Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 15, 2014, Pages 5520-5525

  Tagliabracci, Vincent S ^a   Engel, James L ^a   Wiley, Sandra E ^a   Xiao, Junyu ^a   Gonzalez, David J ^a   Appaiah, Hitesh Nidumanda ^b   Koller, Antonius ^c   Nizet, Victor ^a,d   White, Kenneth E ^b   Dixon, Jack E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Chronic Kidney Disease; Fam20; Familial Tumoral Calcinosis; Phosphate Homeostasis; Rickets

Indexed keywords

FAMILY WITH SEQUENCE SIMILARITY 20 MEMBER C; FIBROBLAST GROWTH FACTOR 23; FURIN; POLYPEPTIDE; POLYPEPTIDE N ACETYLGALACTOSAMINYLTRANSFERASE 3; PROTEIN KINASE; SUBTILISIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPOPHOSPHATEMIA; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION;

CHRONIC KIDNEY DISEASE; FAM20; FAMILIAL TUMORAL CALCINOSIS; PHOSPHATE HOMEOSTASIS; RICKETS;

AMINO ACID SEQUENCE; BASE SEQUENCE; DNA PRIMERS; EXTRACELLULAR MATRIX PROTEINS; FIBROBLAST GROWTH FACTORS; FURIN; GLYCOSYLATION; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; N-ACETYLGALACTOSAMINYLTRANSFERASES; PHOSPHORYLATION; PROTEOLYSIS; SEQUENCE ANALYSIS, DNA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84898775593     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402218111     Document Type: Article

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