The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription

Molecular and Cellular Biology

Volumn 19, Issue 9, 1999, Pages 6085-6097

  Alen, Philippe ^a   Claessens, Frank ^a   Verhoeven, Guido ^a   Rombauts, Wilfried ^a   Peeters, Ben ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; TRANSCRIPTION REGULATION;

EID: 0032784653     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.9.6085     Document Type: Article

References (72)

1. P. Aarnisalo, J. J. Palvimo, and O. A. Jänne. 1998. CREB-binding protein in androgen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA 95:2122-2127.
2. 70/ELE1α with multiple steroid receptors and identification of an internally deleted ELE1β isoform. Mol. Endocrinol. 13:117-128.
3. Anzick, S. L., J. Kononen, R. L. Walker, D. O. Azorsa, M. M. Tanner, X. Y. Guan, G. Sauter, O. P. Kallioniemi, J. M. Trent, and P. S. Meltzer. 1997. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277:965-968.
4. Baniahmad, A., A. C. Kohne, and R. Renkawitz. 1992. A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. EMBO J. 11:1015-1023.
5. Bannister, A. J., and T. Kouzarides, 1996. The CBP co-activator is a histone acetyltransferase. Nature 384:641-643.
6. Beato, M., S. Chavez, and M. Truss. 1996. Transcriptional regulation by steroid hormones. Steroids 61:240-251.
7. Beato, M., and A. Sanchez-Pacheco. 1996. Interaction of steroid hormone receptors with the transcription initiation complex Endocrine Rev. 17:587-609.
8. Berrevoets, C. A., P. Doesburg, K. Steketee, J. Trapman, and A. O. Brinkmann. 1998. Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor 2). Mol. Endocrinol. 12:1172-1183.
9. Blanco, J. C. G., S. Minucci, J. Lu, X. J. Yang, K. K. Walker, H. Chen, R. M. Evans, Y. Nakatani, and K. Ozato. 1998. The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev. 12:1638-1651.
10. Buchert, M., S. Schneider, M. T. Adams, H. P. Hefti, K. Moelling, and C. M. Hovens. 1997. Useful vectors for the two-hybrid system in mammalian cells. BioTechniques 23:396-402.
11. Chamberlain, N. L., D. C. Whitacre, and R. L. Miesfeld. 1996. Delineation of two distinct type 1 activation functions in the androgen receptor aminoterminal domain. J. Biol. Chem. 271:26772-26778.
12. Chen, H., R. J. Lin, R. L. Schlitz, D. Chakravarti, A. Nash, L. Nagy, M. L. Privalsky, Y. Nakatani, and R. Evans. 1997. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569-580.
13. Danielian, P. S., R. White, J. A. Lees, and M. G. Parker. 1992. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11:1025-1033.
14. Ding, X. F., C. M. Anderson, H. Ma, H. Hong, R. M. Uht, P. Kushner, and M. R. Stallcup. 1998. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interaction protein 1(GRIP1) and steroid receptor coactivator 1 (SRC1): multiple motifs with different binding specificities. Mol. Endocrinol. 12:302-313.
15. Doesburg, P., C. W. Kuil, C. A. Berrevoets, K. Steketee, P. W. Faber, E. Mulder, A. O. Brinkmann, and J. Trapman. 1997. Functional in vivo interaction between the amino-terminal and the ligand binding domain of the androgen receptor. Biochemistry 36:1052-1064.
16. Fawell, S. E., J. A. Lees, R. White, and M. G. Parker. 1990. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell 60:953-962.
17. Feng, W., R. C. J. Ribeiro, R. L. Wagner, H. Nguyen, J. W. Apriletti, R. J. Fletterick, J. D. Baxter, P. J. Kushner, and B. L. West. 1998. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science 280:1747-1749.
18. Fronsdal, K., N. Engedal, T. Slagsvold, and F. Saatcioglu. 1998. CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1. J. Biol. Chem. 273:31853-31859.
19. Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736.
20. Henttu, P. M. A., E. Kalkhoven, and M. G. Parker. 1997. AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors. Mol. Cell. Biol. 17:1832-1839.
21. Hong, H., K. Kohli, M. J. Garabedian, and M. R. Stallcup. 1997. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol. 17:2735-2744.
22. Hong, H., B. D. Darimont, H. Ma, L. Yang, K. R. Yamamoto, and M. R. Stallcup. 1999. An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors. J. Biol. Chem. 274:3496-3502.
23. Horwitz, K. B., T. A. Jackson, D. L. Bain, J. K. Richer, G. S. Takimoto, and L. Tung. 1996. Nuclear receptor coactivators and corepressors. Mol. Endocrinol. 10:1167-1177.
24. Ikonen, T., J. J. Palvimo, and O. A. Jänne. 1997. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators. J. Biol. Chem. 272:29821-29828.
25. Jenster, G., H. A. G. M. van der Korput, C. C. J. van Groonhoven, T. H. Van der Kwast, J. Trapman, and A. O. Brinkmann. 1991. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Mol. Endocrinol. 5:1396-1404.
26. Jenster, G., H. A. G. M. van der Korput, J. Trapman, and A. O. Brinkmann, 1995. Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J. Biol. Chem. 270:7341-7346.
27. Jenster, G. 1998. Coactivators and corepressors as mediators of nuclear receptor function: an update. Mol. Cell. Endocrinol. 143:1-7.
28. Jeyakumar. M., M. R. Tanen, and M. K. Bagchi. 1997. Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor. Mol. Endocrinol. 11:755-767.
29. Kalkhoven, E., J. E. Valentin, D. M. Heery, and M. G. Parker. 1998. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J. 17:232-243.
30. Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S.-C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
31. Langley, E., Z. X. Zhou, and E. M. Wilson. 1995. Evidence for an antiparallel orientation of the ligand-activated human androgen receptor dimer. J. Biol. Chem. 270:29983-29990.
32. 2-carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity. J. Biol. Chem. 273: 92-101.
33. Lavinsky, R. M., K. Jepsen, T. Heinzel, J. Torchia, T.-M. Mullen, R. Schiff, A. L. Del-Rio, M. Ricolte, S. Ngo, J. Gemsch, S. G. Hilsenbeck, C. K. Osborne, C. K. Glass, M. G. Rosenfeld, and D. W. Rose. 1998. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. USA 95:2920-2925.
34. Leers, J., E. Treuter, and J. A. Gustaffson. 1998. Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2. Mol. Cell. Biol. 18:5001-6013.
35. Li, H., P. J. Gomes, and D. J. Chen. 1996. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94:8479-8484.
36. Li, H., and D. Chen. 1998. The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation. J. Biol. Chem. 273:5948-5954.
37. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. Evans. 1995. The nuclear receptor superfamily: the second decade. Cell 83:835-839.
38. Marivoet, S., M. Hertogen, G. Verhoeven, and W. Heyns. 1990. Antibodies against synthetic peptide recognise the human and rat androgen receptor. J. Steroid Biochem. Mol. Biol. 37:39-45.
39. McInerney, E. M., M. J. Tsai, B. W. O'Malley, and B. S. Katzenellenbogen. 1996. Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator. Proc. Natl. Acad. Sci. USA 93:10069-10073.
40. Moilanen, A., N. Rouleau, T. Ikonen, J. J. Palvimo, and O. A. Jänne. 1997. The presence of a transcription activation function in the hormone-binding domain of androgen receptor is revealed by studies in yeast cells. FEBS Lett. 412:355-358.
41. Moilanen, A., H. Poukka, U. Karvonen, M. Häkli, O. A. Jänne, and J. J. Palvimo. 1998. Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol. 18:5128-5139.
42. Moras, D., and H. Gronemeyer. 1998. The nuclear receptor ligand-binding domain: structure and function. Curr. Opin. Cell Biol. 10:384-391.
43. Nolte, R. T., G. B. Wisely, S. Westin, J. E. Cobb, M. Lambert, R. Kurokawa, M. Rosenfeld, T. M. Willson, C. K. Glass, and M. V. Milburn. 1998. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ. Nature 395:137-143.
44. Ogryzko, V. V., R. L. Schiltz, V. Russanova, B. H. Howard, and Y. Nakatani. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959.
45. Onate, S. A., S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1995. Sequence and characterization of a coactivator for the steroid hormone receptor super-family. Science 270:1354-1357.
46. Onate, S. A., V. Boonyaratanakornkit, T. E. Spencer, S. Y. Tsai, M. J. Tsai, D. P. Edwards, and B. W. O'Malley. 1998. The steroid receptor coactivator-1 contains multiple receptor interaction domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. J. Biol. Chem. 273:12101-12108.
47. Parker, M. G., and R. White. 1996. Nuclear receptors spring into action. Nat. Struct. Biol. 3:113-115.
48. Plaisance, S., W. VandenBerghe, E. Boone, W. Fiers, and G. Haegeman. 1997. Recombination signal sequence binding protein J kappa is constitutively bound to the NF-kappa B site of the interleukin-6 promoter and acts as a negative regulatory factor. Mol. Cell. Biol. 17:3733-3743.
49. Quigley, C. A., A. De Bellis, K. B. Marschke, M. K. El-Awady, E. M. Wilson, and F. S. French. 1995. Androgen receptor defects: historical, clinical, and molecular perspectives. Endocrine Rev. 16:271-321.
50. Schmidt, S., A. Baniahmad, M. Eggert, S. Schneider, and R. Renkawitz. 1998. Multiple receptor interaction domains of GRIP1 function in synergy. Nucleic Acids. Res. 26:1191-1197.
51. Shiau, A. K., D. Barstad, P. M. Loria, L. Cheng, P. J. Kushner, D. A. Agard, and G. L. Greene. 1999. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95: 927-937.
52. Shibata, H., T. E. Spencer, S. A. Onate, G. Jenster, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1997. Role of coactivators and corepressors in the mechanism of steroid/thyroid receptor action. Recent Prog. Horm. Res. 52:141-165.
53. Simental, J. A., M. Sar, and E. M. Wilson. 1992. Domain functions of the androgen receptor. J. Steroid Biochem. Mol. Biol. 43:37-41.
54. Smith, C. L., Z. Nawaz, and B. W. O'Malley. 1997. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol. Endocrinol. 11:657-666.
55. Spencer, T. E., G. Jenster, M. M. Burcin, C. D. Allis, J. Zhou, C. A. Mizzen, N. J. McKenna, S. A. Onate, S. V. Tsai, M. J. Tsai, and B. W. O'Malley. 1997. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389:194-198.
56. Suen, C. S., T. J. Berrodin, R. Mastroeni, B. J. Cheskis, C. R. Lyttle, and D. E. Frail. 1998. A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J. Biol. Chem. 273:27645-27653.
57. Takeshita, A., P. M. Yen, S. Misti, G. R. Cardona, Y. Liu, and W. W. Chin. 1996. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology 137:3594-3597.
58. Takeshita, A., G. R. Cardona, N. Koibuchi, C. S. Suen, and W. W. Chin. 1997. TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J. Biol. Chem. 272:27629-27634.
59. Takeshita, A., P. M. Yen, M. Ikeda, G. R. Cardona, Y. Liu, N. Koibuchi, E. R. Norwitz, and W. W. Chin. 1998. Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. J. Biol. Chem. 273:21554-21562.
60. Torchia, J., D. W. Rose, J. Inostroza, Y. Kamei, S. Westin, C. Glass, and M. G. Rosenfeld. 1997. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387:677-684.
61. Torchia, J., C. Glass, and M. Rosenfeld. 1998. Co-activators and co-repressors in the integration of transcriptional responses. Curr. Opin. Cell. Biol. 10:373-383.
62. Tsai, M. J., and B. W. O'Malley. 1994. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63: 451-486.
63. Tsai, R. Y. L., and R. R. Reed. 1997. Using a eukaryotic GST fusion vector for proteins difficult to express in E. coli. BioTechniques 23:794-800.
64. Voegel, J. J., M. J. S. Heine, C. Zechel, P. Chambon, and H. Gronemeyer. 1996. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15:3667-3675.
65. Voegel, J. J., M. J. S. Heine, M. Tini, V. Vivat, P. Chambon, and H. Gronemeyer. 1998. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 17:507-519.
66. Webb, P., P. Nguyen, J. Shinsako, C. Anderson, W. Feng, M. P. Nguyen, D. Chen, S. M. Huang, S. Subramanian, E. McKinerney, B. S. Katzenellenbogen, M. R. Stallcup, and P. J. Kushner. 1998. Estrogen receptor activation function 1 works by binding p160 coactivator proteins. Mol. Endocrinol. 12:1605-1618.
67. Williams, S. P., and P. B. Sigler. 1998. Atomic structure of progesterone complexed with its receptor. Nature 393:392-396.
68. Wong, C. I., Z. X. Zhou, M. Sar, and E. M. Wilson. 1993. Steroid requirements for androgen receptor dimerization and DNA binding. J. Biol. Chem. 268:19004-19012.
69. Wurtz, J. M., W. Bourguet, J. P. Renaud, V. Vivat, P. Chambon, D. Moras, and H. Gronemeyer. 1996. A canonical structure for the ligand-binding domain of nuclear receptors. Nat. Struct. Biol. 3:87-94.
70. Xu, J., Z. Nawaz, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1996. The extreme C-terminus of the progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor. Proc. Natl. Acad. Sci. USA 93:12195-12199.
71. Yang, X. J., V. V. Ogryzko, J. I. Nishikawa, B. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 283:319-324.
72. Zhou, G., R. Cummings, Y. Li, S. Mitra, H. A. Wilkinson, A. Elbrecht, J. D. Hermes, J. M. Schaeffer, R. G. Smith, and D. E. Moller. 1998. Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer. Mol. Endocrinol. 12:1594-1604.