-
1
-
-
0024996361
-
Enzymes of androgen formation and degradation in the human prostate
-
DOI 10.1111/j.1749-6632.1990.tb34282.x
-
Bartsch W, Klein H, Schiemann U, Bauer HW, Voigt KD. Enzymes of androgen formation and degradation in the human prostate. Ann NY Acad Sci 1990;595:53-66. (Pubitemid 20282939)
-
(1990)
Annals of the New York Academy of Sciences
, vol.595
, pp. 53-66
-
-
Bartsch, W.1
Klein, H.2
Schiemann, U.3
Bauer, H.W.4
Voigt, K.D.5
-
2
-
-
0031032651
-
The regulation of 17,20 lyase activity
-
DOI 10.1016/S0039-128X(96)00172-9, PII S0039128X96001720
-
Miller WL, Auchus RJ, Geller DH. The regulation of 17,20 lyase activity. Steroids 1997;62:133-142. (Pubitemid 27066997)
-
(1997)
Steroids
, vol.62
, Issue.1
, pp. 133-142
-
-
Miller, W.L.1
Auchus, R.J.2
Geller, D.H.3
-
3
-
-
17144426051
-
5 and by serine phosphorylation of P450c17
-
DOI 10.1074/jbc.M414673200
-
Pandey AV, Miller WL. Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. J Biol Chem 2005;280:13265-13271. (Pubitemid 40517210)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13265-13271
-
-
Pandey, A.V.1
Miller, W.L.2
-
4
-
-
3142657279
-
Colocalization of P450c17 and cytochrome b5 in androgen-synthesizing tissues of the human
-
DOI 10.1095/biolreprod.103.026732
-
Dharia S, Slane A, Jian M, Conner M, Conley AJ, Parker CR Jr. Colocalization of P450c17 and cytochrome b5 in androgen-synthesizing tissues of the human. Biol Reprod 2004;71:83-88. (Pubitemid 38915312)
-
(2004)
Biology of Reproduction
, vol.71
, Issue.1
, pp. 83-88
-
-
Dharia, S.1
Slane, A.2
Jian, M.3
Conner, M.4
Conley, A.J.5
Parker Jr., C.R.6
-
5
-
-
10644266103
-
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
-
DOI 10.1210/er.2003-0030
-
Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 2004;25:947-970. (Pubitemid 39657774)
-
(2004)
Endocrine Reviews
, vol.25
, Issue.6
, pp. 947-970
-
-
Payne, A.H.1
Hales, D.B.2
-
6
-
-
28044470748
-
Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis
-
Akhtar MK, Kelly SL, Kaderbhai MA. Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. J Endocrinol 2005;187:267-274.
-
(2005)
J Endocrinol
, vol.187
, pp. 267-274
-
-
Akhtar, M.K.1
Kelly, S.L.2
Kaderbhai, M.A.3
-
7
-
-
0029099277
-
Kinetic studies of cytochrome P-45017 alpha, lyase dependent androstenedione formation from progesterone
-
Tagashira H, Kominami S, Takemori S. Kinetic studies of cytochrome P-45017 alpha, lyase dependent androstenedione formation from progesterone. Biochemistry 1995;34:10939-10945.
-
(1995)
Biochemistry
, vol.34
, pp. 10939-10945
-
-
Tagashira, H.1
Kominami, S.2
Takemori, S.3
-
9
-
-
0034522440
-
Probing structural and functional domains of human P450c17
-
Auchus RJ, Worthy K, Geller DH, Miller WL. Probing structural and functional domains of human P450c17. Endocr Res 2000;26:695-703. (Pubitemid 32053092)
-
(2000)
Endocrine Research
, vol.26
, Issue.4
, pp. 695-703
-
-
Auchus, R.J.1
Worthy, K.2
Geller, D.H.3
Miller, W.L.4
-
10
-
-
0036180359
-
Comparison of the hamster and human adrenal P450c17 (17α- hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling
-
DOI 10.1016/S0960-0760(01)00172-8, PII S0960076001001728
-
Mathieu AP, Auchus RJ, LeHoux JG. Comparison of the hamster and humanadrenal P450c17 (17 alpha-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling. J Steroid Biochem Mol Biol 2002;80:99-107. (Pubitemid 34178416)
-
(2002)
Journal of Steroid Biochemistry and Molecular Biology
, vol.80
, Issue.1
, pp. 99-107
-
-
Mathieu, A.P.1
Auchus, R.J.2
Lehoux, J.-G.3
-
11
-
-
0033346398
-
Molecular modeling of human p450c17 (17α-hydroxylase/ 17,20-lyase) insights into reaction mechanisms and effects of mutations
-
Auchus RJ, Miller WL. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): Insights into reaction mechanisms and effects of mutations. Mol Endocrinol 1999;13:1169-1182. (Pubitemid 30644304)
-
(1999)
Molecular Endocrinology
, vol.13
, Issue.7
, pp. 1169-1182
-
-
Auchus, R.J.1
Miller, W.L.2
-
12
-
-
7444233759
-
The backdoor pathway to dihydrotestosterone
-
DOI 10.1016/j.tem.2004.09.004, PII S1043276004002140
-
Auchus RJ. The backdoor pathway to dihydrotestosterone. Trends Endocrinol Metab 2004;15:432-438. (Pubitemid 39440726)
-
(2004)
Trends in Endocrinology and Metabolism
, vol.15
, Issue.9
, pp. 432-438
-
-
Auchus, R.J.1
-
13
-
-
41449096419
-
Novel mutation in cytochrome P450c17 causes complete combined 17alpha-hydroxylase/17,20-lyase deficiency
-
Bhangoo A, Aisenberg J, Chartoffe A, Ten S, Wallerstein RJ, Wolf R, Auchus RJ. Novel mutation in cytochrome P450c17 causes complete combined 17alpha-hydroxylase/17,20-lyase deficiency. J Pediatr Endocrinol Metab 2008;21:185-190.
-
(2008)
J Pediatr Endocrinol Metab
, vol.21
, pp. 185-190
-
-
Bhangoo, A.1
Aisenberg, J.2
Chartoffe, A.3
Ten, S.4
Wallerstein, R.J.5
Wolf, R.6
Auchus, R.J.7
-
14
-
-
0028588696
-
Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism
-
Rosenfield RL, Barnes RB, Ehrmann DA. Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1994;79:1686-1692.
-
(1994)
J Clin Endocrinol Metab
, vol.79
, pp. 1686-1692
-
-
Rosenfield, R.L.1
Barnes, R.B.2
Ehrmann, D.A.3
-
15
-
-
38049037834
-
Basic concepts and recent developments in human steroid hormone biosynthesis
-
Ghayee HK, Auchus RJ. Basic concepts and recent developments in human steroid hormone biosynthesis. Rev Endocr Metab Disord 2007;8:289-300.
-
(2007)
Rev Endocr Metab Disord
, vol.8
, pp. 289-300
-
-
Ghayee, H.K.1
Auchus, R.J.2
-
16
-
-
48749100273
-
Association study for single nucleotide polymorphisms in the CYP17A1 gene and polycystic ovary syndrome
-
Park JM, Lee EJ, Ramakrishna S, Cha DH, Baek KH. Association study for single nucleotide polymorphisms in the CYP17A1 gene and polycystic ovary syndrome. Int J Mol Med 2008;22:249-254.
-
(2008)
Int J Mol Med
, vol.22
, pp. 249-254
-
-
Park, J.M.1
Lee, E.J.2
Ramakrishna, S.3
Cha, D.H.4
Baek, K.H.5
-
17
-
-
33847690738
-
The association of 5α-reductase II (SRD5A2) and 17 hydroxylase (CYP17) gene polymorphisms with prostate cancer patients in the Turkish population
-
DOI 10.1089/dna.2006.0534
-
Onen IH, Ekmekci A, Eroglu M, Polat F, Biri H. The association of 5alpha-reductase II (SRD5A2) and 17 hydroxylase (CYP17) gene polymorphisms with prostate cancer patients in the Turkish population. DNA Cell Biol 2007;26:100-107. (Pubitemid 46363875)
-
(2007)
DNA and Cell Biology
, vol.26
, Issue.2
, pp. 100-107
-
-
Onen, I.H.1
Ekmekci, A.2
Eroglu, M.3
Polat, F.4
Biri, H.5
-
18
-
-
16644386946
-
Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: Implication for prostate cancer risk
-
DOI 10.1038/sj.pcan.4500753, PII 4500753
-
Kakinuma H, Tsuchiya N, Habuchi T, Ohyama C, Matsuura S, Wang L, Nakamura A, Kato T. Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5 A2: Implication for prostate cancer risk. Prostate Cancer Prostatic Dis 2004;7:333-337. (Pubitemid 41721792)
-
(2004)
Prostate Cancer and Prostatic Diseases
, vol.7
, Issue.4
, pp. 333-337
-
-
Kakinuma, H.1
Tsuchiya, N.2
Habuchi, T.3
Ohyama, C.4
Matsuura, S.5
Wang, L.6
Nakamura, A.7
Kato, T.8
-
19
-
-
0141634156
-
CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: A population-based study in China
-
DOI 10.1002/ijc.11378
-
Madigan MP, Gao YT, Deng J, Pfeiffer RM, Chang BL, Zheng S, Meyers DA, Stanczyk FZ, Xu J, Hsing AW. CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: A population-based study in China. Int J Cancer 2003;107:271-275. (Pubitemid 37152909)
-
(2003)
International Journal of Cancer
, vol.107
, Issue.2
, pp. 271-275
-
-
Madigan, M.P.1
Gao, Y.-T.2
Deng, J.3
Pfeiffer, R.M.4
Chang, B.-L.5
Zheng, S.6
Meyers, D.A.7
Stanczyk, F.Z.8
Xu, J.9
Hsing, A.W.10
-
20
-
-
34547412884
-
Increased metastatic lymph node 64 and CYP17 expression are associated with high stage prostate cancer
-
DOI 10.1677/JOE-07-0131
-
Stigliano A, Gandini O, Cerquetti L, Gazzaniga P, Misiti S, Monti S, Gradilone A, Falasca P, Poggi M, Brunetti E, Agliano AM, Toscano V. Increased metastatic lymph node 64 and CYP17 expression are associated with high stage prostate cancer. J Endocrinol 2007;194:55-61. (Pubitemid 47162887)
-
(2007)
Journal of Endocrinology
, vol.194
, Issue.1
, pp. 55-61
-
-
Stigliano, A.1
Gandini, O.2
Cerquetti, L.3
Gazzaniga, P.4
Misiti, S.5
Monti, S.6
Gradilone, A.7
Falasca, P.8
Poggi, M.9
Brunetti, E.10
Agliano, A.M.11
Toscano, V.12
-
21
-
-
49249119358
-
Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
-
Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD, Nelson PS. Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth. Cancer Res 2008;68:4447-4454.
-
(2008)
Cancer Res
, vol.68
, pp. 4447-4454
-
-
Montgomery, R.B.1
Mostaghel, E.A.2
Vessella, R.3
Hess, D.L.4
Kalhorn, T.F.5
Higano, C.S.6
True, L.D.7
Nelson, P.S.8
-
22
-
-
51049098138
-
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
-
Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA, Ettinger SL, Gleave ME, Nelson CC. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008;68:6407-6415.
-
(2008)
Cancer Res
, vol.68
, pp. 6407-6415
-
-
Locke, J.A.1
Guns, E.S.2
Lubik, A.A.3
Adomat, H.H.4
Hendy, S.C.5
Wood, C.A.6
Ettinger, S.L.7
Gleave, M.E.8
Nelson, C.C.9
-
23
-
-
42949144171
-
Intracrine androgen metabolism in prostate cancer progression: Mechanisms of castration resistance and therapeutic implications
-
DOI 10.1016/j.beem.2008.01.003, PII S1521690X08000043
-
Mostaghel EA, Nelson PS. Intracrine androgen metabolism in prostate cancer progression: Mechanisms of castration resistance and therapeutic implications. Best Pract Res Clin Endocrinol Metab 2008;22:243-258. (Pubitemid 351611949)
-
(2008)
Best Practice and Research: Clinical Endocrinology and Metabolism
, vol.22
, Issue.2
, pp. 243-258
-
-
Mostaghel, E.A.1
Nelson, P.S.2
-
24
-
-
0024332485
-
Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole
-
DOI 10.1016/0022-4731(89)90384-1
-
Ayub M, Levell MJ. Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J Steroid Biochem 1989;32:515-524. (Pubitemid 19135503)
-
(1989)
Journal of Steroid Biochemistry
, vol.32
, Issue.4
, pp. 515-524
-
-
Ayub, M.1
Levell, M.J.2
-
25
-
-
0023019477
-
Mechanism of inhibition of human testicular steroidogenesis by oral ketoconazole
-
Rajfer J, Sikka SC, Rivera F, Handelsman DJ. Mechanism of inhibition of human testicular steroidogenesis by oral ketoconazole. J Clin Endocrinol Metab 1986;63:1193-1198. (Pubitemid 17173060)
-
(1986)
Journal of Clinical Endocrinology and Metabolism
, vol.63
, Issue.5
, pp. 1193-1198
-
-
Rajfer, J.1
Sikka, S.C.2
Rivera, F.3
Handelsman, D.J.4
-
26
-
-
31344470356
-
Abiraterone. Cougar biotechnology
-
Madan RA, Arlen PM. Abiraterone. Cougar biotechnology. IDrugs 2006;9:49-55.
-
(2006)
IDrugs
, vol.9
, pp. 49-55
-
-
Madan, R.A.1
Arlen, P.M.2
-
27
-
-
53749090666
-
Phase, I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
-
Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, Barrett M, Parker C, Martins V, Folkerd E, Clark J, Cooper CS, Kaye SB, Dearnaley D, Lee G, de Bono JS. Phase, I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 2008;26:4563-4571.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4563-4571
-
-
Attard, G.1
Reid, A.H.2
Yap, T.A.3
Raynaud, F.4
Dowsett, M.5
Settatree, S.6
Barrett, M.7
Parker, C.8
Martins, V.9
Folkerd, E.10
Clark, J.11
Cooper, C.S.12
Kaye, S.B.13
Dearnaley, D.14
Lee, G.15
De Bono, J.S.16
-
28
-
-
1842457650
-
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: A phase III trial (CALGB 9583)
-
DOI 10.1200/JCO.2004.06.037
-
Small EJ, Halabi S, Dawson NA, Stadler WM, Rini BI, Picus J, Gable P, Torti FM, Kaplan E, Vogelzang NJ. Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients:Aphase III trial (CALGB 9583). J Clin Oncol 2004;22:1025-1033. (Pubitemid 41095034)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.6
, pp. 1025-1033
-
-
Small, E.J.1
Halabi, S.2
Dawson, N.A.3
Stadler, W.M.4
Rini, B.I.5
Picus, J.6
Gable, P.7
Torti, F.M.8
Kaplan, E.9
Vogelzang, N.J.10
-
29
-
-
0030999075
-
Ketoconazole retains activity in advanced prostate cancer patients with progression despite flutamide withdrawal
-
DOI 10.1016/S0022-5347(01)64924-3
-
Small EJ, Baron AD, Fippin L, Apodaca D. Ketoconazole retains activity in advanced prostate cancer patients with progression despite flutamide withdrawal. J Urol 1997;157:1204-1207. (Pubitemid 27130781)
-
(1997)
Journal of Urology
, vol.157
, Issue.4
, pp. 1204-1207
-
-
Small, E.J.1
Baron, A.D.2
Fippin, L.3
Apodaca, D.4
-
30
-
-
28544432178
-
Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer
-
DOI 10.1111/j.1464-410X.2005.05821.x
-
Attard G, Belldegrun AS, de Bono JS. Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int 2005;96:1241-1246. (Pubitemid 41743917)
-
(2005)
BJU International
, vol.96
, Issue.9
, pp. 1241-1246
-
-
Attard, G.1
Belldegrun, A.S.2
De Bono, J.S.3
-
31
-
-
14844334129
-
Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
-
DOI 10.1038/sj.bjc.6602316
-
Taylor DD, Gercel-Taylor C. Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer 2005;92:305-311. (Pubitemid 40343146)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.2
, pp. 305-311
-
-
Taylor, D.D.1
Gercel-Taylor, C.2
-
32
-
-
20744436655
-
Exosome-dependent trafficking of HSP70: A novel secretory pathway for cellular stress proteins
-
DOI 10.1074/jbc.M502017200
-
Lancaster GI, Febbraio MA. Exosome-dependent trafficking of HSP70: A novel secretory pathway for cellular stress proteins. J Biol Chem 2005;280:23349-23355. (Pubitemid 40853248)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.24
, pp. 23349-23355
-
-
Lancaster, G.I.1
Febbraio, M.A.2
-
33
-
-
18844395894
-
Revisiting the road to the discovery of exosomes
-
DOI 10.1016/j.bcmd.2005.03.002, PII S1079979605000318
-
Johnstone RM. Revisiting the road to the discovery of exosomes. Blood Cells Mol Dis 2005;34:214-219. (Pubitemid 40693557)
-
(2005)
Blood Cells, Molecules, and Diseases
, vol.34
, Issue.3
, pp. 214-219
-
-
Johnstone, R.M.1
-
34
-
-
33646416463
-
The regulation of exosome secretion: A novel function of the p53 protein
-
Yu X, Harris SL, Levine AJ. The regulation of exosome secretion: A novel function of the p53 protein. Cancer Res 2006;66:4795-4801.
-
(2006)
Cancer Res
, vol.66
, pp. 4795-4801
-
-
Yu, X.1
Harris, S.L.2
Levine, A.J.3
-
35
-
-
0023655719
-
Testosterone inhibits cAMP-induced de Novo synthesis of Leydig cell cytochrome P-450(17 alpha) by an androgen receptor-mediated mechanism
-
Hales DB, Sha LL, Payne AH. Testosterone inhibits cAMP-induced de Novo synthesis of Leydig cell cytochrome P-450(17 alpha) by an androgen receptor-mediated mechanism. J Biol Chem 1987;262:11200-11206.
-
(1987)
J Biol Chem
, vol.262
, pp. 11200-11206
-
-
Hales, D.B.1
Sha, L.L.2
Payne, A.H.3
-
36
-
-
1942539331
-
YB-1 Is Upregulated during Prostate Cancer Tumor Progression and Increases P-Glycoprotein Activity
-
DOI 10.1002/pros.20023
-
Gimenez-Bonafe P, Fedoruk MN, Whitmore TG, Akbari M, Ralph JL, Ettinger S, Gleave ME, Nelson CC. YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity. Prostate 2004;59:337-349. (Pubitemid 38509767)
-
(2004)
Prostate
, vol.59
, Issue.3
, pp. 337-349
-
-
Gimenez-Bonafe, P.1
Fedoruk, M.N.2
Whitmore, T.G.3
Akbari, M.4
Ralph, J.L.5
Ettinger, S.6
Gleave, M.E.7
Nelson, C.C.8
-
37
-
-
1642263200
-
P-Glycoprotein Increases the Efflux of the Androgen Dihydrotestosterone and Reduces Androgen Responsive Gene Activity in Prostate Tumor Cells
-
DOI 10.1002/pros.10354
-
Fedoruk Matthew N, Gimenez-Bonafe P, Guns Emma S, Mayer Lawrence D, Nelson Colleen C. P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells. Prostate 2004;59:77-90. (Pubitemid 38387845)
-
(2004)
Prostate
, vol.59
, Issue.1
, pp. 77-90
-
-
Fedoruk, M.N.1
Gimenez-Bonafe, P.2
Guns, E.S.3
Mayer, L.D.4
Nelson, C.C.5
-
38
-
-
0032741282
-
Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model
-
Gleave M, Tolcher A, Miyake H, Nelson C, Brown B, Beraldi E, Goldie J. Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model. Clin Cancer Res 1999;5:2891-2898. (Pubitemid 29493968)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.10
, pp. 2891-2898
-
-
Gleave, M.1
Tolcher, A.2
Miyake, H.3
Nelson, C.4
Brown, B.5
Beraldi, E.6
Goldie, J.7
-
39
-
-
4644237335
-
Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer
-
DOI 10.1158/0008-5472.CAN-03-3998
-
Rocchi P, So A, Kojima S, Signaevsky M, Beraldi E, Fazli L, Hurtado-Coll A, Yamanaka K, Gleave M. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res 2004;64:6595-6602. (Pubitemid 39297919)
-
(2004)
Cancer Research
, vol.64
, Issue.18
, pp. 6595-6602
-
-
Rocchi, P.1
So, A.2
Kojima, S.3
Signaevsky, M.4
Beraldi, E.5
Fazli, L.6
Hurtado-Coll, A.7
Yamanaka, K.8
Gleave, M.9
-
40
-
-
28244456529
-
Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis
-
DOI 10.1158/0008-5472.CAN-05-1840
-
Rocchi P, Beraldi E, Ettinger S, Fazli L, Vessella RL, Nelson C, Gleave M. Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. Cancer Res 2005;65:11083-11093. (Pubitemid 41713379)
-
(2005)
Cancer Research
, vol.65
, Issue.23
, pp. 11083-11093
-
-
Rocchi, P.1
Beraldi, E.2
Ettinger, S.3
Fazli, L.4
Vessella, R.L.5
Nelson, C.6
Gleave, M.7
-
41
-
-
5744250223
-
Androgen receptor cross-talk with cell signalling pathways
-
DOI 10.1080/08977190412331279908
-
Culig Z. Androgen receptor cross-talk with cell signalling pathways. Growth Factors 2004;22:179-184. (Pubitemid 39377910)
-
(2004)
Growth Factors
, vol.22
, Issue.3
, pp. 179-184
-
-
Culig, Z.1
-
42
-
-
0033022342
-
A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
-
DOI 10.1038/6495
-
Craft N, Shostak Y, Carey M, Sawyers CL. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat Med 1999;5:280-285. (Pubitemid 29124362)
-
(1999)
Nature Medicine
, vol.5
, Issue.3
, pp. 280-285
-
-
Craft, N.1
Shostak, Y.2
Carey, M.3
Sawyers, C.L.4
-
43
-
-
0034455310
-
Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway
-
DOI 10.1210/en.141.6.2257
-
Miyake H, Nelson C, Rennie PS, Gleave ME. Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway. Endocrinology 2000;141:2257-2265. (Pubitemid 32274381)
-
(2000)
Endocrinology
, vol.141
, Issue.6
, pp. 2257-2265
-
-
Miyake, H.1
Nelson, C.2
Rennie, P.S.3
Gleave, M.E.4
-
44
-
-
15844429706
-
Mechanisms of the development of androgen independence in prostate cancer
-
DOI 10.1007/s00345-004-0473-1
-
So A, Gleave M, Hurtado-Col A, Nelson C. Mechanisms of the development of androgen independence in prostate cancer. World J Urol 2005;23:1-9. (Pubitemid 40425164)
-
(2005)
World Journal of Urology
, vol.23
, Issue.1
, pp. 1-9
-
-
So, A.1
Gleave, M.2
Hurtado-Col, A.3
Nelson, C.4
-
45
-
-
0842311632
-
The Androgen Axis in Recurrent Prostate Cancer
-
DOI 10.1158/1078-0432.CCR-1146-03
-
Mohler JL, Gregory CW, Ford OH III, Kim D, Weaver CM, Petrusz P, Wilson EM, French FS. The androgen axis in recurrent prostate cancer. Clin Cancer Res 2004;10:440-448. (Pubitemid 38173980)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.2
, pp. 440-448
-
-
Mohler, J.L.1
Gregory, C.W.2
Ford III, H.3
Kim, D.4
Weaver, C.M.5
Petrusz, P.6
Wilson, E.M.7
French, F.S.8
-
47
-
-
0028944138
-
In vivo amplification of the androgen receptor gene and progression of human prostate cancer
-
Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinanen R, Palmberg C, Palotie A, Tammela T, Isola J, Kallioniemi O. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 1995;9:401-406.
-
(1995)
Nat Genet
, vol.9
, pp. 401-406
-
-
Visakorpi, T.1
Hyytinen, E.2
Koivisto, P.3
Tanner, M.4
Keinanen, R.5
Palmberg, C.6
Palotie, A.7
Tammela, T.8
Isola, J.9
Kallioniemi, O.10
-
48
-
-
15644368237
-
Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer
-
Koivisto P, Kononen J, Palmberg C, Tammela T, Hyytinen E, Isola J, Trapman J, Cleutjens K, Noordzij A, Visakorpi T, Kallioniemi OP. Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res 1997;57:314-319. (Pubitemid 27036612)
-
(1997)
Cancer Research
, vol.57
, Issue.2
, pp. 314-319
-
-
Koivisto, P.1
Kononen, J.2
Palmberg, C.3
Tammela, T.4
Hyytinen, E.5
Isola, J.6
Trapman, J.7
Cleutjens, K.8
Noordzij, A.9
Visakorpi, T.10
Kallioniemi, O.-P.11
-
49
-
-
0035300409
-
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
-
Gregory CW, Johnson RT Jr, Mohler JL, French FS, Wilson EM. Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen. Cancer Res 2001;61:2892-2898. (Pubitemid 32691931)
-
(2001)
Cancer Research
, vol.61
, Issue.7
, pp. 2892-2898
-
-
Gregory, C.W.1
Johnson Jr., R.T.2
Mohler, J.L.3
French, F.S.4
Wilson, E.M.5
-
50
-
-
27644452640
-
Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
-
DOI 10.1158/1078-0432.CCR-05-0525
-
Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin Cancer Res 2005;11:4653-4657. (Pubitemid 41557182)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.13
, pp. 4653-4657
-
-
Titus, M.A.1
Schell, M.J.2
Lih, F.B.3
Tomer, K.B.4
Mohler, J.L.5
-
51
-
-
11144322812
-
Adrenal androgens and intracrinology
-
DOI 10.1055/s-2004-861547
-
Labrie F. Adrenal androgens and intracrinology. Semin Reprod Med 2004;22:299-309. (Pubitemid 40030080)
-
(2004)
Seminars in Reproductive Medicine
, vol.22
, Issue.4
, pp. 299-309
-
-
Labrie, F.1
-
52
-
-
34548395100
-
Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer
-
DOI 10.1038/sj.pcan.4500956, PII 4500956
-
Suzuki K, Nishiyama T, Hara N, Yamana K, Takahashi K, Labrie F. Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer. Prostate Cancer Prostatic Dis 2007;10:301-306. (Pubitemid 47351410)
-
(2007)
Prostate Cancer and Prostatic Diseases
, vol.10
, Issue.3
, pp. 301-306
-
-
Suzuki, K.1
Nishiyama, T.2
Hara, N.3
Yamana, K.4
Takahashi, K.5
Labrie, F.6
-
53
-
-
33749345244
-
Improving the outcome of patients with castration-resistant prostate cancer through rational drug development
-
DOI 10.1038/sj.bjc.6603223, PII 6603223
-
Attard G, Sarker D, Reid A, Molife R, Parker C, de Bono JS. Improving the outcome of patients with castration-resistant prostate cancer through rational drug development. Br J Cancer 2006;95:767-774. (Pubitemid 44498089)
-
(2006)
British Journal of Cancer
, vol.95
, Issue.7
, pp. 767-774
-
-
Attard, G.1
Sarker, D.2
Reid, A.3
Molife, R.4
Parker, C.5
De Bono, J.S.6
-
55
-
-
33749356751
-
Androgen activation of the sterol regulatory element-binding protein pathway: Current insights
-
DOI 10.1210/me.2005-0479
-
Heemers HV, VerhoevenG, Swinnen JV. Androgen activation of the sterol regulatory element-binding protein pathway: Current insights. Mol Endocrinol 2006;20:2265-2277. (Pubitemid 44496400)
-
(2006)
Molecular Endocrinology
, vol.20
, Issue.10
, pp. 2265-2277
-
-
Heemers, H.V.1
Verhoeven, G.2
Swinnen, J.V.3
-
56
-
-
1542615071
-
Dysregulation of Sterol Response Element-Binding Proteins and Downstream Effectors in Prostate Cancer during Progression to Androgen Independence
-
DOI 10.1158/0008-5472.CAN-2148-2
-
Ettinger SL, Sobel R, Whitmore TG, Akbari M, Bradley DR, Gleave ME, Nelson CC. Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence. Cancer Res 2004;64:2212-2221. (Pubitemid 38339475)
-
(2004)
Cancer Research
, vol.64
, Issue.6
, pp. 2212-2221
-
-
Ettinger, S.L.1
Sobel, R.2
Whitmore, T.G.3
Akbari, M.4
Bradley, D.R.5
Gleave, M.E.6
Nelson, C.C.7
-
57
-
-
32644440485
-
Cyclic adenosine 5′-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1
-
DOI 10.1210/en.2005-1091
-
Ozbay T, Rowan A, Leon A, Patel P, Sewer MB. Cyclic adenosine 5′-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. Endocrinology 2006;147:1427-1437. (Pubitemid 43244377)
-
(2006)
Endocrinology
, vol.147
, Issue.3
, pp. 1427-1437
-
-
Ozbay, T.1
Rowan, A.2
Leon, A.3
Patel, P.4
Sewer, M.B.5
-
58
-
-
0032933296
-
The biology of hormone refractory prostate cancer. Why does it develop?
-
Isaacs JT. The biology of hormone refractory prostate cancer. Why does it develop? Urol Clin North Am 1999;26:263-273.
-
(1999)
Urol Clin North Am
, vol.26
, pp. 263-273
-
-
Isaacs, J.T.1
-
59
-
-
33645056171
-
Increased expression of genes converting adrenal androgens to testosterone in androgenin-dependent prostate cancer
-
Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, Febbo PG, Balk SP. Increased expression of genes converting adrenal androgens to testosterone in androgenin-dependent prostate cancer. Cancer Res 2006;66:2815-2825.
-
(2006)
Cancer Res
, vol.66
, pp. 2815-2825
-
-
Stanbrough, M.1
Bubley, G.J.2
Ross, K.3
Golub, T.R.4
Rubin, M.A.5
Penning, T.M.6
Febbo, P.G.7
Balk, S.P.8
-
60
-
-
34250331066
-
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
-
DOI 10.1158/0008-5472.CAN-06-3332
-
Mostaghel EA, Page ST, Lin DW, Fazli L, Coleman IM, True LD, Knudsen B, Hess DL, Nelson CC, Matsumoto AM, Bremner WJ, Gleave ME, Nelson PS. Intraprostatic androgens and androgenregulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer. Cancer Res 2007;67:5033-5041. (Pubitemid 46910214)
-
(2007)
Cancer Research
, vol.67
, Issue.10
, pp. 5033-5041
-
-
Mostaghel, E.A.1
Page, S.T.2
Lin, D.W.3
Fazli, L.4
Coleman, I.M.5
True, L.D.6
Knudsen, B.7
Hess, D.L.8
Nelson, C.C.9
Matsumoto, A.M.10
Bremner, W.J.11
Gleave, M.E.12
Nelson, P.S.13
-
61
-
-
34547106591
-
Pten inactivation and the emergence of androgen-independent prostate cancer
-
Shen MM, Abate-Shen C. Pten inactivation and the emergence of androgen-independent prostate cancer. Cancer Res 2007;67:6535-6538.
-
(2007)
Cancer Res
, vol.67
, pp. 6535-6538
-
-
Shen, M.M.1
Abate-Shen, C.2
-
62
-
-
34548397326
-
Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer
-
DOI 10.2174/156800907781662248
-
Wang Y, Kreisberg JI, Ghosh PM. Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer. Curr Cancer Drug Targets 2007;7:591-604. (Pubitemid 47358145)
-
(2007)
Current Cancer Drug Targets
, vol.7
, Issue.6
, pp. 591-604
-
-
Wang, Y.1
Kreisberg, J.I.2
Ghosh, P.M.3
-
63
-
-
0347407794
-
Akt in prostate cancer: Possible role in androgen-independence
-
DOI 10.2174/1389200033489226
-
Ghosh PM, Malik S, Bedolla R, Kreisberg JI. Akt in prostate cancer: Possible role in androgen-independence. Curr Drug Metab 2003;4:487-496. (Pubitemid 37536869)
-
(2003)
Current Drug Metabolism
, vol.4
, Issue.6
, pp. 487-496
-
-
Ghosh, P.M.1
Malik, S.2
Bedolla, R.3
Kreisberg, J.I.4
-
64
-
-
36849018402
-
Why is PTEN an important tumor suppressor?
-
Li L, Ross AH. Why is PTEN an important tumor suppressor? J Cell Biochem 2007;102:1368-1374.
-
(2007)
J Cell Biochem
, vol.102
, pp. 1368-1374
-
-
Li, L.1
Ross, A.H.2
-
65
-
-
47249090937
-
Targeting prostate cancer based on signal transduction and cell cycle pathways
-
Lee JT, Lehmann BD, Terrian DM, Chappell WH, Stivala F, Libra M, Martelli AM, Steelman LS, McCubrey JA. Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle 2008;7:1745-1762. (Pubitemid 351988740)
-
(2008)
Cell Cycle
, vol.7
, Issue.12
, pp. 1745-1762
-
-
Lee, J.T.1
Lehmann, B.D.2
Terrian, D.M.3
Chappell, W.H.4
Stivala, F.5
Libra, M.6
Martelli, A.M.7
Steelman, L.S.8
McCubrey, J.A.9
-
66
-
-
54049088501
-
Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice
-
Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, Vidal M, Amson R, Telerman A. Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ 2008;15:1723-1733.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1723-1733
-
-
Lespagnol, A.1
Duflaut, D.2
Beekman, C.3
Blanc, L.4
Fiucci, G.5
Marine, J.C.6
Vidal, M.7
Amson, R.8
Telerman, A.9
-
67
-
-
43149120419
-
Exosome function: From tumor immunology to pathogen biology
-
DOI 10.1111/j.1600-0854.2008.00734.x
-
Schorey JS, Bhatnagar S. Exosome function: From tumor immunology to pathogen biology. Traffic 2008;9:871-881. (Pubitemid 351639493)
-
(2008)
Traffic
, vol.9
, Issue.6
, pp. 871-881
-
-
Schorey, J.S.1
Bhatnagar, S.2
-
68
-
-
33748929270
-
Exosomes: A common pathway for a specialized function
-
DOI 10.1093/jb/mvj128
-
van Niel G, Porto-Carreiro I, Simoes S, Raposo G. Exosomes: A common pathway for a specialized function. J Biochem 2006;140:13-21. (Pubitemid 44433541)
-
(2006)
Journal of Biochemistry
, vol.140
, Issue.1
, pp. 13-21
-
-
Van Niel, G.1
Porto-Carreiro, I.2
Simoes, S.3
Raposo, G.4
-
69
-
-
34249302620
-
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
-
DOI 10.1038/ncb1596, PII NCB1596
-
Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007;9:654-659. (Pubitemid 47214727)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.6
, pp. 654-659
-
-
Valadi, H.1
Ekstrom, K.2
Bossios, A.3
Sjostrand, M.4
Lee, J.J.5
Lotvall, J.O.6
-
70
-
-
37349012215
-
Tumour-released exosomes and their implications in cancer immunity
-
DOI 10.1038/sj.cdd.4402237, PII 4402237, Special issue on Tumor stress, cell death and the ensuing immune response
-
Iero M, Valenti R, Huber V, Filipazzi P, Parmiani G, Fais S, Rivoltini L. Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ 2008;15:80-88. (Pubitemid 350286175)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.1
, pp. 80-88
-
-
Iero, M.1
Valenti, R.2
Huber, V.3
Filipazzi, P.4
Parmiani, G.5
Fais, S.6
Rivoltini, L.7
-
71
-
-
3142630225
-
Exosomes: Endosomal-derived vesicles shipping extracellular messages
-
DOI 10.1016/j.ceb.2004.06.003, PII S0955067404000729
-
Fevrier B, Raposo G. Exosomes: Endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 2004;16:415-421. (Pubitemid 38903148)
-
(2004)
Current Opinion in Cell Biology
, vol.16
, Issue.4
, pp. 415-421
-
-
Fevrier, B.1
Raposo, G.2
-
72
-
-
11144353573
-
Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells
-
Hegmans JP, Bard MP, Hemmes A, Luider TM, Kleijmeer MJ, Prins JB, Zitvogel L, Burgers SA, Hoogsteden HC, Lambrecht BN. Proteomic analysis of exosomes secreted by human mesothelioma cells. Am J Pathol 2004;164:1807-1815. (Pubitemid 38529783)
-
(2004)
American Journal of Pathology
, vol.164
, Issue.5
, pp. 1807-1815
-
-
Hegmans, J.P.J.J.1
Bard, M.P.L.2
Hemmes, A.3
Luider, T.M.4
Kleijmeer, M.J.5
Prins, J.-B.6
Zitvogel, L.7
Burgers, S.A.8
Hoogsteden, H.C.9
Lambrecht, B.N.10
-
73
-
-
54249125009
-
Senescence-associated exosome release from human prostate cancer cells
-
Lehmann BD, Paine MS, Brooks AM, McCubrey JA, Renegar RH, Wang R, Terrian DM. Senescence-associated exosome release from human prostate cancer cells. Cancer Res 2008;68:7864-7871.
-
(2008)
Cancer Res
, vol.68
, pp. 7864-7871
-
-
Lehmann, B.D.1
Paine, M.S.2
Brooks, A.M.3
McCubrey, J.A.4
Renegar, R.H.5
Wang, R.6
Terrian, D.M.7
-
74
-
-
0032759925
-
Immunohistochemical analysis of radical prostatectomy specimens after 8 months of neoadjuvant hormonal therapy
-
Paterson RF, Gleave ME, Jones EC, Zubovits JT, Goldenberg SL, Sullivan LD. Immunohistochemical analysis of radical prostatectomy specimens after 8 months of neoadjuvant hormonal therapy. Mol Urol 1999;3:277-286. (Pubitemid 29511047)
-
(1999)
Molecular Urology
, vol.3
, Issue.3
, pp. 277-285
-
-
Paterson, R.F.1
Gleave, M.E.2
Jones, E.C.3
Zubovits, J.T.4
Goldenberg, S.L.5
Sullivan, L.D.6
|