Adeno-associated virus vector-mediated bcl-2 gene transfer into post- ischemic gerbil brain in vivo: Prospects for gene therapy of ischemia-induced neuronal death

Gene Therapy

Volumn 7, Issue 14, 2000, Pages 1244-1249

  Shimazaki, K ^a   Urabe, M ^a   Monahan, J ^b   Ozawa, K ^a   Kawai, N ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b Avigen Inc   (United States)

Author keywords

Adeno associated virus vector; Bcl 2; Delayed neuronal death; Hippocampus; Ischemia

Indexed keywords

DNA FRAGMENT; PROTEIN BCL 2; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; DEFECTIVE VIRUS; FOREBRAIN; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; GERBIL; HIPPOCAMPUS; IN VIVO STUDY; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; VIRUS REPLICATION;

ADENO-ASSOCIATED VIRUS; ANIMALIA; DNA VIRUSES; GERBILLINAE;

EID: 0033914627     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301211     Document Type: Article

References (38)

1. Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity
2. Ischemia-induced neuronal apoptosis
3. Gene expression induced by cerebral ischemia: An apoptotic perspective
4. The changing landscape of ischemic brain injury mechanisms
5. Delayed neuronal death in the gerbil hippocampus following ischemia
6. Temporal profile of neuronal damage in a model of transient forebrain ischemia
7. Internucleosomal DNA fragmentation in gerbil hippocampus following forebrain ischemia
8. Very delayed infraction after mild focal cerebral ischemia: A role for apoptosis?
9. Cytochrome C is released from mitochondoria into the cytosol after cerebral anoxia or ischemia
10. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
11. Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
12. Overexpression of Bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
13. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
14. Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice
15. Prevention of dopaminergic neuron death by adeno-associated virus vector- mediated GDNF gene transfer in rat mesencephalic cells in vitro
16. Behavioral recovery in 5-hydroxydopamine-lesioned rats by contransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors
17. Strategies for gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors
18. Prospects for the use of adeno-associated virus as a vector for human gene therapy
19. Adeno-associated virus vectors for gene therapy
20. Site-specific integration by adeno-associated virus
21. Targeted integration of adeno-associated virus (AAV) into human chromosome 19
22. Efficient gene transfer into nondividing cells by adeno-associated virus- based vectors
23. A bcl-2 expressing viral vector protects cortical neurons from excitotoxity even when administered several hours after the toxic insult
24. 2+ fluxes
25. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria
26. Reduced calcium elevation in hippocampal CA1 neurons of ischemia-tolerant gerbils
27. Molecular characterization of mitochondrial apoptosis-inducing factor
28. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome C
29. Blockade of tetrahydrobiopterin synthesis protects neurons after transient forebrain ischemia in rat: A novel role for the cofactor
30. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
31. Persistent inhibition of protein synthsis precedes delayed neuronal death in post-ischemic gerbil hippocampus
32. 14C] Leucine incorporation into brain proteins in gerbils after transient ischemia: Relationship to selective vulnerability of hippocampus
33. P53 expression in brain after middle cerebral artery occlusion in the rat
34. Expression of the apoptosis-effector gene, Bax is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia
35. Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia
36. Prospects for new restorative and neuroprotective treatments in Parkinson's disease
37. Adeno-associated virus vectors can be efficiently produced without helper virus
38. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation