Oncostatin M activates stat DNA binding and transcriptional activity in primary human fetal astrocytes: Low- and high-passage cells have distinct patterns of stat activation

Cytokine

Volumn 12, Issue 11, 2000, Pages 1647-1655

  Schaefer, Laura K ^a   Wang, Shuguang ^a   Schaefer, Timothy S ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Astrocyte; Cytokine; JAK; Oncostatin M; Stat; Transcription

Indexed keywords

ALPHA 2 MACROGLOBULIN; BETA GALACTOSIDASE; CHLORAMPHENICOL ACETYLTRANSFERASE; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; DNA; GLYCOPROTEIN GP 130; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; ONCOSTATIN M; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN;

ARTICLE; ASTROCYTE; DNA PROTEIN COMPLEX; DNA TRANSCRIPTION; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; REPORTER GENE;

EID: 0033673312     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2000.0774     Document Type: Article

References (32)

1. Oncostatin M: A growth regulator produced by differentiated histiocytic lymphoma cells
2. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp 130-mediated signaling pathway
3. An interleukin-4-induced transcription factor: IL-4 stat
4. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation
5. Stat3 and Stat4: Members of the family of signal transducers and activators of transcription
6. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
7. Activation and association of Stat3 with Src in v-Src-transformed cell lines
8. Stat3 activation by Src induces specific gene regulation and is required for cell transformation
9. Stat3 activation is required for cellular transformation by v-src
10. Expression of signal transducers and activators of transcription proteins in acute leukaemia blasts
11. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
12. Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells
13. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
14. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
15. Transcriptional activation of the p21 (WAF1, CIP1, SDI1) gene by interleukin-6 type cytokines
16. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
17. Association of Stat-dependent transcriptionla activation of P19INK4D with IL-6-induced growth arrest
18. STAT3 is required for the gp 130-mediated full activation of the c-myc gene
19. Inhibition of growth and induction of differentiation of glioma cell lines by oncostatin M (OSM)
20. Growth inhibition of newly established human glioma cell lines by leukaemia inhibitory factor
21. Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA
22. Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alphal-antichymotrypsin expression in human cortical astrocytes
23. Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro
24. Expression of the alpha 2-macroglobulin-encoding gene in rat brain and cultured astrocytes
25. Activation of Stat3 and Stat1 DNA binding and transcriptional activity in human brain tumor cell lines by gp 130 cytokines
26. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
27. Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
28. STAT3 activation is a critical step in gp 130-mediated terminal differentiation and growth arrest of a myeloid cell line
29. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
30. Functional differences between Stat3alpha and Stat3beta
31. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection