Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites and evaluation of their activity by a non cellular assay using recombinant human enzyme

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 19, Issue 1, 2004, Pages 17-32

  Hutschenreuter, Tilman U ^a   Ehmer, Peter B ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

17 hydroxylase C17; 20 lyase; CYP 17; Metabolites; Non cellular assay; Non steroidal inhibitors; Prostate cancer

Indexed keywords

2 (1 TRITYL 1H IMIDAZOL 4 YLMETHYL) 6,7 BISTRITYLOXY 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 2 (1H IMIDAZOL 4 YLMETHYL) 6,7 DIMETHOXY 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 2 (1H IMIDAZOL 4 YLMETHYLENE) 6,7 DIMETHOXY 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 4 (5 METHOXY 7 METHYL 3,7 DIHYDRO 2H 1 OXACYCLOPROPA[A]NAPHTHALEN 1 YLMETHYL) 1H IMIDAZOL; 4 (6 METHOXY 1 METHYL 3,4 DIHYDRONAPHTHALEN 2 YLMETHYL) 1 TRITYL 1H IMIDAZOLE; 4 (6,7 DIMETHOXY 1 METHYL 3,4 DIHYDRONAPHTHALEN 2 YLMETHYL) 1 TRITYL 1H IMIDAZOLE; 4 IMIDAZOL 1 YLMETHYLBIPHENYL 3,4,5 TRIOL; 4' IMIDAZOL 1 YLMETHYLBIPHENYL 2,3,4 TRIOL; 4' IMIDAZOL 1 YLMETHYLBIPHENYL 2,5 DIOL; 4' IMIDAZOL 1 YLMETHYLBIPHENYL 3,4 DIOL; 6 (3H IMIDAZOL 4 YLMETHYL) 5 METHYL 7,8 DIHYDRONAPHTHALEN 2 OL; 6 (3H IMIDAZOL 4 YLMETHYL) 5 METHYLNAPHTHALEN 2 OL; 6 HYDOXY 2 (1H IMIDAZOL 4 YLMETHYLENE) 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 6 HYDROXYTETRALONE; 6 METHOXY 2 (1 TRITYL 1H IMIDAZOL 4 YLMETHYL) 7 TRITYLOXY 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 6,7 DIHYDROXY 2 (1H IMIDAZOL 4 YLMETHYL) 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 6,7 DIMETHOXY (1 TRITYL 1H IMIDAZOL 4 YLMETHYL) 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 7 (1H IMIDAZOL 4 YLMETHYL) 8 METHYL 5,6 DIHYDRONAPHTHALEN 2,3 DIOL; 7 HYDROXY 2 (1H IMIDAZOL 4 YLMETHYL) 6 METHOXY 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 7 HYDROXY 2 (1H IMIDAZOLE 4 YLMETHYLENE) 6 METHOXY 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 7 HYDROXY 6 METHOXY 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; BW 19; BW 95; CYTOCHROME P450 17; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 REDUCTASE; DRUG METABOLITE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME METABOLISM; ESCHERICHIA COLI; IC 50; INTERMETHOD COMPARISON; ISOLATION PROCEDURE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BIODEGRADATION, ENVIRONMENTAL; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; EPOXY COMPOUNDS; ESCHERICHIA COLI; HUMANS; HYDROXYLATION; LETHAL DOSE 50; MALE; NADPH-FERRIHEMOPROTEIN REDUCTASE; PROGESTERONE; RATS; RECOMBINANT PROTEINS; STEROID 17-ALPHA-HYDROXYLASE; TESTOSTERONE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 1242352932     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360310001640913     Document Type: Article

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