Cytoprotection of human umbilical veto endothelial cells against apoptosis and CTL-mediated lysis provided by caspase-resistant Bcl-2 without alterations in growth or activation responses

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4665-4671

  Zheng, Lian ^a   Dengler, Thomas J ^b   Kluger, Martin S ^a,b   Madge, Lisa A ^b   Schechner, Jeffrey S ^a,b   Maher, Stephen E ^a   Pober, Jordan S ^a,b   Bothwell, Alfred L M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL MEDIATED CYTOTOXICITY; CELL PROTECTION; GENE THERAPY; GRAFT REJECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTO ONCOGENE;

EID: 0034192096     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4665     Document Type: Article

References (41)

1. Colvin, R. B., A. H. Cohen, C. Saiontz, S. Bonsib, M. Buick, B. Burkes, S. Certer, T. Cavallo, M. Haas, A. Lindbald, et al. 1997. Evaluation of pathologic criteria for acute and allograft rejection: reproducibility, sensitivity and clinical correlation. J. Am. Soc. Nephrol. 8:1930.
2. Strehlau, J., M. Pavlakin, M. Lipman, M. Shapiro, L. Vasconcellos, W. Harmon, and T. B. Strom. 1997. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc. Natl. Acad. Sci. USA 94:695.
3. Duquesnoy, R. J., J. D. Trager, and A. Zeevi. 1991. Propagation and characterization of lymphocytes from transplant biopsies. Crit. Rev. Immunol. 10:455.
4. Tyler, J. D., S. J. Galli, M. E. Snider, A. M. Dvorak, and D. Steinmuller. 1984. Cloned cytolytic T lymphocytes destroy allogenic tissue in vivo. J. Exp. Med. 159:234.
5. MacKenzie, D. A., H. W. Sollinger, and D. A. Hullet. 1996. Acute graft rejection of human fetal pancreas allografts using donor specific human peripheral blood lymphocytes in the SCID mouse. Transplantation 61:1461.
6. Dvorak, H. F., M. C. Mihm, A. M. Dvorak, B. A. Barnes, E. J. Manseau, and S. J. Galli. 1979. Rejection of first-set skin allografts in man. The microvasculature is the critical target of the immune response. J. Exp. Med. 150:322.
7. Meehan, S. M., R. T. McCluskey, M. Pascual, F. I. Preffer, P. Anderson, S. F. Schlossman, and R. B. Colvin. 1997. Cytotoxicity and apoptosis in human renal allografts: identification, distribution and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA. Lab. Invest. 76:639.
8. Kuypers, D. R. J., J. R. Chapman, P. J. O'Connell, R. D. M. Allen, and B. J. Nankivell. 1999. Predictors of renal transplant histology at three months. Transplantation 67:1222.
9. Hancock, W. W., R. Buelow, M. H. Sayegh, and L. A. Turka. 1998. Antibody-induced transplant arteriosclerosis is prevented by raft expression of anti-oxidant and antiapoptotic-genes. Nat. Med. 4:1392.
10. Bach, F. H., C. Ferran, P. Hechenleitner, W. Mark, N. Koyamada, T. Miyatake, H. Winkler, A. Badrichani, D. Candinas, and W. W. Hancock. 1997. Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nat. Med. 3:196.
11. Kroemer, C. 1997. The proto-oncogene Bcl2 and its role in regulating apoptosis. Nat. Med. 3:614.
12. Chao, D. T., and S. J. Korsmeyer. 1998. Bcl2 family: regulators of cell death. Annu. Rev. Immunol. 16:395.
13. Suda, T., T. Takahashi, P. Golstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169.
14. Sutton, V. R., D. L. Vaux, and J. A. Trapani. 1997. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J. Immunol. 158:5783.
15. Cheng, E. H.-Y., D. G. Kirsch, R. J. Clem, R. Ravi, M. B. Kastan, A. Bedi, K. Ueno, and J. M. Hardwick, 1997. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278:1966.
16. Collins, T., A. M. Krensky, C. Clayberger, W. Fiers, J. Gimbrone, M. A., S. J. Burakoff, and J. S. Pober. 1984. Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts. J. Immunol. 133:1878.
17. Mier, J. W., E. P. Brandon, P. Libby, M. W. Janicka, and F. R. Aronson. 1989. Activated endothelial cells resist lymphokine-activated killer cell mediated injury: possible role of induced cytokines in limiting capillary leak during IL-2 therapy. J. Immunol. 143:2407.
18. Paganin, C. C. Mattuecci, S. Cenzuales, A. Manlovani, and P. Allevena. 1994. IL-4 inhibits binding and cytotoxicity of NK cells to vascular endothelium. Cytokine 6:135.
19. Biedermann, B. C. and J. S. Pober. 1998. Human endothelial cells induce and regulate cytolytic T cell differentiation. J. Immunol. 161:4679.
20. Biedermann, B. C., and J. S. Pober. 1999. Human vascular endothelial cells favor clonal expansion of unusual alloreactive CTL. J. Immunol. 162:7022.
21. Gimbrone, M. A., Jr. 1976. Culture of vascular endothelium. Prog. Hemostasis Thromb. 3:1.
22. + T cells through a CD2/LFA-3 signaling pathway. Eur. J. Immunol. 26:610.
23. al-Ramadi, B. K., H. Zhang, and A. L. M. Bothwell. 1998. Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytes. Proc. Natl. Acad. Sci. USA 95:12498.
24. Kluger, M. S., D. R. Johnson, and J. S. Pober. 1997. Mechanism of sustained E-selectin expression in cultured dermal microvascular endothelial cells. J. Immunol. 158:887.
25. + T-helper and a T-killer cell. Nature 393: 474.
26. Paavonen, T., A. Mennander, I. Lautenschlager, and P. Häyry. 1992. Endothelialitis in accelerated allograft arteriosclerosis in human cardiac transplant recipients. Transplant. Proc. 24:342.
27. Inaba, M., E. Toninelli, G. Vanmeter, J. R. Bender, and M. S. Conte. 1997. Retroviral gene transfer: effects on endothelial cell phenotype. J. Surg. Res. 78: 31.
28. Slowik, M. R., W. Min, T. Ardito, A. Karsan, M. Kashgarian, and J. S. Pober. 1997. Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways. Lab. Invest. 77:257.
29. Madge, L. A., M. R. Sierra-Honigmann, and J. S. Pober. 1999. Apoptosis-inducing agents cause rapid shedding of tumor necrosis factor receptor I (TNFR1). A nonpharmacological explanation for inhibition of TNF-mediated activation. J. Biol. Chem. 274:13643.
30. Tsujimoto, Y., J. Gorham, J. Cossman, E. Jaffe, and C. M. Croce. 1985. The T (14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229:1390.
31. Katsumata, M., R. M. Siegel, and D. C. Louie. 1992. Differential effects of Bc12 on T and B cells in transgenic mice. Proc. Natl. Acad. Sci. USA 89: 11376.
32. Bertrand, R., E. Solary, P. O'Connor, K. W. Kohn, and Y. Pommier. 1994. Induction of a common pathway of apoptosis by staurosporine. Exp. Cell Res. 211:314.
33. Ferraris, C., M. Cooklis, R. R. Polakowska, and A. R. Haake. 1997. Induction of apoptosis through the PKC pathway in cultured dermal papilla fibroblasts. Exp. Cell Res. 234:37.
34. Jayadev, S., B. Liu, A. E. Bielawska, J. Y. Lee, F. Nazaire, M. Y. Pushkareva, L. M. Obeid, and Y. A. Hannun. 1995. Role for ceramide in cell cycle arrest J. Biol. Chem. 270:2047.
35. Gamard, C. J., G. S. Dbaibo, B. Liu, L. M. Obeid, and Y. A. Hannun. 1997. Selective involvement of ceramide in cytokine-induced apoptosis. J. Biol. Chem. 272:16474.
36. Sawai, H., T. Okazaki, Y. Takeda, M. Tashima, H. Sawada, M. Okiema, S. Kishi, H. Omehara, and N. Domae. 1997. Ceramide induced translocation of protein kinase c-δ and -∈ to the cytosol. J. Biol. Chem. 272:2452.
37. 1, serve an anti-inflammatory function in endothelial cells through inhibition of NF-κB. J. Clin. Invest. 103:543.
38. Okuno, S., S. Shimizu, T. Ito, M. Nomura, E. Hamada, Y. Tsujimato, and H. Matsuda. 1998. Bcl2 prevents caspase-independent cell death. J. Biol. Chem. 273:34272.
39. Jans, D. A., V. R. Sutton, P. Jans, C. J. Froelich, and J. A. Trapani. 1999. Bcl-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. J. Biol. Chem. 274:3953.
40. Kagi, D. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265.
41. Richardson, B. C., N. D. Lalwani, K. J. Johnson, and R. M. Marks. 1994. Fas ligand triggers apoptosis in macrophages but not endothelial cells. Eur. J. Immunol. 24:2640.