Estrogen receptor activation function 1 works by binding p160 coactivator proteins

Molecular Endocrinology

Volumn 12, Issue 10, 1998, Pages 1605-1618

  Webb, P ^a   Nguyen, P ^a   Shinsako, J ^a   Anderson, C ^a   Feng, W ^a   Nguyen, M P ^a   Chen, D ^a   Huang, S M ^a   Subramanian, S ^a   McKinerney, E ^a   Katzenellenbogen, B S ^a   Stallcup, M R ^a   Kushner, P J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTROGEN RECEPTOR ALPHA; PROTEIN P160; PROTEIN P300; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; HORMONE DEPENDENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; TRANSACTIVATION;

EID: 0032230350     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.10.0185     Document Type: Article

References (73)

1. Estrogen receptors: Bioactivities and interactions with cell signaling pathways
2. Cloning of a novel estrogen receptor expressed in rat prostate and ovary
3. Editorial: A new actor in the estrogen receptor drama - Enter ER beta
4. Steroid and related receptors
5. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
6. Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha
7. Estrogen receptors alpha and beta form heterodimers on DNA
8. Identification of two transactivation domains in the mouse oestrogen receptor
9. Functional domains of the human estrogen receptor
10. The human estrogen receptor has two independent nonacidic transcriptional activation functions
11. The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific
12. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
13. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
14. Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein
15. Ligand-dependent interaction of nuclear receptors with potential transcriptional intermediary factors (mediators)
16. Nuclear receptor coactivators and corepressors
17. Nuclear receptor coactivators
18. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
19. AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors
20. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
21. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
22. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
23. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding dependent and independent pathways
24. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
25. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
26. The transcriptional coactivator p/CIP binds CBP and mediates nuclear-receptor function
27. R.M.E. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
28. AIB1, a steroid receptor coactivator amplifled in breast and ovarian cancer
29. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
30. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
31. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor
32. RIP-140 interacts with multiple nuclear receptors by means of two distinct sites
33. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1
34. Role of CBP/P300 in nuclear receptor signalling
35. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
36. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
37. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
38. The transcriptional coactivators p300 and CBP are histone acetyltransferases
39. The CBP co-activator is a histone acetyltransferas
40. Steroid receptor coactivator-1 is a histone acetyltransferase
41. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator
42. CREB-binding protein activates transcription through multiple domains
43. The N-terminal transactivation domain of rat estrogen receptor is localized in a hydrophobic domain of eighty amino acids
44. Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells
45. Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation
46. Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region
47. Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity
48. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
49. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
50. Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex
51. Characterization of ligand-dependent phosphorylation of the estrogen receptor
52. Distinct classes of transcriptional activating domains function by different mechanisms
53. Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor
54. Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator
55. Mechanisms of antihormone action
56. Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens
57. Selective interaction of hsp90 with an estrogen receptor ligand-binding domain containing a point mutation
58. The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
59. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
60. Superactive estrogen receptors. Potent activators of gene expression
61. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta
62. Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites
63. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
64. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
65. The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and (*)-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor
66. A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor
67. Transcription factor specific requirements for coactivators and their acetyltransferase functions
68. Differential use of CREB binding protein-coactivator complexes
69. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity
70. Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity
71. Determinants of target gene specificity for steroid/thyroid hormone receptors
72. Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site
73. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor