Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

eLife

Volumn 5, Issue FEBRUARY2016, 2016, Pages

  Mihara, Emiko ^a   Hirai, Hidenori ^a   Yamamoto, Hideki ^b   Tamura Kawakami, Keiko ^a   Matano, Mami ^c   Kikuchi, Akira ^b   Sato, Toshiro ^c   Takagi, Junichi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AFAMIN; APOLIPOPROTEIN A1; BOVINE SERUM ALBUMIN; GLYCOPROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3 PROTEIN; WNT3A PROTEIN; WNT5A PROTEIN; CARRIER PROTEIN; PROTEIN BINDING; SERUM ALBUMIN; WATER;

ARTICLE; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECRETION; ANIMAL; BOVINE; CHEMICAL PHENOMENA; CHEMISTRY; METABOLISM; SOLUBILITY;

ANIMALS; CARRIER PROTEINS; CATTLE; GLYCOPROTEINS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PROTEIN BINDING; SERUM ALBUMIN; SOLUBILITY; WATER; WNT PROTEINS;

EID: 84961262615     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.11621     Document Type: Article

References (33)

1. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. 2007. Increased wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317:807-810. doi: 10.1126/science.1144090
2. Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ. 2003. Dishevelled 2 recruits arrestin 2 to mediate Wnt5A-stimulated endocytosis of frizzled 4. Science 301:1391-1394. doi: 10.1126/science.1082808
3. Dhamdhere GR, Fang MY, Jiang J, Lee K, Cheng D, Olveda RC, Liu B, Mulligan KA, Carlson JC, Ransom RC, Weis WI, Helms JA, Verheyen EM. 2014. Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS ONE 9:e83650. doi: 10.1371/journal.pone.0083650
4. Dieplinger H, Dieplinger B. 2015. Afamin a pleiotropic glycoprotein involved in various disease states. Clinica Chimica Acta 446:105-110. doi: 10.1016/j.cca.2015.04.010
5. Fujii Y, Kaneko M, Neyazaki M, Nogi T, Kato Y, Takagi J. 2014. PA tag: a versatile protein tagging system using a super high affinity antibody against a dodecapeptide derived from human podoplanin. Protein Expression and Purification 95:240-247. doi: 10.1016/j.pep.2014.01.009
6. Green JL, Bauer M, Yum KW, Li Y-C, Cox ML, Willert K, Wahl GM, Van Wijnen A. 2013. Use of a molecular genetic platform technology to produce human wnt proteins reveals distinct local and distal signaling abilities. PLoS ONE 8:e58395. doi: 10.1371/journal.pone.0058395
7. Gross JC, Chaudhary V, Bartscherer K, Boutros M. 2012. Active wnt proteins are secreted on exosomes. Nature Cell Biology 14:1036-1045. doi: 10.1038/ncb2574
8. Han C, Yan D, Belenkaya TY, Lin X. 2005. Drosophila glypicans dally and dally-like shape the extracellular wingless morphogen gradient in the wing disc. Development 132:667-679. doi: 10.1242/dev.01636
9. Holstein TW. 2012. The evolution of the wnt pathway. Cold Spring Harbor Perspectives in Biology 4:a007922. doi: 10.1101/cshperspect.a007922
10. Janda CY, Waghray D, Levin AM, Thomas C, Garcia KC. 2012. Structural basis of wnt recognition by frizzled. Science 337:59-64. doi: 10.1126/science.1222879
11. Kakugawa S, Langton PF, Zebisch M, Howell SA, Chang T-H, Liu Y, Feizi T, Bineva G, O’Reilly N, Snijders AP, Jones EY, Vincent J-P. 2015. Notum deacylates wnt proteins to suppress signalling activity. Nature 519:187-192. doi: 10.1038/nature14259
12. Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W. 2009. Afamin is synthesized by cerebrovascular endothelial cells and mediates a-tocopherol transport across an in vitro model of the blood-brain barrier. Journal of Neurochemistry 108:707-718. doi: 10.1111/j.1471-4159.2008.05796.x
13. Kurayoshi M, Yamamoto H, Izumi S, Kikuchi A. 2007. Post-translational palmitoylation and glycosylation of wnt-5a are necessary for its signalling. Biochemical Journal 402:515-523. doi: 10.1042/BJ20061476
14. Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM. 1994. Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin d-binding protein gene family. The Journal of Biological Chemistry 269:18149-18154.
15. Logan CY, Nusse R. 2004. The Wnt signaling pathway in development and disease. Annual Review of Cell and Developmental Biology 20:781-810. doi:10.1146/annurev.cellbio.20.010403.113126
16. Morrell NT, Leucht P, Zhao L, Kim J-B, ten Berge D, Ponnusamy K, Carre AL, Dudek H, Zachlederova M, McElhaney M, Brunton S, Gunzner J, Callow M, Polakis P, Costa M, Zhang XM, Helms JA, Nusse R, van Lohuizen MMS. 2008. Liposomal packaging generates wnt protein with in vivo biological activity. PLoS ONE 3: e2930. doi: 10.1371/journal.pone.0002930
17. Mulligan KA, Fuerer C, Ching W, Fish M, Willert K, Nusse R. 2012. Secreted wingless-interacting molecule (swim) promotes long-range signaling by maintaining wingless solubility. Proceedings of the National Academy of Sciences of the United states of America 109:370-377. doi: 10.1073/pnas.1119197109
18. Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML. 2012. A uniform human wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation 84:203-213. doi: 10.1016/j.diff.2012.06.004
19. Neumann S, Coudreuse DYM, van der Westhuyzen DR, Eckhardt ERM, Korswagen HC, Schmitz G, Sprong H. 2009. Mammalian Wnt3a is released on lipoprotein particles. Traffic 10:334-343. doi: 10.1111/j.1600-0854.2008.00872.x
20. Nogi T, Sangawa T, Tabata S, Nagae M, Tamura-Kawakami K, Beppu A, Hattori M, Yasui N, Takagi J. 2008. Novel affinity tag system using structurally defined antibody-tag interaction: application to single-step protein purification. Protein Science 17:2120-2126. doi: 10.1110/ps.038299.108
21. Panáková D, Sprong H, Marois E, Thiele C, Eaton S. 2005. Lipoprotein particles are required for hedgehog and wingless signalling. Nature 435:58-65. doi: 10.1038/nature03504
22. Regard JB, Zhong Z, Williams BO, Yang Y. 2012. Wnt signaling in bone development and disease: making stronger bone with wnts. Cold Spring Harbor Perspectives in Biology 4:a007997. doi: 10.1101/cshperspect.a007997
23. Sato T, Stange DE, Ferrante M, Vries RGJ, van Es JH, van den Brink S, van Houdt WJ, Pronk A, van Gorp J, Siersema PD, Clevers H. 2011. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and barrett’s epithelium. Gastroenterology 141:1762-1772. doi: 10.1053/j.gastro.2011.07.050
24. Sato T, Clevers H. 2013. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340:1190-1194. doi: 10.1126/science.1234852
25. Shibamoto S, Higano K, Takada R, Ito F, Takeichi M, Takada S. 1998. Cytoskeletal reorganization by soluble wnt- 3a protein signalling. Genes to Cells 3:659-670. doi: 10.1046/j.1365-2443.1998.00221.
26. Tabata S, Nampo M, Mihara E, Tamura-Kawakami K, Fujii I, Takagi J. 2010. A rapid screening method for cell lines producing singly-tagged recombinant proteins using the tARGET tag system. Journal of Proteomics 73: 1777-1785. doi: 10.1016/j.jprot.2010.05.012
27. Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S. 2006. Monounsaturated fatty acid modification of wnt protein: its role in wnt secretion. Developmental Cell 11:791-801. doi: 10.1016/j.devcel.2006.10.003
28. Ten Berge D, Kurek D, Blauwkamp T, Koole W, Maas A, Eroglu E, Siu RK, Nusse R. 2011. Embryonic stem cells require wnt proteins to prevent differentiation to epiblast stem cells. Nature Cell Biology 13:1070-1075. doi: 10.1038/ncb2314
29. Voegele AF, Jerkovic´ L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H. 2002. Characterization of the vitamin e-binding properties of human plasma afamin. Biochemistry 41:14532-14538. doi: 10.1021/ bi026513v
30. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R. 2003. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423:448-452. doi: 10.1038/nature01611
31. Willert KH. 2008. Isolation and application of bioactive wnt proteins. Methods Mol Biol 468:17-29. doi: 10.1007/ 978-1-59745-249-62
32. Yu Q, Sharma A, Sen JM. 2010. TCF1 and b-catenin regulatet cell development and function. Immunologic Research 47:45-55. doi: 10.1007/s12026-009-8137-2
33. Zimmerman ZF, Moon RT, Chien AJ. 2012. Targeting wnt pathways in disease. Cold Spring Harbor Perspectives in Biology 4:a008086. doi: 10.1101/cshperspect.a008086