Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense

Structure

Volumn 17, Issue 6, 2009, Pages 904-912

  Wiedenheft, Blake ^a   Zhou, Kaihong ^a   Jinek, Martin ^a   Coyle, Scott M ^a   Ma, Wendy ^a   Doudna, Jennifer A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

DNA; MICROBIO; PROTEINS

Indexed keywords

CLUSTERED REGULARY INTERSPACED SHORT PALINDROMIC REPEAT ASSOCIATED GENE 1 PROTEIN; DEOXYRIBONUCLEASE; DOUBLE STRANDED DNA; METAL ION; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DEGRADATION; IMMUNE SYSTEM; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BASE PAIRING; BASE SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; DEOXYRIBONUCLEASES; DIMERIZATION; DNA, BACTERIAL; GENOME; GENOME, BACTERIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROKARYOTIC CELLS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID;

PROKARYOTA;

EID: 66349134987     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2009.03.019     Document Type: Article

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