17,20-Lyase inhibitors. Part 4: Design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 5, 2011, Pages 1751-1770

  Kaku, Tomohiro ^a   Matsunaga, Nobuyuki ^a   Ojida, Akio ^b   Tanaka, Toshimasa ^a   Hara, Takahito ^a   Yamaoka, Masuo ^a   Kusaka, Masami ^a   Tasaka, Akihiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

11 Hydroxylase; 17,20 Lyase; Prostate cancer; Testosterone

Indexed keywords

17,20 LYASE INHIBITOR; 7 [1 HYDROXY 1 (1H IMIDAZOL 4 YL) 2 METHYLPROPYL] 2 METHYL 1,2 DIHYDRO 3H BENZO[E]ISOINDOL 3 ONE; CYTOCHROME P450 3A4; HYDROXYL GROUP; IMIDAZOLE DERIVATIVE; KETONE DERIVATIVE; NAPHTHALENE DERIVATIVE; STEROID 11BETA MONOOXYGENASE; STEROID 17,20 LYASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASYMMETRIC SYNTHESIS; CHIRALITY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HAPLORHINI; IC 50; IN VIVO STUDY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYTOCHROME P-450 CYP3A; DRUG DESIGN; HAPLORHINI; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; LYASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 79952187333     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.017     Document Type: Article

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