CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 18, 2014, Pages 6618-6623

  Hochstrasser, Megan L ^a   Taylor, David W ^a,b   Bhat, Prashant ^a   Guegler, Chantal K ^a   Sternberg, Samuel H ^a   Nogales, Eva ^a,b,c   Doudna, Jennifer A ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CAS3 PROTEIN; CASA PROTEIN; COMPLEMENTARY DNA; DOUBLE STRANDED DNA; GUIDE RNA; HELICASE; NUCLEASE; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CATALYSIS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; DNA DEGRADATION; DNA SEQUENCE; ELECTRON MICROSCOPY; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SUBUNIT; RNA BINDING; RNA INTERFERENCE; RNA SEQUENCE;

BASE SEQUENCE; BINDING SITES; CRISPR-ASSOCIATED PROTEINS; CRYOELECTRON MICROSCOPY; DNA HELICASES; ESCHERICHIA COLI K12; ESCHERICHIA COLI PROTEINS; IMAGING, THREE-DIMENSIONAL; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RNA INTERFERENCE; RNA, BACTERIAL;

EID: 84899794031     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405079111     Document Type: Article

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