Wnt/β-catenin signaling: A promising new target for fibrosis diseases

Physiological Research

Volumn 61, Issue 4, 2012, Pages 337-346

  Guo, Y ^a   Xiao, L ^a   Sun, L ^a   Liu, F ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Catenin; Fibrosis; MicroRNA; TGF ; Wnt

Indexed keywords

BETA CATENIN; MICRORNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; BIOLOGICAL MODEL; FIBROSIS; GENETICS; HUMAN; METABOLISM; REVIEW; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; FIBROSIS; HUMANS; MICRORNAS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; WNT SIGNALING PATHWAY;

EID: 84868650760     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. BAYLE J, FITCH J, JACOBSEN K, KUMAR R, LAFYATIS R, LEMAIRE R: Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol 128: 871-881, 2008.
2. BERGMANN C, AKHMETSHINA A, DEES C, PALUMBO K, ZERR P, BEYER C, ZWERINA J, DISTLER O, SCHETT G, DISTLER JH: Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway. Ann Rheum Dis 70: 2191-2198, 2011.
3. BIERNACKA A, DOBACZEWSKI M, FRANGOGIANNIS NG: TGF-beta signaling in fibrosis. Growth Factors 29: 196-202, 2011.
4. BOVOLENTA P, ESTEVE P, RUIZ JM, CISNEROS E, LOPEZ-RIOS J: Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 121: 737-746, 2008.
5. BRACK AS, CONBOY MJ, ROY S, LEE M, KUO CJ, KELLER C, RANDO TA: Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317: 807-810, 2007.
6. CADIGAN KM, LIU YI: Wnt signaling: complexity at the surface. J Cell Sci 119: 395-402, 2006.
7. CHENG JH, SHE H, HAN YP, WANG J, XIONG S, ASAHINA K, TSUKAMOTO H: Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 294: G39-G49, 2008.
8. CHENG SL, SHAO JS, HALSTEAD LR, DISTELHORST K, SIERRA O, TOWLER DA: Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res 107: 271-282, 2010.
9. CHEON SS, WEI Q, GURUNG A, YOUN A, BRIGHT T, POON R, WHETSTONE H, GUHA A, ALMAN BA: Betacatenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. Faseb J 20: 692-701, 2006.
10. CHIEN AJ, CONRAD WH, MOON RT: A Wnt survival guide: from flies to human disease. J Invest Dermatol 129: 1614-1627, 2009.
11. CHILOSI M, POLETTI V, ZAMO A, LESTANI M, MONTAGNA L, PICCOLI P, PEDRON S, BERTASO M, SCARPA A, MURER B, CANCELLIERI A, MAESTRO R, SEMENZATO G, DOGLIONI C: Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 162: 1495-1502, 2003.
12. CHO JH, GELINAS R, WANG K, ETHERIDGE A, PIPER MG, BATTE K, DAKHALLAH D, PRICE J, BORNMAN D, ZHANG S, MARSH C, GALAS D: Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes. BMC Med Genomics 4: 8, 2010.
13. CLEVERS H: Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480, 2006.
14. DAI C, STOLZ DB, KISS LP, MONGA SP, HOLZMAN LB, LIU Y: Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 20: 1997-2008, 2009.
15. EGER A, STOCKINGER A, PARK J, LANGKOPF E, MIKULA M, GOTZMANN J, MIKULITS W, BEUG H, FOISNER R: beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition. Oncogene 23: 2672-2680, 2004.
16. EMAMI KH, NGUYEN C, MA H, KIM DH, JEONG KW, EGUCHI M, MOON RT, TEO JL, KIM HY, MOON SH, HA JR, KAHN M: A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A 101: 12682-12687, 2004.
17. EZZIE ME, CRAWFORD M, CHO JH, ORELLANA R, ZHANG S, GELINAS R, BATTE K, YU L, NUOVO G, GALAS D, DIAZ P, WANG K, NANA-SINKAM SP: Gene expression networks in COPD: microRNA and mRNA regulation. Thorax 67: 122-131, 2010.
18. FRANKLIN TJ: Therapeutic approaches to organ fibrosis. Int J Biochem Cell Biol 29: 79-89, 1997.
19. GARDNER H, SHEARSTONE JR, BANDARU R, CROWELL T, LYNES M, TROJANOWSKA M, PANNU J, SMITH E, JABLONSKA S, BLASZCZYK M, TAN FK, MAYES MD: Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum 54: 1961-1973, 2006.
20. GRIGORYAN T, WEND P, KLAUS A, BIRCHMEIER W: Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev 22: 2308-2341, 2008.
21. HAO S, HE W, LI Y, DING H, HOU Y, NIE J, HOU FF, KAHN M, LIU Y: Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol 22: 1642-1653, 2011.
22. HE W, DAI C, LI Y, ZENG G, MONGA SP, LIU Y: Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 20: 765-776, 2009.
23. HE W, KANG YS, DAI C, LIU Y: Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 22: 90-103, 2011.
24. HE W, TAN RJ, LI Y, WANG D, NIE J, HOU FF, LIU Y: Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/beta-catenin activity in CKD. J Am Soc Nephrol 23: 294-304, 2012.
25. HEIKKILA E, JUHILA J, LASSILA M, MESSING M, PERALA N, LEHTONEN E, LEHTONEN S, SJEF VERBEEK J, HOLTHOFER H: beta-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys. Nephrol Dial Transplant 25: 2437-2446, 2010.
26. HENDERSON WR JR, CHI EY, YE X, NGUYEN C, TIEN YT, ZHOU B, BOROK Z, KNIGHT DA, KAHN M: Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A 107: 14309-14314, 2010.
27. HUANG H, HE X: Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol 20: 119-125, 2008.
28. JIANG F, PARSONS CJ, STEFANOVIC B: Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 45: 401-409, 2006.
29. KAMINSKI N, ROSAS IO: Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes? Proc Am Thorac Soc 3: 339-344, 2006
30. KATO N, SHIMMURA S, KAWAKITA T, MIYASHITA H, OGAWA Y, YOSHIDA S, HIGA K, OKANO H, TSUBOTA K: Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Invest Ophthalmol Vis Sci 48: 1511-1517, 2007.
31. KIM KK, WEI Y, SZEKERES C, KUGLER MC, WOLTERS PJ, HILL ML, FRANK JA, BRUMWELL AN, WHEELER SE, KREIDBERG JA, CHAPMAN HA: Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119: 213-224, 2009.
32. KIM TH, KIM SH, SEO JY, CHUNG H, KWAK HJ, LEE SK, YOON HJ, SHIN DH, PARK SS, SOHN JW: Blockade of the Wnt/beta-catenin pathway attenuates bleomycin-induced pulmonary fibrosis. Tohoku J Exp Med 223: 45-54, 2011.
33. KONIGSHOFF M, BALSARA N, PFAFF EM, KRAMER M, CHROBAK I, SEEGER W, EICKELBERG O: Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One 3: e2142, 2008.
34. LAM AP, FLOZAK AS, RUSSELL S, WEI J, JAIN M, MUTLU GM, BUDINGER GR, FEGHALI-BOSTWICK CA, VARGA J, GOTTARDI CJ: Nuclear {beta}-catenin is increased in ssc pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol, 45: 915-922, 2011.
35. LEPOURCELET M, CHEN YN, FRANCE DS, WANG H, CREWS P, PETERSEN F, BRUSEO C, WOOD AW, SHIVDASANI RA: Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 5: 91-102, 2004.
36. LI W, ZHU C, CHEN X, LI Y, GAO R, WU Q: Pokeweed antiviral protein down-regulates Wnt/beta-catenin signalling to attenuate liver fibrogenesis in vitro and in vivo. Dig Liver Dis 43: 559-566, 2011.
37. LIN CL, WANG JY, KO JY, HUANG YT, KUO YH, WANG FS: Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction. J Am Soc Nephrol 21: 124-135, 2010.
38. LIU L, CARRON B, YEE HT, YIE TA, HAJJOU M, ROM W: Wnt pathway in pulmonary fibrosis in the bleomycin mouse model. J Environ Pathol Toxicol Oncol 28: 99-108, 2009.
39. MACDONALD BT, SEMENOV MV, HE X: SnapShot: Wnt/beta-catenin signaling. Cell 131: 1204, 2007.
40. MAO B, WU W, DAVIDSON G, MARHOLD J, LI M, MECHLER BM, DELIUS H, HOPPE D, STANNEK P, WALTER C, GLINKA A, NIEHRS C: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417: 664-667, 2002.
41. MASSZI A, FAN L, ROSIVALL L, MCCULLOCH CA, ROTSTEIN OD, MUCSI I, KAPUS A: Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for betacatenin. Am J Pathol 165: 1955-1967, 2004.
42. MEDICI D, HAY ED, OLSEN BR: Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-Tcell factor-4-dependent expression of transforming growth factor-beta3. Mol Biol Cell 19: 4875-4887, 2008.
43. MYUNG SJ, YOON JH, GWAK GY, KIM W, LEE JH, KIM KM, SHIN CS, JANG JJ, LEE SH, LEE SM, LEE HS: Wnt signaling enhances the activation and survival of human hepatic stellate cells. FEBS Lett 581: 2954-2958, 2007.
44. NOBLE PW: Idiopathic pulmonary fibrosis. New insights into classification and pathogenesis usher in a new era therapeutic approaches. Am J Respir Cell Mol Biol 29: S27-S31, 2003.
45. PANDIT KV, MILOSEVIC J, KAMINSKI N: MicroRNAs in idiopathic pulmonary fibrosis. Transl Res 157: 191-199, 2011.
46. PFAFF EM, BECKER S, GUNTHER A, KONIGSHOFF M: Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis. Eur Respir J 37: 79-87, 2011.
47. SAADI-KHEDDOUCI S, BERREBI D, ROMAGNOLO B, CLUZEAUD F, PEUCHMAUR M, KAHN A, VANDEWALLE A, PERRET C: Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene. Oncogene 20: 5972-5981, 2001.
48. SATO M: Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. Acta Derm Venereol 86: 300-307, 2006.
49. SELMAN M, PARDO A, BARRERA L, ESTRADA A, WATSON SR, WILSON K, AZIZ N, KAMINSKI N, ZLOTNIK A: Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med 173: 188-198, 2006.
50. SELMAN M, PARDO A, KAMINSKI N: Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med 5: e62, 2008
51. SHAH S, ISLAM MN, DAKSHANAMURTHY S, RIZVI I, RAO M, HERRELL R, ZINSER G, VALRANCE M, ARANDA A, MORAS D, NORMAN A, WELSH J, BYERS SW: The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol Cell 21: 799-809, 2006.
52. SURENDRAN K, SCHIAVI S, HRUSKA KA: Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 16: 2373-2384, 2005.
53. SURENDRAN K, SIMON TC, LIAPIS H, MCGUIRE JK: Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Kidney Int 65: 2212-2222, 2004.
54. TRENSZ F, HAROUN S, CLOUTIER A, RICHTER MV, GRENIER G: A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway. Am J Physiol Cell Physiol 299: C939-C947, 2010.
55. VON TOERNE C, SCHMIDT C, ADAMS J, KISS E, BEDKE J, PORUBSKY S, GRETZ N, LINDENMEYER MT, COHEN CD, GRONE HJ, NELSON PJ: Wnt pathway regulation in chronic renal allograft damage. Am J Transplant 9: 2223-2239, 2009.
56. VON TOERNE C, BEDKE J, SAFI S, PORUBSKY S, GRETZ N, LOEWE R, NELSON PJ, GRONE HJ: Modulation of Wnt and Hedgehog Signaling Pathways Is Linked to Retinoic Acid-Induced Amelioration of Chronic Allograft Dysfunction. Am J Transplant 12: 55-68, 2012.
57. WANG D, DAI C, LI Y, LIU Y: Canonical Wnt/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria. Kidney Int 80: 1159-1169, 2011.
58. WEI J, BHATTACHARYYA S, TOURTELLOTTE WG, VARGA J: Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev 10: 267-275, 2011.
59. WEI J, MELICHIAN D, KOMURA K, HINCHCLIFF M, LAM AP, LAFYATIS R, GOTTARDI CJ, MACDOUGALD OA, VARGA J: Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum 63: 1707-1717, 2011
60. WILLIS BC, BOROK Z: TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293: L525-L534, 2007.
61. XIE T, LIANG J, GUO R, LIU N, NOBLE PW, JIANG D: Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation. Physiol Genomics 43: 479-487, 2011.
62. XIONG SD, YU K, LIU XH, YIN LH, KIRSCHENBAUM A, YAO S, NARLA G, DIFEO A, WU JB, YUAN Y, HO SM, LAM YW, LEVINE AC: Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells. Int J Cancer 125: 774-782, 2009.
63. ZHOU B, LIU Y, KAHN M, ANN DK, HAN A, WANG H, NGUYEN C, FLODBY P, ZHONG Q, KRISHNAVENI MS, LIEBLER JM, MINOO P, CRANDALL ED, BOROK Z: Interactions between beta-catenin and transforming growth factor-beta signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem 287: 7026-7038, 2012.