Toxicology and immunotoxicology of mercury: A comparative review in fish and humans

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volumn 4, Issue 2, 2001, Pages 161-205

  Sweet, Leonard I ^a   Zelikoff, Judith T ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERCURY; XENOBIOTIC AGENT;

BIOAVAILABILITY; BODY BURDEN; EXPOSURE; FISH; HUMAN; IMMUNE RESPONSE; IMMUNOASSAY; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; METABOLISM; NONHUMAN; POPULATION RISK; REVIEW; RISK ASSESSMENT; SPECIES DIFFERENCE; TOXICOLOGY;

ANIMALS; ENVIRONMENTAL EXPOSURE; FISHES; HUMANS; IMMUNE SYSTEM; IMMUNOTOXINS; MERCURY; WATER POLLUTANTS, CHEMICAL;

EID: 85047698565     PISSN: 10937404     EISSN: None     Source Type: Journal    
DOI: 10.1080/109374001300339809     Document Type: Review

References (400)

1. Breast-feeding exposure of infants to cadmium, lead, and mercury: A public health viewpoint
2. Mercury-induced anti-nucleolar autoantibodies can transgress the membrane of living cells in vivo and in vitro
3. A comparison of health assessment approaches for evaluating the effects of contaminant-related stress on fish populations
4. The melano-macrophage centres of fish: A review
5. Reactive oxygen species formation as biomarkers of methyl mercury and trimethyl tin neurotoxicity
6. Micronuclei induced by selenium, mercury, methylmercury and their mixtures in binucleated blocked fish erythrocyte cells
7. Levels of mercury and pathological changes in patients with organomercury poisoning
8. Seasonal changes in the lymphoid organs of wild brown trout, Salmo trutta L.: A morphometric study
9. Immunotoxicology in fish
10. Alterations of thiol metabolism in human cell lines induced by low amounts of copper, mercury or cadmium ions
11. IgA-IgG disease in the intestine of Brown Norway rats ingesting mercuric chloride
12. Lead and mercury mutagenesis: Type of mutation dependent upon metal concentration
13. 2, superoxide dismutase, and xanthine oxidase
14. Community and population indicators of ecosystem health: Targeting links between levels of biological organisation
15. Semi-parametric modeling of age at achieving developmental milestones after prenatal exposure to methylmercury in the Seychelles child development study
16. Cytochemical demonstration of mercury deposits in trout liver and kidney following methyl mercury intoxication: Differentiation of two mercury pools by selenium
17. Histochemical demonstration of two mercury pools in trout tissues: Mercury in kidney and liver after mercuric chloride exposure
18. Residues of total mercury and methylmercuric salts in lake trout as a function of age
19. Mercuric chloride-induced autoimmunity
20. Methyl mercury poisoning in Iraq
21. The influence of various factors on immune toxicity assessment of pesticide chemicals
22. Indices of mercury contamination during breast feeding in the Amazon Basin
23. Age-related susceptibility to immunotoxicants: Animal data and human parallels
24. Pathology considerations for, and subsequent risk assessment of, chemicals identified as immunosuppressive in routine toxicology
25. Linkages between chemical contaminants and tumors in benthic Great Lakes fish
26. Mammalian immunoassays for predicting the toxicity of malathion in a laboratory fish model
27. Affinity of methylmercury to the site of induction of apoptosis
28. Binding of mercurials to membrane suspensions and undenatured proteins
29. Mercury
30. Environmental chemicals in human milk
31. Inhalation or ingestion of organic or inorganic mercuricals produces autoimmune disease in rats
32. Immunotoxicity of heavy metals in relation to Great Lakes
33. Immunity
34. Mechanisms of signal transduction in the stress response of hepatocytes
35. Autoimmunity induced by metals
36. Autoimmunity caused by xenobiotics
37. The relative semi-quantification of mRNA expression as a useful toxicological endpoint for the identification of embryotoxic/teratogenic substances
38. Impact of diseases on detoxication
39. Effects of in vitro nickel exposure on the macrophage-mediated immune functions of rainbow trout (Oncorhynchus mykiss)
40. Comparison of concentrations of selected metals and organics in fish tissue and sediment in the Grand River, Ohio, and the Southern Lake Erie Drainage Basin
41. 2 and MeHgCl in an insect cell line (Aedes albopictus C6/36)
42. Cytometric profiles of bone marrow and spleen lymphoid cells after mercury exposure in mice
43. Induction of cytochrome P450 as a biomarker for environmental contamination in aquatic ecosystems
44. Uses and future applications of flow cytometry in immunotoxicity testing
45. Toxic responses of the immune system
46. Human immune toxicity
47. The biochemical basis of toxicity
48. Markers of early renal changes induced by industrial pollutants. I. Application to workers exposed to mercury vapour
49. Children's environmental health research - An introduction
50. Toxicity of inorganic and organic mercury compounds in animals
51. Increase of the background human exposure to mercury through fish consumption due to gold mining at the Tapajos river region. Para State, Amazon
52. Consumption of freshwater fish in Kahnawake: Risks and benefits
53. Mercury in the international Great Lakes
54. Unexpectedly high mercury level in pelleted commercial fish feed
55. In vitro assessment of the toxicity of metal compounds IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA
56. The pharmacodynamics of mercury and its compounds with emphasis on the short-chain alkylmercurials
57. Activated human T lymphocytes exhibit reduced susceptibility to methylmercury chloride-induced apoptosis
58. The in vitro effects of mercury on peritoneal leukocytes (PMN and macrophages) from inbred Brown Norway and Lewis rats
59. Mercury exposure in French Guiana: Levels and determinants
60. Cellular bioavailability of natural hormones and environmental contaminants as a function of serum and cytosolic binding factors
61. Carcinogenic human health risks associated with consuming contaminated fish from five Great Lakes areas of concern
62. Postoperative mercury poisoning
63. Mercury in the umbilical cord: Implications for risk assessment for Minamata disease
64. Immunoglobulin E and autoantibodies in mercury-exposed workers
65. Acute pathological effects of inorganic mercury and copper in gills of rainbow trout
66. Immunotoxicology of cadmium and mercury on B-lymphocytes. I. Effects on lymphocyte function
67. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment
68. Apoptosis in the kidney
69. Clinical aspects of potential immunotoxic effects of chemicals 1990
70. Biomarkers: Coming of age for environmental health and risk assessment
71. Role of risk assessment in public health practice
72. Public health implications of environmental exposures
73. Major immunotoxicants
74. Contaminant trends in lake trout and walleye from the Laurentian Great Lakes
75. Mercury and organochlorine exposure from fish consumption in Hong Kong
76. Immunological and biochemical responses in mice treated with mercuric chloride
77. Individual difference of methylmercury metabolism in animals and its significance in methylmercury toxicity
78. Correlation of mercury and selenium in the human kidney
79. The mercury cycle and fish in the Adirondack lakes
80. Effect of inorganic mercury on the immune system
81. Metal-induced autoimmunity
82. 2 in the Brown Norway rat
83. Immune dysregulation and autoimmunity induced by toxic agents
84. Effects of pesticides and other organic pollutants in the aquatic environment on immunity of fish: A review
85. Balancing fish consumption benefits with mercury exposure
86. Placental transport, metabolism, and toxicity of metals
87. Atmospheric deposition of hydrophobic organic contaminants to the Laurentian Great Lakes
88. Mercury hazards to fish, wildlife, and invertebrates: A synoptic review
89. Biological effects in Tilapia nilotica fish as indicators of pollution by cadmium and mercury
90. Mobility of 2,2′,5,5′-tetrachlorobiphenyl in model systems containing bottom sediments and water from the Lower Fox River
91. Metals and related compounds
92. Stress and the modulation of defence mechanisms in fish
93. Metal-metal toxic interactions
94. Biological markers of macrophage activation: Application for fish phagocytes
95. Mercury uptake by LLC-PK1 cells: Dependence on temperature and membrane potential
96. Does amalgam affect the immune system?
97. Speciation of mercury excreted in feces from individuals with amalgam fillings
98. Differential diagnosis between organic and inorganic mercury poisoning in human cases - The pathologic point of view
99. Effects of metals on the humoral immune response
100. Assessment of metals in drinking water with specific references to lead, copper, arsenic, and selenium
101. Opportunities for in vitro assessment of immunotoxicity
102. Kinetic distribution model for chemicals based on results from a standard environmental system
103. Rainbow trout liver slices: A tool for aquatic toxicology
104. The case for atmospheric mercury contamination in remote areas
105. Modulation of nonspecific host defenses in fish
106. Predicting in vivo toxicity
107. Intracellular compartmentation of metals in aquatic organisms: Roles in mechanisms of cell injury
108. Cytogenetic monitoring of fishermen with environmental mercury exposure
109. Mercury distribution in the biota of a Great Lakes estuary: Old Woman Creek, Ohio
110. Toxicology of inorganic mercury
111. An analysis of subjective complaints in a population living in a methylmercury-polluted area
112. Glutathione depletion by xenobiotics in Coturnix coturnix japonica
113. Quantitation of cytokine mRNA expression as an endpoint for prediction and diagnosis of xenobiotic-induced hypersensitivity reactions
114. Metallothionein as an indicator of water quality - Assessment of the bioavailability of cadmium, copper, mercury and zinc in aquatic animals at the cellular level
115. Concepts on biological markers and biomonitoring for metal toxicity
116. Concentrations of blood and hair mercury and serum PCBs in an Ojibwa population that consumes Great Lakes region fish
117. Pharmacodynamics of methyl mercury in the rainbow trout (Salmo gairdneri): Tissue uptake, distribution and excretion
118. The erythrocyte transport and transfer of methylmercury to the tissues of the rainbow trout (Salmo gairdneri)
119. The uptake of methylmercury and methyl-mercury cysteine by the rainbow trout (Salmo gairdneri) kidney
120. Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents from Saginaw Bay, Michigan
121. Are causes knowable? Some consequences of successional versus toxicological interpretations of the Great Lakes Water Quality Agreement
122. Mercury-induced blood anomalies in the fresh water teteost Barbus conchonius
123. Interleukin-4 gene expression in mercury-induced autoimmunity
124. New source identification of mercury contamination in the Great Lakes
125. Factors influencing susceptibility to metals
126. Toxicity assessment of mercury vapor from dental amalgams
127. Mercuric chloride-induced apoptosis is dependent on protein synthesis
128. Mandates to develop non-mammalian models for chemical immunotoxicity evaluation: Are fish a viable alternate to rodents?
129. Toxic effects of metals
130. Factors influencing metal toxicity
131. Cytoskeletal toxicity of heavy metals
132. Organochlorine-associated immunosuppression in prefledgling caspian terns and herring gulls from the Great Lakes: An ecoepidemiological study
133. Accounting for variability in responsiveness in human health risk assessment
134. Final water quality guidance for the Greak Lakes system
135. Allergic and autoimmune reactions to xenobiotics: How do they arise?
136. Fish neoplasms found at high prevalence in polluted waters
137. Aquatic versus mammalian toxicology: Applications of the comparative approach
138. Inhibition of poly (ADP-ribose) polymerase rescues human T lymphocytes from methylmercury-induced apoptosis
139. Do macrophage centres in freshwater fishes reflect the differences in water quality?
140. Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: Role in intrauterine toxicity
141. Metal exposure and toxic responses
142. The influence of salinity on the toxicity of various classes of chemicals to aquatic biota
143. Minamata disease and other mercury syndromes
144. Estimation of target hazard quotients and potential health risks for metals by consumption of seafood in Taiwan
145. Where is mercury deposition coming from?
146. Approaches to the identification and recording of findings in the lymphoreticular organs indicative for immunotoxicity in regulatory type toxicity studies
147. Biological monitoring for mercury within a community with soil and fish contamination
148. Concentrations and hazard assessment of organochlorine contaminants and mercury in smallmouth bass from a remote lake in the Upper Peninsula of Michigan
149. Fish hematology, its uses and significance
150. The Great Lakes: A historical overview
151. Cells, cellular responses, and their markers in chronic toxicity of fishes
152. Combinations of susceptible genotypes and individual responses to toxicants
153. Immune system
154. Molecular mechanisms of toxicant-induced immunosuppression: Role of second messengers
155. Immunotoxicology methods
156. Theory and practice of cytokine assessment in immunotoxicology
157. The nature of hematological response in fish
158. Effects of xenobiotics on macrophage function: Evaluation in vitro
159. Methyl mercury-induced autoimmunity in mice
160. Adverse immunological effects and autoimmunity induced by dental amalgam and ahoy in mice
161. Partitioning and transport of total and methyl mercury in the lower Fox River, Wisconsin
162. Experimental approaches to developmental toxicity of methylmercury
163. Mercuric compounds inhibit human monocyte function by inducing apoptosis: Evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve
164. Accumulation of mercury by plankton and benthic invertebrates in riverine lakes of northern Manitoba (Canada): Importance of regionally and seasonally varying environmental conditions
165. Biological and environmental control of mercury accumulation by fish in lakes and reservoirs of northern Manitoba, Canada
166. Long-range atmospheric transport of mercury to ecosystems, and the importance of anthropogenic emissions - A critical review and evaluation of the published evidence
167. Techniques employed for the assessment of metals in biological systems
168. Accidental acute mercury vapor poisoning
169. +-ATPase activity in largemouth bass (Micropterus salmoides) from three reservoirs with different levels of mercury contamination
170. 2
171. Contaminant effects on ovarian development in English sole (Parophrys vetulus) from Puget Sound, Washington
172. Aquatic chemistry and the human environment
173. General principles in pharmacology and toxicology applicable to children
174. Neonatal toxicology
175. Specific molecular probes for mechanistic studies in toxicology and molecular epidemiology for risk assessment
176. 203Hg retention in relation to age and route of exposure
177. Target organs and systems: Methodologies to assess immune system function
178. Oxidative stress in toxicology: Established mammalian and emerging piscine model systems
179. Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury
180. Sources and present status of the mercury problem
181. Mechanisms of urinary excretion of methylmercury
182. Role of RT6+ lymphocytes in mercury-induced renal autoimmunity: Experimental manipulations of "susceptible" and "resistant" rats
183. Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease
184. Mercury-induced autoimmunity in Brown Norway rats: Kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1
185. Approaches to the evaluation of chemical-induced immunotoxicity
186. The human health hazards of methylmercury
187. Evaluation of chemicals for immunomodulatory effects using an in vitro antibody-producing assay
188. Children's health and the environment: A new agenda for prevention research
189. Physiological and toxicological changes in the skin resulting from the action and interaction of metal ions
190. Fish physiology and metal pollution: Results and experiences from laboratory and field studies
191. Immune modulation by toxic metals
192. Central/peripheral nervous system and immune responses
193. Neurotoxic effects of low-level methylmercury contamination in the Amazonian Basin
194. Chronic toxicity of environmental contaminants: Sentinels and biomarkers
195. Antioxidant and detoxifying fish enzymes as biomarkers of river pollution
196. Mercury and plants in contaminated soils: 1. Uptake, partitioning, and emission to the atmosphere
197. 2 exposure
198. Environmental influences on host immunity
199. Acute exposure to mercury from amalgam: No short-time effect on the peripheral blood lymphocytes in healthy individuals
200. Effects of mercuric chloride and sodium selenite on some immune responses of blue gourami, Trichogaster trichopterus (Pallus)
201. Aquatic pollution-induced immunotoxicity in wildlife species
202. Blood mercury and serum selenium concentrations in reindeer herders in the Arctic area of northern Finland
203. Chemical agents and the immune response
204. Experimental studies on immunosuppression: Approaches and application in risk assessment
205. Exposure to mercury alters early activation events in fish leukocytes
206. Humoral immune parameters in Atlantic cod (Gadus morhua L.) I. The effects of environmental temperature
207. Overview on the protection given by selenium against mercurials
208. Methylmercury exposure and neurotoxicity
209. Blood levels of total and organic mercury in residents of the upper St. Lawrence river basin, Quebec: Association with age, gender, and fish consumption
210. Oxidative metabolism of neutrophils in vitro and human mercury tolerance
211. Mercury in Lake Michigan
212. Tissue uptake and subcellular distribution of mercury
213. Early diagenesis of mercury in the Laurentian Great Lakes
214. Estimating the oral bioavailability of methylmercury to channel catfish (Ictalurus punctatus)
215. Is mercury from dental amalgam an environmental problem?
216. Long-term effects of methylmercuric chloride on three generations of brook trout (Salvelinus fontinalis): Toxicity, accumulation, distribution, and elimination
217. Mercury pollution and macrophage centres in pike (Esox lucius) tissues
218. Influence of salts of some heavy metals on the differential blood count in juvenile Acipenser baeri
219. Microtubules: A susceptible target of methylmercury cytotoxicity
220. Hematological indices of fishes in the evaluation of their toxicoses with reference to Coregonus lavaretus
221. Molecular and cellular pathology in environmental impact assessment
222. The biological exposure indices: A key component in protecting workers from toxic chemicals
223. An analysis of criteria for biological limit values developed in Germany and in the United States
224. Mercury compounds and the immune system: A review
225. Immunological disorders in men exposed to metallic mercury vapour. A review
226. Relative importance of water and food as cadmium sources to an aquatic insect (Chaoborus punctipennis): Implications for predicting Cd bioaccumulation in nature
227. Role of glutathione in mercury disposition
228. Effect of glutathione depletion on metallothionein synthesis induced by paraquat in mice
229. Effects of metals on ion channels
230. Role of neuronal ion channels in mercury intoxication
231. Reference range data for assessing exposure to selected environmental toxicants
232. Detection of micronuclei in peripheral erythrocytes of Cyprinus carpio exposed to metallic mercury
233. Blood and brain mercury levels after chronic gestational exposure to methylmercury in rats
234. Derivation of wildlife values for mercury
235. Elimination of recently absorbed methyl mercury depends on age and gender
236. How does environmental pollution affect red cell function in fish?
237. Evaluation of the critical body burden concept based on inorganic and organic mercury toxicity to rainbow trout (Oncorhynchus mykiss)
238. Biotransformation of methylmercuric salts in the mouse studied by specific determination of inorganic mercury
239. Mercury concentrations in the human brain and kidneys in relation to exposure from dental amalgam fillings
240. Mercury accumulation in tissues from dental staff and controls in relation to exposure
241. Physiologically based models of metal kinetics
242. Fluorescent estimation on cytotoxicity of methylmercury in dissociated rat cerebellar neurons: Its comparison with ionomycin
243. Topics in cancer risk assessment
244. Assessment of apoptosis in xenobiotic-induced immunotoxicity
245. Mercuric chloride toxicity in rat liver mitochondria and isolated hepatocytes
246. Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls
247. Allantoinase in lake trout (Salvelinus namaycush): In vitro effects of PCBs, DDT, and metals
248. Subcellular distribution of mercury in liver of lake trout (Salvelinus namaycush)
249. Industrial discharges of metals to water
250. Effects of environmental pollutants on the C-reactive protein of a freshwater major carp, Catla catla
251. Effects of micronutrients on metal toxicity
252. Molecular epidemiologic research on the effects of environmental pollutants on the fetus
253. Polymorphonuclear phagocytosis and killing in workers exposed to inorganic mercury
254. Measurement of the respiratory burst and chemotaxis in polymorphonuclear leukocytes from mercury-exposed workers
255. A preliminary assessment of the urban pollution in the Great Lakes region
256. Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity
257. Effects of methyl mercury on the cell cycle of primary rat CNS cells in vitro
258. Mercury toxicity
259. B lymphocytes in mercury-exposed workers
260. Immunoglobulin levels in workers exposed to inorganic mercury
261. Regional variation in As, Cu, Hg, and Se and interaction between them
262. Current methods of estimating atmospheric mercury fluxes in remote areas
263. Human exposure to mercury: A critical assessment of the evidence of adverse health effects
264. Exposure and impact assessment of emission from mercury recycling using domestic rabbits
265. Renal alterations following sublethal mercury toxicity: A fish model for aquatic environmental contamination
266. Effect of temperature on accumulation of methylmercuric chloride and p, p′-DDT by rainbow trout (Salmo gairdneri)
267. Methylmercury and inorganic mercury: Uptake, distribution and effect on osmoregutatory mechanisms in fishes
268. Inter-ethnic differences in xenobiotic metabolism
269. Mercury levels along the food chain and risk for exposed populations
270. Lead, mercury, and organochlorine compound levels in cord blood in Quebec
271. Effect of glutathione depletion on tissue deposition of methylmercury in rats
272. The effects of sub-lethal doses of methylmercury and copper, applied singly and jointly, on the immune response of the blue gourami (Trichogaster trichopterus) to viral and bacterial antigens
273. Heavy metal distribution in different fish species from the Mauritania coast
274. 2-induced systemic autoimmunity
275. Immune response to environmental agents
276. Low levels of ionic mercury modulate protein tyrosine phosphorylation in lymphocytes
277. Contaminant-induced immunotoxicology in harbor seals: Wildlife at risk
278. 2+ signals, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons
279. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?
280. Nitric oxide regulation of superoxide and peroxynitrite-dependent reactions
281. Difference by sex and age of mercury concentration in red blood cells
282. Immunotoxicity of cadmium, zinc and mercury after in vivo exposure, alone or in mixture in rainbow trout (Oncorhynchus mykiss)
283. The absorption, blood levels, and excretion of mercury after a single dose of mercury vapor in humans
284. Bcl-2 expression decreases methyl mercury-induced free-radical generation and cell killing in a neural cell line
285. Metal ion-induced toxic histamine release from human basophils and mast cells
286. A comparison of the concentrations of certain pesticides and polychlorinated hydrocarbons in bone marrow and fat tissue
287. Mercury content of fishery products: Data from the last decade
288. Methyl mercury toxicokinetics in channel catfish (Ictalurus punctatus) and largemouth bass (Micropterus salmoides) after intravascular administration
289. The use of histopathological indicators to evaluate contaminant-related stress in fish
290. Lake Michigan fish consumption as a source of polychlorinated biphenyls in human cord serum, maternal serum, and milk
291. Effects of metals on cell-mediated immunity and biological response modulators
292. Reliability and relative validity of fish consumption data obtained in an exposure assessment study among Montreal-area sportfishers
293. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes II. Alterations in cell viability
294. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. I. Suppression of T-cell activation
295. Organomercuric compounds induce cell death in human T-cells
296. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: Evidence of mitochondrial dysfunction
297. Heavy metal-induced changes in the glutathione levels and glutathione reductase/glutathione S-transferase activities in the liver of male mice
298. Effect of glutathione depletion and metallothionein gene expression on arsenic-induced cytotoxicity and c-myc expression in vitro
299. Immunoprophylactic intervention in chemical toxicity and carcinogenicity
300. Metal fluxes across the membranes of aquatic organisms
301. Exposure to mercury in the population
302. Environmental health in the Baltic region - Toxic metals
303. Tilapia (Oreochromis niloticus) and rodents exhibit similar patterns of inhibited antibody production following exposure to immunotoxic chemicals
304. Lymphocyte proliferation assays as potential biomarkers for toxicant exposures
305. Cytotoxicity and accumulation of Hg, Ag, Cd, Cu, Pb, and Zn in human peripheral T and B lymphocytes and monocytes in vitro
306. Environmental distribution and transformation of mercury compounds
307. Mercury-specific lymphocytes: An indication of mercury allergy in man
308. Re-evaluation of the reference dose for methylmercury and assessment of current exposure levels
309. Protein binding of mercury in milk and plasma from mice and man - A comparison between methylmercury and inorganic mercury
310. Comparative study on the inhibition of acetylcholinesterase activity in the freshwater fish Cyprinus carpio by mercury and zinc
311. Toxicological benchmarks for screening contaminants of potential concern for effects on freshwater biota
312. Overview
313. Impacts of mercury, polychlorinated biphenyl, and hexachlorocyclohexane contaminants on human and fish immune cells
314. Detecting contaminant-induced apoptosis and necrosis in lake trout thymocytes via flow cytometry
315. Fish thymocyte viability, apoptosis, and necrosis: In vitro effects of organochlorine contaminants
316. Xenobiotic-induced apoptosis: Significance and potential application as a general biomarker of response
317. Differential determination of ionizable and unionizable (inert) forms of inorganic mercury in animal tissues
318. Effects of inorganic mercury on intracellular calcium levels in rat T lymphocytes
319. Alterations in immune parameters associated with low level methylmercury exposure in mice
320. Effects of lipophilic complex formation on the uptake and distribution of some metals in fish
321. Human health, the Great Lakes, and environmental pollution
322. Cultured rabbit renal proximal straight tubular cells are more susceptible to mercuric chloride than convoluted tubular cells
323. Identification of immunotoxic effects of chemicals and assessment of their relevance to man
324. Modeting the elimination of mercury by fish
325. Effects of Great Lakes fish consumption on the immune system of Sprague-Dawley rats investigated during a two-generation reproductive study. I. Body and organ weights, food consumption, and hematological parameters
326. Speciation of mercury in the primate blood and brain following long-term exposure to methyl mercury
327. Altered cytokine (receptor) mRNA expression as a tool in immunotoxicology
328. Human health implications of environmental contaminants in Arctic Canada: A review
329. Long-term simulation of PCB export from the Fox River to Green Bay
330. Role of oxidative injury in the pathogenesis of merthylmercury neurotoxicity
331. Skin and liver diseases induced in flounder (Platichthys flesus) after long-term exposure to contaminated sediments in large-scale mesocosms
332. In vitro mercury-related cytotoxicity and functional impairment of the immune cells of rainbow trout (Oncorhynchus mykiss)
333. The use of biomarkers to measure the interactive effects of chemicals
334. Relationship between subcellular cadmium distribution in prey and cadmium trophic transfer to a predator
335. Endogenous glutathione conjugates: Occurrence and biological functions
336. Patterns of total mercury concentrations in Onondaga Lake, New York
337. Enhancement of ovalbumin-induced antibody production and mucosal mast cell response by mercury
338. Aspects on health risks of mercury from dental amalgams
339. Trace element reference values in tissues from inhabitants of the European Union. X. A study of 13 elements in blood and urine Of a United Kingdom population
340. Protection against CD95-mediated apoptosis by inorganic mercury in Jurkat T cells
341. Emissions inventory of heavy metals and hydrophobic organics in the Great Lakes basin
342. Assessment of the functional integrity of the humoral immune response
343. Transfer of mercury from benthic invertebrates to fishes in lakes with contrasting fish community structures
344. Environmental immunotoxicology
345. Hematopoietic system
346. Effects of metals on the hematopoietic system and heme metabolism
347. Incidence of heavy metal contamination in water supplies in northern Mexico
348. Metallothionein induction in human peripheral blood lymphocytes by heavy metals
349. Blood and urinary mercury levels as indicators of exposure to mercury vapor
350. Inducible nitric oxide synthase expression in mercury chloride-induced acute tubular necrosis
351. 2-induced acute renal failure
352. Chronic effects of methylmercury in rats. I. Biochemical aspects
353. 0 exposure induces long-lived brain metallothionein
354. Effect of ethanol pretreatment on mercury distribution in organs of fetal guinea pigs following in utero exposure to mercury vapor
355. Distribution and retention of mercury in metallothionein-null mice after exposure to mercury vapor
356. Metallothionein-induced suppression of cytotoxic T lymphocyte function: An important immunoregulatory control
357. Dietary exposure estimates of 30 elements from the UK total diet study
358. Basolateral uptake of inorganic mercury in the kidney
359. Interactions between glutathione and mercury in the kidney, liver, and blood
360. Effects of toxic agents upon fish immune systems: A review
361. Metal pollution-induced immunomodulation in fish
362. Fish immunotoxicology
363. Immunotoxicology across species lines
364. Biomarkers of immunotoxicity in fish and other non-mammalian sentinel species: Predictive value for mammals?
365. Metal immunotoxicology
366. Metal-induced alterations in innate immunity
367. Development of fish peritoneal macrophages as a model for higher vertebrates in immunotoxicological studies. 1. Characterization of trout macrophage morphological, functional, and biochemical properties
368. Assays of reactive oxygen intermediates and antioxidant enzymes: Potential biomarkers for predicting the effects of environmental pollution
369. Heavy metal-induced changes in anti-oxidant enzymes and oxyradical production by fish phagocytes: Application as biomarkers for predicting the immunotoxic effects of metal-polluted aquatic environments