Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

Cell

Volumn 173, Issue 3, 2018, Pages 665-676.e14

  Konermann, Silvana ^a   Lotfy, Peter ^a   Brideau, Nicholas J ^a   Oki, Jennifer ^a   Shokhirev, Maxim N ^a   Hsu, Patrick D ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

alternative splicing; Cas13; CasRx; CRISPR; frontotemporal dementia; gene editing; genome engineering; RNA interference; RNA targeting; tau

Indexed keywords

MESSENGER RNA; RIBONUCLEASE; RNA; TAU PROTEIN; TRANSCRIPTOME; BACTERIAL PROTEIN; GUIDE RNA;

ADENO ASSOCIATED VIRUS; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; ENZYME ACTIVITY; FRONTOTEMPORAL DEMENTIA; GENE SEQUENCE; HUMAN; HUMAN CELL; METAGENOME; MICROBIAL GENOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; REGULATORY RNA SEQUENCE; RNA INTERFERENCE; RUMINOCOCCUS FLAVEFACIENS; ALTERNATIVE RNA SPLICING; ANIMAL; BIOLOGY; CELL DIFFERENTIATION; CYTOLOGY; ESCHERICHIA COLI; GENE EXPRESSION PROFILING; GENETIC ENGINEERING; GENETICS; HEK293 CELL LINE; INDUCED PLURIPOTENT STEM CELL; LENTIVIRUS; METABOLISM; MOUSE; PROCEDURES; RUMINOCOCCUS; SEQUENCE ANALYSIS;

ALTERNATIVE SPLICING; ANIMALS; BACTERIAL PROTEINS; CELL DIFFERENTIATION; COMPUTATIONAL BIOLOGY; CRISPR-CAS SYSTEMS; ESCHERICHIA COLI; GENE EXPRESSION PROFILING; GENETIC ENGINEERING; HEK293 CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LENTIVIRUS; MICE; PROTEIN ENGINEERING; RNA; RNA INTERFERENCE; RNA, GUIDE; RUMINOCOCCUS; SEQUENCE ANALYSIS, RNA; TRANSCRIPTOME;

EID: 85044977102     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.02.033     Document Type: Article

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