016;22(10): 1079-1089.
    • (2016) Nat Med , vol.22 , Issue.10 , pp. 1079-1089
    • Schroeder, B.O.1    Bäckhed, F.2
  • 2
    • 0031581088 scopus 로고    scopus 로고
    • A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1
    • Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem Biophys Res Commun. 1997; 239(2):543-547.
    • (1997) Biochem Biophys Res Commun , vol.239 , Issue.2 , pp. 543-547
    • Sawzdargo, M.1    George, S.R.2    Nguyen, T.3    Xu, S.4    Kolakowski, L.F.5    O'Dowd, B.F.6
  • 5
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • Nilsson NE, Kotarsky K, Owman C, Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun. 2003; 303(4):1047-1052.
    • (2003) Biochem Biophys Res Commun , vol.303 , Issue.4 , pp. 1047-1052
    • Nilsson, N.E.1    Kotarsky, K.2    Owman, C.3    Olde, B.4
  • 6
    • 0037307761 scopus 로고    scopus 로고
    • LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3
    • Senga T, Iwamoto S, Yoshida T, Yokota T, Adachi K, Azuma E, Hamaguchi M, Iwamoto T. LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3. Blood. 2003;101(3):1185-1187.
    • (2003) Blood , vol.101 , Issue.3 , pp. 1185-1187
    • Senga, T.1    Iwamoto, S.2    Yoshida, T.3    Yokota, T.4    Adachi, K.5    Azuma, E.6    Hamaguchi, M.7    Iwamoto, T.8
  • 7
    • 85052504497 scopus 로고    scopus 로고
    • Gpr41 and modulators thereof for the treatment of insulin-related disorders
    • Accessed May 7, 2018
    • Leonard JN, Chu ZL, Bruce MA, Boatman PD. Gpr41 and modulators thereof for the treatment of insulin-related disorders. Google Patents; 2014. Available at: https://patents.google.com/patent/US20080312277A1/en. Accessed May 7, 2018.
    • (2014) Google Patents
    • Leonard, J.N.1    Chu, Z.L.2    Bruce, M.A.3    Boatman, P.D.4
  • 8
    • 85052521802 scopus 로고    scopus 로고
    • Gpr43 and modulators thereof for the treatment of metabolic-related disorders
    • Accessed May 7, 2018
    • Leonard JN, Hakak Y. Gpr43 and modulators thereof for the treatment of metabolic-related disorders. Google Patents; 2006. Available at: https://patents.google.com/patent/US20070077602. Accessed May 7, 2018.
    • (2006) Google Patents
    • Leonard, J.N.1    Hakak, Y.2
  • 9
    • 33646376658 scopus 로고    scopus 로고
    • Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
    • Karaki S, Mitsui R, Hayashi H, Kato I, Sugiya H, Iwanaga T, Furness JB, Kuwahara A. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res. 2006;324(3):353-360.
    • (2006) Cell Tissue Res , vol.324 , Issue.3 , pp. 353-360
    • Karaki, S.1    Mitsui, R.2    Hayashi, H.3    Kato, I.4    Sugiya, H.5    Iwanaga, T.6    Furness, J.B.7    Kuwahara, A.8
  • 11
    • 84878586268 scopus 로고    scopus 로고
    • G-protein-coupled receptors, pancreatic islets, and diabetes
    • Layden BT, Durai V, Lowe WL Jr. G-protein-coupled receptors, pancreatic islets, and diabetes. Nature Education. 2010;3(9):13.
    • (2010) Nature Education , vol.3 , Issue.9 , pp. 13
    • Layden, B.T.1    Durai, V.2    Jr, L.W.L.3
  • 13
    • 51449119654 scopus 로고    scopus 로고
    • Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions
    • Tazoe H, Otomo Y, Kaji I, Tanaka R, Karaki SI, Kuwahara A. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol. 2008;59(Suppl 2): 251-262.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 251-262
    • Tazoe, H.1    Otomo, Y.2    Kaji, I.3    Tanaka, R.4    Karaki, S.I.5    Kuwahara, A.6
  • 14
    • 85014089635 scopus 로고    scopus 로고
    • FFA2 and FFA3 in metabolic regulation
    • Tang C, Offermanns S. FFA2 and FFA3 in metabolic regulation. Handb Exp Pharmacol. 2017;236:205-220.
    • (2017) Handb Exp Pharmacol , vol.236 , pp. 205-220
    • Tang, C.1    Offermanns, S.2
  • 16
    • 57749112018 scopus 로고    scopus 로고
    • Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids
    • Stoddart LA, Smith NJ, Jenkins L, Brown AJ, Milligan G. Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids. J Biol Chem. 2008;283(47):32913-32924.
    • (2008) J Biol Chem , vol.283 , Issue.47 , pp. 32913-32924
    • Stoddart, L.A.1    Smith, N.J.2    Jenkins, L.3    Brown, A.J.4    Milligan, G.5
  • 17
    • 69249214021 scopus 로고    scopus 로고
    • Agonism and allosterism: The pharmacology of the free fatty acid receptors FFA2 and FFA3
    • Milligan G, Stoddart LA, Smith NJ. Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br J Pharmacol. 2009;158(1):146-153.
    • (2009) Br J Pharmacol , vol.158 , Issue.1 , pp. 146-153
    • Milligan, G.1    Stoddart, L.A.2    Smith, N.J.3
  • 18
    • 84870361150 scopus 로고    scopus 로고
    • Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3
    • Hudson BD, Tikhonova IG, Pandey SK, Ulven T, Milligan G. Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem. 2012;287(49): 41195-41209.
    • (2012) J Biol Chem , vol.287 , Issue.49 , pp. 41195-41209
    • Hudson, B.D.1    Tikhonova, I.G.2    Pandey, S.K.3    Ulven, T.4    Milligan, G.5
  • 19
    • 79953216793 scopus 로고    scopus 로고
    • Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: Identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
    • Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem. 2011; 286(12):10628-10640.
    • (2011) J Biol Chem , vol.286 , Issue.12 , pp. 10628-10640
    • Schmidt, J.1    Smith, N.J.2    Christiansen, E.3    Tikhonova, I.G.4    Grundmann, M.5    Hudson, B.D.6    Ward, R.J.7    Drewke, C.8    Milligan, G.9    Kostenis, E.10    Ulven, T.11
  • 23
    • 84870373974 scopus 로고    scopus 로고
    • Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
    • Hudson BD, Christiansen E, Tikhonova IG, Grundmann M, Kostenis E, Adams DR, Ulven T, Milligan G. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs. FASEB J. 2012;26(12):4951-4965.
    • (2012) FASEB J , vol.26 , Issue.12 , pp. 4951-4965
    • Hudson, B.D.1    Christiansen, E.2    Tikhonova, I.G.3    Grundmann, M.4    Kostenis, E.5    Adams, D.R.6    Ulven, T.7    Milligan, G.8
  • 24
    • 85018196459 scopus 로고    scopus 로고
    • FFAR3 modulates insulin secretion and global gene expression in mouse islets
    • Priyadarshini M, Layden BT. FFAR3 modulates insulin secretion and global gene expression in mouse islets. Islets. 2015;7(2): e1045182.
    • (2015) Islets , vol.7 , Issue.2 , pp. e1045182
    • Priyadarshini, M.1    Layden, B.T.2
  • 26
    • 84996553637 scopus 로고    scopus 로고
    • GPR41 modulates insulin secretion and gene expression in pancreatic b-cells and modifies metabolic homeostasis in fed and fasting states
    • Veprik A, Laufer D, Weiss S, Rubins N, Walker MD. GPR41 modulates insulin secretion and gene expression in pancreatic b-cells and modifies metabolic homeostasis in fed and fasting states. FASEB J. 2016;30(11):3860-3869.
    • (2016) FASEB J , vol.30 , Issue.11 , pp. 3860-3869
    • Veprik, A.1    Laufer, D.2    Weiss, S.3    Rubins, N.4    Walker, M.D.5
  • 27
    • 84922620529 scopus 로고    scopus 로고
    • Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
    • Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S. Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med. 2015;21(2): 173-177.
    • (2015) Nat Med , vol.21 , Issue.2 , pp. 173-177
    • Tang, C.1    Ahmed, K.2    Gille, A.3    Lu, S.4    Gröne, H.J.5    Tunaru, S.6    Offermanns, S.7
  • 28
    • 84988923392 scopus 로고    scopus 로고
    • Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists
    • Ang Z, Er JZ, Tan NS, Lu J, Liou YC, Grosse J, Ding JL. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists. Sci Rep. 2016;6(1):34145.
    • (2016) Sci Rep , vol.6 , Issue.1 , pp. 34145
    • Ang, Z.1    Er, J.Z.2    Tan, N.S.3    Lu, J.4    Liou, Y.C.5    Grosse, J.6    Ding, J.L.7
  • 30
    • 85014070872 scopus 로고    scopus 로고
    • Ligands at the free fatty acid receptors 2/3 (GPR43/GPR41)
    • Milligan G, Bolognini D, Sergeev E. Ligands at the free fatty acid receptors 2/3 (GPR43/GPR41). Handb Exp Pharmacol. 2017;236: 17-32.
    • (2017) Handb Exp Pharmacol , vol.236 , pp. 17-32
    • Milligan, G.1    Bolognini, D.2    Sergeev, E.3
  • 31
    • 85019400139 scopus 로고    scopus 로고
    • Complex pharmacology of free fatty acid receptors
    • Milligan G, Shimpukade B, Ulven T, Hudson BD. Complex pharmacology of free fatty acid receptors. Chem Rev. 2017;117(1): 67-110.
    • (2017) Chem Rev , vol.117 , Issue.1 , pp. 67-110
    • Milligan, G.1    Shimpukade, B.2    Ulven, T.3    Hudson, B.D.4
  • 32
    • 85018259615 scopus 로고    scopus 로고
    • Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation
    • Tan JK, McKenzie C, Mariño E, Macia L, Mackay CR. Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation. Annu Rev Immunol. 2017;35(1):371-402.
    • (2017) Annu Rev Immunol , vol.35 , Issue.1 , pp. 371-402
    • Tan, J.K.1    McKenzie, C.2    Mariño, E.3    Macia, L.4    Mackay, C.R.5
  • 33
    • 84881367782 scopus 로고    scopus 로고
    • Metabolic signaling in fuel-induced insulin secretion
    • Prentki M, Matschinsky FM, Madiraju SR. Metabolic signaling in fuel-induced insulin secretion. Cell Metab. 2013;18(2):162-185.
    • (2013) Cell Metab , vol.18 , Issue.2 , pp. 162-185
    • Prentki, M.1    Matschinsky, F.M.2    Madiraju, S.R.3
  • 34
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52(1):102-110.
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 36
    • 67349176115 scopus 로고    scopus 로고
    • Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
    • published correction Nat Rev Drug Discov. 2009;8:369-385
    • Ahrén B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes [published correction appears in Nat Rev Drug Discov. 2009;8:369-385]. Nat Rev Drug Discov. 2009; 8(5):369-385.
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.5 , pp. 369-385
    • Ahrén, B.1
  • 37
    • 84875843482 scopus 로고    scopus 로고
    • Chronic activation of a designer G(q)-coupled receptor improves b cell function
    • Jain S, Ruiz de Azua I, Lu H, White MF, Guettier JM, Wess J. Chronic activation of a designer G(q)-coupled receptor improves b cell function. J Clin Invest. 2013;123(4):1750-1762.
    • (2013) J Clin Invest , vol.123 , Issue.4 , pp. 1750-1762
    • Jain, S.1    Ruiz De Azua, I.2    Lu, H.3    White, M.F.4    Guettier, J.M.5    Wess, J.6
  • 42
    • 84864491110 scopus 로고    scopus 로고
    • Duodenal enteroendocrine I-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors
    • Sykaras AG, Demenis C, Case RM, McLaughlin JT, Smith CP. Duodenal enteroendocrine I-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors. PLoS One. 2012;7(8):e42373.
    • (2012) PLoS One , vol.7 , Issue.8 , pp. e42373
    • Sykaras, A.G.1    Demenis, C.2    Case, R.M.3    McLaughlin, J.T.4    Smith, C.P.5
  • 43
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving beta-cell dysfunction during progression to diabetes
    • Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004;53(Suppl 3): S16-S21.
    • (2004) Diabetes , vol.53 , pp. S16-S21
    • Weir, G.C.1    Bonner-Weir, S.2
  • 45
    • 84949553094 scopus 로고    scopus 로고
    • Linking microbiota to human diseases: A systems biology perspective
    • Wu H, Tremaroli V, Bäckhed F. Linking microbiota to human diseases: a systems biology perspective. Trends Endocrinol Metab. 2015;26(12):758-770.
    • (2015) Trends Endocrinol Metab , vol.26 , Issue.12 , pp. 758-770
    • Wu, H.1    Tremaroli, V.2    Bäckhed, F.3
  • 47
    • 84944675457 scopus 로고    scopus 로고
    • Short, but smart: SCFAs train T cells in the gut to fight autoimmunity in the brain
    • Bhutia YD, Ganapathy V. Short, but smart: SCFAs train T cells in the gut to fight autoimmunity in the brain. Immunity. 2015;43(4): 629-631.
    • (2015) Immunity , vol.43 , Issue.4 , pp. 629-631
    • Bhutia, Y.D.1    Ganapathy, V.2
  • 49
    • 84975230323 scopus 로고    scopus 로고
    • GPR41 and GPR43 in obesity and inflammation - Protective or causative?
    • Ang Z, Ding JL. GPR41 and GPR43 in obesity and inflammation - protective or causative? Front Immunol. 2016;7:28.
    • (2016) Front Immunol , vol.7 , pp. 28
    • Ang, Z.1    Ding, J.L.2
  • 51
    • 84995481695 scopus 로고    scopus 로고
    • The intestinal epithelial barrier: A therapeutic target?
    • Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target? Nat Rev Gastroenterol Hepatol. 2017;14(1): 9-21.
    • (2017) Nat Rev Gastroenterol Hepatol , vol.14 , Issue.1 , pp. 9-21
    • Odenwald, M.A.1    Turner, J.R.2
  • 52
    • 84966716353 scopus 로고    scopus 로고
    • Type 1 diabetes and dysfunctional intestinal homeostasis
    • D'Addio F, Fiorina P. Type 1 diabetes and dysfunctional intestinal homeostasis. Trends Endocrinol Metab. 2016;27(7):493-503.
    • (2016) Trends Endocrinol Metab , vol.27 , Issue.7 , pp. 493-503
    • D'Addio, F.1    Fiorina, P.2
  • 53
    • 84908365772 scopus 로고    scopus 로고
    • Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling
    • Shi G, Sun C, Gu W, Yang M, Zhang X, Zhai N, Lu Y, Zhang Z, Shou P, Zhang Z, Ning G. Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling. J Mol Endocrinol. 2014;53(3):367-380.
    • (2014) J Mol Endocrinol , vol.53 , Issue.3 , pp. 367-380
    • Shi, G.1    Sun, C.2    Gu, W.3    Yang, M.4    Zhang, X.5    Zhai, N.6    Lu, Y.7    Zhang, Z.8    Shou, P.9    Zhang, Z.10    Ning, G.11
  • 56
    • 84940998804 scopus 로고    scopus 로고
    • Pancreatic b-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota
    • Sun J, Furio L, Mecheri R, van der Does AM, Lundeberg E, Saveanu L, Chen Y, van Endert P, Agerberth B, Diana J. Pancreatic b-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota. Immunity. 2015;43(2):304-317.
    • (2015) Immunity , vol.43 , Issue.2 , pp. 304-317
    • Sun, J.1    Furio, L.2    Mecheri, R.3    Van Der Does, A.M.4    Lundeberg, E.5    Saveanu, L.6    Chen, Y.7    Van Endert, P.8    Agerberth, B.9    Diana, J.10
  • 57
    • 85020235398 scopus 로고    scopus 로고
    • Incretin-based therapies: Revisiting their mode of action
    • Layden BT, Wicksteed B, Mauvais-Jarvis F. Incretin-based therapies: revisiting their mode of action. Endocrinology. 2017;158(6): 1560-1563.
    • (2017) Endocrinology , vol.158 , Issue.6 , pp. 1560-1563
    • Layden, B.T.1    Wicksteed, B.2    Mauvais-Jarvis, F.3
  • 58
    • 84927176473 scopus 로고    scopus 로고
    • Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans
    • Rahat-Rozenbloom S, Fernandes J, Gloor GB, Wolever TM. Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans. Int J Obes. 2014;38(12): 1525-1531.
    • (2014) Int J Obes , vol.38 , Issue.12 , pp. 1525-1531
    • Rahat-Rozenbloom, S.1    Fernandes, J.2    Gloor, G.B.3    Wolever, T.M.4
  • 59
    • 84973657314 scopus 로고    scopus 로고
    • Fibre digestibility, abundance of faecal bacteria and plasma acetate concentrations in overweight adult mares
    • Shepherd ML, Ponder MA, Burk AO, Milton SC, Swecker WS Jr. Fibre digestibility, abundance of faecal bacteria and plasma acetate concentrations in overweight adult mares. J Nutr Sci. 2014;3:e10.
    • (2014) J Nutr Sci , vol.3 , pp. e10
    • Shepherd, M.L.1    Ponder, M.A.2    Burk, A.O.3    Milton, S.C.4    Jr, S.W.S.5
  • 60
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-1031.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 61
    • 84903711427 scopus 로고    scopus 로고
    • Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans
    • Fernandes J, Su W, Rahat-Rozenbloom S, Wolever TM, Comelli EM. Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans. Nutr Diabetes. 2014;4(6):e121.
    • (2014) Nutr Diabetes , vol.4 , Issue.6 , pp. e121
    • Fernandes, J.1    Su, W.2    Rahat-Rozenbloom, S.3    Wolever, T.M.4    Comelli, E.M.5
  • 62
    • 84904040700 scopus 로고    scopus 로고
    • Gut carbohydrate metabolism instead of fat metabolism regulated by gut microbes mediates high-fat diet-induced obesity
    • Li M, Gu D, Xu N, Lei F, Du L, Zhang Y, Xie W. Gut carbohydrate metabolism instead of fat metabolism regulated by gut microbes mediates high-fat diet-induced obesity. Benef Microbes. 2014;5(3): 335-344.
    • (2014) Benef Microbes , vol.5 , Issue.3 , pp. 335-344
    • Li, M.1    Gu, D.2    Xu, N.3    Lei, F.4    Du, L.5    Zhang, Y.6    Xie, W.7
  • 66
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57(6):1470-1481.
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 71
    • 84958116286 scopus 로고    scopus 로고
    • The role of the intestinal microbiota in type 1 diabetes mellitus
    • Knip M, Siljander H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol. 2016;12(3):154-167.
    • (2016) Nat Rev Endocrinol , vol.12 , Issue.3 , pp. 154-167
    • Knip, M.1    Siljander, H.2
  • 82
    • 84952338130 scopus 로고    scopus 로고
    • Selective FFA2 agonism appears to act via intestinal PYY to reduce transit and food intake but does not improve glucose tolerance in mouse models
    • Forbes S, Stafford S, Coope G, Heffron H, Real K, Newman R, Davenport R, Barnes M, Grosse J, Cox H. Selective FFA2 agonism appears to act via intestinal PYY to reduce transit and food intake but does not improve glucose tolerance in mouse models. Diabetes. 2015;64(11):3763-3771.
    • (2015) Diabetes , vol.64 , Issue.11 , pp. 3763-3771
    • Forbes, S.1    Stafford, S.2    Coope, G.3    Heffron, H.4    Real, K.5    Newman, R.6    Davenport, R.7    Barnes, M.8    Grosse, J.9    Cox, H.10
  • 84
    • 85052528227 scopus 로고    scopus 로고
    • Free-fatty acid receptors in enteroendocrine cells
    • published online ahead of print April 23, 2018
    • Lu VB, Gribble FM, Reimann F. Free-fatty acid receptors in enteroendocrine cells [published online ahead of print April 23, 2018]. Endocrinology. doi: 10.1210/en.2018-00261.
    • Endocrinology
    • Lu, V.B.1    Gribble, F.M.2    Reimann, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.