Induction of apoptosis in human T-cells by organomercuric compounds: A flow cytometric analysis

Toxicology and Applied Pharmacology

Volumn 143, Issue 2, 1997, Pages 397-406

  Shenker, Bruce J ^a   Datar, Sugandha ^a   Mansfield, Kyle ^a   Shapiro, Irving M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLMERCURIC CHLORIDE; METHYLMERCURIC CHLORIDE; ORGANOMERCURY COMPOUND; PHENYLMERCURY DERIVATIVE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

EID: 0030932709     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8111     Document Type: Article

References (34)

1. Ashour H., Abdel-Rahman M., Khodair A. The mechanism of methyl mercury toxicity in isoilated rat hepatocytes. Toxicol. Lett. 69:1993;87-96.
2. Atchison W. D., Hare M. F. Mechanisms of methylmercury-induced neurotoxicity. FASEB J. 8:1994;622-629.
3. Azuma Y., Onishi Y., Hirata C., Tanimoto Y., Yamada T., Kizaki H. Staurosporine-induced thymocyte apoptosis is inhibited by herbimycin A, a specific inhibitor of protein tyrosine kinase. Biochem. Mol. Biol. Int. 37:1995;635-643.
4. Boadi Y., Urbach J., Brandes J. M., Yannai S. In vitro exposure to mercury and cadmium alters term human placental membrane fluidity. Toxicol. Appl. Pharmacol. 116:1992;17-23.
5. Compton M. M. A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome. Cancer Metastasis Rev. 11:1992;105-119.
6. Cotter T. G. Programmed to die: Cell death in the immune system. Immunologist. 1:1993;191-184.
7. Darzynkiewicz Z., Bruno S., Del Bino G., Borczyca W., Hotz M. A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry. 13:1992;795-808.
8. De Flora S., Bennicelli C., Bagnasco M. Genotoxicity of mercury compounds: A review. Mutat. Res. 317:1994;57-79.
9. Dean J. H., Cornacoff J. B., Luster M. I. Toxicity to the immune system: A review. Immunopharmacology Reviews. 1990;Plenum, New York. p. 377-408.
10. Duque R. E. Interactive data analysis for evaluation of B-cell neoplasia by flow cytometry. Methods Cell Biol. 42:1994;231-242.
11. Fadok V. A., Voelker D. R., Campbell P. A., Cohen J. J., Bratton D. L., Henson P. M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148:1992;2207-2216.
12. 452+. Toxicol. Appl. Pharmacol. 113:1992;267-273.
13. Jungwirth A., Ritter M., Paulmichl M., Lang F. Activation of cell membrane potassium conductance by mercury in cultured renal epitheloid (MDCK) cells. J. Cell. Physiol. 146:1991;25-33.
14. Koopman G., Reutelingsperger C., Kuijten G. A., Keehnen R. M., Pals S. T., van Oers M. H. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoin apoptosis. Blood. 84:1994;1415-1420.
15. Kroemer G., Petit P., Zamzami N., Vayssiere J., Mignotte B. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287.
16. Li X., Melamed M. R., Darzynkiewicz Z. Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color. Exp. Cell Res. 222:1996;28-37.
17. Martin S. J., Reutelingsperger C., McGahon A. J., Rader J. A., van Schie R. C., LaFace D. M., Green D. R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182:1995;1545-1556.
18. McGahon A. J., Martin S. J., Bissonnette R. P., Mahboubi A., Shi Y., Mogil R. J., Nishioka W. K., Green D. R. The end of the (cell) line: Methods for the study of apoptosisin vitro. Methods Cell Biol. 46:1995;153-185.
19. Mollereau B., Decker M., Deas O., Rieux-Laucat F., Hirsch F., Bernard A., Fischer A., Lynch D. H., Charpentier B., Le Deist F., Senik A. CD2-induced apoptosis in activated human peripheral T cells: A Fas-independent pathway that requires early protein tyrosine phosphorylation. J. Immunol. 156:1996;3184-3190.
20. Pushkareva M., Obein L. M., Hannun Y. A. Ceramide: An endogenous regulator of apoptosis and growth suppression. Immunol. Today. 16:1996;294-297.
21. Schmid I., Uittenbogaart C. H., Giorgi J. V. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry. 15:1994;12-20.
22. Schulze-Osthoff K., Walczak H., Droge W., Krammer P. H. Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol. 127:1994.
23. Shenker B. J., Berthold P., Decker S., Mayro J. S., Rooney C., Vitale L. A., Shapiro I. M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. II. Alterations in cell viability. Immunopharmacol. Immunotoxicol. 14:1992;555-577.
24. Shenker B. J., Berthold P., Rooney C., Vitale L. A., DeBolt K., Shapiro I. M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. III. Alterations in B-cell function and viability. Immunopharmacol. Immunotoxicol. 15:1993;87-112.
25. Shenker B. J., Mayro J. S., Rooney C., Vitale L. A., Shapiro I. M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. IV. Alterations in cellular glutathione content. Immunopharmacol. Immunotoxicol. 15:1993;273-290.
26. Shenker B. J., Vitale L., King C. Induction of human T cells that coexpress CD4 and CD8 by an immunomodulatory protein produced byActinobacillus actinomycetemcomitans. Cell. Immunol. 164:1995;36-46.
27. Shenker B. J., Vitale L. A., Kieba I., Harrison G., Berthold P., Golub E., Lally E. T. Flow cytometric analysis of the cytotoxic effects ofActinobacillus actinomycetemcomitans. J. Leuk. Biol. 55:1994;153-160.
28. Tanaka Y., Yoshihara K., Tohno Y., Kojima K., Kameoka M., Kamiya T. Inhibition and down-regulation of poly(ADP-Ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers. Cell. Mol. Biol. 41:1995;771-781.
29. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods. 184:1995;39-51.
30. Walker P. R., Kokileva L., LeBlanc J., Sikorska M. Detection of the initial stages of DNA fragmentation in apoptosis. BioTechniques. 15:1993;1032-1040.
31. White E. Death-defying acts: A meeting review on apoptosis. Genes Dev. 7:1993;2277-2284.
32. Yasutake A., Hirayama K. Acute effects of methylmercury on hepatic and renal glutathione metabolisms in mice. Arch. Toxicol. 68:1994;512-516.
33. Zamzami N., Marchetti P., Castedo M., Zanin C., Vayssiere J., Petit P. X., Kroemer G. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte deathin vivo. J. Exp. Med. 181:1995;1661-1672.
34. Zhang L., Wang C., Radvanyi L. G., Miller R. G. Early detection of apoptosis in defined lymphocyte populations in vivo. J. Immunol. Methods. 181:1995;17-27.