Distribution and retention of mercury in metallothionein-null mice after exposure to mercury vapor

Toxicology

Volumn 139, Issue 1-2, 1999, Pages 129-136

  Yoshida, Minoru ^a   Satoh, Masahiko ^b   Yasutake, Akira ^c   Shimada, Akinori ^d   Sumi, Yawara ^a   Tohyama, Chiharu ^b  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^c NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

Author keywords

Mercury distribution; Mercury vapor; Metallothionein; Null mice

Indexed keywords

MERCURY; METALLOTHIONEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN; CONTROLLED STUDY; INHALATION; KIDNEY; KNOCKOUT MOUSE; LIVER; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TISSUE LEVEL; TOXICOKINETICS; VAPOR;

ADMINISTRATION, INHALATION; ANIMALS; BRAIN; CHROMATOGRAPHY, GEL; KIDNEY; KIDNEY FUNCTION TESTS; LIVER; LIVER FUNCTION TESTS; LUNG; MERCURY; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; TISSUE DISTRIBUTION;

EID: 0032747928     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00117-1     Document Type: Article

References (24)

1. Berlin M. Mercury. Friberg L., Nordberg G.F., Vostal J. Handbook on the Toxicology of Metals. 2nd ed. 1987;387-445 Elsevier Science Publishers BV, Amsterdam.
2. Cherian M.G., Clarkson T.W. Biochemical changes in rat kidney on exposure to elemental mercury vapor: effect on biosynthesis of metallothionein. Chem. Biol. Interact. 12:1976;109-120.
3. Cherian M.G., Goyer R.A. Metallothionein and their role in the metabolism and toxicity. Life Sci. 23:1978;1-10.
4. Clarkson T.W. Mercury. J. Am. Coll. Toxicol. 8:1989;1291-1295.
5. Falnoga I., Kregar I., Skreblin M., Tusek-Znidaric M., Stegnar P. Interaction of mercury in rat brain. Biol. Trace Elem. Res. 37:1993;71-83.
6. Jin N., Kimura M., Yokoi K., Itokawa Y. A gel filtration high-performance liquid chromatographic method for determination of hepatic and renal metallothionein of rat and in comparison with the cadmium-saturation method. Biol. Trace Elem. Res. 36:1993;183-190.
7. Kramer K.K., Liu J., Ghoudhuri S., Klaassen C.D. Induction of metallothionein mRNA and protein in murine astrocyte cultures. Toxicol. App. Toxicol. 136:1996;94-100.
8. Lindstedt G., Skerfving S. Method of analysis. Friberg L., Vostal J. Mercury in the Environment. 1972;3-13 CRC Press, Cleveland, OH.
9. Magos L., Halbach S., Clarkson T.W. Role of catalase in the oxidation of mercury vapor. Biochem. Pharmacol. 27:1977;1373-1377.
10. Masters B.A., Kelly E.J., Quaife C.J., Brinster R.L., Palmiter R.D. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA. 91:1994;584-588.
11. Michalska A., Choo K.H.A. Targeting and germ line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. USA. 90:1993;8088-8092.
12. Nordberg G.F., Skerfving S. Metabolism. Friberg L., Vostal J. Mercury in the Environment. 1972;29-112 CRC Press, Cleveland, OH.
13. Palmiter R.D., Sandgren E.R., Koelleer D.M., Brinster R.L. Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mouse. Mol. Cell. Biol. 13:1993;5266-5275.
14. Satoh M., Nishimura N., Kanayama Y., Naganuma A., Suzuki T., Tohyama C. Enhanced renal toxicity by inorganic mercury in metallothionein-null mice. J. Pharmacol. Exp. Ther. 283:1997;1529-1533.
15. Tohyama C., Shikh Z.A. Metallothionein in plasma and urine of cadmium-exposed rats determined by a signal antibody radioimmunoassay. Fund. App. Toxicol. 1:1981;1-7.
16. Tohyama C., Satoh M., Kodama N., Nihimura H., Choo A., Michalska A., Kanayama Y., Naganuma A. Reduced retention of cadmium in the liver of metallothionein-null mice. Environ. Toxicol. Pharmacol. 1:1996;123-126.
17. Uchida Y., Takio K., Titani K., Ihara Y., Tomonaga Y. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein like protein. Neuron. 7:1991;337-347.
18. Webb M., Cain K. Function of metallothionein. Biochem. Pharmacol. 31:1982;137-142.
19. Yasutake A., Nakano A., Hirayama K. Induction by mercury compounds of brain metallothionein in rats: Hg exposure induces long-lived brain metallothionein. Arch. Toxicol. 72:1998;187-191.
20. Yasutake A., Satoh M., Tohyama C., Hirayama K. Selective and simple quntification of metallothionein III in mouse brain. J. Health Sci. 45:1999;222-225.
21. Yoshida M., Satoh H., Kojima S., Yamamura Y. Metallothionein concentrations and organ retention of mercury in the liver and kidney of the neonatal guinea pig after exposure to mercury vapor. Tohoku J. Exp. Med. 164:1991;13-22.
22. Yoshida M., Satoh H., Sumi Y. Effect of ethanol pretreatment on mercury distribution in organs of fetal guinea pig following in utero exposure to mercury vapor. Toxicology. 119:1997;193-201.
23. Yoshida M., Satoh H., Igarashi M., Akashi K., Yamamura Y., Yoshida K. Acute mercury poisoning by intentional ingestion of mercury chloride. Tohoku J. Exp. Med. 182:1997;347-352.
24. Yoshida M., Satoh M., Shimada A., Yasutake A., Sumi Y., Tohyama C. Pulmonary toxicity caused by acute exposure to mercury vapor is enhanced in metallothionein-null mice. Life Sci. 64:1999;1861-1867.