Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?

Toxicology and Applied Pharmacology

Volumn 147, Issue 2, 1997, Pages 300-311

  Roth, Robert A ^a   Harkema, Jack R ^a   Pestka, James P ^b   Ganey, Patricia E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLYL ALCOHOL; BACTERIUM LIPOPOLYSACCHARIDE; CADMIUM; CARBON TETRACHLORIDE; ENDOTOXIN; HALOTHANE; XENOBIOTIC AGENT;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; DISEASE PREDISPOSITION; ENVIRONMENTAL EXPOSURE; GRAM NEGATIVE BACTERIUM; HUMAN; INTOXICATION; LIVER TOXICITY; NONHUMAN;

EID: 0031422365     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8301     Document Type: Article

References (149)

1. Adachi Y., Moore L. E., Bradford B. U., Gao W., Thurman R. G. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology. 108:1995;218-224.
2. Adamson G. M., Billings R. E. Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes. Arch. Biochem. Biophys. 294:1992;223-229.
3. 2+. Biochem. J. 249:1988;677-685.
4. Anderson O., Nielsen J. B., Svendsen P. Oral cadmium chloride intoxication in mice: Effects of dose on tissue damage, intestinal absorption and relative organ distribution. Toxicology. 48:1988;225-236.
5. Arthur M. J. P., Bentley I. S., Tanner A. R., Kowalski-Saunders P., Millward-Sadler G. H., Wright R. Oxygen-derived free radicals promote hepatic injury in the rat. Gastroenterology. 89:1985;1114-1122.
6. Arthur M. J. P., Kowalski-Saunders P., Wright R. Corynebacterium parvum. Gastroenterology. 91:1986;174-181.
7. Bailey M. E. Endotoxin, bile salts and renal function in obstructive jaundice. Br. J. Surg. 63:1976;774-778.
8. Bautista A. P., Deaciuc I. V., Jaeschke H., Spolarics Z., Spitzer J. J. Hepatic responses to bacterial endotoxin (LPS). Pathophysiology of Shock, Sepsis, and Organ Failure. 1993;Springer-Verlag, Berlin. p. 915-934.
9. Bhagwandeen B. S., Apte M., Manwarring L., Dickeson J. Endotoxin-induced hepatic necrosis in rats on an alcohol diet. J. Pathol. 152:1987;47-53.
10. Bigatello L. M., Broitman S. A., Fattori L., Di Paoli M., Pontello M., Bevilacqua G., Nespoli A. Endotoxemia, encephalopathy, and mortality in cirrhotic patients. Am. J. Gastroenterol. 82:1987;11-15.
11. Bode C., Kugler V., Bode J. C. Endotoxemia in patients with alcoholic and nonalcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J. Hepatol. 4:1987;8-14.
12. Bratich P. M., Buck W. B., Haschek W. M. Prevention of T-2 toxin-induced morphologic effects in the rat by highly activated charcoal. Arch. Toxicol. 64:1990;251-253.
13. Broitman S. A., Gottlieb L. S., Zamchek N. Influence of neomycin and ingested endotoxin in the pathogenesis of choline deficiency cirrhosis in the adult rat. J. Exp. Med. 119:1964;633-641.
14. Brouwer A., Parker S. G., Hendriks H. F. J., Gibbons L., Horan M. A. Production of eicosanoids and cytokines by Kupffer cells from young and old rats stimulated by endotoxin. Clin. Sci. 88:1995;211-217.
15. Brun-Buisson C., Doyon F., Carlet J., Dellamonica P., Gouin F., Lepoutre A., Mercier J., Offenstadt G., Regnier B. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. JAMA. 274:1995;968-974.
16. Burrell R. Human responses to bacterial endotoxin. Circ. Shock. 43:1994;137-153.
17. Calcamuggi G., Lanzio M., Dughera L., Babini G., Emanuelli G. Endotoxin tolerance and polymyxin B modify liver damage and cholestasis induced by a single dose of α-naphthylisothiocyanate in the rat. Arch. Toxicol. 66:1992;126-130.
18. Camara D. S., Caruana J. A. Jr., Schwartz K. A., Montes M., Nolan J. P. D. Proc. Soc. Exp. Biol. Med. 172:1983;255-259.
19. Caramelo C., Fernandez-Gallardo S., Santos J. C., Inarrea P., Sanchez-Crespo M., Lopez-Novoa J. M., Hernando L. Increased levels of platelet-activating factor in blood from patients with cirrhosis of the liver. Eur. J. Clin. Invest. 17:1987;7-11.
20. Casteleijn E., Kuiper J., Van Rooij H. C. J., Kamps J. A. A. M., Koster J. F., van Berkel T. J. C. Endotoxin stimulates glycogenolysis in the liver by means of intercellular communication. J. Biol. Chem. 263:1988a;6953-6955.
21. Casteleijn E., Kuiper J., Van Rooij H. C. J., Kamps J. A. A. M., Koster J. F., van Berkel T. J. C. Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. J. Biol. Chem. 263:1988b;2699-2703.
22. Celis R., Torres A., Gatell J. M., Almela M., Rodriguez-Roisin R., Agusti-Vidal A. Nosocomial pneumonia. A multivariate analysis of risk and prognosis. Chest. 93:1988;318-324.
23. Chensue S. W., Terebuh P. D., Remick D. G., Scales W. E., Kunkel S. L. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Am. J. Pathol. 138:1991;395-402.
24. Colin R., Grandu T., Lemeland J. F., Hecketsweiler P., Galmiche J. P., Le-Grix A., Geffroy Y. Detection of endotoxemia in patients with cryptogenic inflammatory enterocolitis. Gastroenterol. Clin. Biol. 3:1979;15-19.
25. Cooperstock M., Riegle L. Plasma limulus gelation assay in infants and children: Correlation with gram-negative bacterial infection and evidence for "intestinal endotoxemia" Ten Cate J. W., Buller H. R., Sturk A., Levin J. Bacterial Endotoxins. Structure, Biomedical Significance, and Detection with the Limulus Amebocyte Lysate Test. 1985;329-345 A. R. Liss, New York.
26. Cooperstock M. S., Tucker R. P., Baublis J. V. Possible pathogenic role of endotoxin in Reye's syndrome. Lancet. 1:1975;1272-1274.
27. Crippen T. L., Klasing K. C., Hyde D. M. Cytokine-induced neutrophil chemoattractant production by primary rat alveolar type II cells. Inflammation. 19:1995;575-586.
28. Dahm L. J., Schultze A. E., Roth R. A. An antibody to neutrophils attenuates α-naphthylisothiocyanate induced liver injury. J. Pharmacol. Exp. Ther. 256:1991;412-420.
29. Deitch E. A. Role of bacterial translocation in necrotizing enterocolitis. Acta Paediatr. Suppl. 396:1994;33-36.
30. Deitch E. A. Microbial gastrointestinal translocation. Fry D. E. Surgical Infections. 1995;707-715 Little, Brown and Co. Boston.
31. Dieter P., Peters T., Schulze-Specking A., Decker K. Independent regulation of thromboxane and prostaglandin synthesis in liver macrophages. Biochem. Pharmacol. 38:1989;1577-1581.
32. Dixon A. C., Parrillo J. E. Chronic models of endotoxemia and sepsis: Lessons from both a canine peritonitis and a human endotoxemia model. Schlag G., Redl H. Pathophysiology of Shock, Sepsis, and Organ Failure. 1993;1132-1142 Springer-Verlag, Berlin.
33. Donham K., Haglind P., Peterson Y., Rylander R., Belin L. Environmental and health studies of farm workers in Swedish swine confinement buildings. Br. J. Ind. Med. 46:1989;31-37.
34. Dosman J. A., Cotton D. J., Graham B. L., Liu K. Y. R., Frank F., Barnett G. D. Chronic bronchitis and decreased forced expiratory flow rates in lifetime nonsmoking grain workers. Am. Rev. Respir. Dis. 121:1980;11-16.
35. Elinder C. Other toxic effects. Friberg L., Elinder C., Kjellstrom T., Nordberg G. F. Cadmium and Health: A Toxicological and Epidemiological Appraisal. Volume II: Effects and Response. 1986;160-204 CRC Press, Boca Raton.
36. ElSisi A. E. D., Earnest D. L., Sipes I. G. Vitamin A potentiation of carbon tetrachloride hepatotoxicity: Enhanced lipid peroxidation without enhanced biotransformation. Toxicol. Appl. Pharmacol. 119:1993a;289-294.
37. ElSisi A. E. D., Earnest D. L., Sipes I. G. Vitamin A potentiation of carbon tetrachloride hepatotoxicity: Role of liver macrophages and active oxygen species. Toxicol. Appl. Pharmacol. 119:1993b;295-301.
38. ElSisi A. E. D., Hall P., Sim W.-L. W., Earnest D. L., Sipes I. G. Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. Toxicol. Appl. Pharmacol. 119:1993c;280-288.
39. Engstrom L., Torngren S., Rohdin-Alm C. Preoperative endotoxin concentrations in portal and peripheral venous blood in patients undergoing right hemicolectomy for carcinoma. Eur. J. Surg. 158:1992;301-305.
40. Fagon J., Chastre J., Hance A. J., Montravers P., Novara A., Gibert C. Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay. Am. J. Med. 94:1993;281-288.
41. Flaherty D. K., Deck F. H., Cooper J., Bishop K., Winzenburgen P. A., Smith L. R., Bynum L., Witmer W. B. Bacterial endotoxin isolated from a water spray air humidification system as a putative agent of occupation-related lung disease. Infect. Immun. 43:1984;206-212.
42. Formal S. B., Noyes H. E., Schneider H. Experimental Shigella infections. III. Sensitivity of normal, starved and carbon tetrachloride treated guinea pigs to endotoxin. Proc. Soc. Exp. Biol. Med. 103:1960;415-418.
43. Fox E. S., Broitman S. A., Thomas P. Bacterial endotoxins and the liver. Lab. Invest. 63:1990;733-739.
44. Fry D. E. The septic response without infection. Fry D. E. Surgical Infections. 1995a;717-720 Little, Brown and Co. Boston.
45. Fry D. E. The septic response, septic shock, and multiple-organ failure. Fry D. E. Surgical Infections. 1995b;693-705 Little, Brown and Co. Boston.
46. Ghosh S., Latimer R. D., Gray B. M., Harwood R. J., Oduro A. Endotoxin-induced organ injury. Crit. Care Med. 21:1993;S19-S24.
47. Gordon T. Adverse pulmonary effects of machining fluid aerosols. Fundam. Appl. Toxicol. 30:1996;16.
48. Gorodischer R., Kranser J., McDevitt J. J., Nolan J. P., Yaffe S. J. Hepatic microsomal drug metabolism after administration of endotoxin in rats. Biochem. Pharmacol. 25:1976;351-353.
49. 2. Am. J. Physiol. 264:1993;G601-G608.
50. Graham P., Brass N. J. Multiple organ dysfunction: pathophysiology and theraputic modalities. Crit. Care Nurs. Q. 16:1994;8-15.
51. Grandjean P. Individual susceptibility in occupational and environmental toxicology. Toxicol. Lett. 77:1995;105-108.
52. Greenberg S., Chang P., Silverstein S. C. Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages. J. Exp. Med. 177:1993;529-534.
53. Grun M., Liehr H., Rasenack U. Significance of endotoxaemia in experimental "galactosamine hepatitis" in the rat. Acta Hepato-Gastroenterol. Stuttg. 24:1977;64-81.
54. Gunawardhana L., Mobley S. A., Sipes I. G. Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells. Toxicol. Appl. Pharmacol. 119:1993;205-213.
55. Gut J. P., Steffan A. M., Anton M. Kupffer cell functions and frog virus 3 hepatitis in mice and rats. The Reticuloendothelial System and the Pathogenesis of Liver Disease. 1980;Elsevier/North Holland. p. 211-217.
56. Gut J. P., Schmitt S., Bingen A., Anton M., Kirn A. Probable role of endogenous endotoxins in hepatocytolysis during murine hepatitis caused by frog virus 3. J. Infect. Dis. 149:1984;621-629.
57. Gyorgy P. Antibiotics and liver injury. Ann. NY Acad. Sci. 57:1954;925-932.
58. Henson P. M., Doherty D. E., Riches D. W. H., Worthen G. S. LPS and cytokines in lung injury. Brigham K. L. Endotoxin and the Lungs. 1994;267-304 Dekker, New York.
59. Hewett J. A., Schultze A. E., VanCise S., Roth R. A. Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab. Invest. 66:1992;347-361.
60. Hewett J. A., Jean P. A., Kunkel S. L., Roth R. A. Relationship between tumor necrosis factor-α and neutrophils in endotoxin-induced liver injury. Am. J. Physiol. 265:1993;G1011-G1015.
61. Hewett J. A., Roth R. A. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacol. Rev. 45:1993;381-411.
62. Hewett J. A., Roth R. A. The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria. J. Pharmacol. Exp. Ther. 272:1995;53-62.
63. Hill D. A., Roth R. A. α-Naphthylisothiocyanate stimulates neutrophils to release proteases that are toxic to hepatocytesin vitro. Fundam. Appl. Toxicol. 30:1996;64.
64. Hill D. A., Roth R. A. Bile duct epithelial cells exposed to α-naphthylisothiocyanate produce factors which modulate neutrophil-dependent hepatocyte injuryin vitro. Fundam. Appl. Toxicol. 36:1997;227.
65. Hirata K., Kaneko A., Ogawa K., Hayasaka H., Onoe T. Effect of endotoxin on rat liver. Analysis of acid phosphatase isozymes in the liver of normal and endotoxin-treated rats. Lab. Invest. 43:1980;165-171.
66. Ho J. S., Buchweitz J. P., Roth R. A., Ganey P. E. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes. J. Leukocyte Biol. 59:1996;716-724.
67. Hoffman E. O., Cook J. A., Di Luzio N. R., Coover J. A. The effects of acute cadmium administration in the liver and kidney of the rat. Light and electron microscopic studies. Lab. Invest. 32:1975;655-664.
68. Holah J. T., Bloomfield S. F., Walker A. J., Spenceley H. Control of biofilms in the food industry. Wimpenny J., Nichols W., Stickler D., Lapin-Scot H. Bacterial Biofilms and Their Control in Medicine and Industry. 1994;163-168 Bioline, Cardiff.
69. Hurley J. C. Antibiotic-induced release of endotoxin: A therapeutic paradox. Drug Saf. 12:1995;183-195.
70. Jacob A. I., Goldberg P. K., Bloom N., Degenshein G. A., Kozinn P. J. Endotoxin and bacteria in portal blood. Gastroenterology. 72:1977;1268-1270.
71. Jaeschke H., Farhood A., Smith C. W. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am. J. Physiol. 261:1991;G1051-G1056.
72. Jaeschke H., Farhood A., Bautista A. P., Spolarics Z., Spitzer J. J., Smith C. W. Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Hepatology. 17:1993;915-923.
73. Jaeschke H., Smith C. W., Clemens M. G., Ganey P. E., Roth R. A. Mechanisms of inflammatory liver injury: Adhesion molecules and cytotoxicity of neutrophils. Toxicol. Appl. Pharmacol. 139:1996;213-226.
74. Jones G. E., Purves L. R., deChalain T. M., Michell W. L., Blake K. C., Hickman R., Terblanche J. Reticuloendothelial function and plasma fibronectin in a murine model of intra-abdominal sepsis. J. Hepatol. 9:1989;287-294.
75. Kayama F., Yoshida T., Elwell M. R., Luster M. I. Role of tumor necrosis factor-α in cadmium-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 131:1995;224-234.
76. Koyama S., Rennard S. I., Claassen L., Robbins R. A. Antiproteases modulate bronchial epithelial cell responses to endotoxin. Am. J. Pathol. 146:1995;1207-1219.
77. Lang F., Gerok W., Haussinger D. New clues to the pathophysiology of hepatorenal failure. Clin. Invest. 71:1993;93-97.
78. Leach B. E., Forbes J. C. Sulfonamide drugs as protective agents against carbon tetrachloride poisoning. Proc. Soc. Exp. Biol. Med. 48:1941;361-363.
79. Leu H., Kaiser D. L., Mori M., Woolson R. F., Wenzel R. P. Hospital-acquired pneumonia. Attributable mortality and morbidity. Am. J. Epidemiol. 129:1989;1258-1267.
80. Levy E., Path F. C., Ruebner B. H. Hepatic changes produced by a single dose of endotoxin in the mouse. Light microscopy and histochemistry. Am. J. Pathol. 51:1968a;269-285.
81. Levy E., Path F. C., Slusser R. J., Ruebner B. H. Hepatic changes produced by a single dose of endotoxin in the mouse. Electron microscopy. Am. J. Pathol. 52:1968b;477-502.
82. Lichtman S. N., Wang J., Schwab J. H., Lemasters J. J. Comparison of peptidoglycan-polysaccharide and lipopolysaccharide stimulation of Kupffer cells to produce tumor necrosis factor and interleukin-1. Hepatology. 19:1994;1013-1022.
83. Liehr H., Grun M., Seelig H., Seelig R., Reutter W., Heine W. On the pathogenesis of galactosamine hepatitis. Indications of extrahepatocellular mechanisms responsible for liver death. Virchows Arch. B Cell Pathol. 26:1978;331-344.
84. Lind R. C., Gandolfi A. J., Sipes I. G., Brown B. R. The involvement of endotoxin in halothane-associated liver injury. Anesthesiology. 61:1984;544-550.
85. Lowry S. F. Sepsis and its complications: Clinical definitions and therapeutic prospects. Crit. Care Med. 22:1994;S1-S2.
86. Martin C. M., Neal A., Sibbald W. J. Models of sepsis: subacute peritonitis in sheep and rats. Schlag G., Redl H. Pathophysiology of Shock, Sepsis, and Organ Failure. 1993;1119-1131 Springer-Verlag, Berlin.
87. Mattsby-Baltzer I., Sandin M., Ahlstrom B., Allenmark S., Edebo M., Falsen E., Pedersen K., Rodin N., Thompson R. A., Edebo L. Microbial growth and accumulation in industrial metal-working fluids. Appl. Environ. Microbiol. 55:1989;2681-2689.
88. May D. G. Genetic differences in drug disposition. J. Clin. Pharmacol. 34:1994;881-897.
89. Mehendale H. M., Roth R. A., Gandolfi A. J., Klaunig J. E., Lemasters J. J., Curtis L. R. Novel mechanisms in chemically induced hepatotoxicity. FASEB J. 8:1994;1285-1295.
90. Michel O., Kips J., Duchateau J., Vertongen F., Robert L., Collet H., Pauwels R., Sergysels R. Severity of asthma is related to endotoxin in house dust. Am. J. Respir. Crit. Care Med. 154:1996;1641-1646.
91. Michie H. R., Manogue K. B., Spriggs D. R., Revhaug A., O'Dwyer S., Dinarello C. A., Cerami A., Wolff S. M., Wilmore D. W. Detection of circulating tumor necrosis factor after endotoxin administration. N. Engl. J. Med. 318:1988;1481-1486.
92. Mills L. R., Scheuer P. J. Hepatic sinusoidal macrophages in alcoholic liver disease. J. Pathol. 147:1985;127-132.
93. Monshouwer M., Witkamp R. F., Nijmeijer S. M., VanLeengoed L. A. M. G., Vernooy H. C. M., Verheijden J. H. M., VanMiert A. S. J. P. A. M. A lipopolysaccharide-induced acute response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism. J. Vet. Pharm. Ther. 19:1996;382-388.
94. Moroni M., Franzetti F. Bacterial pneumonia in adult patients with HIV infection. J. Chemother. 7:1995;292-306.
95. Moulin F., Pearson J. M., Schultze A. E., Scott M. A., Schwartz K. A., Davis J. M., Ganey P. E., Roth R. A. Thrombin is a distal mediator of lipopolysaccharide-induced liver injury the rat. J. Surg. Res. 65:1996;149-158.
96. Nagaki M., Muto Y., Ohnishi H., Moriwaki H. Significance of tumor necrosis factor (TNF) and interleukin-1 (IL-1) in the pathogenesis of fulminant hepatitis: Possible involvement of serine protease in TNF-mediated liver injury. Gastroenterol. Jpn. 26:1991;448-455.
97. Nolan J. P. Endotoxin, reticuloendothelial function, and liver injury. Hepatology. 1:1981;458-465.
98. Nolan J. P. Intestinal endotoxins as mediators of hepatic injury - An idea whose time has come again. Hepatology. 10:1989;887-891.
99. Nolan J. P., Ali M. V. Endotoxin and the liver. II. Effect of tolerance on carbon tetrachloride-induced injury. J. Med. 4:1973;28-38.
100. Nolan J. P., Camara D. S. Intestinal endotoxins as co-factors in liver injury. Immunol. Invest. 18:1989;325-337.
101. Nolan J. P., Leibowitz A. I. Endotoxin and the liver. III. Modification of acute carbon tetrachloride injury by polymyxin B- an antiendotoxin. Gastroenterology. 75:1978;445-449.
102. Okabe H., Irita K., Kurosawa K., Tagawa K., Koga A., Yamakawa M., Yoshitake J., Takahashi S. Increase in the plasma concentration of reduced glutathione observed in rats with liver damage induced by lipopolysaccharideD. Circ. Shock. 41:1993;268-272.
103. Palmer K. R., Duerden B. I., Holdsworth C. D. Bacteriological and endotoxin studies in cases of ulcerative colitis submitted to surgery. Gut. 21:1980;851-854.
104. Pearson J. M., Schultze A. E., Jean P. A., Roth R. A. Platelet participation in liver injury from gram-negative bacterial lipopolysaccharide in the rat. Shock. 4:1995;178-186.
105. Pearson J. M., Brown A. P., Schultze A. E., Ganey P. E., Roth R. A. Gadolinium chloride treatment attenuates hepatic platelet accumulation after lipopolysaccharide administration. Shock. 5:1996a;408-415.
106. Pearson J. M., Schultze A. E., Schwartz K. A., Scott M. A., Davis J. M., Roth R. A. The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat. J. Pharmacol. Exp. Ther. 278:1996b;278-383.
107. Perl T. M., Dvorak L., Hwang T., Wenzel R. P. Long-term survival and function after suspected gram-negative sepsis. JAMA. 274:1995;338-345.
108. Pernis B., Vigliani E. C., Cavagna C., Finuli M. The role of bacterial endotoxins in occupational diseases caused by inhaling vegetable dusts. Br. J. Ind. Med. 18:1961;120-129.
109. Peterson R. D., Wicklund P. E., Good R. A. Endotoxin activity of house dust extracts. J. Allergy. 35:1964;134-142.
110. Potera C. Biofilms invade microbiology. Science. 273:1996;1795-1797.
111. Prytz H., Holst-Christensen J., Korner B., Liehr H. Portal venous and systemic endotoxaemia in patients without liver disease and systemic endotoxaemia in patients with cirrhosis. Scand. J. Gastroenterol. 11:1976;857-863.
112. Remick D. G., Strieter R. M., Eskandari M. K., Nguyen D. T., Genord M. A., Raiford C. L., Kunkel S. L. Role of tumor necrosis factor-α in lipopolysacchride-induced pathologic alterations. Am. J. Pathol. 136:1990;49-60.
113. Reyes M. P. The aerobic gram-negative bacillary pneumonias. Med. Clin. North Am. 64:1980;363-384.
114. Rutenburg A. M., Sonnenblick E., Koven I., Aprahamian H. A., Reiner L., Fine J. The role of intestinal bacteria in the development of dietary cirrhosis in rats. J. Exp. Med. 106:1957;1-14.
115. Rylander R., Haglind P. Airborne toxins and humidifier disease. Clin. Allergy. 14:1984;109-112.
116. Rylander R., Nordstrand A. Pulmonary cell reactions after exposure to cotton dust extract. Br. J. Ind. Med. 31:1974;220-223.
117. Shedlofsky S. I., Israel B. C., McClain C. J., Hill D. B., Blouin R. A. Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J. Clin. Invest. 94:1994;2209-2214.
118. Shibayama Y. Sinusoidal circulatory disturbance by microthrombosis as a cause of endotoxin-induced hepatic injury. J. Pathol. 151:1987;315-321.
119. Shibayama Y., Asaka S., Urano T., Araki M., Oda K. Role of neutrophils and platelets in the pathogenesis of focal hepatocellular necrosis in endotoxemia. Exp. Toxicol. Pathol. 47:1995;35-39.
120. Sieg D. J., Billings R. E. Lead/cytokine-mediated oxidative DNA damage in cultured mouse hepatocytes. Toxicol. Appl. Pharmacol. 142:1997;106-115.
121. Siegel J. H., Goodzari S., Guadelupi P., Coleman W. P., Malcolm D., Blevins S., Frankenfield D., Badellino M. C., Boetker T., Duek S. D. The host defense to trauma and sepsis: Multiple organ failure as a manifestation of host defense failure disease. Schlag G., Redl H. Pathophysiology of Shock, Sepsis and Organ Failure. 1993;626-664 Springer-Verlag, Berlin.
122. Sleeman H. K., Hardaway R. M. Evaluation of biochemical changes associated with experimental endotoxemia. I. Transaminase activity. Surgery. 61:1967;945-950.
123. Sneed R. A., Grimes S. D., Schultze A. E., Brown A. P., Ganey P. E. Bacterial endotoxin enhances the hepatotoxicity of allyl alcohol. Toxicol. Appl. Pharmacol. 144:1997;77-87.
124. Sonesson H. R. A., Zähringer U., Grimmecke H. D., Westphal O., Rietschel E. T. Bacterial endotoxin. Chemical structure and biological activity. Brigham K. L. Endotoxin and the Lungs. 1994;1-20 Dekker, New York.
125. Spaeth G., Specian R. D., Berg R. D., Deitch E. A. Bulk prevents bacterial translocation induced by oral administration of total parenteral solution. J. P. E. N. 14:1990;442-447.
126. Spitzer J. A., Zhang P., Mayer A. M. S. Functional characterization of peripheral circulating and liver recruited neutrophils in endotoxic rats. J. Leukocyte Biol. 56:1994;166-173.
127. Spitzer J. A., Mayer M. S. Hepatic neutrophil influx: Eicosanoid and superoxide formation in endotoxemia. J. Surg. Res. 55:1993;60-67.
128. Suneja S. K., Wagle D. S., Ram G. C. T-2 toxin induced changes in liver and serum enzymes of rats. Toxicon. 25:1987;793-796.
129. Tai J. H., Pestka J. J. Synergistic interaction between the trichothecene T-2 toxin andSalmonella typhimurium. Toxicol. Lett. 44:1988;191-200.
130. Tarao K., So K., Moroi T., Ikeuchi T., Suyama T. Detection of endotoxin in plasma and ascitic fluid of patients with cirrhosis: its clinical significance. Gastroenterology. 73:1977;539-542.
131. Taylor M. J., Smart R. A., Sharma R. P. Relationship of the hypothalamic-pituitary-adrenal axis with chemically induced immunomodulation. I. Stress-like response after exposure to T-2 toxin. Toxicology. 56:1989;179-195.
132. Taylor M. J., Lafarge-Frayssinet C., Luster M. I., Frayssinet C. Increased endotoxin sensitivity following T-2 toxin treatment is associated with increased absorption of endotoxin. Toxicol. Appl. Pharmacol. 109:1991;51-59.
133. Thet L. A., Wrobel D. J., Crapo J. D., Shelburne J. D. Morphologic aspects of the protection by endotoxin against acute and chronic oxygen-induced lung injury in adult rats. Lab. Invest. 48:1983;448-457.
134. Thomas L. Germs. The Lives of a Cell. Notes of a Biology Watcher. 1974;Viking Press, New York. p. 75-80.
135. Tillotson J. R., Lerner A. M. Pneumonias caused by gram negative bacilli. Medicine. 45:1966;65-76.
136. Torres M., Hall F. L., O'Neill K. Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases. J. Immunol. 150:1993;1563-1578.
137. Trudell J. R., Bendix M., Bosterling B. Hypoxia potentiates killing of hepatocyte monolayers by leukotrienes, hydroperoxyeicosatetraenoic acids, or calcium inonophore A23187. Biochim. Biophys. Acta. 803:1984;338-341.
138. 2. Arch. Biochem. Biophys. 260:1988;521-531.
139. Ulich T. R., Watson L. R., Yin S., Guo K., Wang P., Thang H., del Castillo J. The intratracheal administration of endotoxin and cytokines. Am. J. Pathol. 138:1991;1485-1496.
140. Van Leeuwen P. A. M., Hong R. W., Rounds J. D., Rodrick M., Wilmore D. W. Hepatic failure and coma after liver resection is reversed by manipulation of gut contents: The role of endotoxin. Surgery. 110:1991;169-175.
141. Van Leeuwen P. A. M., Boermeester M. A., Houdijk A. P. J., Ferwerda C. C., Cuesta M. A., Meyer S., Wesdorp R. I. C. Clinical significance of translocation. Gut. 1:1994;S28-S34.
142. Van Scott M. R., Cheng P., Henke D. C., Yankaskas J. R. Cell culture of airway epithelia. Farmer S. G., Hay W. P. The Airway Epithelium. Physiology, Pathophysiology and Pharmacology. 1991;135-167 Dekker, New York.
143. Wenzel R. P., Pinsky M. R., Ulevitch R. J., Young L. Current understanding of sepsis. Clin. Infect. Dis. 22:1996;407-413.
144. Wilkinson S. P., Arroyo V., Gazzard B. G., Moodie H., Williams R. Relation of renal impairment and haemorrhagic diathesis to endotoxaemia in fulminant hepatic failure. Lancet. 1:1974;521-524.
145. Wilkinson S. P., Moodie H., Stamatakis J. D., Kakkar V. V., Williams R. Endotoxaemia and renal failure in cirrhosis and obstructive jaundice. Br. Med. J. 2:1976;1415-1418.
146. Williams J. F., Lowitt S., Szentivanyi A. Endotoxin depression of hepatic mixed-function oxidase system in C3H/HeJ and C3H/HeN mice. Immunopharmacology. 2:1980;285-291.
147. Wise W. C., Cook J. A., Halushka P. V., Knapp D. R. Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. Circ. Res. 46:1980;854-859.
148. Yaffe S. J., Sonawane B. R. Inhibiton of rat hepatic microsomal drug metabolizing enzymes by endotoxin. Fed. Proc. 37:1978;304.
149. Zurovsky Y., Haber C. Antioxidants attenuate endotoxin-gentamicin induced acute renal failure in rats. Scand. J. Urol. Nephrol. 29:1995;147-154.