Blood and brain mercury levels after chronic gestational exposure to methylmercury in rats

Toxicological Sciences

Volumn 50, Issue 1, 1999, Pages 106-116

  Newland, M C ^a   Reile, P A ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

Brain and blood mercury concentrations; Chronic exposure; Methylmercuric chloride; Neurotoxicity; Rat; Ratios of concentration

Indexed keywords

MERCURY; METHYLMERCURIC CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BRAIN WEIGHT; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FETOTOXICITY; FLUID INTAKE; MALE; NEUROTOXICITY; NONHUMAN; PRENATAL EXPOSURE; RAT; TISSUE LEVEL;

ANIMALS; ANIMALS, NEWBORN; AUTOPSY; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; FEMALE; FETUS; MALE; MATERNAL-FETAL EXCHANGE; MERCURY; METHYLMERCURY COMPOUNDS; PREGNANCY; RATS; RATS, LONG-EVANS; TIME FACTORS;

ANIMALIA;

EID: 0032780896     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/50.1.106     Document Type: Article

References (42)

1. Aschner, M., and Aschner, J. L. (1990). Mercury neurotoxicity: Mechanisms of blood-brain barrier transport. Neurosci. Biobehav. Rev. 14, 169-176.
2. Bakir, F., Damluji, S. F., Amin-Zaki, L., Murtadha, M., Khalidi, A., al-Rawi, N. Y., Tikriti, S., Dahahir, H. I., Clarkson, T. W., Smith, J. C., and Doherty, R. A. (1973). Methyl mercury poisoning in Iraq. Science 181, 230-241.
3. Ballatori, N., and Clarkson, T. W. (1982). Developmental changes in the biliary secretion of methylmercury and glutathione. Science 216, 61-63.
4. Bayer, S. A., Altman, J., Russo, R. J., and Xhang, X. (1993). Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. NeuroToxicol. 14, 83-144.
5. Berlin, M., Carlson, J., and Norseth, T. (1975). Dose-dependence of methylmercury metabolism. A study of distribution, biotransformation, and excretion in the squirrel monkey. Arch. Envion. Health 30, 307-313.
6. Berlin, M., and Ulberg, S. (1963). Accumulation and retention of mercury in the mouse. Arch. Environ. Health. 6, 610-616.
7. Burbacher, T. M., Rodier, P. M., and Weiss, B. (1990). Methylmercury developmental neurotoxicity: A comparison of effects in humans and animals. Neurotoxicol. Teratol. 12, 191-202.
8. Cernichiari, E., Toribara, T. Y., Liang, L., Marsh, D. O., Merlin, M. W., Myers, G. J., Cox, C., Shamlaye, C. F., Choisy, O., Davidson, P., and Clarkson, T. W. (1995). Biological monitoring of mercury in the Seychelles study. Neurotoxicology 16, 613-628.
9. Clarkson, T. W., Hursh, J. B., Sager, P. and Syversen, T. L. M. (1988). Mercury. In Biological Monitoring of Toxic Metals, pp. 199-246. Plenum, New York.
10. Council (1989). Biologic Markers in Reproductive Toxicology. National Academy Press, Washington.
11. Eccles, C., and Annau, Z. (1987). Prenatal exposure to methylmercury. In The Toxicity of Methyl Mercury, pp. 114-130. Johns Hopkins University Press, Baltimore.
12. Elsner, J., Hodel, B., Suter, K. E., Oelke, D., Ulbrich, B., Schreiner, G., Cuomo, V., Cagiano, R., Rosengren, L. E., Karlsson, J. E., and Haglid, K. G. (1988). Detection limits of different approaches in behavioral teratology, and correlation of effects with neurochemical parameters. Neurotoxicol. Teratol. 10, 155-167.
13. Elsner, J., Suter, K. E., Ulbrich, B., and Schreiner, G. (1985). Testing strategies in behavioral teratology: IV. review and general conclusions. Neurobehav. Toxicol. Teratol. 8, 585-590.
14. Farris, F. F., Dedrick, R. L., Allen, P. V. and Smith, J. C. (1993). Physiological model for the pharmacokinetics of methylmercury in the growing rat. Toxicol. Appl. Pharmacol. 119. 74-90.
15. Gilbert, S. G., Rice, D. C., and Burbacher, T. M. (1996). Fixed interval/fixed ratio performance in adult monkeys exposed in utero to methylmercury. Neurotoxicol. Teratol. 18, 539-546.
16. Goldey, E. S., O'Callaghan, J. P., Stanton, M. E., Barone, S., and Crofton, K. M. (1994). Developmental neurotoxicity: Evaluation of testing procedures with methylazoxymethanol and methylmercury. Fundam. Appl. Toxicol. 23, 447-464.
17. Gray, D. G. (1995). A physiologically based pharmacokinetic model for methylmercury in the pregnant rat and fetus. Toxicol. Appl. Pharmacol. 132, 91-102.
18. Greener, Y., and Kochen, J. A. (1983). In vitro studies on methylmercury distribution in human blood Teratology 28, 375-387.
19. Inouye, M., Kajiwara, Y., and Hirayama, K. (1986). Dose- and sex-dependent alterations in mercury distribution in fetal mice following methylmercury exposure. J. Toxicol. Environ. Health 19. 425-435.
20. Kajiwara, Y., Yasutake, A., Adachi, T., and Hirayama, K. (1996). Methylmercury transport across the placenta via neutral amino acid carrier. Arch. Toxicol 70, 310-314.
21. Kleinman, L. I. (1975). Fetal renal function and water electrolyte balance. In The Mammalian Fetus: Comparative Biology and Methodology. (E. S. E. Hafez, Ed.), pp. 120-153. Charles C. Thomas, Springfield IL.
22. Lapham, L. W., Cernichiari, E., Cox, C., Myers, G. J., Baggs, R. B., Brewer, R., Shamlaye, C. F., Davidson, P. W., and Clarkson, T. W. (1995). An analysis of autopsy brain tissue from infants prenatally exposed to methylmercury. Neurotoxicol 16, 689-704.
23. Magos, L. (1987). The absorption, distribution, and excretion of methylmercury. In The Toxicity of Methyl Mercury, pp. 24-44. Johns Hopkins University Press, Baltimore.
24. Magos, L., Brown, A. W., Sparrow, S., Bailey, E., Snowden, R. T., and Skipp, W. R. (1985). The comparative toxicology of ethyl- and methylmercury. Arch. Toxicol. 57, 260-267.
25. Magos, L., and Butler, W. H. (1976). The kinetics of methylmercury administered repeatedly to rats. Arch. Toxicol. 35, 25-39.
26. Magos, L., and Clarkson, T. W. (1972). Atomic absorption determination of total, inorganic, and organic mercury in blood. Journal of the AOAC 55, 966-971.
27. Mattison, D. R., Blann, E., and Malek, A. (1991). Physiological alterations during pregancy: impact on toxicokinetics. Fundam. Appl. Toxicol. 16, 215-218.
28. Nielsen, J. B., Andersen, O., and Grandjean, P. (1994). Evaluation of mercury in hair, blood, and muscle as biomarkers for methylmercury exposure in male and female mice. Arch. Toxicol. 68, 317-321.
29. Oskarsson, A., Hallen, I. P., and Sundberg, J. (1995). Exposure to toxic elements via breast milk. Analyst 120, 765-770.
30. Reynolds, W. A., and Pitkin, R. M. (1975). Transplacental passage of meth- ylmercury and its uptake by primate fetal tissue. Proc. Soc. Exp. Biol. Med. 148, 523-526.
31. Rice, D. C., Krewski, D., Collins, B. T., and Willes, R. F. (1989). Pharmacokinetics of methylmercury in the blood of monkeys (Macara fasiculata). Fundam. Appl. Toxicol. 12, 23-33.
32. Schreiner, G., Ulbrich, B., and Bass, R. (1986). Testing strategies in behavioral teratology: II. Discrimination learning.Neurobehav. Toxicol. Teratol. 8, 567-572.
33. Skerfving, S. (1988). Mercury in women exposed to methylmercury through fish consumption and in their newborn babies and breast milk. Bull. Environ. Contam. Toxicol. 41, 475-782.
34. Skerfving, S. (1991). Exposure to mercury in the population. In Advances in Mercury Toxicology. pp. 411-426. Plenam Press, New York.
35. Sundberg, J., Oskarsson, A., and Albanus, L. (1991). Methylmercury exposure during lactation: Milk concentration and tissue uptake of mercury in the neonatal rat. Bull. Environ. Contam. Toxicol. 46, 255-262.
36. Suter, K. E., and Schon, H. (1986). Testing strategies in behavioral teratology: I. Testing battery approach. Neurobehav. Toxicol. Teratol. 8, 561-566.
37. Tanaka, T., Naganuma, A., Miura, N., and Imura, N. (1992). Role of testosterone in gamma-glutamyltranspeptidase-dependent renal methylmercury uptake in mice. Toxicol. Appl. Pharmacol. 112, 58-63.
38. Vahter, M. E., Mottet, N. K., Friberg, L. T., Lind, S. B., Charleston, J. S., and Burbacher, T. M. (1995). Demethylation of methylmercury in different brain sites of Macaca Fascicularis monkeys during long-term subclinical methylmercury exposure. Toxicol. Appl. Pharmacol. 134, 273-284.
39. Vahter, M., Mottet, N. K., Friberg, L., Lind, B., Shen, D. D., and Burbacher, T. (1994). Speciation of mercury in the primate blood and brain following long-term exposure to methylmercury. Toxicol. Appl. Pharmacol. 124, 221-229.
40. Wannag, A. (1976). The importance of organ blood mercury when comparing fetal and maternal rat organ distribution of mercury after methylmercury exposure. Acta Pharmacol. Toxicol. (Copenh.) 38, 289-298.
41. White, J. F., and Rothstein, A. (1973). The interaction of methylmercury with erythrocytes. Toxicol. Appl. Pharmacol. 26, 370-384.
42. Young, J. F., Branham, W. S., Sheehan, D. M., Baker, M. E., Wosilait, W. D., and Luecke, R. H. (1997). Physiological "constants" for PBPK models for pregnancy. J. Toxicol. Environ. Health 52, 385-401.