-
1
-
-
84895057195
-
FGF receptors: cancer biology and therapeutics
-
1 Katoh, M., Nakagama, H., FGF receptors: cancer biology and therapeutics. Med. Res. Rev. 34 (2014), 280–300.
-
(2014)
Med. Res. Rev.
, vol.34
, pp. 280-300
-
-
Katoh, M.1
Nakagama, H.2
-
2
-
-
84925456768
-
Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction
-
2 Carter, E.P., et al. Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Trends Cell Biol. 25 (2015), 221–233.
-
(2015)
Trends Cell Biol.
, vol.25
, pp. 221-233
-
-
Carter, E.P.1
-
4
-
-
18144383021
-
Cellular signaling by fibroblast growth factor receptors
-
4 Eswarakumar, V.P., et al. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16 (2005), 139–149.
-
(2005)
Cytokine Growth Factor Rev.
, vol.16
, pp. 139-149
-
-
Eswarakumar, V.P.1
-
5
-
-
18144413583
-
Fibroblast growth factor signaling in tumorigenesis
-
5 Grose, R., Dickson, C., Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev. 16 (2005), 179–186.
-
(2005)
Cytokine Growth Factor Rev.
, vol.16
, pp. 179-186
-
-
Grose, R.1
Dickson, C.2
-
6
-
-
17844402791
-
Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations
-
6 Wilkie, A.O., Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations. Cytokine Growth Factor Rev. 16 (2005), 187–203.
-
(2005)
Cytokine Growth Factor Rev.
, vol.16
, pp. 187-203
-
-
Wilkie, A.O.1
-
7
-
-
0034464005
-
The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans
-
7 Vajo, Z., et al. The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. Endocr. Rev. 21 (2000), 23–39.
-
(2000)
Endocr. Rev.
, vol.21
, pp. 23-39
-
-
Vajo, Z.1
-
8
-
-
38849125434
-
FGF18 in colorectal tumour cells: autocrine and paracrine effects
-
8 Sonvilla, G., et al. FGF18 in colorectal tumour cells: autocrine and paracrine effects. Carcinogenesis 29 (2008), 15–24.
-
(2008)
Carcinogenesis
, vol.29
, pp. 15-24
-
-
Sonvilla, G.1
-
9
-
-
84958886107
-
Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer
-
9 Holdman, X.B., et al. Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer. Breast Cancer Res., 17, 2015, 141.
-
(2015)
Breast Cancer Res.
, vol.17
, pp. 141
-
-
Holdman, X.B.1
-
10
-
-
84876993950
-
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
-
10 Jain, R.K., Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J. Clin. Oncol. 31 (2013), 2205–2218.
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 2205-2218
-
-
Jain, R.K.1
-
11
-
-
84858760109
-
Combining immunotherapy and targeted therapies in cancer treatment
-
11 Vanneman, M., Dranoff, G., Combining immunotherapy and targeted therapies in cancer treatment. Nat. Rev. Cancer 12 (2012), 237–251.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 237-251
-
-
Vanneman, M.1
Dranoff, G.2
-
12
-
-
80555148939
-
FGF23 induces left ventricular hypertrophy
-
12 Faul, C., et al. FGF23 induces left ventricular hypertrophy. J. Clin. Invest. 121 (2011), 4393–4408.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4393-4408
-
-
Faul, C.1
-
13
-
-
84959036645
-
Inflammatory mediators and clinical outcome in patients with advanced heart failure receiving cardiac resynchronization therapy
-
13 Belperio, J., et al. Inflammatory mediators and clinical outcome in patients with advanced heart failure receiving cardiac resynchronization therapy. Am. J. Cardiol. 117 (2016), 617–625.
-
(2016)
Am. J. Cardiol.
, vol.117
, pp. 617-625
-
-
Belperio, J.1
-
14
-
-
84883312340
-
Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks
-
14 Katoh, M., Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks. Int. J. Mol. Med. 32 (2013), 763–767.
-
(2013)
Int. J. Mol. Med.
, vol.32
, pp. 763-767
-
-
Katoh, M.1
-
15
-
-
84906826372
-
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
-
15 Suh, J.M., et al. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 513 (2014), 436–439.
-
(2014)
Nature
, vol.513
, pp. 436-439
-
-
Suh, J.M.1
-
16
-
-
78649677069
-
Genetic basis of potential therapeutic strategies for craniosynostosis
-
16 Melville, H., et al. Genetic basis of potential therapeutic strategies for craniosynostosis. Am. J. Med. Genet. 152A (2010), 3007–3015.
-
(2010)
Am. J. Med. Genet.
, vol.152A
, pp. 3007-3015
-
-
Melville, H.1
-
17
-
-
84886309237
-
Genotype and clinical care correlations in craniosynostosis: findings from a cohort of 630 Australian and New Zealand patients
-
17 Roscioli, T., et al. Genotype and clinical care correlations in craniosynostosis: findings from a cohort of 630 Australian and New Zealand patients. Am. J. Med. Genet. 163C (2013), 259–270.
-
(2013)
Am. J. Med. Genet.
, vol.163C
, pp. 259-270
-
-
Roscioli, T.1
-
18
-
-
84857688284
-
Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias
-
18 Foldynova-Trantirkova, S., et al. Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias. Hum. Mutat. 33 (2012), 29–41.
-
(2012)
Hum. Mutat.
, vol.33
, pp. 29-41
-
-
Foldynova-Trantirkova, S.1
-
19
-
-
84942194341
-
Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications
-
19 Helsten, T., et al. Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. Cancer Metastasis Rev. 34 (2015), 479–496.
-
(2015)
Cancer Metastasis Rev.
, vol.34
, pp. 479-496
-
-
Helsten, T.1
-
20
-
-
84959535644
-
Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes
-
20 Maher, G.J., et al. Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 2454–2459.
-
(2016)
Proc. Natl. Acad. Sci. U. S. A.
, vol.113
, pp. 2454-2459
-
-
Maher, G.J.1
-
21
-
-
38549138410
-
Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome
-
21 Kim, S.H., et al. Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome. J. Neuroendocrinol. 20 (2007), 141–163.
-
(2007)
J. Neuroendocrinol.
, vol.20
, pp. 141-163
-
-
Kim, S.H.1
-
22
-
-
34748813638
-
Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway
-
22 Shams, I., et al. Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. Mol. Cell. Biol. 27 (2007), 6903–6912.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6903-6912
-
-
Shams, I.1
-
23
-
-
84982903342
-
FGFR2 risk SNPs confer breast cancer risk by augmenting estrogen responsiveness
-
23 Campbell, T.M., et al. FGFR2 risk SNPs confer breast cancer risk by augmenting estrogen responsiveness. Carcinogenesis 37 (2016), 741–750.
-
(2016)
Carcinogenesis
, vol.37
, pp. 741-750
-
-
Campbell, T.M.1
-
24
-
-
84870376109
-
Cancer genetics and genomics of human FOX family genes
-
24 Katoh, M., et al. Cancer genetics and genomics of human FOX family genes. Cancer Lett. 328 (2013), 198–206.
-
(2013)
Cancer Lett.
, vol.328
, pp. 198-206
-
-
Katoh, M.1
-
25
-
-
84946434638
-
10q26.1 microdeletion: redefining the critical regions for microcephaly, genital anomalies
-
25 Choucair, N., et al. 10q26.1 microdeletion: redefining the critical regions for microcephaly, genital anomalies. Am. J. Med. Genet. 167A (2015), 2707–2713.
-
(2015)
Am. J. Med. Genet.
, vol.167A
, pp. 2707-2713
-
-
Choucair, N.1
-
26
-
-
84959366306
-
Mutation spectra of histone methyltransferases with canonical SET domains and EZH2-targeted therapy
-
26 Katoh, M., Mutation spectra of histone methyltransferases with canonical SET domains and EZH2-targeted therapy. Epigenomics 8 (2016), 285–305.
-
(2016)
Epigenomics
, vol.8
, pp. 285-305
-
-
Katoh, M.1
-
27
-
-
84904040040
-
Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions
-
27 Mutsaers, H.A., et al. Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions. J. Clin. Endocrinol. Metab. 99E (2014), 1361–1367.
-
(2014)
J. Clin. Endocrinol. Metab.
, vol.99E
, pp. 1361-1367
-
-
Mutsaers, H.A.1
-
28
-
-
84959911385
-
Mosaic activating mutations in FGFR1 cause encephalocraniocutaneous lipomatosis
-
28 Bennett, J.T., et al. Mosaic activating mutations in FGFR1 cause encephalocraniocutaneous lipomatosis. Am. J. Hum. Genet. 98 (2016), 579–587.
-
(2016)
Am. J. Hum. Genet.
, vol.98
, pp. 579-587
-
-
Bennett, J.T.1
-
29
-
-
84926150193
-
Blaschko line acne on pre-existent hypomelanosis reflecting a mosaic FGFR2 mutation
-
29 Kiritsi, D., et al. Blaschko line acne on pre-existent hypomelanosis reflecting a mosaic FGFR2 mutation. Br. J. Dermatol. 172 (2015), 1125–1127.
-
(2015)
Br. J. Dermatol.
, vol.172
, pp. 1125-1127
-
-
Kiritsi, D.1
-
30
-
-
33746754183
-
Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
-
30 Hafner, C., et al. Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. J. Clin. Invest. 116 (2006), 2201–2207.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2201-2207
-
-
Hafner, C.1
-
31
-
-
84941941913
-
Fibroblast growth factor receptor 1 gene amplification in gastric adenocarcinoma
-
31 Schäfer, M.H., et al. Fibroblast growth factor receptor 1 gene amplification in gastric adenocarcinoma. Hum. Pathol. 46 (2015), 1488–1495.
-
(2015)
Hum. Pathol.
, vol.46
, pp. 1488-1495
-
-
Schäfer, M.H.1
-
32
-
-
84893786820
-
Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy
-
32 Ross, J.S., et al. Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy. Mod. Pathol. 27 (2014), 271–280.
-
(2014)
Mod. Pathol.
, vol.27
, pp. 271-280
-
-
Ross, J.S.1
-
33
-
-
84897022815
-
Comprehensive molecular characterization of urothelial bladder carcinoma
-
33 Cancer Genome Atlas Research Network, Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507 (2014), 315–322.
-
(2014)
Nature
, vol.507
, pp. 315-322
-
-
Cancer Genome Atlas Research Network1
-
34
-
-
84925488324
-
Rationale for targeting fibroblast growth factor receptor signaling in breast cancer
-
34 André, F., Cortés, J., Rationale for targeting fibroblast growth factor receptor signaling in breast cancer. Breast Cancer Res. Treat. 150 (2015), 1–8.
-
(2015)
Breast Cancer Res. Treat.
, vol.150
, pp. 1-8
-
-
André, F.1
Cortés, J.2
-
35
-
-
84954469968
-
The FGFR landscape in cancer: analysis of 4,853 tumors by next-generation sequencing
-
35 Helsten, T., et al. The FGFR landscape in cancer: analysis of 4,853 tumors by next-generation sequencing. Clin. Cancer Res. 22 (2016), 259–267.
-
(2016)
Clin. Cancer Res.
, vol.22
, pp. 259-267
-
-
Helsten, T.1
-
36
-
-
84978880012
-
FGFR inhibitors: effects on cancer cells, tumor microenvironment and whole-body homeostasis
-
36 Katoh, M., FGFR inhibitors: effects on cancer cells, tumor microenvironment and whole-body homeostasis. Int. J. Mol. Med. 38 (2016), 3–15.
-
(2016)
Int. J. Mol. Med.
, vol.38
, pp. 3-15
-
-
Katoh, M.1
-
37
-
-
84938286765
-
Functions of fibroblast growth factor receptors in cancer defined by novel translocations and mutations
-
37 Gallo, L.H., et al. Functions of fibroblast growth factor receptors in cancer defined by novel translocations and mutations. Cytokine Growth Factor Rev. 26 (2015), 425–449.
-
(2015)
Cytokine Growth Factor Rev.
, vol.26
, pp. 425-449
-
-
Gallo, L.H.1
-
38
-
-
84947253949
-
Deep sequencing in conjunction with expression and functional analyses reveals activation of FGFR1 in Ewing sarcoma
-
38 Agelopoulos, K., et al. Deep sequencing in conjunction with expression and functional analyses reveals activation of FGFR1 in Ewing sarcoma. Clin. Cancer Res. 21 (2015), 4935–4946.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 4935-4946
-
-
Agelopoulos, K.1
-
39
-
-
84966457637
-
Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use
-
39 Patani, H., et al. Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. Oncotarget 7 (2016), 24252–24268.
-
(2016)
Oncotarget
, vol.7
, pp. 24252-24268
-
-
Patani, H.1
-
40
-
-
58749107496
-
Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma
-
40 Gartside, M.G., et al. Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma. Mol. Cancer Res. 7 (2009), 41–54.
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 41-54
-
-
Gartside, M.G.1
-
41
-
-
80052866912
-
Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition
-
41 Metzner, T., et al. Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition. J. Invest. Dermatol. 131 (2011), 2087–2095.
-
(2011)
J. Invest. Dermatol.
, vol.131
, pp. 2087-2095
-
-
Metzner, T.1
-
42
-
-
29944447205
-
Comprehensive profiling of 8p11-12 amplification in breast cancer
-
42 Gelsi-Boyer, V., et al. Comprehensive profiling of 8p11-12 amplification in breast cancer. Mol. Cancer Res. 3 (2005), 655–667.
-
(2005)
Mol. Cancer Res.
, vol.3
, pp. 655-667
-
-
Gelsi-Boyer, V.1
-
43
-
-
84960532558
-
Characterization of FGFR1 locus in sqNSCLC reveals a broad and heterogeneous amplicon
-
43 Rooney, C., et al. Characterization of FGFR1 locus in sqNSCLC reveals a broad and heterogeneous amplicon. PLoS One, 11, 2016, e0149628.
-
(2016)
PLoS One
, vol.11
, pp. e0149628
-
-
Rooney, C.1
-
44
-
-
84881482012
-
A TC classification-based predictor for multiple myeloma using multiplexed real-time quantitative PCR
-
44 Kaiser, M.F., et al. A TC classification-based predictor for multiple myeloma using multiplexed real-time quantitative PCR. Leukemia 27 (2013), 1754–1757.
-
(2013)
Leukemia
, vol.27
, pp. 1754-1757
-
-
Kaiser, M.F.1
-
45
-
-
84925368747
-
Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy
-
45 Schelch, K., et al. Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy. Am. J. Respir. Crit. Care Med. 190 (2014), 763–772.
-
(2014)
Am. J. Respir. Crit. Care Med.
, vol.190
, pp. 763-772
-
-
Schelch, K.1
-
46
-
-
84982957799
-
Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230
-
Published online May 20, 2016
-
46 Blackwell, C., et al. Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230. Oncotarget., 2016, 10.18632/oncotarget.9515 Published online May 20, 2016.
-
(2016)
Oncotarget.
-
-
Blackwell, C.1
-
47
-
-
84949643860
-
From epistaxis to bone pain: report of two cases illustrating the clinicopathological spectrum of phosphaturic mesenchymal tumour with fibroblast growth factor receptor 1 immunohistochemical and cytogenetic analyses
-
47 Mok, Y., et al. From epistaxis to bone pain: report of two cases illustrating the clinicopathological spectrum of phosphaturic mesenchymal tumour with fibroblast growth factor receptor 1 immunohistochemical and cytogenetic analyses. Histopathology 68 (2016), 925–930.
-
(2016)
Histopathology
, vol.68
, pp. 925-930
-
-
Mok, Y.1
-
48
-
-
84861414679
-
Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT–SSX2
-
48 Garcia, C.B., et al. Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT–SSX2. Oncogene 31 (2012), 2323–2334.
-
(2012)
Oncogene
, vol.31
, pp. 2323-2334
-
-
Garcia, C.B.1
-
49
-
-
84955286381
-
Angiocrine functions of organ-specific endothelial cells
-
49 Rafii, S., et al. Angiocrine functions of organ-specific endothelial cells. Nature 529 (2016), 316–325.
-
(2016)
Nature
, vol.529
, pp. 316-325
-
-
Rafii, S.1
-
50
-
-
84983609840
-
Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury
-
50 House, S.L., et al. Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 310H (2016), 559–571.
-
(2016)
Am. J. Physiol. Heart Circ. Physiol.
, vol.310H
, pp. 559-571
-
-
House, S.L.1
-
51
-
-
47049131698
-
FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities
-
51 Allerstorfer, S., et al. FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities. Oncogene 27 (2008), 4180–4190.
-
(2008)
Oncogene
, vol.27
, pp. 4180-4190
-
-
Allerstorfer, S.1
-
52
-
-
80054914476
-
Characterization of FGF receptor expression in human neutrophils, their contribution to chemotaxis
-
52 Haddad, L.E., et al. Characterization of FGF receptor expression in human neutrophils, their contribution to chemotaxis. Am. J. Physiol. Cell Physiol. 301C (2011), 1036–1045.
-
(2011)
Am. J. Physiol. Cell Physiol.
, vol.301C
, pp. 1036-1045
-
-
Haddad, L.E.1
-
53
-
-
84959894121
-
FGF23 signaling impairs neutrophil recruitment and host defense during CKD
-
53 Rossaint, J., et al. FGF23 signaling impairs neutrophil recruitment and host defense during CKD. J. Clin. Invest. 126 (2016), 962–974.
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 962-974
-
-
Rossaint, J.1
-
54
-
-
84955557590
-
2 D in macrophages
-
2 D in macrophages. FEBS Lett. 590 (2016), 53–67.
-
(2016)
FEBS Lett.
, vol.590
, pp. 53-67
-
-
Han, X.1
-
55
-
-
84871676561
-
FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression
-
55 Chen, P.Y., et al. FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2 (2012), 1684–1696.
-
(2012)
Cell Rep.
, vol.2
, pp. 1684-1696
-
-
Chen, P.Y.1
-
56
-
-
84892832431
-
Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
-
56 Jetten, N., et al. Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. Angiogenesis 17 (2014), 109–118.
-
(2014)
Angiogenesis
, vol.17
, pp. 109-118
-
-
Jetten, N.1
-
57
-
-
84955209323
-
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
-
57 Degirolamo, C., et al. Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat. Rev. Drug Discov. 15 (2016), 51–69.
-
(2016)
Nat. Rev. Drug Discov.
, vol.15
, pp. 51-69
-
-
Degirolamo, C.1
-
58
-
-
84951170385
-
Role of fibroblast growth factors in organ regeneration and repair
-
58 El Agha, E., et al. Role of fibroblast growth factors in organ regeneration and repair. Semin. Cell Dev. Biol. 53 (2016), 76–84.
-
(2016)
Semin. Cell Dev. Biol.
, vol.53
, pp. 76-84
-
-
El Agha, E.1
-
59
-
-
84941781254
-
Therapeutic uses of FGFs
-
59 Zhang, J., Li, Y., Therapeutic uses of FGFs. Semin. Cell Dev. Biol. 53 (2016), 144–154.
-
(2016)
Semin. Cell Dev. Biol.
, vol.53
, pp. 144-154
-
-
Zhang, J.1
Li, Y.2
-
60
-
-
79958118819
-
Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
-
60 Belch, J., et al. Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia. Lancet 377 (2011), 1929–1937.
-
(2011)
Lancet
, vol.377
, pp. 1929-1937
-
-
Belch, J.1
-
61
-
-
84904392112
-
Macrophages, immunity, and metabolic disease
-
61 McNelis, J.C., Olefsky, J.M., Macrophages, immunity, and metabolic disease. Immunity 41 (2014), 36–48.
-
(2014)
Immunity
, vol.41
, pp. 36-48
-
-
McNelis, J.C.1
Olefsky, J.M.2
-
62
-
-
84978128486
-
The genetic architecture of type 2 diabetes
-
62 Fuchsberger, C., et al. The genetic architecture of type 2 diabetes. Nature 536 (2016), 41–47.
-
(2016)
Nature
, vol.536
, pp. 41-47
-
-
Fuchsberger, C.1
-
63
-
-
84959935277
-
A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors
-
63 Tolcher, A.W., et al. A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors. Ann. Oncol. 27 (2016), 526–532.
-
(2016)
Ann. Oncol.
, vol.27
, pp. 526-532
-
-
Tolcher, A.W.1
-
64
-
-
84884676713
-
Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice
-
64 Garcia, S., et al. Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice. Sci. Transl. Med., 5, 2013, 203ra124.
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 203ra124
-
-
Garcia, S.1
-
65
-
-
84897560527
-
Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia
-
65 Carpenter, T.O., et al. Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia. J. Clin. Invest. 124 (2014), 1587–1597.
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 1587-1597
-
-
Carpenter, T.O.1
-
66
-
-
84860120185
-
AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family
-
66 Gavine, P.R., et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 72 (2012), 2045–2056.
-
(2012)
Cancer Res.
, vol.72
, pp. 2045-2056
-
-
Gavine, P.R.1
-
67
-
-
84921044642
-
Dovitinib (CHIR258, TKI258): structure, development and preclinical and clinical activity
-
67 Porta, C., et al. Dovitinib (CHIR258, TKI258): structure, development and preclinical and clinical activity. Future Oncol. 11 (2015), 39–50.
-
(2015)
Future Oncol.
, vol.11
, pp. 39-50
-
-
Porta, C.1
-
68
-
-
84959121178
-
In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer
-
68 Verstraete, M., et al. In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer. BMC Cancer, 15, 2015, 946.
-
(2015)
BMC Cancer
, vol.15
, pp. 946
-
-
Verstraete, M.1
-
69
-
-
84871491773
-
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor
-
69 Guagnano, V., et al. FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. Cancer Discov. 2 (2012), 1118–1133.
-
(2012)
Cancer Discov.
, vol.2
, pp. 1118-1133
-
-
Guagnano, V.1
-
70
-
-
70350507997
-
AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
-
70 O'Hare, T., et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 16 (2009), 401–412.
-
(2009)
Cancer Cell
, vol.16
, pp. 401-412
-
-
O'Hare, T.1
-
72
-
-
85026597143
-
Preclinical antitumor activity of ASP5878, a novel inhibitor of FGFR1, 2, 3 and 4, in FGF19-expressing hepatocellular carcinoma
-
Abstract nr A172
-
72 Futami, T., et al. Preclinical antitumor activity of ASP5878, a novel inhibitor of FGFR1, 2, 3 and 4, in FGF19-expressing hepatocellular carcinoma. Mol Cancer Ther., 14(Suppl. 2), 2015 Abstract nr A172.
-
(2015)
Mol Cancer Ther.
, vol.14
-
-
Futami, T.1
-
73
-
-
84918793590
-
The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
-
73 Nakanishi, Y., et al. The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. Mol. Cancer Ther. 13 (2014), 2547–2558.
-
(2014)
Mol. Cancer Ther.
, vol.13
, pp. 2547-2558
-
-
Nakanishi, Y.1
-
74
-
-
84995797569
-
Characterization of E7090: a novel and selective FGFR inhibitor
-
Abstract nr 3778
-
74 Miyano, S., Characterization of E7090: a novel and selective FGFR inhibitor. Cancer Res., 76(14 Suppl.), 2015 Abstract nr 3778.
-
(2015)
Cancer Res.
, vol.76
, Issue.14
-
-
Miyano, S.1
-
75
-
-
81055124246
-
A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models
-
75 Zhao, G., et al. A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models. Mol. Cancer Ther. 10 (2011), 2200–2210.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 2200-2210
-
-
Zhao, G.1
-
76
-
-
84909594628
-
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
-
76 Tan, L., et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), E4869–E4877.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. E4869-E4877
-
-
Tan, L.1
-
77
-
-
84939482520
-
First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway
-
77 Hagel, M., et al. First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway. Cancer Discov. 5 (2015), 424–437.
-
(2015)
Cancer Discov.
, vol.5
, pp. 424-437
-
-
Hagel, M.1
-
78
-
-
84951102104
-
Dysregulated FGF signaling in neoplastic disorders
-
78 Tanner, Y., Grose, R.P., Dysregulated FGF signaling in neoplastic disorders. Semin. Cell Dev. Biol. 53 (2016), 126–135.
-
(2016)
Semin. Cell Dev. Biol.
, vol.53
, pp. 126-135
-
-
Tanner, Y.1
Grose, R.P.2
-
79
-
-
84875302265
-
Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets
-
79 Wöhrle, S., et al. Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. J. Bone Miner. Res. 28 (2013), 899–911.
-
(2013)
J. Bone Miner. Res.
, vol.28
, pp. 899-911
-
-
Wöhrle, S.1
-
80
-
-
84988498946
-
Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model
-
80 Komla-Ebri, D., et al. Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model. J. Clin. Invest. 126 (2016), 1871–1884.
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 1871-1884
-
-
Komla-Ebri, D.1
-
81
-
-
84866322989
-
ALKoma: a cancer subtype with a shared target
-
81 Mano, H., ALKoma: a cancer subtype with a shared target. Cancer Discov. 2 (2012), 495–502.
-
(2012)
Cancer Discov.
, vol.2
, pp. 495-502
-
-
Mano, H.1
-
82
-
-
84939575246
-
Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine
-
82 Katayama, R., et al. Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine. Clin. Cancer Res. 21 (2015), 2227–2235.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 2227-2235
-
-
Katayama, R.1
-
83
-
-
84905366894
-
Acquired resistance to TKIs in solid tumours: learning from lung cancer
-
83 Camidge, D.R., et al. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat. Rev. Clin. Oncol. 11 (2014), 473–481.
-
(2014)
Nat. Rev. Clin. Oncol.
, vol.11
, pp. 473-481
-
-
Camidge, D.R.1
-
84
-
-
84977580702
-
Kinase inhibitor-responsive genotypes in EGFR mutated lung adenocarcinomas: moving past common point mutations or indels into uncommon kinase domain duplications and rearrangements
-
84 Costa, D.B., Kinase inhibitor-responsive genotypes in EGFR mutated lung adenocarcinomas: moving past common point mutations or indels into uncommon kinase domain duplications and rearrangements. Transl. Lung Cancer Res. 5 (2016), 331–337.
-
(2016)
Transl. Lung Cancer Res.
, vol.5
, pp. 331-337
-
-
Costa, D.B.1
-
85
-
-
84902335851
-
Crenolanib is a selective type I pan-FLT3 inhibitor
-
85 Smith, C.C., et al. Crenolanib is a selective type I pan-FLT3 inhibitor. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 5319–5324.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 5319-5324
-
-
Smith, C.C.1
-
86
-
-
84979995721
-
Characterizing and overriding the structural mechanism of the quizartinib-resistant FLT3 ‘gatekeeper’ F691L mutation with PLX3397
-
86 Smith, C.C., et al. Characterizing and overriding the structural mechanism of the quizartinib-resistant FLT3 ‘gatekeeper’ F691L mutation with PLX3397. Cancer Discov. 5 (2015), 668–679.
-
(2015)
Cancer Discov.
, vol.5
, pp. 668-679
-
-
Smith, C.C.1
-
87
-
-
84961761090
-
Cancer stem-like cells act via distinct signaling pathways in promoting late stages of malignant progression
-
87 da Silva-Diz, V., et al. Cancer stem-like cells act via distinct signaling pathways in promoting late stages of malignant progression. Cancer Res. 76 (2016), 1245–1259.
-
(2016)
Cancer Res.
, vol.76
, pp. 1245-1259
-
-
da Silva-Diz, V.1
-
88
-
-
84880525684
-
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2–FGFR1 autocrine growth loop
-
88 Ware, K.E., et al. A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2–FGFR1 autocrine growth loop. Oncogenesis, 2, 2013, e39.
-
(2013)
Oncogenesis
, vol.2
, pp. e39
-
-
Ware, K.E.1
-
89
-
-
84879859652
-
Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer
-
89 André, F., et al. Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer. Clin. Cancer Res. 19 (2013), 3693–3702.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 3693-3702
-
-
André, F.1
-
90
-
-
84982958036
-
High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial
-
90 Pearson, A., et al. High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial. Cancer Discov. 6 (2016), 838–851.
-
(2016)
Cancer Discov.
, vol.6
, pp. 838-851
-
-
Pearson, A.1
-
91
-
-
84929114925
-
Detection, characterization, and inhibition of FGFR-TACC fusions in IDH wild-type glioma
-
91 Di Stefano, A.L., et al. Detection, characterization, and inhibition of FGFR-TACC fusions in IDH wild-type glioma. Clin. Cancer Res. 21 (2015), 3307–3317.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 3307-3317
-
-
Di Stefano, A.L.1
-
92
-
-
84945186800
-
Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors
-
92 Tabernero, J., et al. Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 33 (2015), 3401–3408.
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 3401-3408
-
-
Tabernero, J.1
-
93
-
-
84942163775
-
Targeting FGFR signaling in cancer
-
93 Touat, M., et al. Targeting FGFR signaling in cancer. Clin. Cancer Res. 21 (2015), 2684–2694.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 2684-2694
-
-
Touat, M.1
-
94
-
-
34547794178
-
PD-1 and PD-1 ligands: from discovery to clinical application
-
94 Okazaki, T., Honjo, T., PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 19 (2007), 813–824.
-
(2007)
Int. Immunol.
, vol.19
, pp. 813-824
-
-
Okazaki, T.1
Honjo, T.2
-
95
-
-
84928774156
-
The future of immune checkpoint therapy
-
95 Sharma, P., Allison, J.P., The future of immune checkpoint therapy. Science 348 (2015), 56–61.
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
96
-
-
61649087689
-
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing
-
96 Warzecha, C.C., et al. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol. Cell 33 (2009), 591–601.
-
(2009)
Mol. Cell
, vol.33
, pp. 591-601
-
-
Warzecha, C.C.1
-
97
-
-
84894463722
-
Novel insights into breast cancer genetic variance through RNA sequencing
-
97 Horvath, A., et al. Novel insights into breast cancer genetic variance through RNA sequencing. Sci. Rep., 3, 2013, 2256.
-
(2013)
Sci. Rep.
, vol.3
, pp. 2256
-
-
Horvath, A.1
-
98
-
-
84947764978
-
The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells
-
98 Liang, Y.C., et al. The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells. Oncotarget 6 (2015), 38046–38060.
-
(2015)
Oncotarget
, vol.6
, pp. 38046-38060
-
-
Liang, Y.C.1
-
99
-
-
84897940136
-
Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers
-
99 Wendt, M.K., et al. Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers. Breast Cancer Res., 16, 2014, R24.
-
(2014)
Breast Cancer Res.
, vol.16
, pp. R24
-
-
Wendt, M.K.1
-
100
-
-
84930418435
-
HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition
-
100 Ranieri, D., et al. HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition. Int. J. Cancer 137 (2015), 61–72.
-
(2015)
Int. J. Cancer
, vol.137
, pp. 61-72
-
-
Ranieri, D.1
-
101
-
-
84946854584
-
miR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition
-
101 Wang, L., et al. miR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition. Oncotarget 6 (2015), 35978–35990.
-
(2015)
Oncotarget
, vol.6
, pp. 35978-35990
-
-
Wang, L.1
-
102
-
-
84929482180
-
Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non–cancerous and cancerous diseases
-
102 Katoh, M., Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non–cancerous and cancerous diseases. Front. Cell Dev. Biol., 2, 2014, 61.
-
(2014)
Front. Cell Dev. Biol.
, vol.2
, pp. 61
-
-
Katoh, M.1
-
103
-
-
84928412212
-
Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway
-
103 Wang, F., et al. Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget 6 (2015), 7899–7917.
-
(2015)
Oncotarget
, vol.6
, pp. 7899-7917
-
-
Wang, F.1
-
104
-
-
84928568039
-
miR-223 regulates adipogenic and osteogenic differentiation of mesenchymal stem cells through a C/EBPs/miR-223/FGFR2 regulatory feedback loop
-
104 Guan, X., et al. miR-223 regulates adipogenic and osteogenic differentiation of mesenchymal stem cells through a C/EBPs/miR-223/FGFR2 regulatory feedback loop. Stem Cells 33 (2015), 1589–1600.
-
(2015)
Stem Cells
, vol.33
, pp. 1589-1600
-
-
Guan, X.1
-
105
-
-
84873347374
-
The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma
-
105 Parker, B.C., et al. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J. Clin. Invest. 123 (2013), 855–865.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 855-865
-
-
Parker, B.C.1
-
106
-
-
85011095959
-
Long non-coding RNA regulation of epithelial–mesenchymal transition in cancer metastasis
-
106 Xu, Q., et al. Long non-coding RNA regulation of epithelial–mesenchymal transition in cancer metastasis. Cell Death Dis., 7, 2016, e2254.
-
(2016)
Cell Death Dis.
, vol.7
, pp. e2254
-
-
Xu, Q.1
-
107
-
-
84929270304
-
A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature
-
107 Gonzalez, I., et al. A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature. Nat. Struct. Mol. Biol. 22 (2015), 370–376.
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 370-376
-
-
Gonzalez, I.1
-
108
-
-
84962216200
-
Long noncoding RNA FGFR3-AS1 promotes osteosarcoma growth through regulating its natural antisense transcript FGFR3
-
108 Sun, J., et al. Long noncoding RNA FGFR3-AS1 promotes osteosarcoma growth through regulating its natural antisense transcript FGFR3. Mol. Biol. Rep. 43 (2016), 427–436.
-
(2016)
Mol. Biol. Rep.
, vol.43
, pp. 427-436
-
-
Sun, J.1
-
109
-
-
84978646294
-
Budget impact and cost-effectiveness: can we afford precision medicine in oncology?
-
109 Doble, B., Budget impact and cost-effectiveness: can we afford precision medicine in oncology?. Scand. J. Clin. Lab. Invest. 18 (2016), 1–6.
-
(2016)
Scand. J. Clin. Lab. Invest.
, vol.18
, pp. 1-6
-
-
Doble, B.1
|