Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17α-hydroxylase/c17-20-lyase) and 5α-reductase types 1 and 2

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4266-4277

  Hartmann, R W ^a   Hector, M ^a   Haidar, S ^a   Ehmer, P B ^a   Reichert, W ^a   Jose, J ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXYIMINOPREGN 4 EN 3 ONE; 20 HYDROXYIMINOPREGNA 5,14,16 TRIEN 3BETA OL; 20 HYDROXYIMINOPREGNA 5,16 DIEN 3BETA OL; 21 HYDROXYIMINO 21 METHYLPREGN 4 EN 3 ONE; 21 HYDROXYIMINO 21 METHYLPREGN 4 ENE 3,6 DIONE; 21 HYDROXYIMINOPREGN 4 EN 3 ONE; 21 HYDROXYIMINOPREGNA 4,17(20) DIEN 3 ONE; 21 HYDROXYIMINOPREGNA 5,17(20) DIEN 3BETA OL; CYTOCHROME P450 INHIBITOR; UNCLASSIFIED DRUG;

ANDROGEN SYNTHESIS; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG SYNTHESIS; DRUG USE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROSTATE CANCER; PROSTATE DISEASE; PROSTATE HYPERTROPHY; RAT; TESTOSTERONE BLOOD LEVEL;

ANIMALS; CELL LINE; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; MALE; MICROSOMES; OXIMES; PREGNENOLONE; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; STEROID 17-ALPHA-HYDROXYLASE; TESTIS; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0034597612     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001008m     Document Type: Article

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