A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 30, 2014, Pages 11163-11168

  Sampson, Timothy R ^a,b   Napier, Brooke A ^a,b,f   Schroeder, Max R ^a   Louwen, Rogier ^c   Zhao, Jinshi ^d   Chin, Chui Yoke ^b   Ratner, Hannah K ^a,b   Llewellyn, Anna C ^a,b,g   Jones, Crystal L ^a,b,h   Laroui, Hamed ^e   Merlin, Didier ^e   Zhou, Pei ^d   Endtz, Hubert P ^c   Weiss, David S ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e GEORGIA STATE UNIVERSITY   (United States)

^f STANFORD UNIVERSITY   (United States)

^g NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^h WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Gene regulation; Innate immune evasion

Indexed keywords

CASPASE 9; INFLAMMASOME; POLYMYXIN B; TOLL LIKE RECEPTOR 2;

ANIMAL EXPERIMENT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL PHENOMENA AND FUNCTIONS; CRISPR CAS SYSTEM; CYTOTOXICITY; DELETION MUTANT; FRANCISELLA NOVICIDA; KNOCKOUT MOUSE; MACROPHAGE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

GENE REGULATION; INNATE IMMUNE EVASION;

ANIMALS; BACTERIAL PROTEINS; CELL MEMBRANE; DRUG RESISTANCE, BACTERIAL; FRANCISELLA; GRAM-NEGATIVE BACTERIAL INFECTIONS; IMMUNE EVASION; INFLAMMASOMES; INVERTED REPEAT SEQUENCES; LIPOPROTEINS; MICE; MICE, KNOCKOUT;

EID: 84904988731     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323025111     Document Type: Article

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