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Volumn 432, Issue , 2016, Pages 56-65

Update on FGF23 and Klotho signaling

Author keywords

Bone; FGF23; Fibroblast growth factor 23; Kidney; Klotho; Parathyroid gland

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; GLYCOSIDASE; KLOTHO PROTEIN; RECEPTOR; BETA GLUCURONIDASE; FIBROBLAST GROWTH FACTOR;

EID: 84969262871     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2016.05.008     Document Type: Article
Times cited : (91)

References (121)
  • 1
    • 84864781443 scopus 로고    scopus 로고
    • FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway
    • Andrukhova, O., Zeitz, U., Goetz, R., Mohammadi, M., Lanske, B., Erben, R.G., FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway. Bone 51 (2012), 621–628.
    • (2012) Bone , vol.51 , pp. 621-628
    • Andrukhova, O.1    Zeitz, U.2    Goetz, R.3    Mohammadi, M.4    Lanske, B.5    Erben, R.G.6
  • 5
    • 84942194319 scopus 로고    scopus 로고
    • Experimental myocardial infarction upregulates circulating fibroblast growth factor-23
    • Andrukhova, O., Slavic, S., Odorfer, K.I., Erben, R.G., Experimental myocardial infarction upregulates circulating fibroblast growth factor-23. J. Bone Min. Res. 30 (2015), 1831–1839.
    • (2015) J. Bone Min. Res. , vol.30 , pp. 1831-1839
    • Andrukhova, O.1    Slavic, S.2    Odorfer, K.I.3    Erben, R.G.4
  • 6
    • 84856530695 scopus 로고    scopus 로고
    • Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo
    • Anour, R., Andrukhova, O., Ritter, E., Zeitz, U., Erben, R.G., Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo. PLoS One, 7, 2012, e31376.
    • (2012) PLoS One , vol.7 , pp. e31376
    • Anour, R.1    Andrukhova, O.2    Ritter, E.3    Zeitz, U.4    Erben, R.G.5
  • 8
    • 84930917948 scopus 로고    scopus 로고
    • Revisiting the NaCl cotransporter regulation by with No-lysine kinases
    • Bazua-Valenti, S., Gamba, G., Revisiting the NaCl cotransporter regulation by with No-lysine kinases. Am. J. Physiol. Cell Physiol. 308 (2015), C779–C791.
    • (2015) Am. J. Physiol. Cell Physiol. , vol.308 , pp. C779-C791
    • Bazua-Valenti, S.1    Gamba, G.2
  • 11
    • 84887485721 scopus 로고    scopus 로고
    • Deliberate total parathyroidectomy: a potentially novel therapy for tumor-induced hypophosphatemic osteomalacia
    • Bhadada, S.K., Palnitkar, S., Qiu, S., Parikh, N., Talpos, G.B., Rao, S.D., Deliberate total parathyroidectomy: a potentially novel therapy for tumor-induced hypophosphatemic osteomalacia. J. Clin. Endocrinol. Metab. 98 (2013), 4273–4278.
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 4273-4278
    • Bhadada, S.K.1    Palnitkar, S.2    Qiu, S.3    Parikh, N.4    Talpos, G.B.5    Rao, S.D.6
  • 16
    • 77949898754 scopus 로고    scopus 로고
    • WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C
    • Cha, S.K., Huang, C.L., WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C. J. Biol. Chem. 285 (2010), 6604–6611.
    • (2010) J. Biol. Chem. , vol.285 , pp. 6604-6611
    • Cha, S.K.1    Huang, C.L.2
  • 17
    • 47749148805 scopus 로고    scopus 로고
    • Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
    • Cha, S.K., Ortega, B., Kurosu, H., Rosenblatt, K.P., Kuro, O., Huang, C.L., Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 9805–9810.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 9805-9810
    • Cha, S.K.1    Ortega, B.2    Kurosu, H.3    Rosenblatt, K.P.4    Kuro, O.5    Huang, C.L.6
  • 20
    • 84960155963 scopus 로고    scopus 로고
    • Conditional deletion of murine Fgf23: interruption of the normal skeletal responses to phosphate challenge and rescue of genetic hypophosphatemia
    • (in press)
    • Clinkenbeard, E.L., Cass, T.A., Ni, P., Hum, J.M., Bellido, T., Allen, M.R., White, K.E., Conditional deletion of murine Fgf23: interruption of the normal skeletal responses to phosphate challenge and rescue of genetic hypophosphatemia. J. Bone Min. Res., 2016 (in press).
    • (2016) J. Bone Min. Res.
    • Clinkenbeard, E.L.1    Cass, T.A.2    Ni, P.3    Hum, J.M.4    Bellido, T.5    Allen, M.R.6    White, K.E.7
  • 23
    • 34248522825 scopus 로고    scopus 로고
    • Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community
    • Dhingra, R., Sullivan, L.M., Fox, C.S., Wang, T.J., D'Agostino, R.B. Sr., Gaziano, J.M., Vasan, R.S., Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch. Intern. Med. 167 (2007), 879–885.
    • (2007) Arch. Intern. Med. , vol.167 , pp. 879-885
    • Dhingra, R.1    Sullivan, L.M.2    Fox, C.S.3    Wang, T.J.4    D'Agostino, R.B.5    Gaziano, J.M.6    Vasan, R.S.7
  • 24
    • 84959343944 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and parathyroid hormone predict extent of aortic valve calcifications in patients with mild to moderate chronic kidney disease
    • Di Lullo, L., Gorini, A., Bellasi, A., Morrone, L.F., Rivera, R., Russo, L., Santoboni, A., Russo, D., Fibroblast growth factor 23 and parathyroid hormone predict extent of aortic valve calcifications in patients with mild to moderate chronic kidney disease. Clin. Kidney J. 8 (2015), 732–736.
    • (2015) Clin. Kidney J. , vol.8 , pp. 732-736
    • Di Lullo, L.1    Gorini, A.2    Bellasi, A.3    Morrone, L.F.4    Rivera, R.5    Russo, L.6    Santoboni, A.7    Russo, D.8
  • 27
    • 65649103814 scopus 로고    scopus 로고
    • Initial FGF23-mediated signaling occurs in the distal convoluted tubule
    • Farrow, E.G., Davis, S.I., Summers, L.J., White, K.E., Initial FGF23-mediated signaling occurs in the distal convoluted tubule. J. Am. Soc. Nephrol. 20 (2009), 955–960.
    • (2009) J. Am. Soc. Nephrol. , vol.20 , pp. 955-960
    • Farrow, E.G.1    Davis, S.I.2    Summers, L.J.3    White, K.E.4
  • 30
    • 74449094013 scopus 로고    scopus 로고
    • Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
    • Galitzer, H., Ben Dov, I.Z., Silver, J., Naveh-Many, T., Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int. 77 (2010), 211–218.
    • (2010) Kidney Int. , vol.77 , pp. 211-218
    • Galitzer, H.1    Ben Dov, I.Z.2    Silver, J.3    Naveh-Many, T.4
  • 37
    • 84959020477 scopus 로고    scopus 로고
    • Conditional deletion of Fgfr1 in the proximal and distal tubule identifies distinct roles in phosphate and calcium transport
    • Han, X., Yang, J., Li, L., Huang, J., King, G., Quarles, L.D., Conditional deletion of Fgfr1 in the proximal and distal tubule identifies distinct roles in phosphate and calcium transport. PLoS One, 11, 2016, e0147845.
    • (2016) PLoS One , vol.11 , pp. e0147845
    • Han, X.1    Yang, J.2    Li, L.3    Huang, J.4    King, G.5    Quarles, L.D.6
  • 38
    • 33846566785 scopus 로고    scopus 로고
    • Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice
    • Hesse, M., Frohlich, L.F., Zeitz, U., Lanske, B., Erben, R.G., Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice. Matrix Biol. 26 (2007), 75–84.
    • (2007) Matrix Biol. , vol.26 , pp. 75-84
    • Hesse, M.1    Frohlich, L.F.2    Zeitz, U.3    Lanske, B.4    Erben, R.G.5
  • 42
    • 66649090939 scopus 로고    scopus 로고
    • Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression
    • Ichikawa, S., Sorenson, A.H., Austin, A.M., Mackenzie, D.S., Fritz, T.A., Moh, A., Hui, S.L., Econs, M.J., Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. Endocrinology 150 (2009), 2543–2550.
    • (2009) Endocrinology , vol.150 , pp. 2543-2550
    • Ichikawa, S.1    Sorenson, A.H.2    Austin, A.M.3    Mackenzie, D.S.4    Fritz, T.A.5    Moh, A.6    Hui, S.L.7    Econs, M.J.8
  • 46
    • 33846884647 scopus 로고    scopus 로고
    • WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4
    • Jiang, Y., Ferguson, W.B., Peng, J.B., WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Am. J. Physiol. Ren. Physiol. 292 (2007), F545–F554.
    • (2007) Am. J. Physiol. Ren. Physiol. , vol.292 , pp. F545-F554
    • Jiang, Y.1    Ferguson, W.B.2    Peng, J.B.3
  • 49
    • 79958735303 scopus 로고    scopus 로고
    • Phosphate and FGF-23
    • Juppner, H., Phosphate and FGF-23. Kidney Int.(Suppl.), 2011, S24–S27.
    • (2011) Kidney Int. , Issue.Suppl. , pp. S24-S27
    • Juppner, H.1
  • 50
    • 77957668094 scopus 로고    scopus 로고
    • FGF-23: more than a regulator of renal phosphate handling?
    • Juppner, H., Wolf, M., Salusky, I.B., FGF-23: more than a regulator of renal phosphate handling?. J. Bone Min. Res. 25 (2010), 2091–2097.
    • (2010) J. Bone Min. Res. , vol.25 , pp. 2091-2097
    • Juppner, H.1    Wolf, M.2    Salusky, I.B.3
  • 51
    • 84944529419 scopus 로고    scopus 로고
    • FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes
    • Kaneko, I., Saini, R.K., Griffin, K.P., Whitfield, G.K., Haussler, M.R., Jurutka, P.W., FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes. J. Endocrinol. 226 (2015), 155–166.
    • (2015) J. Endocrinol. , vol.226 , pp. 155-166
    • Kaneko, I.1    Saini, R.K.2    Griffin, K.P.3    Whitfield, G.K.4    Haussler, M.R.5    Jurutka, P.W.6
  • 56
    • 78049481921 scopus 로고    scopus 로고
    • Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
    • Krajisnik, T., Olauson, H., Mirza, M.A., Hellman, P., Akerstrom, G., Westin, G., Larsson, T.E., Bjorklund, P., Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients. Kidney Int. 78 (2010), 1024–1032.
    • (2010) Kidney Int. , vol.78 , pp. 1024-1032
    • Krajisnik, T.1    Olauson, H.2    Mirza, M.A.3    Hellman, P.4    Akerstrom, G.5    Westin, G.6    Larsson, T.E.7    Bjorklund, P.8
  • 57
    • 84890807103 scopus 로고    scopus 로고
    • Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism
    • Kuro-o, M., Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. Nat. Rev. Nephrol. 9 (2013), 650–660.
    • (2013) Nat. Rev. Nephrol. , vol.9 , pp. 650-660
    • Kuro-o, M.1
  • 61
    • 32544451956 scopus 로고    scopus 로고
    • Coordinated control of renal Ca2+ handling
    • Lambers, T.T., Bindels, R.J., Hoenderop, J.G., Coordinated control of renal Ca2+ handling. Kidney Int. 69 (2006), 650–654.
    • (2006) Kidney Int. , vol.69 , pp. 650-654
    • Lambers, T.T.1    Bindels, R.J.2    Hoenderop, J.G.3
  • 62
    • 3042634460 scopus 로고    scopus 로고
    • Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
    • Larsson, T., Marsell, R., Schipani, E., Ohlsson, C., Ljunggren, O., Tenenhouse, H.S., Juppner, H., Jonsson, K.B., Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145 (2004), 3087–3094.
    • (2004) Endocrinology , vol.145 , pp. 3087-3094
    • Larsson, T.1    Marsell, R.2    Schipani, E.3    Ohlsson, C.4    Ljunggren, O.5    Tenenhouse, H.S.6    Juppner, H.7    Jonsson, K.B.8
  • 63
    • 77958475282 scopus 로고    scopus 로고
    • Does blockade of the Renin-Angiotensin-aldosterone system slow progression of all forms of kidney disease?
    • Lattanzio, M.R., Weir, M.R., Does blockade of the Renin-Angiotensin-aldosterone system slow progression of all forms of kidney disease?. Curr. Hypertens. Rep. 12 (2010), 369–377.
    • (2010) Curr. Hypertens. Rep. , vol.12 , pp. 369-377
    • Lattanzio, M.R.1    Weir, M.R.2
  • 65
    • 13844318061 scopus 로고    scopus 로고
    • Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice
    • Li, S.A., Watanabe, M., Yamada, H., Nagai, A., Kinuta, M., Takei, K., Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct. Funct. 29 (2004), 91–99.
    • (2004) Cell Struct. Funct. , vol.29 , pp. 91-99
    • Li, S.A.1    Watanabe, M.2    Yamada, H.3    Nagai, A.4    Kinuta, M.5    Takei, K.6
  • 66
    • 79952161016 scopus 로고    scopus 로고
    • Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype
    • Li, H., Martin, A., David, V., Quarles, L.D., Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype. Am. J. Physiol. Endocrinol. Metab. 300 (2011), E508–E517.
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.300 , pp. E508-E517
    • Li, H.1    Martin, A.2    David, V.3    Quarles, L.D.4
  • 67
    • 84860778116 scopus 로고    scopus 로고
    • Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23
    • Lim, K., Lu, T.S., Molostvov, G., Lee, C., Lam, F.T., Zehnder, D., Hsiao, L.L., Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation 125 (2012), 2243–2255.
    • (2012) Circulation , vol.125 , pp. 2243-2255
    • Lim, K.1    Lu, T.S.2    Molostvov, G.3    Lee, C.4    Lam, F.T.5    Zehnder, D.6    Hsiao, L.L.7
  • 70
    • 84856720641 scopus 로고    scopus 로고
    • Regulation and function of the FGF23/klotho endocrine pathways
    • Martin, A., David, V., Quarles, L.D., Regulation and function of the FGF23/klotho endocrine pathways. Physiol. Rev. 92 (2012), 131–155.
    • (2012) Physiol. Rev. , vol.92 , pp. 131-155
    • Martin, A.1    David, V.2    Quarles, L.D.3
  • 71
    • 79952701331 scopus 로고    scopus 로고
    • The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity
    • Martuseviciene, G., Hofman-Bang, J., Clausen, T., Olgaard, K., Lewin, E., The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity. Kidney Int. 79 (2011), 742–748.
    • (2011) Kidney Int. , vol.79 , pp. 742-748
    • Martuseviciene, G.1    Hofman-Bang, J.2    Clausen, T.3    Olgaard, K.4    Lewin, E.5
  • 72
    • 84959020183 scopus 로고    scopus 로고
    • Secreted and transmembrane alphaklotho isoforms have different spatio-temporal profiles in the brain during aging and Alzheimer's disease progression
    • Masso, A., Sanchez, A., Gimenez-Llort, L., Lizcano, J.M., Canete, M., Garcia, B., Torres-Lista, V., Puig, M., Bosch, A., Chillon, M., Secreted and transmembrane alphaklotho isoforms have different spatio-temporal profiles in the brain during aging and Alzheimer's disease progression. PLoS. One, 10, 2015, e0143623.
    • (2015) PLoS. One , vol.10 , pp. e0143623
    • Masso, A.1    Sanchez, A.2    Gimenez-Llort, L.3    Lizcano, J.M.4    Canete, M.5    Garcia, B.6    Torres-Lista, V.7    Puig, M.8    Bosch, A.9    Chillon, M.10
  • 73
    • 0032567647 scopus 로고    scopus 로고
    • Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein
    • Matsumura, Y., Aizawa, H., Shiraki-Iida, T., Nagai, R., Kuro-o, M., Nabeshima, Y., Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem. Biophys. Res. Commun. 242 (1998), 626–630.
    • (1998) Biochem. Biophys. Res. Commun. , vol.242 , pp. 626-630
    • Matsumura, Y.1    Aizawa, H.2    Shiraki-Iida, T.3    Nagai, R.4    Kuro-o, M.5    Nabeshima, Y.6
  • 74
    • 40449098229 scopus 로고    scopus 로고
    • WNK kinases and renal sodium transport in health and disease: an integrated view
    • McCormick, J.A., Yang, C.L., Ellison, D.H., WNK kinases and renal sodium transport in health and disease: an integrated view. Hypertension 51 (2008), 588–596.
    • (2008) Hypertension , vol.51 , pp. 588-596
    • McCormick, J.A.1    Yang, C.L.2    Ellison, D.H.3
  • 75
    • 84964267910 scopus 로고    scopus 로고
    • Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription
    • Meir, T., Durlacher, K., Pan, Z., Amir, G., Richards, W.G., Silver, J., Naveh-Many, T., Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. Kidney Int. 86 (2014), 1106–1115.
    • (2014) Kidney Int. , vol.86 , pp. 1106-1115
    • Meir, T.1    Durlacher, K.2    Pan, Z.3    Amir, G.4    Richards, W.G.5    Silver, J.6    Naveh-Many, T.7
  • 79
    • 84900558089 scopus 로고    scopus 로고
    • Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice
    • Myakala, K., Motta, S., Murer, H., Wagner, C.A., Koesters, R., Biber, J., Hernando, N., Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice. Am. J. Physiol. Ren. Physiol. 306 (2014), F833–F843.
    • (2014) Am. J. Physiol. Ren. Physiol. , vol.306 , pp. F833-F843
    • Myakala, K.1    Motta, S.2    Murer, H.3    Wagner, C.A.4    Koesters, R.5    Biber, J.6    Hernando, N.7
  • 80
    • 77449126558 scopus 로고    scopus 로고
    • In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels
    • Ohnishi, M., Nakatani, T., Lanske, B., Razzaque, M.S., In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels. Circ. Cardiovasc. Genet. 2 (2009), 583–590.
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 583-590
    • Ohnishi, M.1    Nakatani, T.2    Lanske, B.3    Razzaque, M.S.4
  • 81
    • 84892774990 scopus 로고    scopus 로고
    • Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion
    • Olauson, H., Lindberg, K., Amin, R., Sato, T., Jia, T., Goetz, R., Mohammadi, M., Andersson, G., Lanske, B., Larsson, T.E., Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion. PLoS Genet., 9, 2013, e1003975.
    • (2013) PLoS Genet. , vol.9 , pp. e1003975
    • Olauson, H.1    Lindberg, K.2    Amin, R.3    Sato, T.4    Jia, T.5    Goetz, R.6    Mohammadi, M.7    Andersson, G.8    Lanske, B.9    Larsson, T.E.10
  • 96
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • Sitara, D., Razzaque, M.S., Hesse, M., Yoganathan, S., Taguchi, T., Erben, R.G., Juppner, H., Lanske, B., Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 23 (2004), 421–432.
    • (2004) Matrix Biol. , vol.23 , pp. 421-432
    • Sitara, D.1    Razzaque, M.S.2    Hesse, M.3    Yoganathan, S.4    Taguchi, T.5    Erben, R.G.6    Juppner, H.7    Lanske, B.8
  • 97
    • 84859384642 scopus 로고    scopus 로고
    • Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor
    • Streicher, C., Zeitz, U., Andrukhova, O., Rupprecht, A., Pohl, E., Larsson, T.E., Windisch, W., Lanske, B., Erben, R.G., Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor. Endocrinology 153 (2012), 1795–1805.
    • (2012) Endocrinology , vol.153 , pp. 1795-1805
    • Streicher, C.1    Zeitz, U.2    Andrukhova, O.3    Rupprecht, A.4    Pohl, E.5    Larsson, T.E.6    Windisch, W.7    Lanske, B.8    Erben, R.G.9
  • 98
    • 34250667000 scopus 로고    scopus 로고
    • Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice
    • Stubbs, J.R., Liu, S., Tang, W., Zhou, J., Wang, Y., Yao, X., Quarles, L.D., Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J. Am. Soc. Nephrol. 18 (2007), 2116–2124.
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 2116-2124
    • Stubbs, J.R.1    Liu, S.2    Tang, W.3    Zhou, J.4    Wang, Y.5    Yao, X.6    Quarles, L.D.7
  • 100
    • 0033763097 scopus 로고    scopus 로고
    • Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
    • The ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat. Genet. 26 (2000), 345–348.
    • (2000) Nat. Genet. , vol.26 , pp. 345-348
  • 107
    • 36048958880 scopus 로고    scopus 로고
    • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1
    • Weinman, E.J., Biswas, R.S., Peng, G., Shen, L., Turner, C.L., E X, Steplock, D., Shenolikar, S., Cunningham, R., Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. J. Clin. Invest 117 (2007), 3412–3420.
    • (2007) J. Clin. Invest , vol.117 , pp. 3412-3420
    • Weinman, E.J.1    Biswas, R.S.2    Peng, G.3    Shen, L.4    Turner, C.L.5    E X6    Steplock, D.7    Shenolikar, S.8    Cunningham, R.9
  • 108
    • 80054810431 scopus 로고    scopus 로고
    • FGF-23-mediated inhibition of renal phosphate transport in mice requires NHERF-1 and synergizes with PTH
    • Weinman, E.J., Steplock, D., Shenolikar, S., Biswas, R., FGF-23-mediated inhibition of renal phosphate transport in mice requires NHERF-1 and synergizes with PTH. J. Biol. Chem. 286 (2011), 37216–37221.
    • (2011) J. Biol. Chem. , vol.286 , pp. 37216-37221
    • Weinman, E.J.1    Steplock, D.2    Shenolikar, S.3    Biswas, R.4
  • 111
    • 84055193412 scopus 로고    scopus 로고
    • Increased circulating levels of FGF23: an adaptive response in primary hyperparathyroidism?
    • Witteveen, J.E., van Lierop, A.H., Papapoulos, S.E., Hamdy, N.A., Increased circulating levels of FGF23: an adaptive response in primary hyperparathyroidism?. Eur. J. Endocrinol. 166 (2012), 55–60.
    • (2012) Eur. J. Endocrinol. , vol.166 , pp. 55-60
    • Witteveen, J.E.1    van Lierop, A.H.2    Papapoulos, S.E.3    Hamdy, N.A.4
  • 112
    • 84902250298 scopus 로고    scopus 로고
    • Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease
    • Wolf, M., White, K.E., Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease. Curr. Opin. Nephrol. Hypertens. 23 (2014), 411–419.
    • (2014) Curr. Opin. Nephrol. Hypertens. , vol.23 , pp. 411-419
    • Wolf, M.1    White, K.E.2
  • 113
    • 84919782510 scopus 로고    scopus 로고
    • Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms
    • Wolf, M.T., An, S.W., Nie, M., Bal, M.S., Huang, C.L., Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms. J. Biol. Chem. 289 (2014), 35849–35857.
    • (2014) J. Biol. Chem. , vol.289 , pp. 35849-35857
    • Wolf, M.T.1    An, S.W.2    Nie, M.3    Bal, M.S.4    Huang, C.L.5
  • 114
    • 84905474545 scopus 로고    scopus 로고
    • Osteocyte-specific deletion of Fgfr1 suppresses FGF23
    • Xiao, Z., Huang, J., Cao, L., Liang, Y., Han, X., Quarles, L.D., Osteocyte-specific deletion of Fgfr1 suppresses FGF23. PLoS One, 9, 2014, e104154.
    • (2014) PLoS One , vol.9 , pp. e104154
    • Xiao, Z.1    Huang, J.2    Cao, L.3    Liang, Y.4    Han, X.5    Quarles, L.D.6
  • 115
    • 84871726896 scopus 로고    scopus 로고
    • Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
    • Xie, J., Cha, S.K., An, S.W., Kuro, O., Birnbaumer, L., Huang, C.L., Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat. Commun., 3, 2012, 1238.
    • (2012) Nat. Commun. , vol.3 , pp. 1238
    • Xie, J.1    Cha, S.K.2    An, S.W.3    Kuro, O.4    Birnbaumer, L.5    Huang, C.L.6
  • 116
    • 84929391863 scopus 로고    scopus 로고
    • Molecular basis of Klotho: from gene to function in aging
    • Xu, Y., Sun, Z., Molecular basis of Klotho: from gene to function in aging. Endocr. Rev. 36 (2015), 174–193.
    • (2015) Endocr. Rev. , vol.36 , pp. 174-193
    • Xu, Y.1    Sun, Z.2
  • 117
    • 0034703619 scopus 로고    scopus 로고
    • Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain
    • Yamashita, T., Yoshioka, M., Itoh, N., Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem. Biophys. Res. Commun. 277 (2000), 494–498.
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 494-498
    • Yamashita, T.1    Yoshioka, M.2    Itoh, N.3
  • 120
    • 84863638352 scopus 로고    scopus 로고
    • Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice
    • Yuan, Q., Sato, T., Densmore, M., Saito, H., Schuler, C., Erben, R.G., Lanske, B., Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice. PLoS Genet., 8, 2012, e1002726.
    • (2012) PLoS Genet. , vol.8 , pp. e1002726
    • Yuan, Q.1    Sato, T.2    Densmore, M.3    Saito, H.4    Schuler, C.5    Erben, R.G.6    Lanske, B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.