Mir-155, a central modulator of T-cell responses

European Journal of Immunology

Volumn 44, Issue 1, 2014, Pages 11-15

  Lind, Evan F ^a,b   Ohashi, Pamela S ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

CD8 T cells; Cellular activation; Immune responses; Mir 155

Indexed keywords

MICRORNA 155;

ARTICLE; AUTOIMMUNITY; BASE PAIRING; GENE EXPRESSION PROFILING; HUMAN; INFECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; TUMOR IMMUNITY;

ANIMALS; ANTIGENS, NEOPLASM; AUTOIMMUNITY; GENOME; HUMANS; IMMUNITY, CELLULAR; IMMUNOMODULATION; INFECTION; MICE; MICRORNAS; NEOPLASMS; T-LYMPHOCYTES;

EID: 84892452073     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343962     Document Type: Article

References (41)

1. Clurman, B. E. and Hayward, W. S., Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. Mol. Cell Biol. 1989. 9: 2657-2664.
2. Tam, W., Ben-Yehuda, D. and Hayward, W. S., bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA. Mol. Cell Biol. 1997. 17: 1490-1502.
3. Eis, P. S., Tam, W., Sun, L., Chadburn, A., Li, Z., Gomez, M. F., Lund, E. et al., Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. U. S. A. 2005. 102: 3627-3632.
4. Kluiver, J., Poppema, S., de Jong, D., Blokzijl, T., Harms, G., Jacobs, S., Kroesen, B. J. et al., BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J. Pathol. 2005. 207: 243-249.
5. Costinean, S., Zanesi, N., Pekarsky, Y., Tili, E., Volinia, S., Heerema, N. and Croce, C. M., Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 2006. 103: 7024-7029.
6. Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S. et al., Requirement of bic/microRNA-155 for normal immune function. Science 2007. 316: 608-611.
7. Thai, T. H., Calado, D. P., Casola, S., Ansel, K. M., Xiao, C., Xue, Y., Murphy, A. et al., Regulation of the germinal center response by microRNA-155. Science 2007. 316: 604-608.
8. Gracias, D. T., Stelekati, E., Hope, J. L., Boesteanu, A. C., Doering, T. A., Norton, J., Mueller, Y. M. et al., The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat. Immunol. 2013. 14: 593-602.
9. Dudda, J. C., Salaun, B., Ji, Y., Palmer, D. C., Monnot, G. C., Merck, E., Boudousquie, C. et al., MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity 2013. 38: 742-753.
10. Kim, J. I., Ho, I. C., Grusby, M. J. and Glimcher, L. H., The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 1999. 10: 745-751.
11. Banerjee, A., Schambach, F., DeJong, C. S., Hammond, S. M. and Reiner, S. L., Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur. J. Immunol. 2010. 40: 225-231.
12. Lu, L. F., Thai, T. H., Calado, D. P., Chaudhry, A., Kubo, M., Tanaka, K., Loeb, G. B. et al., Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 2009. 30: 80-91.
13. Kohlhaas, S., Garden, O. A., Scudamore, C., Turner, M., Okkenhaug, K. and Vigorito, E., Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J. Immunol. 2009. 182: 2578-2582.
14. Junker, A., Krumbholz, M., Eisele, S., Mohan, H., Augstein, F., Bittner, R., Lassmann, H. et al., MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 2009. 132: 3342-3352.
15. Stanczyk, J., Pedrioli, D. M., Brentano, F., Sanchez-Pernaute, O., Kolling, C., Gay, R. E., Detmar, M. et al., Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum. 2008. 58: 1001-1009.
16. Sonkoly, E., Janson, P., Majuri, M. L., Savinko, T., Fyhrquist, N., Eidsmo, L., Xu, N. et al., MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J. Allergy Clin. Immunol. 2010. 126: 581-589, e581-520.
17. Croxford, A. L., Mair, F. and Becher, B., IL-23: One cytokine in control of autoimmunity. Eur. J. Immunol. 2012. 42: 2263-2273.
18. O'Connell, R. M., Kahn, D., Gibson, W. S., Round, J. L., Scholz, R. L., Chaudhuri, A. A., Kahn, M. E. et al., MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 2010. 33: 607-619.
19. Murugaiyan, G., Beynon, V., Mittal, A., Joller, N. and Weiner, H. L., Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J. Immunol. 2011. 187: 2213-2221.
20. Hu, R., Huffaker, T. B., Kagele, D. A., Runtsch, M. C., Bake, E., Chaudhuri, A. A., Round, J. L. et al., MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression. J. Immunol. 2013. 190: 5972-5980.
21. Yao, R., Ma, Y. L., Liang, W., Li, H. H., Ma, Z. J., Yu, X. and Liao, Y. H., MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS One 2012. 7: e46082.
22. Bluml, S., Bonelli, M., Niederreiter, B., Puchner, A., Mayr, G., Hayer, S., Koenders, M. I. et al., Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum. 2011. 63: 1281-1288.
23. Moisan, J., Grenningloh, R., Bettelli, E., Oukka, M. and Ho, I. C., Ets-1 is a negative regulator of Th17 differentiation. J. Exp. Med. 2007. 204: 2825-2835.
24. Chen, Z., Laurence, A. and O'Shea, J. J., Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin. Immunol. 2007. 19: 400-408.
25. Haak, S., Croxford, A. L., Kreymborg, K., Heppner, F. L., Pouly, S., Becher, B. and Waisman, A., IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 2009. 119: 61-69.
26. Huffaker, T. B., Hu, R., Runtsch, M. C., Bake, E., Chen, X., Zhao, J., Round, J. L. et al., Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity. Cell Rep. 2012. 2: 1697-1709.
27. O'Connell, R. M., Chaudhuri, A. A., Rao, D. S. and Baltimore, D., Inositol phosphatase SHIP1 is a primary target of miR-155. Proc. Natl. Acad. Sci. U. S. A. 2009. 106: 7113-7118.
28. Tarasenko, T., Kole, H. K., Chi, A. W., Mentink-Kane, M. M., Wynn, T. A. and Bolland, S., T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc. Natl. Acad. Sci. U. S. A. 2007. 104: 11382-11387.
29. Oertli, M., Engler, D. B., Kohler, E., Koch, M., Meyer, T. F. and Muller, A., MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis. J. Immunol. 2011. 187: 3578-3586.
30. Tsai, C. Y., Allie, S. R., Zhang, W. and Usherwood, E. J., MicroRNA miR-155 affects antiviral effector and effector memory CD8 T cell differentiation. J. Virol. 2013. 87: 2348-2351.
31. Lind, E. F., Elford, A. R. and Ohashi, P. S., Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges. J. Immunol. 2013. 190: 1210-1216.
32. Lefrancois, L. and Obar, J. J., Once a killer, always a killer: from cytotoxic T cell to memory cell. Immunol. Rev. 2010. 235: 206-218.
33. Cui, W., Liu, Y., Weinstein, J. S., Craft, J. and Kaech, S. M., An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 2011. 35: 792-805.
34. Obar, J. J. and Lefrancois, L., Early events governing memory CD8+ T-cell differentiation. Int. Immunol. 2010. 22: 619-625.
35. Lefrancois, L., Development, trafficking, and function of memory T-cell subsets. Immunol. Rev. 2006. 211: 93-103.
36. Wu, T., Wieland, A., Araki, K., Davis, C. W., Ye, L., Hale, J. S. and Ahmed, R., Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proc. Natl. Acad. Sci. U. S. A. 2007. 109: 9965-9970.
37. Wu, H., Neilson, J. R., Kumar, P., Manocha, M., Shankar, P., Sharp, P. A. and Manjunath, N., miRNA profiling of naive, effector and memory CD8 T cells. PLoS One 2007. 2: e1020.
38. Salaun, B., Yamamoto, T., Badran, B., Tsunetsugu-Yokota, Y., Roux, A., Baitsch, L., Rouas, R. et al., Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets. J. Transl. Med. 2011. 9: 44-52.
39. Almanza, G., Fernandez, A., Volinia, S., Cortez-Gonzalez, X., Croce, C. M. and Zanetti, M., Selected microRNAs define cell fate determination of murine central memory CD8 T cells. PLoS One 2010. 5: e11243.
40. Huang, X., Shen, Y., Liu, M., Bi, C., Jiang, C., Iqbal, J., McKeithan, T. W. et al., Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma. Am. J. Pathol. 2012. 181: 26-33.
41. Cremer, T. J., Ravneberg, D. H., Clay, C. D., Piper-Hunter, M. G., Marsh, C. B., Elton, T. S., Gunn, J. S. et al., MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One 2009. 4: e8508.