Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/c17,20-lyase and 5α-reductase

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 10, 1998, Pages 1683-1693

  Ling, Yang Zhi ^a,d   Li, Ji Song ^d   Kato, Katsuya ^b,d   Liu, Yang ^d   Wang, Xin ^d   Klus, Gregory T ^d   Marat, Kirk ^c,d   Nnane, Ivo P ^d   Brodie, Angela M H ^d  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c UNIVERSITY OF MANITOBA   (Canada)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERIUM; CYTOCHROME P450; FINASTERIDE; KETOCONAZOLE; LITHIUM DERIVATIVE; PREGNANE DERIVATIVE; SODIUM BOROHYDRIDE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; STEROID 5ALPHA REDUCTASE; ZINC;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; REDUCTION; STEREOCHEMISTRY;

ANDROGENS; ANIMALS; AZIRIDINES; ENZYME INHIBITORS; HUMANS; IMINES; KETOCONAZOLE; MALE; MICROSOMES; OXIMES; PREGNADIENES; PREGNENES; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0031759097     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00110-2     Document Type: Article

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