메뉴 건너뛰기




Volumn 8, Issue 5, 2012, Pages 276-286

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; PARATHYROID HORMONE; PHOSPHATE; VITAMIN D;

EID: 84859956031     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2011.218     Document Type: Review
Times cited : (220)

References (130)
  • 1
    • 77955035304 scopus 로고    scopus 로고
    • Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    • Ferron, M. et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142, 296-308 (2010).
    • (2010) Cell , vol.142 , pp. 296-308
    • Ferron, M.1
  • 2
    • 77955082747 scopus 로고    scopus 로고
    • Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
    • Fulzele, K. et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142, 309-319 (2010).
    • (2010) Cell , vol.142 , pp. 309-319
    • Fulzele, K.1
  • 3
    • 79959507054 scopus 로고    scopus 로고
    • GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo
    • Pi, M., Wu, Y. & Quarles, L. D. GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo. J. Bone Miner. Res. 26, 1680-1683 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 1680-1683
    • Pi, M.1    Wu, Y.2    Quarles, L.D.3
  • 4
    • 0141500265 scopus 로고    scopus 로고
    • Evidence for a bone-kidney axis regulating phosphate homeostasis
    • Quarles, L. D. Evidence for a bone-kidney axis regulating phosphate homeostasis. J. Clin. Invest. 112, 642-646 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 642-646
    • Quarles, L.D.1
  • 5
    • 38149134409 scopus 로고    scopus 로고
    • Functional evolutionary history of the mouse Fgf gene family
    • Itoh, N. & Ornitz, D. M. Functional evolutionary history of the mouse Fgf gene family. Dev. Dyn. 237, 18-27 (2008).
    • (2008) Dev. Dyn. , vol.237 , pp. 18-27
    • Itoh, N.1    Ornitz, D.M.2
  • 6
    • 0242443214 scopus 로고    scopus 로고
    • Integrative nuclear FGFR1 signaling (INFS) as a part of a universal "feed-forward-and-gate" signaling module that controls cell growth and differentiation
    • Stachowiak, M. K. et al. Integrative nuclear FGFR1 signaling (INFS) as a part of a universal "feed-forward-and-gate" signaling module that controls cell growth and differentiation. J. Cell. Biochem. 90, 662-691 (2003).
    • (2003) J. Cell. Biochem. , vol.90 , pp. 662-691
    • Stachowiak, M.K.1
  • 7
    • 0034703619 scopus 로고    scopus 로고
    • Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain
    • Yamashita, T., Yoshioka, M. & Itoh, N. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem. Biophys. Res. Commun. 277, 494-498 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 494-498
    • Yamashita, T.1    Yoshioka, M.2    Itoh, N.3
  • 8
    • 0141844575 scopus 로고    scopus 로고
    • Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX
    • Liu, S. et al. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J. Biol. Chem. 278, 37419-37426 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 37419-37426
    • Liu, S.1
  • 9
    • 33745850756 scopus 로고    scopus 로고
    • Pathogenic role of Fgf23 in Hyp mice
    • Liu, S. et al. Pathogenic role of Fgf23 in Hyp mice. Am. J. Physiol. Endocrinol. Metab. 291, E38-E49 (2006).
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Liu, S.1
  • 10
    • 34547267177 scopus 로고    scopus 로고
    • Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease
    • Stubbs, J., Liu, S. & Quarles, L. D. Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease. Semin. Dial. 20, 302-308 (2007).
    • (2007) Semin. Dial. , vol.20 , pp. 302-308
    • Stubbs, J.1    Liu, S.2    Quarles, L.D.3
  • 11
    • 33646578195 scopus 로고    scopus 로고
    • Regulation of fibroblast growth factor-23 signaling by klotho
    • Kurosu, H. et al. Regulation of fibroblast growth factor-23 signaling by klotho. J. Biol. Chem. 281, 6120-6123 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 6120-6123
    • Kurosu, H.1
  • 12
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • Urakawa, I. et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770-774 (2006).
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1
  • 13
    • 26844564690 scopus 로고    scopus 로고
    • Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23
    • Yu, X. et al. Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology 146, 4647-4656 (2005).
    • (2005) Endocrinology , vol.146 , pp. 4647-4656
    • Yu, X.1
  • 14
    • 79952161016 scopus 로고    scopus 로고
    • Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype
    • Li, H., Martin, A. C., David, V. & Quarles, L. D. Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype. Am. J. Physiol. Endocrinol. Metab. 300, E508-E517 (2010).
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.300
    • Li, H.1    Martin, A.C.2    David, V.3    Quarles, L.D.4
  • 15
    • 26844568409 scopus 로고    scopus 로고
    • Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism
    • Shimada, T. et al. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am. J. Physiol. Renal Physiol. 289, F1088-F1095 (2005).
    • (2005) Am. J. Physiol. Renal Physiol. , vol.289
    • Shimada, T.1
  • 16
    • 14344279878 scopus 로고    scopus 로고
    • Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
    • Shimada, T. et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl Acad. Sci. USA 98, 6500-6505 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 6500-6505
    • Shimada, T.1
  • 17
    • 9244240970 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders
    • Bai, X., Miao, D., Li, J., Goltzman, D. & Karaplis, A. C. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 145, 5269-5279 (2004).
    • (2004) Endocrinology , vol.145 , pp. 5269-5279
    • Bai, X.1    Miao, D.2    Li, J.3    Goltzman, D.4    Karaplis, A.C.5
  • 18
    • 3042634460 scopus 로고    scopus 로고
    • Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
    • Larsson, T. et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145, 3087-3094 (2004).
    • (2004) Endocrinology , vol.145 , pp. 3087-3094
    • Larsson, T.1
  • 19
    • 0036019481 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin
    • Fukumoto, S. & Yamashita, T. Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin. Curr. Opin. Nephrol. Hypertens. 11, 385-389 (2002).
    • (2002) Curr. Opin. Nephrol. Hypertens. , vol.11 , pp. 385-389
    • Fukumoto, S.1    Yamashita, T.2
  • 20
    • 1642416884 scopus 로고    scopus 로고
    • Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
    • Shimada, T. et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin. Invest. 113, 561-568 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 561-568
    • Shimada, T.1
  • 21
    • 0035186837 scopus 로고    scopus 로고
    • Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23
    • White, K. E. et al. Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Kidney Int. 60, 2079-2086 (2001).
    • (2001) Kidney Int. , vol.60 , pp. 2079-2086
    • White, K.E.1
  • 22
    • 76549112800 scopus 로고    scopus 로고
    • Relevant use of Klotho in FGF19 subfamily signaling system in vivo
    • Tomiyama, K. et al. Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc. Natl Acad. Sci. USA 107, 1666-1671 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 1666-1671
    • Tomiyama, K.1
  • 23
    • 0029943353 scopus 로고    scopus 로고
    • 3-24-hydroxylase, a multicatalytic enzyme
    • 3-24- hydroxylase, a multicatalytic enzyme. Biochemistry 35, 8465-8472 (1996).
    • (1996) Biochemistry , vol.35 , pp. 8465-8472
    • Beckman, M.J.1
  • 24
    • 1642480053 scopus 로고    scopus 로고
    • 3-1 α-hydroxylase knockout mice
    • 3-1 α-hydroxylase knockout mice. Kidney Int. 65, 531-539 (2004).
    • (2004) Kidney Int. , vol.65 , pp. 531-539
    • Hoenderop, J.G.1
  • 25
    • 4143096850 scopus 로고    scopus 로고
    • The genomic response of the mouse kidney to low-phosphate diet is altered in X-linked hypophosphatemia
    • Meyer, M. H., Dulde, E. & Meyer, R. A. Jr. The genomic response of the mouse kidney to low-phosphate diet is altered in X-linked hypophosphatemia. Physiol. Genomics 18, 4-11 (2004).
    • (2004) Physiol. Genomics , vol.18 , pp. 4-11
    • Meyer, M.H.1    Dulde, E.2    Meyer Jr., R.A.3
  • 26
    • 42449126730 scopus 로고    scopus 로고
    • Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23
    • Marsell, R. et al. Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23. Nephrol. Dial. Transplant. 23, 827-833 (2008).
    • (2008) Nephrol. Dial. Transplant. , vol.23 , pp. 827-833
    • Marsell, R.1
  • 27
    • 57449105957 scopus 로고    scopus 로고
    • Endocrine functions of bone in mineral metabolism regulation
    • Quarles, L. D. Endocrine functions of bone in mineral metabolism regulation. J. Clin. Invest. 118, 3820-3828 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 3820-3828
    • Quarles, L.D.1
  • 28
    • 13544270218 scopus 로고    scopus 로고
    • An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia
    • Benet-Pagès, A., Orlik, P., Strom, T. M. & Lorenz-Depiereux, B. An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum. Mol. Genet. 14, 385-390 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 385-390
    • Benet-Pagès, A.1    Orlik, P.2    Strom, T.M.3    Lorenz-Depiereux, B.4
  • 29
    • 23844457598 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed
    • Larsson, T. et al. Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed. Endocrinology 146, 3883-3891 (2005).
    • (2005) Endocrinology , vol.146 , pp. 3883-3891
    • Larsson, T.1
  • 30
    • 34247545717 scopus 로고    scopus 로고
    • Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals
    • Sitara, D. et al. Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Am. J. Pathol. 169, 2161-2170 (2006).
    • (2006) Am. J. Pathol. , vol.169 , pp. 2161-2170
    • Sitara, D.1
  • 31
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • Sitara, D. et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 23, 421-432 (2004).
    • (2004) Matrix Biol. , vol.23 , pp. 421-432
    • Sitara, D.1
  • 32
    • 33745828096 scopus 로고    scopus 로고
    • Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation
    • Kato, K. et al. Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. J. Biol. Chem. 281, 18370-18377 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 18370-18377
    • Kato, K.1
  • 33
    • 34249883939 scopus 로고    scopus 로고
    • How fibroblast growth factor 23 works
    • Liu, S. & Quarles, L. D. How fibroblast growth factor 23 works. J. Am. Soc. Nephrol. 18, 1637-1647 (2007).
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 1637-1647
    • Liu, S.1    Quarles, L.D.2
  • 34
    • 78650776871 scopus 로고    scopus 로고
    • Phylogenomics of phosphoinositide lipid kinases: Perspectives on the evolution of second messenger signaling and drug discovery
    • Brown, J. R. & Auger, K. R. Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery. BMC Evol. Biol. 11, 4 (2010).
    • (2010) BMC Evol. Biol. , vol.11 , pp. 4
    • Brown, J.R.1    Auger, K.R.2
  • 35
    • 76649095643 scopus 로고    scopus 로고
    • Familial tumoral calcinosis: From characterization of a rare phenotype to the pathogenesis of ectopic calcification
    • Sprecher, E. Familial tumoral calcinosis: from characterization of a rare phenotype to the pathogenesis of ectopic calcification. J. Invest. Dermatol. 130, 652-660 (2010).
    • (2010) J. Invest. Dermatol. , vol.130 , pp. 652-660
    • Sprecher, E.1
  • 36
    • 34047247196 scopus 로고    scopus 로고
    • Hypophosphatemic rickets in opsismodysplasia
    • Zeger, M. D. et al. Hypophosphatemic rickets in opsismodysplasia. J. Pediatr. Endocrinol. Metab. 20, 79-86 (2007).
    • (2007) J. Pediatr. Endocrinol. Metab. , vol.20 , pp. 79-86
    • Zeger, M.D.1
  • 37
    • 33645757920 scopus 로고    scopus 로고
    • Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    • Moe, S. et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 69, 1945-1953 (2006).
    • (2006) Kidney Int. , vol.69 , pp. 1945-1953
    • Moe, S.1
  • 38
    • 37149047561 scopus 로고    scopus 로고
    • Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
    • Liu, S., Tang, W., Zhou, J., Vierthaler, L. & Quarles, L. D. Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. Am. J. Physiol. Endocrinol. Metab. 293, E1636-E1644 (2007).
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Liu, S.1    Tang, W.2    Zhou, J.3    Vierthaler, L.4    Quarles, L.D.5
  • 39
    • 38849170631 scopus 로고    scopus 로고
    • Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia
    • Yuan, B. et al. Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. J. Clin. Invest. 118, 722-734 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 722-734
    • Yuan, B.1
  • 40
    • 0034805353 scopus 로고    scopus 로고
    • FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate
    • Bowe, A. E. et al. FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem. Biophys. Res. Commun. 284, 977-981 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.284 , pp. 977-981
    • Bowe, A.E.1
  • 41
    • 3242656464 scopus 로고    scopus 로고
    • FGF23 is processed by proprotein convertases but not by PHEX
    • Benet-Pagès, A. et al. FGF23 is processed by proprotein convertases but not by PHEX. Bone 35, 455-462 (2004).
    • (2004) Bone , vol.35 , pp. 455-462
    • Benet-Pagès, A.1
  • 43
    • 85047685774 scopus 로고    scopus 로고
    • Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: A perPHEXing problem
    • Quarles, L. D. & Drezner, M. K. Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: a perPHEXing problem. J. Clin. Endocrinol. Metab. 86, 494-496 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 494-496
    • Quarles, L.D.1    Drezner, M.K.2
  • 44
    • 33750454816 scopus 로고    scopus 로고
    • Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    • Feng, J. Q. et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat. Genet. 38, 1310-1315 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 1310-1315
    • Feng, J.Q.1
  • 45
    • 52649142085 scopus 로고    scopus 로고
    • Pathogenic role of Fgf23 in Dmp1-null mice
    • Liu, S. et al. Pathogenic role of Fgf23 in Dmp1-null mice. Am. J. Physiol. Endocrinol. Metab. 295, E254-E261 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295
    • Liu, S.1
  • 46
    • 80051940630 scopus 로고    scopus 로고
    • Dentin matrix protein 1 (DMP1) signals via cell surface integrin
    • Wu, H et al. Dentin matrix protein 1 (DMP1) signals via cell surface integrin. J. Biol. Chem. 286, 29462-29469 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 29462-29469
    • Wu, H.1
  • 47
    • 0347723963 scopus 로고    scopus 로고
    • Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1
    • Steiglitz, B. M., Ayala, M., Narayanan, K., George, A. & Greenspan, D. S. Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1. J. Biol. Chem. 279, 980-986 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 980-986
    • Steiglitz, B.M.1    Ayala, M.2    Narayanan, K.3    George, A.4    Greenspan, D.S.5
  • 48
    • 73449107721 scopus 로고    scopus 로고
    • MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell
    • Chaussain, C. et al. MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell. Eur. Cell. Mater. 18, 84-95 (2009).
    • (2009) Eur. Cell. Mater. , vol.18 , pp. 84-95
    • Chaussain, C.1
  • 49
    • 4644312298 scopus 로고    scopus 로고
    • Expression of SIBLINGs and their partner MMPs in salivary glands
    • Ogbureke, K. U. & Fisher, L. W. Expression of SIBLINGs and their partner MMPs in salivary glands. J. Dent. Res. 83, 664-670 (2004).
    • (2004) J. Dent. Res. , vol.83 , pp. 664-670
    • Ogbureke, K.U.1    Fisher, L.W.2
  • 50
    • 77953427179 scopus 로고    scopus 로고
    • ASARM mineralization hypothesis: A bridge too far?
    • David, V. & Quarles, L. D. ASARM mineralization hypothesis: a bridge too far? J. Bone Miner. Res. 25, 692-694 (2010).
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 692-694
    • David, V.1    Quarles, L.D.2
  • 51
    • 12244263475 scopus 로고    scopus 로고
    • Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression
    • Bai, X. et al. Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Mol. Endocrinol. 16, 2913-2925 (2002).
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2913-2925
    • Bai, X.1
  • 52
    • 20844431717 scopus 로고    scopus 로고
    • Overexpression of human PHEX under the human b-actin promoter does not fully rescue the Hyp mouse phenotype
    • Erben, R. G. et al. Overexpression of human PHEX under the human b-actin promoter does not fully rescue the Hyp mouse phenotype. J. Bone Miner. Res. 20, 1149-1160 (2005).
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 1149-1160
    • Erben, R.G.1
  • 53
    • 0036479315 scopus 로고    scopus 로고
    • Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype
    • Liu, S., Guo, R., Tu, Q. & Quarles, L. D. Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype. J. Biol. Chem. 277, 3686-3697 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 3686-3697
    • Liu, S.1    Guo, R.2    Tu, Q.3    Quarles, L.D.4
  • 54
    • 76049105171 scopus 로고    scopus 로고
    • Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets
    • Lorenz-Depiereux, B., Schnabel, D., Tiosano, D., Häusler, G. & Strom, T. M. Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets. Am. J. Hum. Genet. 86, 267-272 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 267-272
    • Lorenz-Depiereux, B.1    Schnabel, D.2    Tiosano, D.3    Häusler, G.4    Strom, T.M.5
  • 55
    • 76049121613 scopus 로고    scopus 로고
    • Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene
    • Levy-Litan, V. et al. Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene. Am. J. Hum. Genet. 86, 273-278 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 273-278
    • Levy-Litan, V.1
  • 56
    • 79551608437 scopus 로고    scopus 로고
    • Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD)
    • Chen, I. P., Wang, L., Jiang, X., Aguila, H. L. & Reichenberger, E. J. A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD). Hum. Mol. Genet. 20, 948-961 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 948-961
    • Chen, I.P.1    Wang, L.2    Jiang, X.3    Aguila, H.L.4    Reichenberger, E.J.A.5
  • 57
    • 69449107033 scopus 로고    scopus 로고
    • Novel regulators of Fgf23 expression and mineralization in Hyp bone
    • Liu, S. et al. Novel regulators of Fgf23 expression and mineralization in Hyp bone. Mol. Endocrinol. 23, 1505-1518 (2009).
    • (2009) Mol. Endocrinol. , vol.23 , pp. 1505-1518
    • Liu, S.1
  • 58
    • 60749133542 scopus 로고    scopus 로고
    • Peripheral vascular calcification in long-haemodialysis patients: Associated factors and survival consequences
    • Jean, G. et al. Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences. Nephrol. Dial. Transplant. 24, 948-955 (2009).
    • (2009) Nephrol. Dial. Transplant. , vol.24 , pp. 948-955
    • Jean, G.1
  • 59
    • 19944430581 scopus 로고    scopus 로고
    • Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation
    • White, K. E. et al. Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. Am. J. Hum. Genet. 76, 361-367 (2005).
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 361-367
    • White, K.E.1
  • 60
    • 10744227966 scopus 로고    scopus 로고
    • Thyroid hormone activates fibroblast growth factor receptor-1 in bone
    • Stevens, D. A. et al. Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol. Endocrinol. 17, 1751-1766 (2003).
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1751-1766
    • Stevens, D.A.1
  • 61
    • 80051687775 scopus 로고    scopus 로고
    • Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling
    • Martin, A. et al. Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J. 25, 2551-2562 (2011).
    • (2011) FASEB J. , vol.25 , pp. 2551-2562
    • Martin, A.1
  • 62
    • 80053211073 scopus 로고    scopus 로고
    • FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF23 signaling and regulating FGF23 expression in bone
    • Wohrle, S. et al. FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF23 signaling and regulating FGF23 expression in bone. J. Bone Miner. Res. 26, 2486-2497 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 2486-2497
    • Wohrle, S.1
  • 63
    • 77449129443 scopus 로고    scopus 로고
    • Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO
    • Xiao, L. et al. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. J. Biol. Chem. 285, 2834-2846 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 2834-2846
    • Xiao, L.1
  • 64
    • 0042838268 scopus 로고    scopus 로고
    • bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells
    • Nauman, E. A., Sakata, T., Keaveny, T. M., Halloran, B. P. & Bikle, D. D. bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calcif. Tissue Int. 73, 147-152 (2003).
    • (2003) Calcif. Tissue Int. , vol.73 , pp. 147-152
    • Nauman, E.A.1    Sakata, T.2    Keaveny, T.M.3    Halloran, B.P.4    Bikle, D.D.5
  • 65
    • 0033305507 scopus 로고    scopus 로고
    • Bone anabolic effects of basic fibroblast growth factor in ovariectomized rats
    • Liang, H., Pun, S. & Wronski, T. J. Bone anabolic effects of basic fibroblast growth factor in ovariectomized rats. Endocrinology 140, 5780-5788 (1999).
    • (1999) Endocrinology , vol.140 , pp. 5780-5788
    • Liang, H.1    Pun, S.2    Wronski, T.J.3
  • 66
    • 77957855494 scopus 로고    scopus 로고
    • Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term
    • Uzum, A. K. et al. Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term. Eur. J. Endocrinol. 163, 825-831 (2010).
    • (2010) Eur. J. Endocrinol. , vol.163 , pp. 825-831
    • Uzum, A.K.1
  • 67
    • 70350330869 scopus 로고    scopus 로고
    • Bone formation regulates circulating concentrations of fibroblast growth factor 23
    • Samadfam, R., Richard, C., Nguyen-Yamamoto, L., Bolivar, I. & Goltzman, D. Bone formation regulates circulating concentrations of fibroblast growth factor 23. Endocrinology 150, 4835-4845 (2009).
    • (2009) Endocrinology , vol.150 , pp. 4835-4845
    • Samadfam, R.1    Richard, C.2    Nguyen-Yamamoto, L.3    Bolivar, I.4    Goltzman, D.5
  • 69
    • 58149394434 scopus 로고    scopus 로고
    • Hypophosphatemia with elevations in serum fibroblast growth factor 23 in a child with Jansen's metaphyseal chondrodysplasia
    • Brown, W. W. et al. Hypophosphatemia with elevations in serum fibroblast growth factor 23 in a child with Jansen's metaphyseal chondrodysplasia. J. Clin. Endocrinol. Metab. 94, 17-20 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 17-20
    • Brown, W.W.1
  • 70
    • 80052303008 scopus 로고    scopus 로고
    • Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo
    • Rhee, Y. et al. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone 49, 636-643 (2011).
    • (2011) Bone , vol.49 , pp. 636-643
    • Rhee, Y.1
  • 71
    • 85047691059 scopus 로고    scopus 로고
    • FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting
    • Riminucci, M. et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J. Clin. Invest. 112, 683-692 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 683-692
    • Riminucci, M.1
  • 72
    • 33645405335 scopus 로고    scopus 로고
    • Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia
    • Kobayashi, K. et al. Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. Life Sci. 78, 2295-2301 (2006).
    • (2006) Life Sci. , vol.78 , pp. 2295-2301
    • Kobayashi, K.1
  • 73
    • 33646367420 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    • Liu, S. et al. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J. Am. Soc. Nephrol. 17, 1305-1315 (2006).
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 1305-1315
    • Liu, S.1
  • 74
    • 28444486604 scopus 로고    scopus 로고
    • 3 upregulates FGF23 gene expression in bone: The final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport
    • 3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G1036-G1042 (2005).
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.289
    • Kolek, O.I.1
  • 75
    • 8444223088 scopus 로고    scopus 로고
    • Bone as a source of FGF23: Regulation by phosphate?
    • Mirams, M., Robinson, B. G., Mason, R. S. & Nelson, A. E. Bone as a source of FGF23: regulation by phosphate? Bone 35, 1192-1199 (2004).
    • (2004) Bone , vol.35 , pp. 1192-1199
    • Mirams, M.1    Robinson, B.G.2    Mason, R.S.3    Nelson, A.E.4
  • 76
    • 33845322655 scopus 로고    scopus 로고
    • Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
    • Nishida, Y. et al. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int. 70, 2141-2147 (2006).
    • (2006) Kidney Int. , vol.70 , pp. 2141-2147
    • Nishida, Y.1
  • 77
    • 0344945402 scopus 로고    scopus 로고
    • Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers
    • Larsson, T., Nisbeth, U., Ljunggren, O., Jüppner, H. & Jonsson, K. B. Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int. 64, 2272-2279 (2003).
    • (2003) Kidney Int. , vol.64 , pp. 2272-2279
    • Larsson, T.1    Nisbeth, U.2    Ljunggren, O.3    Jüppner, H.4    Jonsson, K.B.5
  • 78
    • 79951895648 scopus 로고    scopus 로고
    • Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease
    • Moe, S. M. et al. Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. Clin. J. Am. Soc. Nephrol. 6, 257-264 (2011).
    • (2011) Clin. J. Am. Soc. Nephrol. , vol.6 , pp. 257-264
    • Moe, S.M.1
  • 79
    • 15944376583 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men
    • Ferrari, S. L., Bonjour, J. P. & Rizzoli, R. Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. J. Clin. Endocrinol. Metab. 90, 1519-1524 (2005).
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 1519-1524
    • Ferrari, S.L.1    Bonjour, J.P.2    Rizzoli, R.3
  • 80
    • 33746406756 scopus 로고    scopus 로고
    • Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
    • Burnett, S. A. et al. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J. Bone Miner. Res. 21, 1187-1196 (2006).
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 1187-1196
    • Burnett, S.A.1
  • 81
    • 79951926433 scopus 로고    scopus 로고
    • Effects of dietary phosphate and calcium intake on fibroblast growth factor-23
    • Vervloet, M. G. et al. Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. Clin. J. Am. Soc. Nephrol. 6, 383-389 (2011).
    • (2011) Clin. J. Am. Soc. Nephrol. , vol.6 , pp. 383-389
    • Vervloet, M.G.1
  • 82
    • 33747719260 scopus 로고    scopus 로고
    • Dietary phosphorus regulates serum fibroblast growth factor23 concentrations in healthy men
    • Antoniucci, D. M., Yamashita, T. & Portale, A. A. Dietary phosphorus regulates serum fibroblast growth factor23 concentrations in healthy men. J. Clin. Endocrinol. Metab. 91, 3144-3149 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 3144-3149
    • Antoniucci, D.M.1    Yamashita, T.2    Portale, A.A.3
  • 83
    • 27844501565 scopus 로고    scopus 로고
    • Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice
    • Perwad, F. et al. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 146, 5358-5364 (2005).
    • (2005) Endocrinology , vol.146 , pp. 5358-5364
    • Perwad, F.1
  • 84
    • 36849017126 scopus 로고    scopus 로고
    • The parathyroid is a target organ for FGF23 in rats
    • Ben-Dov, I. Z. et al. The parathyroid is a target organ for FGF23 in rats. J. Clin. Invest. 117, 4003-4008 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 4003-4008
    • Ben-Dov, I.Z.1
  • 85
    • 34948866160 scopus 로고    scopus 로고
    • Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism
    • Kawata, T. et al. Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J. Am. Soc. Nephrol. 18, 2683-2688 (2007).
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 2683-2688
    • Kawata, T.1
  • 86
    • 77957993384 scopus 로고    scopus 로고
    • PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: A bone parathyroid feedback loop
    • Lavi-Moshayoff, V., Wasserman, G., Meir, T., Silver, J. & Naveh-Many, T. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am. J. Physiol. Renal Physiol. 299, F882-F889 (2010).
    • (2010) Am. J. Physiol. Renal Physiol. , vol.299
    • Lavi-Moshayoff, V.1    Wasserman, G.2    Meir, T.3    Silver, J.4    Naveh-Many, T.5
  • 87
    • 4444308167 scopus 로고    scopus 로고
    • Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism
    • Sato, T. et al. Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism. Am. J. Kidney Dis. 44, 481-487 (2004).
    • (2004) Am. J. Kidney Dis. , vol.44 , pp. 481-487
    • Sato, T.1
  • 88
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o, M. et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390, 45-51 (1997).
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1
  • 89
    • 13844318061 scopus 로고    scopus 로고
    • Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice
    • Li, S. A. et al. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct. Funct. 29, 91-99 (2004).
    • (2004) Cell Struct. Funct. , vol.29 , pp. 91-99
    • Li, S.A.1
  • 90
    • 79955578020 scopus 로고    scopus 로고
    • PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
    • Rhee, Y. et al. PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J. Bone Miner. Res. 26, 1035-1046 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 1035-1046
    • Rhee, Y.1
  • 91
    • 74449094013 scopus 로고    scopus 로고
    • Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
    • Galitzer, H., Ben-Dov, I. Z., Silver, J. & Naveh-Many, T. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int. 77, 211-218 (2010).
    • (2010) Kidney Int. , vol.77 , pp. 211-218
    • Galitzer, H.1    Ben-Dov, I.Z.2    Silver, J.3    Naveh-Many, T.4
  • 92
    • 75749129364 scopus 로고    scopus 로고
    • FGF23-parathyroid interaction: Implications in chronic kidney disease
    • Komaba, H. & Fukagawa, M. FGF23-parathyroid interaction: implications in chronic kidney disease. Kidney Int. 77, 292-298 (2010).
    • (2010) Kidney Int. , vol.77 , pp. 292-298
    • Komaba, H.1    Fukagawa, M.2
  • 93
    • 78349288025 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 production in bone is directly regulated by 1α,25-dihydroxyvitamin D, but not PTH
    • Saji, F. et al. Fibroblast growth factor 23 production in bone is directly regulated by 1α,25-dihydroxyvitamin D, but not PTH. Am. J. Physiol. Renal Physiol. 299, F1212-F1217 (2010).
    • (2010) Am. J. Physiol. Renal Physiol. , vol.299
    • Saji, F.1
  • 94
    • 9644290893 scopus 로고    scopus 로고
    • Fibroblast growth factor 23, parathyroid hormone, and 1α,25-dihydroxyvitamin D in surgically treated primary hyperparathyroidism
    • Tebben, P. J., Singh, R. J., Clarke, B. L. & Kumar, R. Fibroblast growth factor 23, parathyroid hormone, and 1α,25-dihydroxyvitamin D in surgically treated primary hyperparathyroidism. Mayo Clin. Proc. 79, 1508-1513 (2004).
    • (2004) Mayo Clin. Proc. , vol.79 , pp. 1508-1513
    • Tebben, P.J.1    Singh, R.J.2    Clarke, B.L.3    Kumar, R.4
  • 95
    • 67649099265 scopus 로고    scopus 로고
    • Regulation of fibroblast growth factor 23 production in bone in uremic rats
    • Saji, F. et al. Regulation of fibroblast growth factor 23 production in bone in uremic rats. Nephron Physiol. 111, 59-66 (2009).
    • (2009) Nephron Physiol. , vol.111 , pp. 59-66
    • Saji, F.1
  • 96
    • 77955662315 scopus 로고    scopus 로고
    • Dysregulation of renal vitamin D metabolism in the uremic rat
    • Helvig, C. F. et al. Dysregulation of renal vitamin D metabolism in the uremic rat. Kidney Int. 78, 463-472 (2010).
    • (2010) Kidney Int. , vol.78 , pp. 463-472
    • Helvig, C.F.1
  • 97
    • 79953038259 scopus 로고    scopus 로고
    • The osteoblast: An insulin target cell controlling glucose homeostasis
    • Clemens, T. L. & Karsenty, G. The osteoblast: an insulin target cell controlling glucose homeostasis. J. Bone Miner. Res. 26, 677-680 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 677-680
    • Clemens, T.L.1    Karsenty, G.2
  • 98
    • 79958799468 scopus 로고    scopus 로고
    • Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3
    • Bhandaru, M. et al. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int. 80, 61-67 (2011).
    • (2011) Kidney Int. , vol.80 , pp. 61-67
    • Bhandaru, M.1
  • 99
    • 0346849707 scopus 로고    scopus 로고
    • Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
    • Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K. & Nabeshima, Y. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol. Endocrinol. 17, 2393-2403 (2003).
    • (2003) Mol. Endocrinol. , vol.17 , pp. 2393-2403
    • Tsujikawa, H.1    Kurotaki, Y.2    Fujimori, T.3    Fukuda, K.4    Nabeshima, Y.5
  • 100
    • 0032489424 scopus 로고    scopus 로고
    • Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein
    • Shiraki-Iida, T. et al. Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 424, 6-10 (1998).
    • (1998) FEBS Lett. , vol.424 , pp. 6-10
    • Shiraki-Iida, T.1
  • 101
    • 73749087404 scopus 로고    scopus 로고
    • Klotho
    • Kuro-o, M. Klotho. Pflugers Arch. 459, 333-343 (2010).
    • (2010) Pflugers Arch. , vol.459 , pp. 333-343
    • Kuro-o, M.1
  • 102
    • 0141525564 scopus 로고    scopus 로고
    • Serum FGF23 levels in normal and disordered phosphorus homeostasis
    • Weber, T. J., Liu, S., Indridason, O. S. & Quarles, L. D. Serum FGF23 levels in normal and disordered phosphorus homeostasis. J. Bone Miner. Res. 18, 1227-1234 (2003).
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 1227-1234
    • Weber, T.J.1    Liu, S.2    Indridason, O.S.3    Quarles, L.D.4
  • 103
    • 79551500014 scopus 로고    scopus 로고
    • Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease
    • Isakova, T. et al. Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease. Nephrol. Dial. Transplant. 26, 584-591 (2011).
    • (2011) Nephrol. Dial. Transplant. , vol.26 , pp. 584-591
    • Isakova, T.1
  • 104
    • 77749334660 scopus 로고    scopus 로고
    • Early control of PTH and FGF23 in normophosphatemic CKD patients: A new target in CKD-MBD therapy?
    • Oliveira, R. B. et al. Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy? Clin. J. Am. Soc. Nephrol. 5, 286-291 (2010).
    • (2010) Clin. J. Am. Soc. Nephrol. , vol.5 , pp. 286-291
    • Oliveira, R.B.1
  • 105
    • 31544450766 scopus 로고    scopus 로고
    • Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats
    • Nagano, N. et al. Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats. Kidney Int. 69, 531-537 (2006).
    • (2006) Kidney Int. , vol.69 , pp. 531-537
    • Nagano, N.1
  • 106
    • 19944433609 scopus 로고    scopus 로고
    • Circulating FGF-23 is regulated by 1α,25-dihydroxyvitamin D3 and phosphorus in vivo
    • Saito, H. et al. Circulating FGF-23 is regulated by 1α,25- dihydroxyvitamin D3 and phosphorus in vivo. J. Biol. Chem. 280, 2543-2549 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 2543-2549
    • Saito, H.1
  • 107
    • 49649122544 scopus 로고    scopus 로고
    • Direct binding of integrin αvβ3 to FGF1 plays a role in FGF1 signaling
    • Mori, S. et al. Direct binding of integrin αvβ3 to FGF1 plays a role in FGF1 signaling. J. Biol. Chem. 283, 18066-18075 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 18066-18075
    • Mori, S.1
  • 108
    • 0036384265 scopus 로고    scopus 로고
    • Inhibition of MEPE cleavage by Phex
    • Guo, R. et al. Inhibition of MEPE cleavage by Phex. Biochem. Biophys. Res. Commun. 297, 38-45 (2002).
    • (2002) Biochem. Biophys. Res. Commun. , vol.297 , pp. 38-45
    • Guo, R.1
  • 109
    • 12344250943 scopus 로고    scopus 로고
    • Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: A model for impaired mineralization in X-linked rickets (HYP)
    • Rowe, P. S. et al. Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP). Bone 36, 33-46 (2005).
    • (2005) Bone , vol.36 , pp. 33-46
    • Rowe, P.S.1
  • 110
    • 33846938087 scopus 로고    scopus 로고
    • Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo
    • Lu, Y. et al. Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Dev. Biol. 303, 191-201 (2007).
    • (2007) Dev. Biol. , vol.303 , pp. 191-201
    • Lu, Y.1
  • 111
    • 75149115329 scopus 로고    scopus 로고
    • FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts
    • Rached, M. T. et al. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab. 11, 147-160 (2010).
    • (2010) Cell Metab. , vol.11 , pp. 147-160
    • Rached, M.T.1
  • 112
    • 2642546399 scopus 로고    scopus 로고
    • Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis
    • Topaz, O. et al. Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat. Genet. 36, 579-581 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 579-581
    • Topaz, O.1
  • 113
    • 43749088566 scopus 로고    scopus 로고
    • A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
    • Ichikawa, S. et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J. Musculoskelet. Neuronal Interact. 7, 318-319 (2007).
    • (2007) J. Musculoskelet. Neuronal Interact. , vol.7 , pp. 318-319
    • Ichikawa, S.1
  • 114
    • 57749208909 scopus 로고    scopus 로고
    • Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: Time for a paradigm shift?
    • Wetmore, J. B. & Quarles, L. D. Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift? Nat. Clin. Pract. Nephrol. 5, 24-33 (2009).
    • (2009) Nat. Clin. Pract. Nephrol. , vol.5 , pp. 24-33
    • Wetmore, J.B.1    Quarles, L.D.2
  • 115
    • 33750576187 scopus 로고    scopus 로고
    • Mortality risk among hemodialysis patients receiving different vitamin D analogs
    • Tentori, F. et al. Mortality risk among hemodialysis patients receiving different vitamin D analogs. Kidney Int. 70, 1858-1865 (2006).
    • (2006) Kidney Int. , vol.70 , pp. 1858-1865
    • Tentori, F.1
  • 116
    • 5644225678 scopus 로고    scopus 로고
    • Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    • Young, E. W. et al. Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am. J. Kidney Dis. 44 (Suppl.), 34-38 (2004).
    • (2004) Am. J. Kidney Dis. , vol.44 , Issue.SUPPL. , pp. 34-38
    • Young, E.W.1
  • 118
    • 3543139492 scopus 로고    scopus 로고
    • Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    • Block, G. A. et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J. Am. Soc. Nephrol. 15, 2208-2218 (2004).
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 2208-2218
    • Block, G.A.1
  • 119
    • 49249104701 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    • Gutiérrez, O. M. et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N. Engl. J. Med. 359, 584-592 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 584-592
    • Gutiérrez, O.M.1
  • 120
    • 27744545673 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
    • Gutierrez, O. et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J. Am. Soc. Nephrol. 16, 2205-2215 (2005).
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 2205-2215
    • Gutierrez, O.1
  • 121
    • 78049463249 scopus 로고    scopus 로고
    • Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease
    • Hasegawa, H. et al. Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int. 78, 975-980 (2010).
    • (2010) Kidney Int. , vol.78 , pp. 975-980
    • Hasegawa, H.1
  • 122
    • 2342481131 scopus 로고    scopus 로고
    • FGF-23 in patients with end-stage renal disease on hemodialysis
    • Imanishi, Y. et al. FGF-23 in patients with end-stage renal disease on hemodialysis. Kidney Int. 65, 1943-1946 (2004).
    • (2004) Kidney Int. , vol.65 , pp. 1943-1946
    • Imanishi, Y.1
  • 123
    • 69849099560 scopus 로고    scopus 로고
    • Fibroblast growth factor 23: Uremic toxin or innocent bystander in chronic kidney disease?
    • Stubbs, J. R. & Quarles, L. D. Fibroblast growth factor 23: uremic toxin or innocent bystander in chronic kidney disease? Nephrol. News Issues 23, 33-34 (2009).
    • (2009) Nephrol. News Issues , vol.23 , pp. 33-34
    • Stubbs, J.R.1    Quarles, L.D.2
  • 124
    • 77949378067 scopus 로고    scopus 로고
    • Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD
    • Stubbs, J. R., Idiculla, A., Slusser, J., Menard, R. & Quarles, L. D. Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD. J. Am. Soc. Nephrol. 21, 353-361 (2010).
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 353-361
    • Stubbs, J.R.1    Idiculla, A.2    Slusser, J.3    Menard, R.4    Quarles, L.D.5
  • 125
    • 79953737375 scopus 로고    scopus 로고
    • The bone and beyond: 'Dem bones' are made for more than walking
    • Quarles, L. D. The bone and beyond: 'Dem bones' are made for more than walking. Nat. Med. 17, 428-430 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 428-430
    • Quarles, L.D.1
  • 126
  • 127
    • 79952148734 scopus 로고    scopus 로고
    • Clinical practice. Vitamin D insufficiency
    • Rosen, C. J. Clinical practice. Vitamin D insufficiency. N. Engl. J. Med. 364, 248-254 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 248-254
    • Rosen, C.J.1
  • 128
    • 77952996999 scopus 로고    scopus 로고
    • The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: The Heart and Soul Study
    • Parker, B. D. et al. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann. Intern. Med. 152, 640-648 (2010).
    • (2010) Ann. Intern. Med. , vol.152 , pp. 640-648
    • Parker, B.D.1
  • 129
    • 34548497123 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: The Mild to Moderate Kidney Disease (MMKD) Study
    • Fliser, D. et al. Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study. J. Am. Soc. Nephrol. 18, 2600-2608 (2007).
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 2600-2608
    • Fliser, D.1
  • 130
    • 78650889020 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-23 is associated with fat mass and dyslipidemia in two independent cohorts of elderly individuals
    • Mirza, M. A. et al. Circulating fibroblast growth factor-23 is associated with fat mass and dyslipidemia in two independent cohorts of elderly individuals. Arterioscler. Thromb. Vasc. Biol. 31, 219-227 (2011).
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 219-227
    • Mirza, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.