The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation

Journal of Heart and Lung Transplantation

Volumn 34, Issue 9, 2015, Pages 1211-1214

  Richter, Manfred ^a   Lautze, Hans Jürgen ^b   Walther, Thomas ^a   Braun, Thomas ^c   Kostin, Sawa ^c   Kubin, Thomas ^c  

^a Department of Cardiac Surgery ^*  (Germany)

^b KERCKHOFF HEART CENTER   (Germany)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; ALPHA SMOOTH MUSCLE ACTIN; ATRIAL NATRIURETIC FACTOR; FIBROBLAST GROWTH FACTOR 23; MONOCYTE CHEMOTACTIC PROTEIN 1; ONCOSTATIN M; ONCOSTATIN M RECEPTOR; ONCOSTATIN M RECEPTOR BETA; RANTES; STAT3 PROTEIN; FIBROBLAST GROWTH FACTOR;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEOMICS; RAT; TRANSCRIPTOMICS; ANIMAL; BLOOD; CELL CULTURE; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; CELLS, CULTURED; FIBROBLAST GROWTH FACTORS; HEART FAILURE; HUMANS; MICE; RECEPTORS, ONCOSTATIN M;

EID: 84938929605     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2015.06.007     Document Type: Letter

References (5)

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2. Richter M. Oncostatin M induces FGF23 expression in cardiomyocytes. J Clin Exp Cardiol 2013.
3. J. Poling, P. Gajawada, M. Richter, and et al. Therapeutic targeting of the oncostatin M receptor-beta prevents inflammatory heart failure Basic Res Cardiol 109 2014 396
4. V.S. Tagliabracci, J.L. Engel, S.E. Wiley, and et al. Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis Proc Natl Acad Sci USA 111 2014 5520 5525
5. R. Goetz, Y. Nakada, M.C. Hu, and et al. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation Proc Natl Acad Sci USA 107 2010 407 412