Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Science

Volumn 359, Issue 6378, 2018, Pages 920-926

  Vlachogiannis, Georgios ^a   Hedayat, Somaieh ^a   Vatsiou, Alexandra ^a   Jamin, Yann ^a   Fernández Mateos, Javier ^a   Khan, Khurum ^a,b   Lampis, Andrea ^a   Eason, Katherine ^a   Huntingford, Ian ^a   Burke, Rosemary ^a   Rata, Mihaela ^a   Koh, Dow Mu ^a,b   Tunariu, Nina ^a,b   Collins, David ^a   Hulkki Wilson, Sanna ^a   Ragulan, Chanthirika ^a   Spiteri, Inmaculada ^a   Moorcraft, Sing Yu ^b   Chau, Ian ^b   Rao, Sheela ^b   Watkins, David ^b   Fotiadis, Nicos ^b   Bali, Maria ^a,b   Darvish Damavandi, Mahnaz ^a   Lote, Hazel ^a,b   Eltahir, Zakaria ^a   Smyth, Elizabeth C ^b   Begum, Ruwaida ^b   Clarke, Paul A ^a   Hahne, Jens C ^a   Dowsett, Mitchell ^b   De Bono, Johann ^a   Workman, Paul ^a   Sadanandam, Anguraj ^a   Fassan, Matteo ^c   Sansom, Owen J ^d   Eccles, Suzanne ^a   Starling, Naureen ^b   Braconi, Chiara ^a,b   Sottoriva, Andrea ^a   Robinson, Simon P ^a   Cunningham, David ^b   Valeri, Nicola ^a,b   more..

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY OF PADOVA   (Italy)

^d BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; APITOLISIB; BERZOSERTIB; CETUXIMAB; CISPLATIN; FLUOROURACIL; LAPATINIB; PACLITAXEL; PALBOCICLIB; REGORAFENIB; TIPIRACIL PLUS TRIFLURIDINE; VEMURAFENIB; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; BIOBANK; CANCER SURVIVAL; CELL VIABILITY; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATIONAL STUDY; DIGESTIVE SYSTEM CANCER; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ESOPHAGUS CANCER; EX VIVO STUDY; GENOTYPE; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METASTASIS; MOUSE; NONHUMAN; ORGANOID; PELVIC METASTASIS; PERITONEUM METASTASIS; PERSONALIZED MEDICINE; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; EVALUATION STUDY; GASTROINTESTINAL TUMOR; GENOMICS; METABOLISM; PATHOLOGY; PROCEDURES;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; GASTROINTESTINAL NEOPLASMS; GENOMICS; HUMANS; MICE; NEOPLASM METASTASIS; ORGANOIDS; PHENYLUREA COMPOUNDS; PRECISION MEDICINE; PYRIDINES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85042318736     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aao2774     Document Type: Article

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