Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor 2)

Molecular Endocrinology

Volumn 12, Issue 8, 1998, Pages 1172-1183

  Berrevoets, C A ^a   Doesburg, P ^a   Steketee, K ^a   Trapman, J ^a   Brinkmann, A O ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; DIMERIZATION; GENE MUTATION; GENETIC TRANSCRIPTION; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION;

EID: 0032230283     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.8.0153     Document Type: Article

References (41)

1. Control of transcription activation by steroid hormone receptors
2. Differential recognition of target genes by nuclear receptor monomers, dimers and heterodimers
3. The steroid and thyroid hormone receptor superfamily
4. Gene regulation by steroid hormones
5. Nuclear receptors enhance our understanding of transcription regulation
6. Steroid and related receptors
7. Nuclear receptor coactivators and corepressors
8. Identification of two transcription activation units in the N-terminal domain of the human androgen receptor
9. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
10. Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor
11. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: Presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity
12. A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors
13. Human estrogen receptor ligand activity inversion mutants: Receptors that interpret antiestrogens as estrogens and discriminate among different antiestrogens
14. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor
15. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
16. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1
17. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
18. Steroid receptor induction of gene transcription: A two-step model
19. A canonical structure for the ligand-binding domain of nuclear receptors
20. Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor
21. Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer
22. Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor
23. Dimerization characteristics of the DNA- and steroid-binding domains of the androgen receptor
24. Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF
25. Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator
26. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
27. RAC3, a steroid receptor-associated coactivator that is related to SRC-1 and TIF2
28. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
29. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization
30. The human androgen receptor: Domain structure, genomic organization and regulation of expression
31. Synergism between androgens and protein kinase-C on androgen-regulated gene expression
32. Transcriptional regulation of androgen receptor gene expression in Sertoli cells and other cell types
33. Functional domains of the human glucocorticoid receptor
34. Properties of natural and hybrid murine alpha interferons
35. The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens
36. Ligand-induced conformational alterations of the androgen receptor analyzed by limited trypsinization. Studies on the mechanism of antiandrogen action
37. Improved method for high efficiency transformation of intact yeast cells
38. Hormone-induced dissociation of the androgen receptor-heat-shock protein complex: Use of a new monoclonal antibody to distinguish transformed from nontransformed receptors
39. Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor
40. Epitope prediction and confirmation for the human androgen receptor: Generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy