Epicatechin potentiation of glucose-stimulated insulin secretion in INS-1 cells is not dependent on its antioxidant activity

Acta Pharmacologica Sinica

Volumn 39, Issue 5, 2018, Pages 893-902

  Yang, Kaiyuan ^a   Chan, Catherine B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

CaMKII signaling pathway; epicatechin; flavonoids; GPR40; GW1100; hyperglycemia; insulin secretion; KN 93; oxidative stress

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; EPICATECHIN; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; BENZOIC ACID; BENZYLAMINE DERIVATIVE; CATECHIN; FATTY ACID; G PROTEIN COUPLED RECEPTOR; G-PROTEIN-COUPLED RECEPTOR 40, RAT; GW1100; HYDROGEN PEROXIDE; LIGAND; PYRIMIDINE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HYPERGLYCEMIA; IN VITRO STUDY; INS-1 CELL LINE; INSULIN RELEASE; INTRACELLULAR SIGNALING; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DOSE RESPONSE; DRUG EFFECT; METABOLISM; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; BENZOATES; BENZYLAMINES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CATECHIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; GLUCOSE; HYDROGEN PEROXIDE; INSULIN; INSULIN-SECRETING CELLS; LIGANDS; PYRIMIDINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 85046643848     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2017.174     Document Type: Article

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