1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6356-6374

  Ruchelman, Alexander L ^a   Man, Hon Wah ^a   Chen, Roger ^a   Liu, Wei ^a   Lu, Ling ^a   Cedzik, Dorota ^a   Zhang, Ling ^a   Leisten, Jim ^a   Collette, Alice ^a   Narla, Rama Krishna ^a   Raymon, Heather K ^a   Muller, George W ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

Anticancer; Antitubulin; Combretastatin A 4 (CA 4); HCT 116; Phosphodiesterase 4 (PDE4); Tumor necrosis factor (TNF )

Indexed keywords

ALKENE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; TUBULIN; TUBULIN MODULATOR;

ANIMAL; ARTICLE; CELL PROLIFERATION; CELL STRAIN HCT116; CHEMICAL STRUCTURE; CHEMISTRY; COLORECTAL TUMOR; DRUG EFFECT; HUMAN; IC 50; METABOLISM; MOLECULAR DYNAMICS; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKENES; ANIMALS; ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PHOSPHODIESTERASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 85047687331     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.068     Document Type: Article

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