Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Cell

Volumn 174, Issue 4, 2018, Pages 856-869.e17

  Nanki, Kosaku ^a   Toshimitsu, Kohta ^a   Takano, Ai ^a   Fujii, Masayuki ^a   Shimokawa, Mariko ^a   Ohta, Yuki ^a   Matano, Mami ^a   Seino, Takashi ^a   Nishikori, Shingo ^a,b   Ishikawa, Keiko ^a   Kawasaki, Kenta ^a   Togasaki, Kazuhiro ^a   Takahashi, Sirirat ^a   Sukawa, Yasutaka ^a   Ishida, Hiroki ^a   Sugimoto, Shinya ^a   Kawakubo, Hirofumi ^a   Kim, Jihoon ^c   Kitagawa, Yuko ^a   Sekine, Shigeki ^d   Koo, Bon Kyoung ^c   Kanai, Takanori ^a   Sato, Toshiro ^a   more..

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

^d NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

CRISPR Cas9; Gastric cancers; Organoids; Stem cell niche; Wnt signaling

Indexed keywords

PROTEIN P53; PROTEIN R SPONDIN; TUMOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN; CADHERIN; CDH1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; RSPO1 PROTEIN, HUMAN; THROMBOSPONDIN; TP53 PROTEIN, HUMAN; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GENETICS; CANCER TISSUE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; EPIGENETICS; GENE KNOCKOUT; GENE LIBRARY; GENETIC ASSOCIATION; GENETIC ENGINEERING; GENETIC SCREENING; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; ORGANOID; PHENOTYPE; PRIORITY JOURNAL; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR XENOGRAFT; ADENOCARCINOMA; ANIMAL; APOPTOSIS; CARCINOGENESIS; CELL PROLIFERATION; DRUG SCREENING; GENETICS; METABOLISM; MUTATION; NONOBESE DIABETIC MOUSE; PATHOLOGY; SCID MOUSE; STOMACH; STOMACH TUMOR; TUMOR CELL CULTURE;

ADENOCARCINOMA; ANIMALS; ANTIGENS, CD; APOPTOSIS; BIOMARKERS, TUMOR; CADHERINS; CARCINOGENESIS; CELL PROLIFERATION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; HUMANS; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MUTATION; ORGANOIDS; STOMACH; STOMACH NEOPLASMS; THROMBOSPONDINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; WNT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85050811688     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.07.027     Document Type: Article

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