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Volumn 9, Issue MAY, 2018, Pages

Paracrine effects of FGF23 on the heart

Author keywords

Autocrine; Cardiac fibrosis; Cardiac remodeling; Endothelial dysfunction; Fibroblast growth factor 23; Left ventricular hypertrophy; Paracrine

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSINOGEN; C REACTIVE PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 16; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTOR 9; FIBROBLAST GROWTH FACTOR RECEPTOR; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STAT PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

EID: 85047566910     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2018.00278     Document Type: Review
Times cited : (77)

References (112)
  • 1
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • Itoh N, Ornitz DM. Evolution of the Fgf and Fgfr gene families. Trends Genet (2004) 20:563-9. doi: 10.1016/j.tig.2004.08.007
    • (2004) Trends Genet , vol.20 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 2
    • 79251501315 scopus 로고    scopus 로고
    • Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
    • Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem (2011) 149:121-30. doi: 10.1093/jb/mvq121
    • (2011) J Biochem , vol.149 , pp. 121-130
    • Itoh, N.1    Ornitz, D.M.2
  • 3
    • 84926520018 scopus 로고    scopus 로고
    • The fibroblast growth factor signaling pathway
    • Ornitz DM, Itoh N. The fibroblast growth factor signaling pathway. Wiley Interdiscip Rev Dev Biol (2015) 4:215-66. doi: 10.1002/wdev.176
    • (2015) Wiley Interdiscip Rev Dev Biol , vol.4 , pp. 215-266
    • Ornitz, D.M.1    Itoh, N.2
  • 4
    • 84962448787 scopus 로고    scopus 로고
    • Genetic insights into the mechanisms of Fgf signaling
    • Brewer JR, Mazot P, Soriano P. Genetic insights into the mechanisms of Fgf signaling. Genes Dev (2016) 30:751-71. doi: 10.1101/gad.277137.115
    • (2016) Genes Dev , vol.30 , pp. 751-771
    • Brewer, J.R.1    Mazot, P.2    Soriano, P.3
  • 5
    • 85013960868 scopus 로고    scopus 로고
    • Roles of FGF signals in heart development, health, and disease
    • Itoh N, Ohta H, Nakayama Y, Konishi M. Roles of FGF signals in heart development, health, and disease. Front Cell Dev Biol (2016) 4:110. doi: 10.3389/fcell.2016.00110
    • (2016) Front Cell Dev Biol , vol.4 , pp. 110
    • Itoh, N.1    Ohta, H.2    Nakayama, Y.3    Konishi, M.4
  • 6
    • 0028608075 scopus 로고
    • Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
    • Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, et al. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell (1994) 79:1015-24. doi: 10.1016/0092-8674(94)90032-9
    • (1994) Cell , vol.79 , pp. 1015-1024
    • Spivak-Kroizman, T.1    Lemmon, M.A.2    Dikic, I.3    Ladbury, J.E.4    Pinchasi, D.5    Huang, J.6
  • 7
    • 18144423534 scopus 로고    scopus 로고
    • Structural basis for fibroblast growth factor receptor activation
    • Mohammadi M, Olsen SK, Ibrahimi OA. Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev (2005) 16:107-37. doi: 10.1016/j.cytogfr.2005.01.008
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 107-137
    • Mohammadi, M.1    Olsen, S.K.2    Ibrahimi, O.A.3
  • 9
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature (2006) 444:770-4. doi: 10.1038/nature05315
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3    Iijima, K.4    Hasegawa, H.5    Okawa, K.6
  • 10
    • 34247565954 scopus 로고    scopus 로고
    • Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
    • Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol (2007) 27:3417-28. doi: 10.1128/MCB.02249-06
    • (2007) Mol Cell Biol , vol.27 , pp. 3417-3428
    • Goetz, R.1    Beenken, A.2    Ibrahimi, O.A.3    Kalinina, J.4    Olsen, S.K.5    Eliseenkova, A.V.6
  • 11
    • 34547192748 scopus 로고    scopus 로고
    • Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels
    • Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, et al. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron (2007) 55:449-63. doi: 10.1016/j.neuron.2007.07.006
    • (2007) Neuron , vol.55 , pp. 449-463
    • Goldfarb, M.1    Schoorlemmer, J.2    Williams, A.3    Diwakar, S.4    Wang, Q.5    Huang, X.6
  • 12
    • 77957376253 scopus 로고    scopus 로고
    • Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse
    • Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, et al. Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol (2010) 24:2050-64. doi: 10.1210/me.2010-0142
    • (2010) Mol Endocrinol , vol.24 , pp. 2050-2064
    • Fon Tacer, K.1    Bookout, A.L.2    Ding, X.3    Kurosu, H.4    John, G.B.5    Wang, L.6
  • 13
    • 84884536419 scopus 로고    scopus 로고
    • Pathophysiological roles of FGF signaling in the heart
    • Itoh N, Ohta H. Pathophysiological roles of FGF signaling in the heart. Front Physiol (2013) 4:247. doi: 10.3389/fphys.2013.00247
    • (2013) Front Physiol , vol.4 , pp. 247
    • Itoh, N.1    Ohta, H.2
  • 14
    • 33744937606 scopus 로고    scopus 로고
    • Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    • Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem (2006) 281:15694-700. doi: 10.1074/jbc.M601252200
    • (2006) J Biol Chem , vol.281 , pp. 15694-15700
    • Zhang, X.1    Ibrahimi, O.A.2    Olsen, S.K.3    Umemori, H.4    Mohammadi, M.5    Ornitz, D.M.6
  • 15
    • 84875421249 scopus 로고    scopus 로고
    • Exploring mechanisms of FGF signalling through the lens of structural biology
    • Goetz R, Mohammadi M. Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol (2013) 14:166-80. doi: 10.1038/nrm3528
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 166-180
    • Goetz, R.1    Mohammadi, M.2
  • 16
    • 84925456768 scopus 로고    scopus 로고
    • Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction
    • Carter EP, Fearon AE, Grose RP. Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Trends Cell Biol (2015) 25:221-33. doi: 10.1016/j.tcb.2014.11.003
    • (2015) Trends Cell Biol , vol.25 , pp. 221-233
    • Carter, E.P.1    Fearon, A.E.2    Grose, R.P.3
  • 17
    • 2142746439 scopus 로고    scopus 로고
    • FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    • Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res (2004) 19:429-35. doi: 10.1359/JBMR.0301264
    • (2004) J Bone Miner Res , vol.19 , pp. 429-435
    • Shimada, T.1    Hasegawa, H.2    Yamazaki, Y.3    Muto, T.4    Hino, R.5    Takeuchi, Y.6
  • 18
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature (1997) 390:45-51. doi: 10.1038/36285
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1    Matsumura, Y.2    Aizawa, H.3    Kawaguchi, H.4    Suga, T.5    Utsugi, T.6
  • 20
    • 68049085792 scopus 로고    scopus 로고
    • FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    • Gattineni J, Bates C, Twombley K, Dwarakanath V, Robinson ML, Goetz R, et al. FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal Physiol (2009) 297:F282-91. doi: 10.1152/ajprenal.90742.2008
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F282-F291
    • Gattineni, J.1    Bates, C.2    Twombley, K.3    Dwarakanath, V.4    Robinson, M.L.5    Goetz, R.6
  • 22
    • 84859956031 scopus 로고    scopus 로고
    • Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism
    • Quarles LD. Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism. Nat Rev Endocrinol (2012) 8:276-86. doi: 10.1038/nrendo.2011.218
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 276-286
    • Quarles, L.D.1
  • 23
    • 84942194319 scopus 로고    scopus 로고
    • Experimental myocardial infarction upregulates circulating fibroblast growth factor-23
    • Andrukhova O, Slavic S, Odorfer KI, Erben RG. Experimental myocardial infarction upregulates circulating fibroblast growth factor-23. J Bone Miner Res (2015) 30:1831-9. doi: 10.1002/jbmr.2527
    • (2015) J Bone Miner Res , vol.30 , pp. 1831-1839
    • Andrukhova, O.1    Slavic, S.2    Odorfer, K.I.3    Erben, R.G.4
  • 24
    • 84994083573 scopus 로고    scopus 로고
    • FGF23 promotes myocardial fibrosis in mice through activation of beta-catenin
    • Hao H, Li X, Li Q, Lin H, Chen Z, Xie J, et al. FGF23 promotes myocardial fibrosis in mice through activation of beta-catenin. Oncotarget (2016) 7:64649-64. doi: 10.18632/oncotarget.11623
    • (2016) Oncotarget , vol.7 , pp. 64649-64664
    • Hao, H.1    Li, X.2    Li, Q.3    Lin, H.4    Chen, Z.5    Xie, J.6
  • 25
    • 84983740565 scopus 로고    scopus 로고
    • Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease
    • Leifheit-Nestler M, Grosse Siemer R, Flasbart K, Richter B, Kirchhoff F, Ziegler WH, et al. Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease. Nephrol Dial Transplant (2016) 31:1088-99. doi: 10.1093/ndt/gfv421
    • (2016) Nephrol Dial Transplant , vol.31 , pp. 1088-1099
    • Leifheit-Nestler, M.1    Grosse Siemer, R.2    Flasbart, K.3    Richter, B.4    Kirchhoff, F.5    Ziegler, W.H.6
  • 28
    • 84881535981 scopus 로고    scopus 로고
    • Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor
    • Zanchi C, Locatelli M, Benigni A, Corna D, Tomasoni S, Rottoli D, et al. Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor. PLoS One (2013) 8:e70775. doi: 10.1371/journal.pone.0070775
    • (2013) PLoS One , vol.8
    • Zanchi, C.1    Locatelli, M.2    Benigni, A.3    Corna, D.4    Tomasoni, S.5    Rottoli, D.6
  • 29
    • 84901913047 scopus 로고    scopus 로고
    • Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease
    • Spichtig D, Zhang H, Mohebbi N, Pavik I, Petzold K, Stange G, et al. Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease. Kidney Int (2014) 85:1340-50. doi: 10.1038/ki.2013.526
    • (2014) Kidney Int , vol.85 , pp. 1340-1350
    • Spichtig, D.1    Zhang, H.2    Mohebbi, N.3    Pavik, I.4    Petzold, K.5    Stange, G.6
  • 30
    • 85015743972 scopus 로고    scopus 로고
    • Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia
    • Mace ML, Gravesen E, Nordholm A, Hofman-Bang J, Secher T, Olgaard K, et al. Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia. Kidney Int (2017) 92:165-78. doi: 10.1016/j.kint.2017.01.015
    • (2017) Kidney Int , vol.92 , pp. 165-178
    • Mace, M.L.1    Gravesen, E.2    Nordholm, A.3    Hofman-Bang, J.4    Secher, T.5    Olgaard, K.6
  • 31
    • 85020867180 scopus 로고    scopus 로고
    • FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
    • Smith ER, Tan SJ, Holt SG, Hewitson TD. FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts. Sci Rep (2017) 7:3345. doi: 10.1038/s41598-017-02709-w
    • (2017) Sci Rep , vol.7 , pp. 3345
    • Smith, E.R.1    Tan, S.J.2    Holt, S.G.3    Hewitson, T.D.4
  • 32
    • 85043494809 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model
    • Sugiura H, Matsushita A, Futaya M, Teraoka A, Akiyama KI, Usui N, et al. Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model. PLoS One (2018) 13:e0191706. doi: 10.1371/journal.pone.0191706
    • (2018) PLoS One , vol.13
    • Sugiura, H.1    Matsushita, A.2    Futaya, M.3    Teraoka, A.4    Akiyama, K.I.5    Usui, N.6
  • 33
  • 35
    • 49249104701 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    • Gutierrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med (2008) 359:584-92. doi: 10.1056/NEJMoa0706130
    • (2008) N Engl J Med , vol.359 , pp. 584-592
    • Gutierrez, O.M.1    Mannstadt, M.2    Isakova, T.3    Rauh-Hain, J.A.4    Tamez, H.5    Shah, A.6
  • 36
    • 84878487994 scopus 로고    scopus 로고
    • FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy
    • Touchberry CD, Green TM, Tchikrizov V, Mannix JE, Mao TF, Carney BW, et al. FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. Am J Physiol Endocrinol Metab (2013) 304:E863-73. doi: 10.1152/ajpendo.00596.2012
    • (2013) Am J Physiol Endocrinol Metab , vol.304 , pp. E863-E873
    • Touchberry, C.D.1    Green, T.M.2    Tchikrizov, V.3    Mannix, J.E.4    Mao, T.F.5    Carney, B.W.6
  • 37
    • 84945942478 scopus 로고    scopus 로고
    • Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy
    • Grabner A, Amaral AP, Schramm K, Singh S, Sloan A, Yanucil C, et al. Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy. Cell Metab (2015) 22:1020-32. doi: 10.1016/j.cmet.2015.09.002
    • (2015) Cell Metab , vol.22 , pp. 1020-1032
    • Grabner, A.1    Amaral, A.P.2    Schramm, K.3    Singh, S.4    Sloan, A.5    Yanucil, C.6
  • 38
    • 66349097180 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    • Gutierrez OM, Januzzi JL, Isakova T, Laliberte K, Smith K, Collerone G, et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation (2009) 119:2545-52. doi: 10.1161/CIRCULATIONAHA.108.844506
    • (2009) Circulation , vol.119 , pp. 2545-2552
    • Gutierrez, O.M.1    Januzzi, J.L.2    Isakova, T.3    Laliberte, K.4    Smith, K.5    Collerone, G.6
  • 40
    • 77956884451 scopus 로고    scopus 로고
    • FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease
    • Yilmaz MI, Sonmez A, Saglam M, Yaman H, Kilic S, Demirkaya E, et al. FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease. Kidney Int (2010) 78:679-85. doi: 10.1038/ki.2010.194
    • (2010) Kidney Int , vol.78 , pp. 679-685
    • Yilmaz, M.I.1    Sonmez, A.2    Saglam, M.3    Yaman, H.4    Kilic, S.5    Demirkaya, E.6
  • 42
    • 84882238083 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is not associated with and does not induce arterial calcification
    • Scialla JJ, Lau WL, Reilly MP, Isakova T, Yang HY, Crouthamel MH, et al. Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int (2013) 83:1159-68. doi: 10.1038/ki.2013.3
    • (2013) Kidney Int , vol.83 , pp. 1159-1168
    • Scialla, J.J.1    Lau, W.L.2    Reilly, M.P.3    Isakova, T.4    Yang, H.Y.5    Crouthamel, M.H.6
  • 43
    • 84957866830 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is associated with left ventricular hypertrophy, not with uremic vasculopathy in peritoneal dialysis patients
    • Sarmento-Dias M, Santos-Araujo C, Poinhos R, Oliveira B, Silva IS, Silva LS, et al. Fibroblast growth factor 23 is associated with left ventricular hypertrophy, not with uremic vasculopathy in peritoneal dialysis patients. Clin Nephrol (2016) 85:135-41. doi: 10.5414/CN108716
    • (2016) Clin Nephrol , vol.85 , pp. 135-141
    • Sarmento-Dias, M.1    Santos-Araujo, C.2    Poinhos, R.3    Oliveira, B.4    Silva, I.S.5    Silva, L.S.6
  • 45
    • 61849155234 scopus 로고    scopus 로고
    • Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients
    • Hsu HJ, Wu MS. Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients. Am J Med Sci (2009) 337:116-22. doi: 10.1097/MAJ.0b013e3181815498
    • (2009) Am J Med Sci , vol.337 , pp. 116-122
    • Hsu, H.J.1    Wu, M.S.2
  • 46
    • 77956159370 scopus 로고    scopus 로고
    • FGF-23 and future cardiovascular events in patients with chronic kidney disease before initiation of dialysis treatment
    • Seiler S, Reichart B, Roth D, Seibert E, Fliser D, Heine GH. FGF-23 and future cardiovascular events in patients with chronic kidney disease before initiation of dialysis treatment. Nephrol Dial Transplant (2010) 25:3983-9. doi: 10.1093/ndt/gfq309
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 3983-3989
    • Seiler, S.1    Reichart, B.2    Roth, D.3    Seibert, E.4    Fliser, D.5    Heine, G.H.6
  • 47
    • 79958724181 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    • Isakova T, Xie H, Yang W, Xie D, Anderson AH, Scialla J, et al. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA (2011) 305:2432-9. doi: 10.1001/jama.2011.826
    • (2011) JAMA , vol.305 , pp. 2432-2439
    • Isakova, T.1    Xie, H.2    Yang, W.3    Xie, D.4    Anderson, A.H.5    Scialla, J.6
  • 48
    • 79953880208 scopus 로고    scopus 로고
    • Serum fibroblast growth factor-23 (FGF-23) levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients
    • Kirkpantur A, Balci M, Gurbuz OA, Afsar B, Canbakan B, Akdemir R, et al. Serum fibroblast growth factor-23 (FGF-23) levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients. Nephrol Dial Transplant (2011) 26:1346-54. doi: 10.1093/ndt/gfq539
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 1346-1354
    • Kirkpantur, A.1    Balci, M.2    Gurbuz, O.A.3    Afsar, B.4    Canbakan, B.5    Akdemir, R.6
  • 49
    • 70450230670 scopus 로고    scopus 로고
    • Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    • Mirza MA, Larsson A, Melhus H, Lind L, Larsson TE. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis (2009) 207:546-51. doi: 10.1016/j.atherosclerosis.2009.05.013
    • (2009) Atherosclerosis , vol.207 , pp. 546-551
    • Mirza, M.A.1    Larsson, A.2    Melhus, H.3    Lind, L.4    Larsson, T.E.5
  • 50
    • 77952996999 scopus 로고    scopus 로고
    • The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study
    • Parker BD, Schurgers LJ, Brandenburg VM, Christenson RH, Vermeer C, Ketteler M, et al. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann Intern Med (2010) 152:640-8. doi: 10.7326/0003-4819-152-10-201005180-00004
    • (2010) Ann Intern Med , vol.152 , pp. 640-648
    • Parker, B.D.1    Schurgers, L.J.2    Brandenburg, V.M.3    Christenson, R.H.4    Vermeer, C.5    Ketteler, M.6
  • 51
    • 80755172594 scopus 로고    scopus 로고
    • The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation
    • Seiler S, Cremers B, Rebling NM, Hornof F, Jeken J, Kersting S, et al. The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation. Eur Heart J (2011) 32:2688-96. doi: 10.1093/eurheartj/ehr215
    • (2011) Eur Heart J , vol.32 , pp. 2688-2696
    • Seiler, S.1    Cremers, B.2    Rebling, N.M.3    Hornof, F.4    Jeken, J.5    Kersting, S.6
  • 52
    • 84871768555 scopus 로고    scopus 로고
    • Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community
    • Arnlov J, Carlsson AC, Sundstrom J, Ingelsson E, Larsson A, Lind L, et al. Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community. Kidney Int (2013) 83:160-6. doi: 10.1038/ki.2012.327
    • (2013) Kidney Int , vol.83 , pp. 160-166
    • Arnlov, J.1    Carlsson, A.C.2    Sundstrom, J.3    Ingelsson, E.4    Larsson, A.5    Lind, L.6
  • 53
    • 84883287183 scopus 로고    scopus 로고
    • Associations between fibroblast growth factor 23 and cardiac characteristics in pediatric heart failure
    • Isakova T, Houston J, Santacruz L, Schiavenato E, Somarriba G, Harmon WG, et al. Associations between fibroblast growth factor 23 and cardiac characteristics in pediatric heart failure. Pediatr Nephrol (2013) 28:2035-42. doi: 10.1007/s00467-013-2515-7
    • (2013) Pediatr Nephrol , vol.28 , pp. 2035-2042
    • Isakova, T.1    Houston, J.2    Santacruz, L.3    Schiavenato, E.4    Somarriba, G.5    Harmon, W.G.6
  • 54
    • 84883628520 scopus 로고    scopus 로고
    • Association between circulating fibroblast growth factor 23, alpha-klotho, and the left ventricular ejection fraction and left ventricular mass in cardiology inpatients
    • Shibata K, Fujita S, Morita H, Okamoto Y, Sohmiya K, Hoshiga M, et al. Association between circulating fibroblast growth factor 23, alpha-klotho, and the left ventricular ejection fraction and left ventricular mass in cardiology inpatients. PLoS One (2013) 8:e73184. doi: 10.1371/journal.pone.0073184
    • (2013) PLoS One , vol.8
    • Shibata, K.1    Fujita, S.2    Morita, H.3    Okamoto, Y.4    Sohmiya, K.5    Hoshiga, M.6
  • 56
    • 84922393685 scopus 로고    scopus 로고
    • Pathophysiological impact of serum fibroblast growth factor 23 in patients with nonischemic cardiac disease and early chronic kidney disease
    • Imazu M, Takahama H, Asanuma H, Funada A, Sugano Y, Ohara T, et al. Pathophysiological impact of serum fibroblast growth factor 23 in patients with nonischemic cardiac disease and early chronic kidney disease. Am J Physiol Heart Circ Physiol (2014) 307:H1504-11. doi: 10.1152/ajpheart.00331.2014
    • (2014) Am J Physiol Heart Circ Physiol , vol.307 , pp. H1504-H1511
    • Imazu, M.1    Takahama, H.2    Asanuma, H.3    Funada, A.4    Sugano, Y.5    Ohara, T.6
  • 57
    • 84902826865 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 and cardiovascular disease in the general population: the multi-ethnic study of atherosclerosis
    • Kestenbaum B, Sachs MC, Hoofnagle AN, Siscovick DS, Ix JH, Robinson-Cohen C, et al. Fibroblast growth factor-23 and cardiovascular disease in the general population: the multi-ethnic study of atherosclerosis. Circ Heart Fail (2014) 7:409-17. doi: 10.1161/CIRCHEARTFAILURE.113.000952
    • (2014) Circ Heart Fail , vol.7 , pp. 409-417
    • Kestenbaum, B.1    Sachs, M.C.2    Hoofnagle, A.N.3    Siscovick, D.S.4    Ix, J.H.5    Robinson-Cohen, C.6
  • 58
    • 84902142347 scopus 로고    scopus 로고
    • Plasma FGF23 and the risk of stroke: the Northern Manhattan Study (NOMAS)
    • Wright CB, Dong C, Stark M, Silverberg S, Rundek T, Elkind MS, et al. Plasma FGF23 and the risk of stroke: the Northern Manhattan Study (NOMAS). Neurology (2014) 82:1700-6. doi: 10.1212/WNL.0000000000000410
    • (2014) Neurology , vol.82 , pp. 1700-1706
    • Wright, C.B.1    Dong, C.2    Stark, M.3    Silverberg, S.4    Rundek, T.5    Elkind, M.S.6
  • 59
    • 84943418755 scopus 로고    scopus 로고
    • Association of fibroblast growth factor-23 levels and angiotensin-converting enzyme inhibition in chronic systolic heart failure
    • Wohlfahrt P, Melenovsky V, Kotrc M, Benes J, Jabor A, Franekova J, et al. Association of fibroblast growth factor-23 levels and angiotensin-converting enzyme inhibition in chronic systolic heart failure. JACC Heart Fail (2015) 3:829-39. doi: 10.1016/j.jchf.2015.05.012
    • (2015) JACC Heart Fail , vol.3 , pp. 829-839
    • Wohlfahrt, P.1    Melenovsky, V.2    Kotrc, M.3    Benes, J.4    Jabor, A.5    Franekova, J.6
  • 60
    • 84965145976 scopus 로고    scopus 로고
    • Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure
    • Andersen IA, Huntley BK, Sandberg SS, Heublein DM, Burnett JC Jr. Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure. Nephrol Dial Transplant (2016) 31:767-72. doi: 10.1093/ndt/gfv398
    • (2016) Nephrol Dial Transplant , vol.31 , pp. 767-772
    • Andersen, I.A.1    Huntley, B.K.2    Sandberg, S.S.3    Heublein, D.M.4    Burnett, J.C.5
  • 61
    • 84960191962 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is associated with subclinical cerebrovascular damage: the Northern Manhattan Study
    • Wright CB, Shah NH, Mendez AJ, Derosa JT, Yoshita M, Elkind MS, et al. Fibroblast growth factor 23 is associated with subclinical cerebrovascular damage: the Northern Manhattan Study. Stroke (2016) 47:923-8. doi: 10.1161/STROKEAHA.115.012379
    • (2016) Stroke , vol.47 , pp. 923-928
    • Wright, C.B.1    Shah, N.H.2    Mendez, A.J.3    Derosa, J.T.4    Yoshita, M.5    Elkind, M.S.6
  • 62
    • 84862122363 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and the heart
    • Faul C. Fibroblast growth factor 23 and the heart. Curr Opin Nephrol Hypertens (2012) 21:369-75. doi: 10.1097/MNH.0b013e32835422c4
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 369-375
    • Faul, C.1
  • 63
    • 84889875899 scopus 로고    scopus 로고
    • The role of fibroblast growth factor-23 in cardiorenal syndrome
    • Kovesdy CP, Quarles LD. The role of fibroblast growth factor-23 in cardiorenal syndrome. Nephron Clin Pract (2013) 123:194-201. doi: 10.1159/000353593
    • (2013) Nephron Clin Pract , vol.123 , pp. 194-201
    • Kovesdy, C.P.1    Quarles, L.D.2
  • 64
    • 84969262871 scopus 로고    scopus 로고
    • Update on FGF23 and klotho signaling
    • Erben RG. Update on FGF23 and klotho signaling. Mol Cell Endocrinol (2016) 432:56-65. doi: 10.1016/j.mce.2016.05.008
    • (2016) Mol Cell Endocrinol , vol.432 , pp. 56-65
    • Erben, R.G.1
  • 65
    • 84969988387 scopus 로고    scopus 로고
    • The role of fibroblast growth factor 23 and klotho in uremic cardiomyopathy
    • Grabner A, Faul C. The role of fibroblast growth factor 23 and klotho in uremic cardiomyopathy. Curr Opin Nephrol Hypertens (2016) 25:314-24. doi: 10.1097/MNH.0000000000000231
    • (2016) Curr Opin Nephrol Hypertens , vol.25 , pp. 314-324
    • Grabner, A.1    Faul, C.2
  • 66
  • 67
    • 85035076743 scopus 로고    scopus 로고
    • Pleiotropic actions of FGF23
    • Erben RG. Pleiotropic actions of FGF23. Toxicol Pathol (2017) 45:904-10. doi: 10.1177/0192623317737469
    • (2017) Toxicol Pathol , vol.45 , pp. 904-910
    • Erben, R.G.1
  • 68
    • 85002261155 scopus 로고    scopus 로고
    • Cardiac actions of fibroblast growth factor 23
    • Faul C. Cardiac actions of fibroblast growth factor 23. Bone (2017) 100:69-79. doi: 10.1016/j.bone.2016.10.001
    • (2017) Bone , vol.100 , pp. 69-79
    • Faul, C.1
  • 69
    • 84990821404 scopus 로고    scopus 로고
    • Extrarenal effects of FGF23
    • Haffner D, Leifheit-Nestler M. Extrarenal effects of FGF23. Pediatr Nephrol (2017) 32:753-65. doi: 10.1007/s00467-016-3505-3
    • (2017) Pediatr Nephrol , vol.32 , pp. 753-765
    • Haffner, D.1    Leifheit-Nestler, M.2
  • 70
    • 84864579854 scopus 로고    scopus 로고
    • FGF-23: the rise of a novel cardiovascular risk marker in CKD
    • Heine GH, Seiler S, Fliser D. FGF-23: the rise of a novel cardiovascular risk marker in CKD. Nephrol Dial Transplant (2012) 27:3072-81. doi: 10.1093/ndt/gfs259
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 3072-3081
    • Heine, G.H.1    Seiler, S.2    Fliser, D.3
  • 71
    • 85047687476 scopus 로고    scopus 로고
    • Roles of phosphate and fibroblast growth factor 23 in cardiovascular disease
    • Scialla JJ, Wolf M. Roles of phosphate and fibroblast growth factor 23 in cardiovascular disease. Nat Rev Nephrol (2014) 10:268-78. doi: 10.1038/nrneph.2014.49
    • (2014) Nat Rev Nephrol , vol.10 , pp. 268-278
    • Scialla, J.J.1    Wolf, M.2
  • 72
    • 84978732056 scopus 로고    scopus 로고
    • Association between FGF23, alpha-klotho, and cardiac abnormalities among patients with various chronic kidney disease stages
    • Tanaka S, Fujita S, Kizawa S, Morita H, Ishizaka N. Association between FGF23, alpha-klotho, and cardiac abnormalities among patients with various chronic kidney disease stages. PLoS One (2016) 11:e0156860. doi: 10.1371/journal.pone.0156860
    • (2016) PLoS One , vol.11
    • Tanaka, S.1    Fujita, S.2    Kizawa, S.3    Morita, H.4    Ishizaka, N.5
  • 73
    • 14344279878 scopus 로고    scopus 로고
    • Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
    • Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, Takeda S, et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A (2001) 98:6500-5. doi: 10.1073/pnas.101545198
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6500-6505
    • Shimada, T.1    Mizutani, S.2    Muto, T.3    Yoneya, T.4    Hino, R.5    Takeda, S.6
  • 74
    • 33644878033 scopus 로고    scopus 로고
    • Acute heart failure syndromes: current state and framework for future research
    • Gheorghiade M, Zannad F, Sopko G, Klein L, Pina IL, Konstam MA, et al. Acute heart failure syndromes: current state and framework for future research. Circulation (2005) 112:3958-68. doi: 10.1161/CIRCULATIONAHA.105.590091
    • (2005) Circulation , vol.112 , pp. 3958-3968
    • Gheorghiade, M.1    Zannad, F.2    Sopko, G.3    Klein, L.4    Pina, I.L.5    Konstam, M.A.6
  • 75
    • 85029280785 scopus 로고    scopus 로고
    • Genetic ablation of Fgf23 or klotho does not modulate experimental heart hypertrophy induced by pressure overload
    • Slavic S, Ford K, Modert M, Becirovic A, Handschuh S, Baierl A, et al. Genetic ablation of Fgf23 or klotho does not modulate experimental heart hypertrophy induced by pressure overload. Sci Rep (2017) 7:11298. doi: 10.1038/s41598-017-10140-4
    • (2017) Sci Rep , vol.7 , pp. 11298
    • Slavic, S.1    Ford, K.2    Modert, M.3    Becirovic, A.4    Handschuh, S.5    Baierl, A.6
  • 77
    • 74049114704 scopus 로고    scopus 로고
    • Intramyocardial fibroblast myocyte communication
    • Kakkar R, Lee RT. Intramyocardial fibroblast myocyte communication. Circ Res (2010) 106:47-57. doi: 10.1161/CIRCRESAHA.109.207456
    • (2010) Circ Res , vol.106 , pp. 47-57
    • Kakkar, R.1    Lee, R.T.2
  • 78
    • 0032748024 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 mediates pressure-induced hypertrophic response
    • Schultz JE, Witt SA, Nieman ML, Reiser PJ, Engle SJ, Zhou M, et al. Fibroblast growth factor-2 mediates pressure-induced hypertrophic response. J Clin Invest (1999) 104:709-19. doi: 10.1172/JCI7315
    • (1999) J Clin Invest , vol.104 , pp. 709-719
    • Schultz, J.E.1    Witt, S.A.2    Nieman, M.L.3    Reiser, P.J.4    Engle, S.J.5    Zhou, M.6
  • 79
    • 33845647351 scopus 로고    scopus 로고
    • High-but not low-molecular weight FGF-2 causes cardiac hypertrophy in vivo; possible involvement of cardiotrophin-1
    • Jiang ZS, Jeyaraman M, Wen GB, Fandrich RR, Dixon IM, Cattini PA, et al. High-but not low-molecular weight FGF-2 causes cardiac hypertrophy in vivo; possible involvement of cardiotrophin-1. J Mol Cell Cardiol (2007) 42:222-33. doi: 10.1016/j.yjmcc.2006.09.002
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 222-233
    • Jiang, Z.S.1    Jeyaraman, M.2    Wen, G.B.3    Fandrich, R.R.4    Dixon, I.M.5    Cattini, P.A.6
  • 80
    • 77449129443 scopus 로고    scopus 로고
    • Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and klotho
    • Xiao L, Naganawa T, Lorenzo J, Carpenter TO, Coffin JD, Hurley MM. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and klotho. J Biol Chem (2010) 285:2834-46. doi: 10.1074/jbc.M109.030577
    • (2010) J Biol Chem , vol.285 , pp. 2834-2846
    • Xiao, L.1    Naganawa, T.2    Lorenzo, J.3    Carpenter, T.O.4    Coffin, J.D.5    Hurley, M.M.6
  • 81
    • 84872874858 scopus 로고    scopus 로고
    • Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro
    • Xiao L, Esliger A, Hurley MM. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res (2013) 28:35-45. doi: 10.1002/jbmr.1721
    • (2013) J Bone Miner Res , vol.28 , pp. 35-45
    • Xiao, L.1    Esliger, A.2    Hurley, M.M.3
  • 82
    • 84866127175 scopus 로고    scopus 로고
    • A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model
    • Dai B, David V, Martin A, Huang J, Li H, Jiao Y, et al. A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model. PLoS One (2012) 7:e44161. doi: 10.1371/journal.pone.0044161
    • (2012) PLoS One , vol.7
    • Dai, B.1    David, V.2    Martin, A.3    Huang, J.4    Li, H.5    Jiao, Y.6
  • 83
    • 84877090354 scopus 로고    scopus 로고
    • Loss of klotho contributes to kidney injury by derepression of Wnt/beta-catenin signaling
    • Zhou L, Li Y, Zhou D, Tan RJ, Liu Y. Loss of klotho contributes to kidney injury by derepression of Wnt/beta-catenin signaling. J Am Soc Nephrol (2013) 24:771-85. doi: 10.1681/ASN.2012080865
    • (2013) J Am Soc Nephrol , vol.24 , pp. 771-785
    • Zhou, L.1    Li, Y.2    Zhou, D.3    Tan, R.J.4    Liu, Y.5
  • 84
    • 85029719844 scopus 로고    scopus 로고
    • FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-beta autoinduction
    • Smith ER, Holt SG, Hewitson TD. FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-beta autoinduction. Int J Biochem Cell Biol (2017) 92:63-78. doi: 10.1016/j.biocel.2017.09.009
    • (2017) Int J Biochem Cell Biol , vol.92 , pp. 63-78
    • Smith, E.R.1    Holt, S.G.2    Hewitson, T.D.3
  • 85
    • 82955232388 scopus 로고    scopus 로고
    • beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target
    • Lam AP, Gottardi CJ. beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol (2011) 23:562-7. doi: 10.1097/BOR.0b013e32834b3309
    • (2011) Curr Opin Rheumatol , vol.23 , pp. 562-567
    • Lam, A.P.1    Gottardi, C.J.2
  • 86
    • 84868650760 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: a promising new target for fibrosis diseases
    • Guo Y, Xiao L, Sun L, Liu F. Wnt/beta-catenin signaling: a promising new target for fibrosis diseases. Physiol Res (2012) 61:337-46
    • (2012) Physiol Res , vol.61 , pp. 337-346
    • Guo, Y.1    Xiao, L.2    Sun, L.3    Liu, F.4
  • 87
    • 85048717712 scopus 로고    scopus 로고
    • FGF23 is induced by activated renin-angiotensin-aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts
    • Leifheit-Nestler M, Kirchhoff F, Nespor J, Richter B, Soetje B, Klintschar M, et al. FGF23 is induced by activated renin-angiotensin-aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts. Nephrol Dial Transplant (2018). doi: 10.1093/ndt/gfy006
    • (2018) Nephrol Dial Transplant
    • Leifheit-Nestler, M.1    Kirchhoff, F.2    Nespor, J.3    Richter, B.4    Soetje, B.5    Klintschar, M.6
  • 88
    • 67650892239 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community
    • Mirza MA, Larsson A, Lind L, Larsson TE. Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community. Atherosclerosis (2009) 205:385-90. doi: 10.1016/j.atherosclerosis.2009.01.001
    • (2009) Atherosclerosis , vol.205 , pp. 385-390
    • Mirza, M.A.1    Larsson, A.2    Lind, L.3    Larsson, T.E.4
  • 89
    • 77951726222 scopus 로고    scopus 로고
    • Fibroblast growth factor (FGF)-23 and fetuin-A in calcified carotid atheroma
    • Voigt M, Fischer DC, Rimpau M, Schareck W, Haffner D. Fibroblast growth factor (FGF)-23 and fetuin-A in calcified carotid atheroma. Histopathology (2010) 56:775-88. doi: 10.1111/j.1365-2559.2010.03547.x
    • (2010) Histopathology , vol.56 , pp. 775-788
    • Voigt, M.1    Fischer, D.C.2    Rimpau, M.3    Schareck, W.4    Haffner, D.5
  • 91
    • 84979633752 scopus 로고    scopus 로고
    • Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells
    • Richter B, Haller J, Haffner D, Leifheit-Nestler M. Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells. Pflugers Arch (2016) 468:1621-35. doi: 10.1007/s00424-016-1858-x
    • (2016) Pflugers Arch , vol.468 , pp. 1621-1635
    • Richter, B.1    Haller, J.2    Haffner, D.3    Leifheit-Nestler, M.4
  • 92
    • 84929378196 scopus 로고    scopus 로고
    • Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling
    • Frieler RA, Mortensen RM. Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling. Circulation (2015) 131:1019-30. doi: 10.1161/CIRCULATIONAHA.114.008788
    • (2015) Circulation , vol.131 , pp. 1019-1030
    • Frieler, R.A.1    Mortensen, R.M.2
  • 94
    • 84979011044 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease
    • Singh S, Grabner A, Yanucil C, Schramm K, Czaya B, Krick S, et al. Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease. Kidney Int (2016) 90:985-96. doi: 10.1016/j.kint.2016.05.019
    • (2016) Kidney Int , vol.90 , pp. 985-996
    • Singh, S.1    Grabner, A.2    Yanucil, C.3    Schramm, K.4    Czaya, B.5    Krick, S.6
  • 95
    • 84941997451 scopus 로고    scopus 로고
    • Chronic sustained inflammation links to left ventricular hypertrophy and aortic valve sclerosis: a new link between S100/RAGE and FGF23
    • Yan L, Bowman MA. Chronic sustained inflammation links to left ventricular hypertrophy and aortic valve sclerosis: a new link between S100/RAGE and FGF23. Inflamm Cell Signal (2014) 1:e279. doi: 10.14800/ics.279
    • (2014) Inflamm Cell Signal , vol.1
    • Yan, L.1    Bowman, M.A.2
  • 97
    • 80755156297 scopus 로고    scopus 로고
    • Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling
    • Kubin T, Poling J, Kostin S, Gajawada P, Hein S, Rees W, et al. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell (2011) 9:420-32. doi: 10.1016/j.stem.2011.08.013
    • (2011) Cell Stem Cell , vol.9 , pp. 420-432
    • Kubin, T.1    Poling, J.2    Kostin, S.3    Gajawada, P.4    Hein, S.5    Rees, W.6
  • 98
    • 0033673312 scopus 로고    scopus 로고
    • Oncostatin M activates stat DNA binding and transcriptional activity in primary human fetal astrocytes: low-and high-passage cells have distinct patterns of stat activation
    • Schaefer LK, Wang S, Schaefer TS. Oncostatin M activates stat DNA binding and transcriptional activity in primary human fetal astrocytes: low-and high-passage cells have distinct patterns of stat activation. Cytokine (2000) 12:1647-55. doi: 10.1006/cyto.2000.0774
    • (2000) Cytokine , vol.12 , pp. 1647-1655
    • Schaefer, L.K.1    Wang, S.2    Schaefer, T.S.3
  • 99
    • 0033929853 scopus 로고    scopus 로고
    • Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38
    • Van Wagoner NJ, Choi C, Repovic P, Benveniste EN. Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38. J Neurochem (2000) 75:563-75. doi: 10.1046/j.1471-4159.2000.0750563.x
    • (2000) J Neurochem , vol.75 , pp. 563-575
    • Van Wagoner, N.J.1    Choi, C.2    Repovic, P.3    Benveniste, E.N.4
  • 100
    • 38749092254 scopus 로고    scopus 로고
    • Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis
    • Arita K, South AP, Hans-Filho G, Sakuma TH, Lai-Cheong J, Clements S, et al. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet (2008) 82:73-80. doi: 10.1016/j.ajhg.2007.09.002
    • (2008) Am J Hum Genet , vol.82 , pp. 73-80
    • Arita, K.1    South, A.P.2    Hans-Filho, G.3    Sakuma, T.H.4    Lai-Cheong, J.5    Clements, S.6
  • 102
    • 84938929605 scopus 로고    scopus 로고
    • The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation
    • Richter M, Lautze HJ, Walther T, Braun T, Kostin S, Kubin T. The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation. J Heart Lung Transplant (2015) 34:1211-4. doi: 10.1016/j.healun.2015.06.007
    • (2015) J Heart Lung Transplant , vol.34 , pp. 1211-1214
    • Richter, M.1    Lautze, H.J.2    Walther, T.3    Braun, T.4    Kostin, S.5    Kubin, T.6
  • 103
    • 84955557590 scopus 로고    scopus 로고
    • Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages
    • Han X, Li L, Yang J, King G, Xiao Z, Quarles LD. Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages. FEBS Lett (2016) 590:53-67. doi: 10.1002/1873-3468.12040
    • (2016) FEBS Lett , vol.590 , pp. 53-67
    • Han, X.1    Li, L.2    Yang, J.3    King, G.4    Xiao, Z.5    Quarles, L.D.6
  • 104
    • 84958962587 scopus 로고    scopus 로고
    • Enhanced FGF23 production in mice expressing PI3K-insensitive GSK3 is normalized by beta-blocker treatment
    • Fajol A, Chen H, Umbach AT, Quarles LD, Lang F, Foller M. Enhanced FGF23 production in mice expressing PI3K-insensitive GSK3 is normalized by beta-blocker treatment. FASEB J (2016) 30:994-1001. doi: 10.1096/fj.15-279943
    • (2016) FASEB J , vol.30 , pp. 994-1001
    • Fajol, A.1    Chen, H.2    Umbach, A.T.3    Quarles, L.D.4    Lang, F.5    Foller, M.6
  • 105
    • 84863550146 scopus 로고    scopus 로고
    • FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality
    • Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, et al. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest (2012) 122:2543-53. doi: 10.1172/JCI61405
    • (2012) J Clin Invest , vol.122 , pp. 2543-2553
    • Shalhoub, V.1    Shatzen, E.M.2    Ward, S.C.3    Davis, J.4    Stevens, J.5    Bi, V.6
  • 106
    • 84902287981 scopus 로고    scopus 로고
    • Anti-fibroblast growth factor 23 antibody therapy
    • Fukumoto S. Anti-fibroblast growth factor 23 antibody therapy. Curr Opin Nephrol Hypertens (2014) 23:346-51. doi: 10.1097/01.mnh.0000447012.98357.da
    • (2014) Curr Opin Nephrol Hypertens , vol.23 , pp. 346-351
    • Fukumoto, S.1
  • 107
    • 84995785776 scopus 로고    scopus 로고
    • Therapeutics targeting FGF signaling network in human diseases
    • Katoh M. Therapeutics targeting FGF signaling network in human diseases. Trends Pharmacol Sci (2016) 37:1081-96. doi: 10.1016/j.tips.2016.10.003
    • (2016) Trends Pharmacol Sci , vol.37 , pp. 1081-1096
    • Katoh, M.1
  • 108
    • 84902107350 scopus 로고    scopus 로고
    • Fibroblast growth factor-23, cardiovascular prognosis, and benefit of angiotensin-converting enzyme inhibition in stable ischemic heart disease
    • Udell JA, Morrow DA, Jarolim P, Sloan S, Hoffman EB, O'donnell TF, et al. Fibroblast growth factor-23, cardiovascular prognosis, and benefit of angiotensin-converting enzyme inhibition in stable ischemic heart disease. J Am Coll Cardiol (2014) 63:2421-8. doi: 10.1016/j.jacc.2014.03.026
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2421-2428
    • Udell, J.A.1    Morrow, D.A.2    Jarolim, P.3    Sloan, S.4    Hoffman, E.B.5    O'donnell, T.F.6
  • 109
    • 85039949075 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure
    • Ter Maaten JM, Voors AA, Damman K, Van Der Meer P, Anker SD, Cleland JG, et al. Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure. Int J Cardiol (2018) 253:84-90. doi: 10.1016/j.ijcard.2017.10.010
    • (2018) Int J Cardiol , vol.253 , pp. 84-90
    • Ter Maaten, J.M.1    Voors, A.A.2    Damman, K.3    Van Der Meer, P.4    Anker, S.D.5    Cleland, J.G.6
  • 110
    • 84921614751 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and the antiproteinuric response to dietary sodium restriction during renin-angiotensin-aldosterone system blockade
    • Humalda JK, Lambers Heerspink HJ, Kwakernaak AJ, Slagman MC, Waanders F, Vervloet MG, et al. Fibroblast growth factor 23 and the antiproteinuric response to dietary sodium restriction during renin-angiotensin-aldosterone system blockade. Am J Kidney Dis (2015) 65:259-66. doi: 10.1053/j.ajkd.2014.07.022
    • (2015) Am J Kidney Dis , vol.65 , pp. 259-266
    • Humalda, J.K.1    Lambers Heerspink, H.J.2    Kwakernaak, A.J.3    Slagman, M.C.4    Waanders, F.5    Vervloet, M.G.6
  • 111
    • 84902250298 scopus 로고    scopus 로고
    • Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease
    • Wolf M, White KE. Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease. Curr Opin Nephrol Hypertens (2014) 23:411-9. doi: 10.1097/01.mnh.0000447020.74593.6f
    • (2014) Curr Opin Nephrol Hypertens , vol.23 , pp. 411-419
    • Wolf, M.1    White, K.E.2
  • 112
    • 84954448498 scopus 로고    scopus 로고
    • Normal 25-hydroxyvitamin D levels are associated with less proteinuria and attenuate renal failure progression in children with CKD
    • Shroff R, Aitkenhead H, Costa N, Trivelli A, Litwin M, Picca S, et al. Normal 25-hydroxyvitamin D levels are associated with less proteinuria and attenuate renal failure progression in children with CKD. J Am Soc Nephrol (2016) 27:314-22. doi: 10.1681/ASN.2014090947
    • (2016) J Am Soc Nephrol , vol.27 , pp. 314-322
    • Shroff, R.1    Aitkenhead, H.2    Costa, N.3    Trivelli, A.4    Litwin, M.5    Picca, S.6


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