Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17α-hydroxylase/C17-20-lyase (P450 17)

Journal of Medicinal Chemistry

Volumn 43, Issue 23, 2000, Pages 4437-4445

  Hartmann, R W ^a   Hector, M ^a   Wachall, B G ^a   Palusczak, A ^a   Palzer, M ^a   Huch, V ^a   Veith, M ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AZETIDINE DERIVATIVE; AZIRIDINE DERIVATIVE; ENZYME INHIBITOR; ETHYLENE OXIDE DERIVATIVE; HETEROCYCLIC COMPOUND; KETOCONAZOLE; LIAROZOLE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANDROGEN SYNTHESIS; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HORMONE INHIBITION; STEREOCHEMISTRY;

ANDROSTENOLS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; IMINES; MALE; MICROSOMES; PREGNENOLONE; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; TESTOSTERONE;

EID: 0034676307     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991070n     Document Type: Article

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