Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155

Cell Reports

Volumn 23, Issue 7, 2018, Pages 2142-2156

  Stelekati, Erietta ^a   Chen, Zeyu ^a   Manne, Sasikanth ^a   Kurachi, Makoto ^a   Ali, Mohammed Alkhatim ^a   Lewy, Keith ^a   Cai, Zhangying ^a,b   Nzingha, Kito ^a   McLane, Laura M ^a   Hope, Jennifer L ^c,d   Fike, Adam J ^c   Katsikis, Peter D ^d   Wherry, E John ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PEKING UNIVERSITY   (China)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

CD8 T cell; checkpoint blockade; chronic infection; exhaustion; microRNA; miR155; PD 1; T cell exhaustion

Indexed keywords

CYTOKINE; MICRORNA 155; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; FOSL2 PROTEIN, MOUSE; MICRORNA; MIRN155 MICRORNA, MOUSE; TRANSCRIPTION FACTOR FRA 2;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; BLAST CELL; CD8+ T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOSTIMULATION; INFECTION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC DISEASE; COMMUNICABLE DISEASE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM; PATHOLOGY; PHENOTYPE; TIME FACTOR;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC DISEASE; COMMUNICABLE DISEASES; FOS-RELATED ANTIGEN-2; GENE EXPRESSION REGULATION; LYMPHOCYTE SUBSETS; MICE, INBRED C57BL; MICRORNAS; PHENOTYPE; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 85047145332     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2018.04.038     Document Type: Article

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