Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 23, 2018, Pages E5307-E5316

  Shmakov, Sergey A ^a,b   Makarova, Kira S ^b   Wolf, Yuri I ^b   Severinov, Konstantin V ^a,c,d   Koonin, Eugene V ^b  

^a SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

Computational genomics; CRISPR Cas; Gene neighborhoods; Membrane proteins; Signaling

Indexed keywords

MEMBRANE PROTEIN; CRISPR ASSOCIATED PROTEIN;

ARCHAEON; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL MEMBRANE; CONTROLLED STUDY; CRISPR CAS SYSTEM; GENE IDENTIFICATION; GENE LOCUS; GENE SEQUENCE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ARCHAEAL GENOME; BACTERIUM; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COMPUTER SIMULATION; GENETIC SCREENING; GENETICS; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PHYLOGENY;

ARCHAEA; BACTERIA; BASE SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; COMPUTER SIMULATION; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; EVOLUTION, MOLECULAR; GENES, BACTERIAL; GENETIC TESTING; GENOME, ARCHAEAL; GENOME, BACTERIAL; PHYLOGENY;

EID: 85048018731     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1803440115     Document Type: Article

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