High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 308, Issue 7, 2015, Pages E573-E582

  Mosser, Rockann E ^a,b   Maulis, Matthew F ^a,b   Moullé, Valentine S ^d   Dunn, Jennifer C ^a,b   Carboneau, Bethany A ^c   Arasi, Kavin ^b   Pappan, Kirk ^f   Poitout, Vincent ^d,e   Gannon, Maureen ^a,b,c  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

^f METABOLON INC   (United States)

Author keywords

High fat diet; Insulin resistance; Mouse models; cell mass; cell proliferation

Indexed keywords

ALPHA HYDROXYBUTYRIC ACID; GLUCOSE; HYDROXYBUTYRIC ACID; UNCLASSIFIED DRUG; FAT INTAKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WEIGHT GAIN; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; FAT INTAKE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; METABOLISM; PHARMACOLOGY; PHYSIOLOGY; TIME;

ANIMALS; CELL PROLIFERATION; DIET, HIGH-FAT; DIETARY FATS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; TIME FACTORS;

EID: 84926353507     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00460.2014     Document Type: Article

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