Tetrahydronaphthalenes: Influence of heterocyclic substituents on inhibition of steroidogenic enzymes P450 arom and P450 17

Journal of Medicinal Chemistry

Volumn 39, Issue 4, 1996, Pages 834-841

  Wächter, Gerald A ^a   Hartmann, Rolf W ^a   Sergejew, Tom ^a   Grün, Gertrud L ^a   Ledergerber, Dorothea ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 IMIDAZOLYLMETHYLENE) 1 TETRALONE; AMINOGLUTETHIMIDE; ANDROGEN; AROMATASE INHIBITOR; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450; ESTROGEN; FADROZOLE; KETOCONAZOLE; TETRALIN DERIVATIVE; THROMBOXANE SYNTHASE; THROMBOXANE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANDROGEN SYNTHESIS; ARTICLE; BREAST CARCINOMA; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INACTIVATION; ESTROGEN SYNTHESIS; HUMAN; NONHUMAN; PROSTATE CARCINOMA; RAT; STEROIDOGENESIS;

AMINOGLUTETHIMIDE; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; AROMATASE INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FADROZOLE; FEMALE; HUMANS; INDICATORS AND REAGENTS; KINETICS; MALE; MOLECULAR STRUCTURE; NAPHTHALENES; PLACENTA; RATS; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; THROMBOXANE-A SYNTHASE;

EID: 0030059847     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950377t     Document Type: Article

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